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The unfolded protein response signaling and retinal Müller cell metabolism

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Neural Regeneration Research 2018年第11期13卷 1861-1870页

作者： Kristen kelly j.shua j.Wang Sarah X.zhang Department of Ophthalmology and Neuroscience Program Ross Eye InstituteUniversity at BuffaloState University of New York SUNY Eye Institute State University of New YorkBuffaloNYUSA

The retina is one of the most energy demanding tissues in the body. Like most neurons in the central nervous system, retinal neurons consume high amounts of adenosine-5′-triphosphate（ATP） to generate visual signal and transmit the information to the brain. Disruptions in retinal metabolism can cause neuronal dysfunction and degeneration resulting in severe visual impairment and even blindness. The homeostasis of retinal metabolism is tightly controlled by multiple signaling pathways, such as the unfolded protein response（UPR）, and the close interactions between retinal neurons and other retinal cell types including vascular cells and Müller glia. The UPR is a highly conserved adaptive cellular response and can be triggered by many physiological stressors and pathophysiological conditions. Activation of the UPR leads to changes in glycolytic rate, ATP production, de novo serine synthesis, and the hexosamine biosynthetic pathway, which are considered critical components of Müller glia metabolism and provide metabolic support to surrounding neurons. When these pathways are disrupted, neurodegeneration occurs rapidly. In this review, we summarize recent advance in studies of the UPR in Müller glia and highlight the potential role of the UPR in retinal degeneration through regulation of Müller glia metabolism.

关键词： unfolded protein response retina Müller glia metabolism neurodegeneration X-box binding protein 1 glycolysis glucose transporter

Exploring device physics of perovskite solar cell via machine learning with limited samples

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j.urnal of Energy Chemistry 2024年第7期94卷 441-448页

作者： Shanshan Zhao j.e Wang Zhongli Guo Hongqiang Luo Lihua Lu Yuanyuan Tian Zhuoying j.ang j.ng zhang Mengyu Chen Lin Li Cheng Li School of Electronic Science and Engineering Xiamen UniversityXiamen 361005FujianChina Future Display Institute of Xiamen Xiamen 361005FujianChina

Perovskite solar cells(PsCs)have developed tremendously over the past ***,the key factors influencing the power conversion efficiency(PCE)of PSCs remain incompletely understood,due to the complexity and coupling of these structural and compositional *** this research,we demon-strate an effective approach to optimize PSCs performance via machine learning(ML).To address chal-lenges posed by limited samples,we propose a feature mask(FM)method,which augments training samples through feature transformation rather than synthetic *** this approach,squeeze-and-excitation residual network(SEResNet)model achieves an accuracy with a root-mean-square-error(RMSE)of 0.833%and a pearson's correlation coefficient(r)of ***,we employ the permu-tation importance(PI)algorithm to investigate key features for ***,we predict PCE through high-throughput screenings,in which we study the relationship between PCE and chemical *** that,we conduct experiments to validate the consistency between predicted results by ML and experimental *** this work,ML demonstrates the capability to predict device performance,extract key parameters from complex systems,and accelerate the transition from laboratory findings to commercialapplications.

关键词： Perovskite solar cell Machine learning Device physics Performance prediction Limited samples

Differential introgression suggests candidate beneficial and barrier loci between two parapatric subspecies of pearson＇s horseshoe bat Rhinolophus pearsoni

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Current Zoology 2016年第4期62卷 405-412页

作者： Xiuguang MAO Shuyi zhang Stephen j. ROSSlTER Institute of Estuarine and Coastal Research East China Normal University Shanghai 200062 China School of Biological and Chemical Sciences Queen Mary University of London London E14NS UK

Observations that rates of introgression between taxa can vary across loci are increasingly common. Here, we test for differential locus-wise introgression in 2 parapatric subspecies of pearson＇s horseshoe bat （Rhinolophus pearsoni chinensis and R. p. pearsoni）. To efficiently identify putative speciation genes and/or beneficial genes in our current system, we used a candidate gene approach by including loci from X chromosome that are suggested to be more likely involved in reproductive isolation in other organisms and loci underlying hearing that have been suggested to spread across the hybrid zone in another congeneric species. Phylogenetic and coalescent analyses were performed at 2 X-linked, 4 hearing genes, as well as 2 other autosomal loci individually. Likelihood ratio tests could not rej.ct the model of zero gene flow at 2 X-linked and 2 autosomal genes. In contrast, gene flow was supported at 3 of 4 hearing genes. While this introgression could be adaptive, we cannot rule out stochastic processes. Our results highlight the utility of the candidate gene approach in searching for speciation genes and/or beneficial genes across the species boundary in natural populations.

