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Symptom presentation and evolution in the first 48 hours after injury are associated with return to play after concussion in elite Rugby Union

作者： Christine p.Stewart parul Christine Kerry J.Schulze Stever C.LeClerq keith p.west jr. Subarna K.Khatry 张喆庆 postdoctoral Fellow Center for Human NutritionJohns Hopkins Bloomberg School of Public Health615 N.Wolfe St.Rm W2505BaltimoreMD21205

背景和目的:已知孕期营养不良与子代续后心血管疾病风险有关,但孕期妇女微量元素营养状况的长期影响尚未确定。方法:利用整群随机抽样、对照实验方法,将妊娠妇女分为四组,1)维生素A(VA)组,也即对照组;2)叶酸组(FA);3)叶酸+铁+锌组(FAFeZ...

背景和目的:已知孕期营养不良与子代续后心血管疾病风险有关,但孕期妇女微量元素营养状况的长期影响尚未确定。方法:利用整群随机抽样、对照实验方法,将妊娠妇女分为四组,1)维生素A(VA)组,也即对照组;2)叶酸组(FA);3)叶酸+铁+锌组(FAFeZn);4)多种营养素组(MM)。对这些母亲所生小孩从出生开始进行随访观察,在6

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Journal of Sport and Health Science 2024年第3期13卷 387-397页

作者： Ross Tucker Matt Cross keith Stokes Lindsay Starling Rosy Hyman Simon Kemp Stephen west Martin Raftery Eanna Falvey James Brown Institute of Sport and Exercise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland premiership Rugby London SW1V 1PXUK Centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collaborating Centre on Injury and Illness prevention in Sport(UKCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of Tropical Medicine London WC1E 7HTUK Sport Injury prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Department of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carnegie Applied Rugby Research(CARR)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Return to play(RTp)in elite rugby is managed using a 6-stage graduated RTp protocol,which can result in clearance to play within 1 week of *** aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RTp)to identify whether a more conservative graduated RTp may be ***:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive *** were classified as shorter or longer returns,depending on whether RTp occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,***,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RTp time were explored using odds ratios(OR,longer ***).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or ***:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and *** and balance performance were not associated with longer return and did not affect median days ***:Symptom presentation and evolution within 48 h of concussion were associated with longer RTp *** may guide a more conservative approach to RTp,while still adhering to individualized concussion management principles.

关键词： Brain injury Concussion management General return to play Medical management

Neuroendocrine facets of behavior and toxicology

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Aquaculture and Fisheries 2024年第3期9卷 337-338页

作者： keith B.Tierney Balasubramanian Senthilkumaran Department of Biological Sciences and the School of Public HealthUniversity of AlbertaEdmontonABT6G 2E9Canada Department of Animal Biology School of Life SciencesUniversity of HyderabadP O Central UniversityGachibowliHyderabad500046TelanganaIndia

professor ***,who I came to know as Senthil,came over to visit the University of Alberta in the summer of 2022 in connection with his Global Ambassador Fellowship program at University of Saskatechewan,***,there was that reason to visit,but there was another one as well,one that tied us *** years before Senthil had been considered for a postdoctoral fellowship with the legend that was Dick ***,it didn’t materialize and then he moved to Japan to do his post Doc Under *** *** had been Dean and a preeminent endocrinologist at the U of A.I came to know Dick near the end of my phD;he had brought me out to Bamfield Marine Sciences Centre to carryout research using their then-new,and very expensive,simulated *** left an incredible mark on all of us that knew him;he represented all that was wonderful and achievable in *** spent time with him was akin to shaking Sinatra’s hand,at least in the world of biology in that *** this common history,Senthil and I were fast friends.

