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Se及Cu_2Se纳米线的大面积合成及其纳米电子学器件性能

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化工新型材料 2008年第9期36卷 26-28页

作者：赵云覃东欢陶洪兰林峰 keith Chan 华南理工大学特种功能材料及其制备新技术教育部重点实验室广州510641 加州大学圣地亚哥分校材料科学工程及磁记录研究中心加州920930407

通过液相化学反应制备了高质量硒(Se)纳米线,同时以Se纳米线为模板,合成了Cu2Se纳米线。利用透射电镜(TEM)、高分辨透射电镜(HRTEM)以及X射线衍射仪(XRD)研究了纳米线的形貌结构特征。结果显示,Se纳米线为单晶结构,生长方向沿其[001]面... 详细信息

通过液相化学反应制备了高质量硒(Se)纳米线,同时以Se纳米线为模板,合成了Cu2Se纳米线。利用透射电镜(TEM)、高分辨透射电镜(HRTEM)以及X射线衍射仪(XRD)研究了纳米线的形貌结构特征。结果显示,Se纳米线为单晶结构,生长方向沿其[001]面。结合先进的光刻技术及磁控溅射,成功制备了Se和Cu2Se纳米电子学器件。初步测试表明,这种Se纳米线为p型半导体,而Cu2Se纳米线则表现出明显的相变行为。这些发现有利于开发纳米线场效应晶体管以及相变存储器件方面的应用。

关键词： Se Cu2Se 纳米线

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用C++设计二维、三维分形图形程序第一版

1995年

作者：（美）Mark Finlay （美）keith A.Blanton 曹康等译

261 p. ; 26 CM 含磁盘一个

ISBN: (纸本)7030048288

261 p. ; 26 CM 含磁盘一个

关键词：图形软件 C语言程序设计

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人工表层角膜镜片术的研究现状

国外医学（眼科学分册） 1993年第1期17卷 8-10页

作者： keith p.Thompson Khalil Hanna 陈剑李志杰

应用人工表层角膜镜片可克服人组织表层角膜镜片的许多不足。有可能用于角膜镜片的生物材料包括:胶原(Ⅰ、Ⅲ或Ⅳ型),胶原-水凝胶聚合物,生物活性合成剂及可涂敷的水凝胶。生物材料应具有良好的光学透明性,角膜上皮细胞能够在其上移行... 详细信息

应用人工表层角膜镜片可克服人组织表层角膜镜片的许多不足。有可能用于角膜镜片的生物材料包括:胶原(Ⅰ、Ⅲ或Ⅳ型),胶原-水凝胶聚合物,生物活性合成剂及可涂敷的水凝胶。生物材料应具有良好的光学透明性,角膜上皮细胞能够在其上移行和粘附,对溶质渗透性良好及对角膜蛋白酶不发生变化。不用削除前弹力膜,通过粘稠物质、激光焊接或直接粘附等方法将人工镜片直接贴附于角膜的 Bowman 氏膜上,以改善人工表层镜片术的效果。

关键词：角膜人工角膜镜片手术屈光不正

Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade

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World Journal of Gastrointestinal Oncology 2017年第9期9卷 354-362页

作者： Travis Edward Grotz Richard E Royal paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart keith Francis Fournier Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center Department of Medical Oncology at the University of Texas MD Anderson Cancer Center Department of Radiology at the University of Texas MD Anderson Cancer Center Department of pathology at the University of Texas MD Anderson Cancer Center Department of SurgicalOncology at the University of Texas MD Anderson Cancer Center

AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards *** There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(p pectively(p pendent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, p = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, p previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, p = 0.03) and peritoneal carcinomatosis index(pCI)(HR = 1.05, 95%CI: 1.02-1.08, p = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, p = 0.01), pCI(HR = 1.10, 95%CI: 1.03-1.16, p = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, p = 0.03). Tumor grade and pCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms.