关键词： gene flow hybridization hybrid zone reproductive isolation.

A homozygous nonsense mutation in DNAj.30 causes Leber’s hereditary optic neuropathy with Leigh-like phenotypes

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Genes & Diseases 2023年第4期10卷 1165-1168页

作者： Chao Shen Kitty Wang Wei Li Alvaro Serrano kelly Powers Chengwan zhang j.anj.n Chen Miao Sun Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Division of Medical Genetics Department of PediatricsChildren’s Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Division of Neurology Children’s Hospital Los AngelesLos AngelesCA 90027USA Division of Genomic Medicine Department of Pathology and Laboratory MedicineChildren’s Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

Nuclear encoded genes can cause early-onset mitochon-dria-related disorders such as Leigh or Leigh-like *** in DNAj.30 have been implicated in mitochondria-related diseases such as Leber’s hereditary optic neuropa-thy(LHON)and Williams syndrome(WS).However,the role of DNAj.30 in disease progression concerning mitochon-drial dysfunction has yet to be fully *** we report a 12-year-old boy with acute dystonia onset at age 10.

关键词： Leigh Leber acute

中性粒细胞弹性蛋白酶抑制剂治疗艾滋病合并急性肺损伤/急性呼吸窘迫综合征的疗效分析

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中国艾滋病性病 2024年第8期30卷 815-819页

作者：张乐李翔李海雯张艳罗季沈含章张洪涛张开义昆明市第三人民医院(云南省传染性疾病临床医学中心) 昆明650041 云南省怒江傈僳族自治州人民医院云南怒江673299

目的本研究旨在探讨中性粒细胞弹性蛋白酶抑制剂(NEI)在治疗艾滋病合并急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)中的效果。方法本研究采用回顾性病例对照研究设计,选取昆明市第三人民医院2022年1月1日至2023年12月31日期间收治的艾滋... 详细信息

目的本研究旨在探讨中性粒细胞弹性蛋白酶抑制剂(NEI)在治疗艾滋病合并急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)中的效果。方法本研究采用回顾性病例对照研究设计,选取昆明市第三人民医院2022年1月1日至2023年12月31日期间收治的艾滋病合并ALI/ARDS患者83例为研究对象,采用SPSS 26.0软件进行t检验、χ^(2)检验,使用pearson相关系数分析观察指标之间的相关性。结果共选取83例患者依据有无使用NEI进行分组,仅接受常规治疗(常规组)60例,在常规治疗基础上加用NEI(NEI组)23例,两组病例基线资料比较差异无统计学意义(P>0.05);治疗后观察指标对比分析,NEI组氧合指数(PaO2/FiO2)[(185.8±34.7)mmHg]、IL-10[(28.7±7.5)pg/mL]高于常规组[(167.3±31.2)mmHg、(14.9±3.5)pg/mL];NEI组白细胞计数[(9.2±2.2)×10^(9)/L]、C反应蛋白[(9.7±3.5)mg/L]、IL-6[(32.5±9.8)pg/mL]、IL-8[(29.0±7.1)pg/mL]低于常规组[(10.5±2.3)×10^(9)/L、(13.2±4.1)mg/L、(45.6±12.3)pg/m、(35.3±8.4)pg/mL];治疗预后影响对比分析,NEI组患者平均非机械通气天数(10.8±3.1)d,高于常规组(8.7±2.8)d(Ppearson相关系数分析,白细胞计数、C反应蛋白、IL-6和IL-10与28 d病死率均呈正相关,其中IL-10与28 d病死率的相关系数为0.24。结论NEI能有效改善艾滋病合并ALI/ARDS患者的氧合情况、降低炎症指标,并提高抗炎因子水平,增加非机械通气天数及降低28 d病死率。

关键词：艾滋病中性粒细胞弹性蛋白酶抑制剂急性肺损伤/急性呼吸窘迫综合征

不同菌种对芫根发酵液风味物质及抗氧化性能的影响

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食品与发酵工业 2024年第16期50卷 211-220,I0003-I0005页