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The signal-transduction pathways of the peripheral olfactory organ and their impairment in vertebrates

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Aquaculture and Fisheries 2024年第3期9卷 388-403页

作者： Arash Shahriari Bouthaina Aoudi keith B.Tierney College of Natural and Applied Sciences Faculty of ScienceBiological SciencesEdmontonABT6G 2E9Canada Department of Civil and Environmental Engineering University of AlbertaEdmontonABT6G 1H9Canada College of Health Sciences School of Public HealthEdmontonABT6G 1C9Canada

Animals rely on olfaction to detect and process invaluable chemical information about their *** olfaction to function,chemicals must first be detected,which leads to the activation of signal-transduction pathways at the peripheral olfactory *** the olfactory system is in direct contact with the environment,the system is constantly vulnerable to damage by contaminants entering the atmosphere or *** may have a variety of effects,including disrupting olfactory signals generated during chemical detection,or altering numerous targets along the signal transduction *** any impairment of chemical detection,animals may be unable to rely on olfaction to make correct decisions about their environment and thus their *** other reviews have focussed on olfactory toxicology in general,here we specifically explore how contaminants may affect the signal-transduction pathways at various points and link those changes to olfactory functionality across vertebrates with a focus on fishes.

关键词： Olfaction Signal-transduction Vertebrate Fish

Is salmonid migration at risk from chemical information disruption?

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Aquaculture and Fisheries 2024年第3期9卷 378-387页

作者： keith B.Tierney Gregory G.pyle Biological Sciences College of Natural and Applied SciencesEdmontonABT6G 2E9Canada School of public Health College of Health SciencesEdmontonABT6G 1C9Canada Department of Biological Sciences University of LethbridgeLethbridgeABT1K 3M4Canada

Good information is the basis for good *** many invaluable salmon species,chemical information is necessary to guide and fine-tune their migrations to and from freshwater mating grounds.A problem is that salmon of the current world are running a gauntlet of toxic chemicals arising from diverse anthropogenic inputs and these chemicals are known to disrupt *** is sufficient evidence that effluents from cities,mines,agriculture and industry contain chemicals that can rapidly,and sometimes irreversibly,impair the olfactory sense that salmon use to gather *** toxic inputs may not only be strong enough to impair migration,but be strong enough to redirect salmon away from their *** is also evidence that some synthetic chemicals may serve as the basis for ‘new’ information and be useful in making correct migratory *** the plus side,there are examples of new regulations that limit the input of chemicals of known olfactory toxicity,but on the minus side,increased urbanization and global climate change will likely increase the number and/or severity of some neurotoxic *** we identify the specific avenues of chemical risks to information disruption and in so doing prioritize and rank the risks to migrating *** data collected here can be used to lay the foundation for modelling the effects of anthropogenic inputs on information disruption in diverse salmonid species from around the world and therefore help secure their longevity in a changing chemical environment.

关键词： Salmon migration Ocean ranching Chemical information disruption Homing disruption Olfactory toxicity

Back to the drawing board:Overview of the next generation of combination therapy for inflammatory bowel disease

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World Journal of Gastroenterology 2024年第25期30卷 3182-3184页

作者： Jeffrey A Lowell Michael J Farber keith Sultan Department of Medicine Zucker School of Medicine at HofstraNorth Shore University Hospital-Long Island Jewish Medical CenterManhassetNY 11030United States preclinical Studies New York Institute of Technology College of Osteopathic MedicineGlen HeadNY 11545United States Division of Gastroenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States

Inflammatory bowel disease(IBD)is entering a potentially new era of combined *** et al provide an insightful review of the current state of combination therapy,with a focus on the use of a combined biologic and immunomodulator,as well as emerging data on the future potential of dual-biologic therapy(DBT).While current evidence for DBT is limited,encouraging safety profiles and ongoing trials suggest a brighter future for this *** importance of controlled trials should be stressed in establishing new treatment *** prospective randomized trials of DBT and perhaps future combinations of biologics and small molecule therapies will hopefully guide the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Immunomodulators Dual-therapy Combination therapy

A predictive model for ethylene-mediated auxin and cytokinin patterning in the Arabidopsis root

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plant Communications 2024年第7期5卷 120-137页

