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A case of laparoscopic hepatectomy for recurrent hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第4期16卷 526-530页

作者： Tan To Cheung kelvin kwok-chai ng Ronnie Tung-ping Poon See Ching Chan Chung Mau Lo Sheung Tat Fan Department of Surgery The University of Hong Kong 102 PokFu Lam RoadQueen Mary HospitalHong Kong China

Conventional hepatectomy is an effective way to treat hepatocellular ***,it is invasive and *** use of laparoscopy in hepatectomy,while technically demanding,reduces surgical invasiveness and stressfulness but still achieves complete resection with adequate *** with conventional hepatectomy,laparoscopic hepatectomy provides a better chance and situation for further surgery in the case of recurrence of hepatocellular *** aged patients can successfully endure repeated hepatectomy using laparoscopy,as shown in the present *** report presents a case of repeated laparoscopic hepatectomy treating hepatocellular carcinoma and its recurrence in an aged patient having cirrhosis,a disease causing extra difficulty for performing laparoscopic *** report also describes techniques of the operation and displays characteristic results of laparoscopic hepatectomy such as smaller wounds,less blood loss,less pain,less scars and adhesion,shorter postoperative hospital stay,and faster recovery.

关键词： Hepatocellular carcinoma Laparoscopic resection Recurrent hepatocellular carcinoma Elderly Hepatectomy

A novel non-invasive model to predict high-risk varices in cirrhotic patients

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 530-532页

作者： kelvin K.C.ng Department of Surgery The Chinese University of Hong Kong Medical CentreHong KongChina

Acute variceal bleeding is one of the most common and potentially life-threatening complications in patients with liver *** is conventionally diagnosed by oesophagogastroduodenoscopy,which is invasive to patients and carries hospital *** would be more cost-effective if non-invasive tests could screen out high-risk patients who developed acute variceal bleeding requiring endoscopic *** can potentially reduce the need for invasive procedures for cirrhotic *** recent years,there have been advancements in non-invasive methods for assessing the risk of variceal *** include transient elastography(FibroScan)of the liver and spleen,platelet count,imaging modalities[ultrasound or magnetic resonance imaging(MRI)],and non-invasive liver function tests[Child-Pugh score or the Model for End-Stage Liver Disease(MELD)score].The 2015 Baveno VI consensus is developed by an international panel of experts to improve the diagnosis and management of portal hypertension and its complications,specifically focusing on variceal bleeding in patients with cirrhosis(1).The consensus emphasizes using noninvasive methods to screen out high-risk varices(HRV)requiring therapeutic *** key features of the Baveno VI criteria include a liver stiffness measurement(LSM)150,000/*** can confidently rule out *** has been proven to avoid unnecessary endoscopy up to 40%with a specificity of up to 46%(2).In recent years,spleen stiffness measurement(SSM)has been a useful tool to assess portal hypertension and to predict ***,the revised Baveno VII consensus in 2022 recommends SSM≤40 kPa would avoid more unnecessary endoscopy in patients who fall outside Baveno VI criteria,with a missed HRV rate of<5%(3).

关键词： Non-invasive model high-risk varices cirrhosis

Mg/MgO interfaces as efficient hydrogen evolution cathodes causing accelerated corrosion of additive manufactured Mg alloys:A DFT analysis

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Journal of Magnesium and Alloys 2024年第1期12卷 110-119页

作者： Man-Fai ng Kai Xiang Kuah Teck Leong Tan Daniel John Blackwood Department of Materials Science&Engineering National University of Singapore9 Engineering Drive 1Singapore 117575Republic of Singapore Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A∗STAR)1 Fusionopolis Way#16-16 ConnexisSingapore 138632Republic of Singapore

The corrosion rates of additive-manufactured Mg alloys are higher than their as-cast counterparts,possibly due to increased kinetics for the hydrogen evolution reaction on secondary phases,which may include oxide *** kelvin Probe Force Microscopy demonstrated that MgO inclusions could act as cathodes for Mg corrosion,but their low conductivity likely precludes ***,the density of state calculations through density functional theory using hybrid HSE06 functional revealed overlapping electronic states at the Mg/MgO interface,which facilitates electron transfers and participates in redox *** determination of the hydrogen absorption energy at the Mg/MgO interface reveals it to be an excellent catalytic site,with HER being found to be a factor of 23x more efficient at the interface than on metallic *** results not only support the plausibility of the Mg/MgO interface being an effective cathode to the adjacent anodic Mg matrix during corrosion but also contribute to the understanding of the enhanced cathodic activities observed during the anodic dissolution of magnesium.