作者：陈天荣张玉红西藏自治区农牧科学院农产品开发与食品科学研究所西藏拉萨850000

芫根具有显著的抗氧化、抗缺氧、降糖降脂等功效,市场前景广阔,但其发酵产品研究较少。基于电子鼻、电子舌及顶空-固相微萃取-气质联用(headspace-solid-phase microextraction-gas chromatography-mass spectrometry, HS-SPME-GC-MS)比较了4种不同菌种(LL-6-1:植物乳杆菌,CD5:副干酪乳杆菌,j.M5:发酵乳杆菌,j.-1:马克斯克鲁维酵母菌)发酵对芫根发酵液风味物质的影响,采用酶比色法测定DPPH自由基、羟自由基、超氧阴离子自由基清除率及总抗氧化能力。电子鼻、电子舌和HS-SPME-GC-MS结果均表明4种不同菌种芫根发酵液风味物质之间存在差异。HS-SPME-GC-MS在4种芫根发酵液中共检测出92种挥发性物质,包括醇类、酚类、醚类、醛类、酸类、酮类、酯类及其他类。通过电子鼻与HS-SPME-GC-MS结果的pearson相关分析筛选出11种差异挥发性物质,其中3-甲基-1-丁醇、乙醇、乙酸戊酯、1-丁烯-4-异硫氰酸酯、苯乙醇、4-乙基-苯酚等为发酵液形成不同风味的主要物质基础。抗氧化结果表明j.-1菌种芫根发酵液具有较好的DPPH自由基、羟自由基清除能力,且总抗氧化能力较强。

关键词：芫根发酵液顶空-气相色谱-质谱风味物质抗氧化

Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function

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Cellular & Molecular Immunology 2021年第2期18卷 328-338页

作者： j.an Huang j.an Peng j.mes Alexander pearson Georgios Efthimiou Youj.a Hu Ningwen Tai Yanpeng Xing Luyao zhang j.anlei Gu j.anping j.ang Hongyu Zhao Zhiguang Zhou F.Susan Wong Li Wen National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology(Central South University)Ministry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya HospitalCentral South UniversityChangshaHunanChina Section of Endocrinology Department of Internal MedicineSchool of MedicineYale UniversityNew HavenCTUSA Division of Infection and Immunity School of MedicineCardiff UniversityCardiffUK Department of Microbiology University of HullHullUK Department of Gastrointestinal Surgery of the First Hospital of j.lin University ChangchunJilinChina Department of Biostatistics Data Science&GeneticsYale School of Public HealthNew HavenCTUSA

Innate immunity mediated by Toll-like receptors(TLRs),which can recognize pathogen molecular patterns,plays a critical role in type 1 diabetes ***7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and host tissue cells;however,its role in type 1 diabetes development remains *** our study,we discovered that Tlr7-deficient(Tlr7^(−/−))nonobese diabetic(NOD)mice,a model of human type 1 diabetes,exhibited a significantly delayed onset and reduced incidence of type 1 diabetes compared with Tlr7-sufficient(Tlr7^(+/+))NOD *** investigations showed that Tlr7 deficiency significantly altered B-cell differentiation and immunoglobulin ***,Tlr7^(−/−)NOD B cells were found to suppress diabetogenic CD4^(+)T-cell responses and protect immunodeficient NOD mice from developing diabetes induced by diabetogenic T *** addition,we found that Tlr7 deficiency suppressed the antigen-presenting functions of B cells and inhibited cytotoxic CD8^(+)T-cell activation by downregulating the expression of both nonclassical and classical MHC class I(MHC-I)molecules on B *** data suggest that TLR7 contributes to type 1 diabetes development by regulating B-cell functions and subsequent interactions with T ***,therapeutically targeting TLR7 may prove beneficial for disease protection.

