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Multiple myeloma survival in New south Wales, Australia, by treatment era to 2020

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Cancer Biology & Medicine 2024年第8期21卷 703-711页

作者： Eleonora Feletto Qingwei Luo Anna kelly Marianne Weber David Goldsbury Katherine Barron Karen Canfell Xue Qin Yu The Daffodil Centre The University of SydneyA Joint Venture with Cancer Council NSWSydney NSW 2006Australia

Objective: Australia has relatively high multiple myeloma(MM) incidence and mortality rates. Advancements in MM treatment over recent decades have driven improvements in MM survival in high-income countries;however, reporting in Australia is limited. We investigated temporal trends in population-wide MM survival across 3 periods of treatment advancements in New south Wales(NsW), ***: Individuals with an MM diagnosis in the NsW Cancer Registry between 1985 and 2015 with vital follow-up to 2020, were categorized into 3 previously defined treatment eras according to their diagnosis date(1985±1995, chemotherapy only;1996±2007, autologous stem cell transplantation;and 2008±2015, novel agents including proteasome inhibitors and immunomodulatory drugs). Both relative survival and cause-specific survival according to Fine and Gray's competing risks cumulative incidence function were calculated by treatment era and age at ***: Overall, 11,591 individuals were included in the study, with a median age of 70 years at diagnosis. Five-year relative survival improved over the 36-year(1985±2020) study period(31.0% in 1985±1995;41.9% in 1996±2007;and 56.1% in 2008±2015). For individuals diagnosed before 70 years of age, the 5-year relative survival nearly doubled, from 36.5% in 1985±1995 to 68.5% in 2008±2015. Improvements for those > 70 years of age were less pronounced between 1985±1995 and 1996±2007;however, significant improvements were observed for those diagnosed in 2008±2015. similar overall and age-specific patterns were observed for causespecific survival. After adjustment for gender and age at diagnosis, treatment era was strongly associated with both relative and cause-specific survival(P sions: survival of individuals with MM is improving in Australia with treatment advances. However, older age groups continue to experience poor survival outcomes with only modest improvements over time. Given the increasing prevalence of MM in

关键词： Multiple myeloma cancer epidemiology survival analysis competing risk analysis Australia

ZenZone App-One Teenager's Answer to Digital Distractions

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城市漫步（GBA版） 2024年第1期 50-51页

作者： Ned kelly 不详

When shanghai American school Puxi student Luke Penaloza's gaming device broke,he found his academic performance saw a stark *** was a revelation,and one that inspired him to develop ZenZone.

关键词： One Zen App

A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren s.kelly Jennifer A.Munley Erick E.Pons Kolenkode B.Kannan Elizabeth M.Whitley Letitia E.Bible Philip A.Efron Alicia M.Mohr Department of surgery and sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHs),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(BM)erythroid progenitor(CFU-GEMM,BFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CsF)and right lung histologic injury were assessed on day 7,with significance defined as p valuessults:Polytrauma resulted in markedly more profound inhibition of weight gain compared to LCHs(p=0.0002)along with elevated plasma TLR4(pspleen to body weight ratios(p=0.004).Both LCHs and PT demonstrated suppression of CFU-E and BFU-E growth compared to naive(psma G-CsF was elevated in PT compared to both na?ve and LCHs(ps and PT demonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:Multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

非洲Okavango裂谷及邻区三维剪切波速度与径向各向异性结构研究

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地球物理学报 2024年第10期67卷 3796-3813页

作者：王拓王旭陈凌喻志超胡少乾 stephen s.Gao kelly H.Liu 中国科学院地质与地球物理研究所岩石圈演化与环境演变全国重点实验室北京100029 中国科学院大学地球与行星科学学院北京100049 中国地质大学地球物理与空间信息学院地球内部多尺度成像湖北省重点实验室武汉430074 Department of Earth sciences and Engineering Missouri University of Science and TechnologyRollaMO 65409USA

非洲Okavango裂谷是东非裂谷系最年轻且仍处于发育初期阶段的裂谷,研究其地下结构及变形特征有助于深入了解东非裂谷系裂解初期结构构造特征,并进一步完善对裂谷系裂解动力学机制的认识.本文收集Okavango裂谷区域内41个宽频地震台站的... 详细信息

