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劳埃晶体学时代的到来

生物物理学报 2002年第1期18卷 1-10页

作者：任重 Dominique Bourgeois John R.Helliwell keith Moffat Vukica Srajer Barry L.Stoddard 沈月全杨晓静任匡一顾茵 Department of Biochemistry and Molecular Biology and Consortium for Advanced Radiation Sources European Synchrotron Radiation Facility BP22038043 Grenoble CedexFranceand UPR9015/IBS41 Avenuedes Martyrs Department of Chemistry University of Manchester program in Structural Biology Division of Basic SciencesFred Hutchinson Cancer Research Center 中国科学院生物物理研究所 Renz ResearchInc.任氏研究所

Singer等人（1993）的研究表明通过仔细选择一个特异的底物有可能改变一个多步反应的动力学轨迹；pH跳跃能提供一个有效的，依赖于扩散的方法在整个晶体范围内触发一个慢催化事件。在这个例子中，丝氨酸蛋白酶胰蛋白酶在亲核反应残基Ser... 详细信息

Singer等人（1993）的研究表明通过仔细选择一个特异的底物有可能改变一个多步反应的动力学轨迹；pH跳跃能提供一个有效的，依赖于扩散的方法在整个晶体范围内触发一个慢催化事件。在这个例子中，丝氨酸蛋白酶胰蛋白酶在亲核反应残基Ser195处被p-胍基苯甲酸（GB）酰化。在这个底物很容易形成一个酰基化酶中间物，但进行水解和再生游离酶却很慢。

关键词：蛋白质晶体学劳埃技术实验方法

Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative

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World Journal of Gastrointestinal Oncology 2020年第7期12卷 756-767页

作者： Jennifer L Leiting Jordan M Cloyd Ahmed Ahmed keith Fournier Andrew J Lee Sophie Dessureault Seth Felder Jula Veerapong Joel M Baumgartner Callisia Clarke Harveshp Mogal Charles A Staley Mohammad Y Zaidi Sameer H patel Syed A Ahmad Ryan J Hendrix Laura Lambert Daniel E Abbott Courtney pokrzywa Mustafa Raoof Christopher J LaRocca Fabian M Johnston Jonathan Greer Travis E Grotz Division of Hepatobiliary and pancreas Surgery Mayo ClinicRochesterMN 55901United States Division of Surgical Oncology Department of SurgeryThe Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgical Oncology University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastrointestinal Oncology Moffitt Cancer CenterDepartment of Oncologic SciencesMorsani College of MedicineTampaFL 33612United States Division of Surgical Oncology Department of SurgeryUniversity of CaliforniaSan DiegoCA 92093United States Division of Surgical Oncology Department of SurgeryMedical College of WisconsinMilwaukeeWI 53226United States Division of Surgical Oncology Winship Cancer InstituteEmory UniversityAtlantaGA 30322United States Department of Surgery University of Cincinnati College of MedicineCincinnatiOH 45267United States Division of Surgical Oncology Department of SurgeryUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States peritoneal Surface Malignancy program Section of Surgical Oncology Huntsman Cancer InstituteUniversity of UtahSalt Lake CityUT 84112United States Division of Surgical Oncology Department of SurgeryUniversity of WisconsinMadisonWI 53792United States Christopher La Rocca Division of Surgical OncologyDepartment of SurgeryCity of Hope National Medical CenterDuarteCA 91010United States Department of Surgery Johns Hopkins UniversityBaltimoreMD 21287United States

BACKGROUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIpEC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal *** To evaluate the impact of HIpEC method on post-operative and long-term survival *** patients undergoing CRS with HIpEC from 2000-2017 were identified in the United States HIpEC collaborative ***-operative,recurrence,and overall survival outcomes were compared between those who received open vs closed *** Of the 1812 patients undergoing curative-intent CRS and HIpEC,372(21%)patients underwent open HIpEC and 1440(79%)underwent closed *** was no difference in re-operation or severe complications between the two *** HIpEC had higher rates of 90-d readmission while open HIpEC had a higher rate of 90-d *** multi-variable analysis,closed HIpEC technique was not a significant predictor for overall survival(hazards ratio:0.75,95%confidence interval:0.51-1.10,p=0.14)or recurrence-free survival(hazards ratio:1.39,95%confidence interval:1.00-1.93,p=0.05)in the entire *** findings remained consistent in the appendiceal and the colorectal *** In this multi-institutional analysis,the HIpEC method was not independently associated with relevant post-operative or long-term *** technique may be left to the discretion of the operating surgeon.