关键词： Hyperthermic intraperitoneal chemotherapy pseudomyxoma peritonei Histology Grade prognostic Outcomes

Benchmarking the performance of Bayesian optimization across multiple experimental materials science domains

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npj Computational Materials 2021年第1期7卷 1742-1751页

作者： Qiaohao Liang Aldair E.Gongora Zekun Ren Armi Tiihonen Zhe Liu Shijing Sun James R.Deneault Daniil Bash Flore Mekki-Berrada Saif A.Khan Kedar Hippalgaonkar Benji Maruyama keith A.Brown John Fisher III Tonio Buonassisi Massachusetts Institute of Technology CambridgeMAUnited States Boston University BostonMAUnited States Singapore-MIT Alliance for Research and Technology SingaporeSingapore Air Force Research Laboratory DaytonOhioUnited States Agency for Science Technology and Research(A*STAR)SingaporeSingapore National University of Singapore SingaporeSingapore present address:Aalto University EspooFinland present address:Northwestern polytechincal University(NpU) Xi’anShaanxi P.R.China

Bayesian optimization(BO)has been leveraged for guiding autonomous and high-throughput experiments in materials ***,few have evaluated the efficiency of BO across a broad range of experimental materials *** this work,we quantify the performance of BO with a collection of surrogate model and acquisition function pairs across five diverse experimental materials *** defining acceleration and enhancement metrics for materials optimization objectives,we find that surrogate models such as Gaussian process(Gp)with anisotropic kernels and Random Forest(RF)have comparable performance in BO,and both outperform the commonly used Gp with isotropic *** with anisotropic kernels has demonstrated the most robustness,yet RF is a close alternative and warrants more consideration because it is free from distribution assumptions,has smaller time complexity,and requires less effort in initial hyperparameter *** also raise awareness about the benefits of using Gp with anisotropic kernels in future materials optimization campaigns.

关键词： optimization performance acceleration

Substance p plays a Key Role in Hydrogen Sulfide-Induced Lung Inflammation

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Substance P Plays a Key Role in Hydrogen Sulfide-Induced Lun...

Calcium transients in postganglionic sympathetic neurons are enhanced in hypertensive rats

第十五届国际药理学大会

作者： Bhatia Madhav Ng Siaw Wei Moore philip keith National University of Singapore National University of Singapore Singapore National University of Singapore

＜正＞ Hydrogen sulfide （H2S） is a naturally occurring gas. which has been shown to be a potent vasodilator. Using different experimental models （such as caerulein- in- duced acute pancreatitis,car rageenan- induced hindpaw edema, and LpS - induced endotoxemia）. we have earlier shown that H2S acts as a mediator of inflammation. In this study, we have investigated the involvement of substance p in H2S - induced lung *** administration of NaHS （10 mg/kg）,an H2S donor, to mice caused a significant increase in circulating levels of substance p （1.86 fold increase over control）.H2S alone could also cause lung inflammation, as evidenced by 1.58 fold increase over control in lung myeloperoxidase activity and histologicalevidence of lung injury. In substance p deficient mice, the preprotachykinin-A （ppT-A） knockout mice. H2S did not cause any lung inflammation. Furthermore, pretreatment of mice with Cp- 96,345 （2.5 mg/kg, i.p.）, an antagonist of the neurokinin-1 （NK-1） receptor, protected mice against lung inflammation caused by H2S. These results demonstrate a key role of Sp in H2S - induced lung injury.

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Calcium transients in postganglionic sympathetic neurons are...

Unsteady boundary layers on flapping wings

2008北京国际生理科学学术大会

作者： LEE Chee-Wan BUCKLER keith pATERSON David J Department of physiology Anatomy and GeneticsSherrington BuildingParks RoadUniversity of OxfordOxfordOXl 3PTUnited Kingdom