非洲Okavango裂谷是东非裂谷系最年轻且仍处于发育初期阶段的裂谷,研究其地下结构及变形特征有助于深入了解东非裂谷系裂解初期结构构造特征,并进一步完善对裂谷系裂解动力学机制的认识.本文收集Okavango裂谷区域内41个宽频地震台站的连续波形数据,采用背景噪声技术获取Rayleigh和Love波相速度频散数据,进一步通过直接成像技术获得研究区地下50 km深度范围内的三维剪切波速度和径向各向异性结构.剪切波速度和径向各向异性结果显示,Okavango裂谷的中地壳具有低速和负径向各向异性(V_(sH)sV))的特征,支持裂谷地壳内存在熔融物质的观点.然而,裂谷的下地壳及上地幔顶部呈现较高的剪切波速度,表明地壳内的熔融物质可能并非源自地幔,因而不支持幔源物质侵入地壳诱发裂谷发育的机制.裂谷的下地壳及上地幔顶部呈现正径向各向异性(V_(sH)>V_(sV))的特征,结合前人资料,本文认为Okavango裂谷的发育可能是在先存构造薄弱带上由板内相对运动所提供的水平方向构造应力诱发的.此外,我们的结果还显示,在邻区Zimbabwe克拉通西南部,中、下地壳呈现出负径向各向异性,这一观测支持Okavango岩墙群侵入地壳导致该区域地壳增厚的认识.

关键词： Okavango裂谷裂谷发育机制背景噪声剪切波速度径向各向异性

Acute Colonic Pseudo-Obstruction (ACPO): An Expanding Colon with Unusual Risk Factors

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Open Journal of Internal Medicine 2024年第2期14卷 167-174页

作者： kelly schulte Alyson Terry Grace Boyle Dmitriy scherbak HCA Healthone sky Ridge Medical Center Lone Tree Colorado USA

The distention of the colon without mechanical or anatomical obstruction, Acute Colonic Pseudo-obstruction (ACPO), is a common condition occurring in the critically ill. ACPO in the setting of an acute pulmonary embolism and embolic stroke is a rarity. A 76-year-old female with shortness of breath, left hemiparesis and right-sided paresthesias presented with acute pulmonary embolism and acute infarcts of the left caudate nucleus, thalamus and occipital lobe. Her hospitalization was complicated with persistent distention of the large bowel without dilation of the small bowel. Empiric antibiotics were initiated without improvement and laboratory studies including Clostridium difficile were negative. she underwent nasogastric decompression and two decompressive colonoscopies with a resolution of her symptoms. This case illustrates an example of acute abdominal distension, without underlying etiology, in the setting of acute embolism of the pulmonary and cerebral vasculature. Early identification and action with decompressive colonoscopy were key to preventing further bowel damage or rupture.

关键词： Acute Colonic Pseudo-Obstruction ACPO Ogilvie’s syndrome Colonic Dilation Acute Embolic Infarcts Cerebrovascular Accident Pulmonary Embolism PE

storylines of family medicine Ⅵ:ways of being—in the office with patients

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Family Medicine and Community Health 2024年第S03期12卷 52-60页

作者： William B Ventres Leslie A stone Lisa A LaVallee David Loxterkamp Jonisha R Brown Dael M Waxman Peter s Dorward Jeanne Cawse-Lucas Larry B Mauksch Autumn M Kieber-Emmons Benjamin F Crabtree William L Miller Veronica M Brohm Timothy P Daaleman kelly Bossenbroek Fedoriw Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA MAHEC Family Medicine Residency Mountain Area Health Education CenterAshevilleNorth CarolinaUSA Bucksport Regional Health Center BucksportMaineUSA Family Medicine Atrium HealthCharlotteNorth CarolinaUSA southfield Medical Practice EdinburghUK Family Medicine University of Washington School of MedicineSeattleWashingtonUSA Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA Morsani College of Medicine University of South FloridaTampaFloridaUSA Family Medicine and Community Health Rutgers Robert Wood Johnson Medical SchoolPiscatawayNew JerseyUSA Cancer Institute of New Jersey New BrunswickNew JerseyUSA Family Medicine UNC School of MedicineChapel HillNorth CarolinaUSA

storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the UsA and elsewhere around the ***‘Ⅵ:ways of being—in the office with patients’,authors address the following themes:‘Patient-centred care—cultivating deep listening skills’,‘Doctor as witness’,‘Words matter’,‘Understanding others—metaphor and its use in medicine’,‘Communicating with patients—making good use of time’,‘The patient-centred medical home—aspirations for the future’,‘Routine,ceremony or drama?’and‘The life course’.May readers better appreciate the nuances of patient care through these essays.