关键词： Magnesium Magnesium oxide Interface Hydrogen evolution DFT

Heterogeneous numerical modelling for the auto thermal reforming of crude glycerol in a fixed bed reactor

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Chinese Journal of Chemical Engineering 2022年第2期35卷 261-268页

作者： Jason Williams Hussameldin Ibrahim Nima Karimi kelvin Tsun Wai ng Clean Energy Technologies Research Institute Process Systems EngineeringFaculty of Engineering and Applied ScienceUniversity of ReginaRegina SK S4S 0A2Canada Environmental Systems Engineering Faculty of Engineering and Applied ScienceUniversity of ReginaRegina SK S4S 0A2Canada

A mathematical model for the catalytic autothermal reforming(ATR)reaction of synthetic crude glycerol to hydrogen in a fixed bed tubular reactor(FBTR)and over an in-house developed metal oxide catalyst is presented in this *** heterogeneous model equations account for a two-phase system of solid catalyst and bulk feed ***,the ATR of crude glycerol reaction scheme and intrinsic kinetic rate model over an active,selective,and stable nickel-based catalyst were integrated in the developed ***,the model was validated using experimental data generated in our labs for the ATR of synthetic crude *** modelling results adequately described the detailed gas product composition and distribution,temperature profiles,and conversion propagation in the axial direction of the fixed bed reactor over a wide range of reaction temperature(773–923 K)and mass-time(12.71–158.23 g cat·min·(mol C)^(-1)).The crude glycerol conversion predicted with the model showing a close resemblance to those obtained experimentally with an average absolute deviation(AAD)of less than 8%.The maximum crude glycerol conversion and hydrogen yield were found to be 92%and 3 mol hydrogen/mol crude glycerol,***,the gas product concentration profile in the reactor was adequately described(90%)accuracy with a hydrogen concentration of 39%(volume).

关键词： Hydrogen crude glycerol Autothermal reforming Numerical analysis Fixed-bed reactor

Fabrication of three-dimensional islet models by geometry-controlled hanging drop method

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Acta Mechanica Sinica 2019年第2期35卷 329-337页

作者： Bin Gao Ce Jing kelvin ng Belinda Pingguan-Murphy Qingzhen Yang Department of Endocrinology and Metabolism The First Affiliated Hospital Air Force Military Medical University Xi’an 710032 China Outpatient Department of Lanzhou Military Region 940 Hospital Joint Logistics Support Force of the People's Liberation Army of China Lanzhou 730000 China Department of Biomedical Engineering Faculty of Engineering University of Malaya Kuala Lumpur 50603 Malaysia Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 China Bioinspired Engineering and Biomechanics Center (BEBC) Xi’an Jiaotong University Xi’an 710049 China

Hanging-drop method has been widely used to fabricate three-dimensional (3D) in vitro tissue models due to its advantages such as being easy to perform, inexpensive, and permitting precise control of cell spheroid formation. The geometry of hanging drop may play a critical role on the formation of cell spheroids, which, however, has not been explored. In this study, we developed a modified hanging-drop platform that enables the production of cell spheroids in a high-throughput manner by controlling hanging drop geometry with defined spreading ring. The surface tension force is proportional to the spreading ring and gravitational force is determined by the droplet volume, and the geometry can be determined by the balance between surface tension and gravity.β-TC-6 cell spheroids with optimized diameters were fabricated as 3D in vitro islet models. The models show morphology similar to primary islets and have functionality that more closely resembles primary islets than two-dimensional cell culture. The developed platform holds great potential for engineering well-controlled in vitro tissue models for various applications such as physiological and pathological studies, drug screening, as well as transplantation for treatment purpose.

关键词： Hanging drop cell culture Mechanical microenvironment Drop geometry 3D islet spheroids

You shall never walk alone:burnout and depression amongst healthcare professionals

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 678-681页

作者： kelvin Lin Chieh ng Chen Liu Institute of Mental Health SingaporeSingapore United Family Hospital BeijingChina

There are two stages of tsunami,first is the earthquake in deep sea,followed by *** are three waves of pandemic,the death toll,economic and social disruption,and a psychological storm that is looming in the distance *** this time of worldwide COVID-19 pandemic,to date,we have seen over 200 million cases worldwide,and the death toll is in excess of 4 million,and there are various news reports coming in about devastating economic and social ***,numerous studies report that the public,as well as the healthcare professionals are at heightened risk mental health problems in the short and longer term from pandemic.