Hypertension is associated with noradrenergic hyperactivity and oxidative *** previous works have already shown that sympathetic hyper-responsiveness seen in hypertension can result from impairment of nitric oxide(NO)-cyclic guanosine monophosphate(cGMp) pathway,and may be rescued with targeted gene transfer with neuronal nitric oxide synthase(NOS).We tested the hypothesis that Ca signalling in postganglionic sympathetic neurons is enhanced in spontaneously hypertensive rats(SHR) because of impaired NO-cGMp signalling. Superior cervical ganglia(SCG) were enzymatically isolated from age-matched SHR and normotensive Wistar-Kyoto (WKY) *** Ca concentration([Ca]) was measured with ratio imaging using *** were briefly perfused with Tyrode’s solution containing 100 mmol/L KCl to induce membrane depolarization, and the resultant transient increase in[Ca] was *** young(4-5 weeks) rats,peak voltage-gated[Ca] transients were slightly higher(12.9%) in SHR(1.24±0.06μmol/L,n=19) compared with WKY rats[(1.10±0.06)μmol/L,n=15,p=0.06].In contrast,in adult SHR(16-18 weeks) the[Ca] transients were 21.4%[(1.70±0.05)μmol/L,n=7]higher than in adult WKY rats[(1.41±0.07)μmol/L,n=11,ppared with prehypertensive(4-5 weeks) SHR(pp pathway can effect Ca transients,we tested the effects of a NOS inhibitor(N-nitro-L-arginine methyl ester,1 mmol/L) and a soluble guanylyl cyclase inhibitor[1H-(1,2,4)-oxadiazolo-(4,3-a)-quinoxalin-1-one,10μmol/L].These chemicals did not altered the voltage-gated[Ca] transients in *** conclusion,Ca transients in postganglionic sympathetic neurons in the adult SHR are enhanced when compared with *** enhancement appears to coincide with the development of *** overall responses are consistent with the hypothesis that enhanced Ca signalling may contribute to the noradrenergic hyperactivity observed in hypertension.

关键词： hypertension sympathetic neuron calcium nitric oxide

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Unsteady boundary layers on flapping wings

African Americans,hypertension and the renin angiotensin system

23rd International Congress of Theoretical and Applied Mechanics

作者： Dmitry Kolomenskiy keith Moffatt Marie Farge Kai Schneider Centre Europeen de Recherche et de Formation Avancée en Calcul Scientifique ToulouseFrance Department of Applied Mathematics and Theoretical physics University of CambridgeCambridgeUK LMD-IpSL-CNRS Ecole Normale SupérieureParisFrance M2p2-CNRS and CM Aix-Marseille UniversitéMarseilleFrance

＜正＞Flow near the trailing edges of insect wings during the high Reynolds number clap-fling-sweep process is related to unsteady stagnation-point *** solutions to this problem are *** are exact solutions of the Navi...

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World Journal of Cardiology 2014年第9期6卷 878-889页

作者： Sandra F Williams Susanne B Nicholas Nosratola D Vaziri keith C Norris Department of Endocrinology Cleveland Clinic Department of Clinical Biomedical Science Charles E Schmidt College of MedicineFlorida Atlantic University Division of Nephrology and Division of Endocrinology Diabetes and HypertensionDepartment of Medicine David Geffen School of MedicineUniversity of California Division of Nephrology and Hypertension Departments of MedicinePhysiology and BiophysicsUniversity of California Division of General Internal Medicine and Health Services Research Los AngelesCA 90024United States Department of Medicine David Geffen School of Medicine University of California

African Americans have exceptionally high rates of hypertension and hypertension related complications. It is commonly reported that the blood pressure lowering efficacy of renin angiotensin system(RAS) inhibitors is attenuated in African Americans due to a greater likelihood of having a low renin profile. Therefore these agents are often not recommended as initial therapy in African Americans with hypertension. However, the high prevalence of comorbid conditions, such as diabetes, cardiovascular and chronic kidney disease makes treatment with RAS inhibitors more compelling. Despite lower circulating renin levels and a less significant fall in blood pressure in response to RAS inhibitors in African Americans, numerous clinical trials support the efficacy of RAS inhibitors to improve clinical outcomes in this population, especially in those with hypertension and risk factors for cardiovascular and related diseases. Here, we discuss the rationale of RAS blockade as part of a comprehensive approach to attenuate the high rates of premature morbidity and mortality associated with hypertension among African Americans.

关键词： African American Blood pressure Ethnicity Hypertension Renin Angiotensin