作者： Simon Moore George Jervis Jennifer F.Topping Chunli Chen Junli Liu keith Lindsey Department of Biosciences Durham UniversitySouth RoadDurham DH13LEUK Hubei Hongshan Laboratory College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Huazhong Agricultural UniversityWuhanHubei 430070China

The interaction between auxin and cytokinin is important in many aspects of plant *** measurements of both auxin and cytokinin concentration and reporter gene expression clearly show the coexistence of auxin and cytokinin concentration patterning in Arabidopsis root ***,in the context of crosstalk among auxin,cytokinin,and ethylene,little is known about how auxin and cytokinin concentration patterns simultaneously emerge and how they regulate each other in the Arabidopsis *** work utilizes a wide range of experimental observations to propose a mechanism for simultaneous patterning of auxin and cytokinin *** addition to revealing the regulatory relationships between auxin and cytokinin,this mechanism shows that ethylene signaling is an important factor in achieving simultaneous auxin and cytokinin patterning,while also predicting other experimental *** the mechanism with a realistic in silico root model reproduces experimental observations of both auxin and cytokinin *** made by the mechanism can be compared with a variety of experimental observations,including those obtained by our group and other independent experiments reported by other *** of these predictions include patterning of auxin biosynthesis rate,changes in pIN1 and pIN2 patterns in pin3,4,7 mutants,changes in cytokinin patterning in the pls mutant,pLS patterning,and various trends in different *** research reveals a plausible mechanism for simultaneous patterning of auxin and cytokinin concentrations in Arabidopsis root development and suggests a key role for ethylene pattern integration.

关键词： Arabidopsis root auxin patterning cytokinin patterning ethylene signaling in silico digital root spatiotemporal modeling

Hepatic vein reconstruction during hepatectomy:A feasible and underused technique

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Hepatobiliary & pancreatic Diseases International 2024年第4期23卷 421-427页

作者： Manish Ahuja Kunal Joshi Chris Coldham paulo Muiesan Bobby Dasari Manuel Abradelo Ravi Marudanayagam Darius Mirza John Isaac David Bartlett Nikolaos A Chatzizacharias Robert p Sutcliffe keith J Roberts Department of HpB and Liver Transplant Surgery University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Immunology and Immunotherapy University of BirminghamBirminghamUK

Complete surgical resection(R0)of liver tumors,primary or metastatic,remains the main objective in management of primary and metastatic liver tumors[1].Tumors invading to the proximity of the hepatic venous outflow pose a peculiar challenge to achieve R0 resections,because this location may render a tumor *** median survival of patients with liver tumor without surgery is less than 12 months[2].Even with surgery,post-hepatectomy liver failure and subsequently increased mortality are the main problems associated with complex resection[3].Moreover,when the vein is affected,vein resection and subsequent reconstruction are *** resection is a standard practice in liver resection and transplantation[4],for example,hepatic vein reconstruction during a living-donor liver transplant,porto-mesenteric axis reconstruction during resection of advanced pancreatic cancer and caval reconstruction during resection of retroperitoneal ***,novel techniques like total hepatic vascular exclusion(HVE)[5],veno-venous bypass[6]and ex vivo hepatic resection[7,8]have facilitated curative resections of tumors close to one or more major hepatic veins.

关键词： hepatectomy surgery mortality

Matt Cutts: Try something new for 30 days

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新世纪智能 2024年第40期 17-19页

作者： keith

当你开始感叹生活枯燥，每天的生活除上学放学、吃饭看书、洗漱睡觉之外再无乐趣可言时，不妨试着改变你的生活方式：培养一种新的爱好，每天做一件你喜欢做的事情，或者培养一种新的生活习惯。每天只需努力一点点，你的生活就会因此而...

当你开始感叹生活枯燥，每天的生活除上学放学、吃饭看书、洗漱睡觉之外再无乐趣可言时，不妨试着改变你的生活方式：培养一种新的爱好，每天做一件你喜欢做的事情，或者培养一种新的生活习惯。每天只需努力一点点，你的生活就会因此而大不相同。A few years ago, I felt like I was stuck in a rut,

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