关键词： Type 1 diabetes Toll-like receptor 7 B cell

Interfacial Charge Transfer in Nanoscale Polymer Transistors

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Nano Research 2008年第4期1卷 341-350页

作者： j.ffrey H.Worne Raj.v Giridharagopal Kevin F.kelly Douglas Natelson Department of Electrical and Computer Engineering Rice University6100 Main St.HoustonTX 77005USA Department of Physics and Astronomy Rice University6100 Main St.HoustonTX 77005USA

Interfacial charge transfer plays an essential role in establishing the relative alignment of the metal Fermi level and the energy bands of organic *** the details remain elusive in many systems,this charge transfer has been inferred in a number of photoemission *** present electronic transport measurements in very short channel(Ltance and the zero gate voltage conductance are consistent with such charge *** channel conduction in devices with Pt contacts is greatly enhanced compared to analogous devices with Au contacts,consistent with charge transfer *** current scanning tunneling microscopy(ACSTM)provides further evidence that holes are transferred from Pt into P3HT,while much less charge transfer takes place at the Au/P3HT interface.

关键词： Organic semiconductors band alignment charge transfer organic field-effect transistor scanning tunneling microscopy

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北部湾北部海域大型底栖动物的群落结构特征

南方农业学报 2024年第2期55卷 299-310页

作者：穆文丹裴丽伊朱祖浩张丽贾仁明张秋丰自然资源部第四海洋研究所/自然资源部热带海洋生态系统与生物资源重点实验室/广西北部湾海洋资源环境与可持续发展重点实验室广西北海536000

【目的】探明北部湾北部海域大型底栖动物的物种组成、群落结构、多样性及其与环境因子的相关性,为北部湾北部海域生态监测、环境评价和大型底栖动物多样性保护提供数据支撑,也为北部湾北部海域海洋资源的可持续开发利用提供科学依据。... 详细信息

【目的】探明北部湾北部海域大型底栖动物的物种组成、群落结构、多样性及其与环境因子的相关性,为北部湾北部海域生态监测、环境评价和大型底栖动物多样性保护提供数据支撑,也为北部湾北部海域海洋资源的可持续开发利用提供科学依据。【方法】于2020年10—11月(秋季)和2021年4—5月(春季)对北部湾北部海域共20个调查站位进行大型底栖动物取样,统计底栖动物丰度、生物量、优势度(Y)和种类更替率,并计算Shannon-Wiener多样性指数(H')、Margalef丰富度指数(D)和Pielou均匀度指数(j.),通过相似性百分比分析(SIMPER)确定划分群落时的主要物种,以ABC曲线(丰度/生物量)分析大型底栖动物群落受干扰情况,并利用SPSS 24.0分析环境因子与大型底栖动物多样性(H'、j.和D)的pearson相关性。【结果】春季调查共鉴定出50种大型底栖动物,隶属于9个门类,优势种有12种;秋季调查共鉴定出40种,隶属于5个门类,优势种有10种;春、秋两季大型底栖动物的共有优势种为光亮倍棘蛇尾、疣吻沙蚕和日本文昌鱼。春季大型底栖动物平均丰度为143.11 ind/m^(2),秋季为186.38 ind/m^(2);春季大型底栖动物平均生物量为18.92 g/m^(2),秋季为24.15 g/m^(2);春季大型底栖动物多样性明显高于秋季,具体表现为:春季H'(1.566)>秋季H'(1.126),春季j.(0.780)>秋季j.(0.613),春季D(0.694)>秋季D(0.548)。在春季,北部湾北部海域各站位的大型底栖动物群落结构可划分为五大类群,在秋季可划分为四大类群,两季均存在的特征种为光亮倍棘蛇尾和日本文昌鱼。pearson相关分析结果表明:春季大型底栖动物的H'、j.和D与各环境因子均无显著相关性(P>0.05),结合ABC曲线分析可知北部湾北部海域春季大型底栖动物群落受到的干扰较小;在秋季,H'与溶解氧呈显著正相关(Pj.与溶解氧和pH呈显著正相关,与磷酸盐、硝酸盐及溶解态无机氮显著负相关;D与溶解氧呈极显著正相关(P<0.01),与水温、磷酸盐、硝酸盐及溶解态无机氮呈显著负相关。【结论】北部湾北部海域可能存在中度污染或干扰,尤其是秋季的生物群落结构稳定性较差;水温、溶解氧、磷酸盐、硝酸盐及溶解态无机氮等环境因子是影响秋季大型底栖动物群落的主要环境因子,即控制氮、磷输入是维持北部湾海域生态平衡的重要举措。

关键词：大型底栖动物群落结构生物多样性环境因子北部湾北部海域