关键词： centre illustration dimensions

Psychiatric sequelae of Chronic Pruritic Dermatoses

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Open Journal of Medical Psychology 2024年第2期13卷 25-38页

作者： kelly Frasier Vivian Li Kathleen Click Christina Dudzik Michelle sobotka Evadne Rodriguez Karina stech Nuvance Health/Vassar Brothers Medical Center Poughkeepsie NY USA school of Osteopathic Medicine Kansas City University Kansas City MO USA Touro College of Osteopathic Medicine Middleton Campus Middletown NY USA Abrazo Health Network Goodyear AZ USA school of Medicine University of Missouri-Columbia Columbia MO USA Lewis Katz school of Medicine at Temple University Philadelphia PA USA

This comprehensive review investigates the significant psychological impact and profound psychological comorbidities found in individuals suffering from chronic pruritic dermatoses, including atopic dermatitis, chronic urticaria, and prurigo nodularis. Highlighting the complex, reciprocal relationship between pruritus and psychiatric conditions such as depression, anxiety, and sleep disturbances, this paper elucidates the comprehensive impact of dermatological disorders on the skin in addition to the far-reaching effects on an individual’s psychological well-being. By evaluating the efficacy of integrated psychodermatological interventions, including cognitive behavioral therapy, mindfulness practices, pharmacological treatments, and innovative telepsychiatry and digital health solutions, this review aims to lay the foundation for a more holistic approach to treatment of concurrent dermatological and psychiatric conditions. Future research endeavors should delve deeper into the mechanistic foundation of the pruritus-psychiatry interface, the refinement of tailored treatment strategies, and the evaluation of long-term patient outcomes. In doing so, this review seeks to contribute to the optimization of patient care and well-being, underscoring the pivotal role of addressing both dermatological and psychological needs in achieving comprehensive health outcomes.

关键词： Psychodermatology Chronic Pruritic Dermatoses Psychological Comorbidities Integrated Interventions Pruritus-Psychiatry Interface

Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto s.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle kelly G.stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

Polycystic Ovarian syndrome (PCOs): Exploring Its Impact on Obstetrical Outcomes

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1111-1123页

作者： Ranjitha Vasa Gayatri Venkataraman kelly Gorman Rythika Francis Elise Zwicklbauer Julia Fisher Polina safovich Mudar Dalloul Ozgul Muneyyirci-Delale Department of Obstetrics and Gynecology SUNY Downstate Health Science University Brooklyn United States of America Department of Obstetrics and Gynecology Kings County Hospital Center NYC Health and Hospitals Brooklyn United States of America

Polycystic ovarian syndrome (PCOs) disrupts ovulation leading to both infertility and miscarriage;yet, its impact on obstetrical outcomes remains largely uncertain due to conflicting findings. We analyzed data from the CDC Pregnancy Risk Assessment of Monitoring system, specifically standard Core and Phase 8 responses, with 9549 respondents across the United states through sPss 28 software in this cross-sectional study. Two variables assessed PCOs status in respondents: history of PCOs and PCOs during pregnancy. With a history of PCOs, there were significantly increased odds of diabetic (OR 1.665, p sive disorders (OR 1.589, p sarean section (C/s) (OR 1.489, p s (PPROM) (OR 2.081, p s diagnosed during pregnancy, there were significantly greater odds of diabetes (OR 3.278, p sive disorders (OR 2.935, p significantly decreased risk for small for gestational age (2 standard deviations) (OR 0.337, p = 0.024). PCOs is a significant risk factor that contributes to maternal morbidity. Our results support the hypothesis that PCOs’ impact extends well into a woman’s obstetrical journey, with varying degrees of associated adverse maternal and fetal risks. Preliminary pathophysiologic explanations associated with PCOs gestational diabetes include pre-existing insulin resistance. Meanwhile, altered placentation and endovascular changes associated with PCOs secondary to a baseline deranged metabolic environment predispose patients to developing hypertensive disorders, PPROM, and preterm delivery. Associations between neonatal mortality and C/s can be attributed to elevated maternal body mass index. The pathophysiologic link between PCOs and the above obstetrical outcomes still remains unknown, necessitating further investigation;however, this study identifies the outcomes that

关键词： PCOs Polycystic Ovarian syndrome Obstetrics Reproduction Pregnancy