关键词： storm earthquake alone

What have we known so far about microplastics in drinking water treatment?A timely review

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Frontiers of Environmental Science & Engineering 2022年第5期16卷 39-56页

作者： Jinkai Xue Seyed Hesam-Aldin Samaei Jianfei Chen Ariana Doucet kelvin Tsun Wai ng Environmental Systems Engineering Faculty of Engineering&Applied ScienceUniversity of Regina3737 Wascana ParkwayRegina SK S4S 0A2Canada

Microplastics(MPs)have been widely detected in drinking water sources and tap water,raising the concern of the effectiveness of drinking water treatment plants(DWTPs)in protecting the public from exposure to MPs through drinking *** collected and analyzed the available research articles up to August 2021 on MPs in drinking water treatment(DWT),including laboratory-and full-scale *** article summarizes the major MP compositions(materials,sizes,shapes,and concentrations)in drinking water sources,and critically reviews the removal efficiency and impacts of MPs in various drinking water treatment *** discussed drinking water treatment processes include coagulation-flocculation(CF),membrane filtration,sand filtration,and granular activated carbon(GAC)*** DWT processes that are purposed for particle removal are generally effective in reducing MPs in *** influential factors to MP removal are discussed,such as coagulant type and dose,MP material,shape and size,and water *** is anticipated that better MP removal can be achieved by optimizing the treatment ***,the article framed the major challenges and future research directions on MPs and nanoplastics(NPs)in DWT.

关键词： Microplastics Drinking water treatment Coagulation Flocculation Membrane Filtration

A Causality-guided Statistical Approach for Modeling Extreme Mei-yu Rainfall Based on Known Large-scale Modes——A Pilot Study

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Advances in Atmospheric Sciences 2022年第11期39卷 1925-1940页

作者： kelvin S.ng Gregor C.LECKEBUSCH Kevin I.HODGES School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUnited Kingdom Department of Meteorology and NCAS University of ReadingReading RG66BBUnited Kingdom

Extreme Mei-yu rainfall(MYR)can cause catastrophic impacts to the economic development and societal welfare in *** significant improvements have been made in climate models,they often struggle to simulate local-to-regional extreme rainfall(e.g.,MYR).Yet,large-scale climate modes(LSCMs)are relatively well represented in climate *** there exists a close relationship between MYR and various LSCMs,it might be possible to develop causality-guided statistical models for MYR prediction based on *** statistical models could then be applied to climate model simulations to improve the representation of MYR in climate *** this pilot study,it is demonstrated that skillful causality-guided statistical models for MYR can be constructed based on known *** relevancy of the selected predictors for statistical models are found to be consistent with the *** importance of temporal resolution in constructing statistical models for MYR is also shown and is in good agreement with the *** results demonstrate the reliability of the causality-guided approach in studying complex circulation systems such as the East Asian summer monsoon(EASM).Some limitations and possible improvements of the current approach are *** application of the causality-guided approach opens up a new possibility to uncover the complex interactions in the EASM in future studies.

关键词： extreme rainfall Mei-yu front causality-guided approach large-scale climate modes

Stereotactic radiotherapy and the potential role of magnetic resonance-guided adaptive techniques for pancreatic cancer

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World Journal of Gastroenterology 2022年第7期28卷 745-754页

作者： Tai Ermongkonchai Richard Khor Vijayaragavan Muralidharan Niall Tebbutt kelvin Lim Numan Kutaiba Sweet Ping ng Department of Radiation Oncology Olivia Newton-John Cancer Centre at Austin HealthHeidelberg 3084VictoriaAustralia Department of Surgery Austin HealthHeidelberg 3084VictoriaAustralia Department of Medical Oncology Olivia Newton-John Cancer Centre at Austin HealthHeidelberg 3084VictoriaAustralia Department of Diagnostic Radiology Austin HealthHeidelberg 3084VictoriaAustralia

BACKGROUND Pancreatic cancer is a malignancy with one of the poorest prognoses amongst all *** with unresectable tumours either receive palliative care or undergo various chemoradiotherapy *** techniques are often associated with acute gastrointestinal toxicities,as adjacent critical structures such as the duodenum ultimately limits delivered *** body radiotherapy(SBRT)is an advanced radiation technique that delivers highly ablative radiation split into several fractions,with a steep dose fall-off outside target *** To discuss the latest data on SBRT and whether there is a role for magnetic resonance-guided techniques in multimodal management of locally advanced,unresectable pancreatic *** We conducted a search on multiple large databases to collate the latest records on radiotherapy techniques used to treat pancreatic *** of 1229 total records retrieved from our search,36 studies were included in this *** Studies indicate that SBRT is associated with improved clinical efficacy and toxicity profiles compared to conventional radiotherapy *** dose escalation to the tumour with SBRT is limited by the poor soft-tissue visualisation of computed tomography imaging during radiation planning and treatment *** resonance-guided techniques have been introduced to improve imaging quality,enabling treatment plan adaptation and re-optimisation before delivering each *** Therefore,SBRT may lead to improved survival outcomes and safer toxicity profiles compared to conventional techniques,and the addition of magnetic resonance-guided techniques potentially allows dose escalation and conversion of unresectable tumours to operable cases.

关键词： Magnetic resonance imaging Pancreatic cancer Radiotherapy Stereotactic Adaptive techniques