关键词： Mucinous appendiceal carcinoma Cytoreductive surgery Multi-institutional

pilot Study on the Effects of partially Restored Riparian plant Communities on Habitat Quality and Biodiversity along First-Order Tributaries of the Lower St. Johns River

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Journal of Water Resource and protection 2010年第9期2卷 771-782页

作者： Anthony M. Rossi Daniel C. Moon Dale Casamatta Kelly Smith Christopher Bentzien Jason McGregor Alyson Norwich Emilie perkerson Ralph perkerson Joanna Savinon keith Stokes Dean Doebberfuhl 不详

The St. Johns River is one of the premiere waterways in the southeastern United States, but it is increasingly affected by anthropogenic disturbances and influences such as excessive loading of nutrients. In the current pilot project, small native plant communities (“garden sites”) were established along sections of riparian corridors of five first-order tributaries in residential-commercial areas that drain into the lower St. Johns River in north Florida. In addition, four “non-garden” (control) tributaries were monitored for comparison. Garden sites included five species native to the area;20 plants of each species on both banks (200 total plants). These sites were used to assess the ability of partially restored riparian areas to ameliorate nutrient loading and water quality and determine their impact on local biodiversity in disturbed suburban drainage systems. partially restored sites showed a significant reduction in both NO3- and p concentrations in both soil and water samples compared to control sites. For instance, soil NO3- levels were reduced by 14% in garden sites, while water samples were 30% lower. Moreover, both plant species richness and Shannon diversity (H’) were significantly higher at partially restored sites, 33 and 19% respectively, compared to control streams after two years. Garden sites also had significantly higher terrestrial and invertebrate diversity than non-restored tributaries. Intermittent patches of partially restored habitat along suburban riparian corridors may provide a practical cost-effective technique for improving ecosystem function, water quality and increasing biodiversity along these frequently disturbed lotic habitats. Trends detected in the current study may have general implications for riparian restoration and reduction of nutrient loading in these small tributaries and, ultimately, effect water quality of the lower St. Johns River basin.

关键词： Riparian Restoration Biodiversity Soil and Water Quality

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光动力疗法治疗非小细胞肺癌

国际病理科学与临床杂志 2013年第3期33卷 185-197页

作者： Charles B Simone II Joseph S Friedberg Eli Glatstein James p Stevenson Daniel H Sterman Stephen M Hahn keith A Cengel 袁光金李金銮朱宇熹凌扬 Department of Radiation Oncology Department of Surgery Division of Thoracic Surgery Department of Medicine Division ofMedical Oncology Department of Medicine Division of PulmonaryAllergy and Critical CareHospital of the University of PennsylvaniaPhiladelphiaPAUSA 解放军第82医院肿瘤内科江苏淮安215008 福建省肿瘤医院放疗科福州350014 重庆医科大学附一院肿瘤科重庆400042 日本京都大学附属病院放射性肿瘤科苏州大学附属常州肿瘤医院肿瘤内科常州江苏213001

光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软... 详细信息

光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。

关键词：光动力疗法肺癌支气管内姑息疗法非小细胞肺癌

Catalytic Acylation of Anisole over Some Zeolites

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Chemical Research in Chinese Universities 2000年第3期16卷 191-197页

作者： ZHAO Zhen hua (College of Chemistry and Chemical Technology, Hunan Normal University, Changsha 410081, p. R. China) (Received Sept. 22, 1999) 湖南师范大学湖南长沙 41 0 0 81

Methoxyacetophenone(4 MAp) was synthesized by the acylation of anisole with acetic anhydride in the presence of HY zeolite. The addition of an appropriate amount of some solvent such as dichloromethane, chloroform, carbon disulfide or chlorobenzene to the reaction system can improve the yield of the acylated product to a certain extent. HY zeolite used can be recovered, and reused after being regenerated, obtaining almost the same yield of 4 MAp as the fresh zeolite.

关键词： Acylation HY zeolite Catalyst Anisole Acetic anhydride Synthesis Aromatic ketone

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长屈肌移植治疗慢性跟腱病的解剖和临床应用

中华显微外科杂志 2017年第5期40卷 472-477页

作者：毛海蛟史增元董文伟徐达传宁波大学医学院附属医院骨科美国宾西法尼亚大学附属医院足踝外科中心南方医科大学人体解剖学教研室

目的探讨不同手术切取长屈肌腱(FHLT)转移修复慢性跟腱病的临床效果。方法取64侧足标本,观测Henry结节处FHLT和趾长屈肌腱(FDLT)之间腱束联合并进行分型。测量单切口、双切口和小切口技术切取FHLT的长度。2012年1月至2015年6月,临床上... 详细信息

目的探讨不同手术切取长屈肌腱(FHLT)转移修复慢性跟腱病的临床效果。方法取64侧足标本,观测Henry结节处FHLT和趾长屈肌腱(FDLT)之间腱束联合并进行分型。测量单切口、双切口和小切口技术切取FHLT的长度。2012年1月至2015年6月,临床上应用双切口技术切取FHLT转移修复慢性跟腱病10例。根据美国矫形足踝协会(AOFAS)踝与后足疗效评价标准评分为(63.04 ±7.75)分。临床上应用双切口切取FHLT,做跟骨隧道反折后与跟腱编织缝合。结果 Henry结节处发现两种不同腱束联合。I型:腱束起于近端FHLT止于远端FDLT占96.9%(62/64),II型:一侧腱束起于近端FHLT止于远端FDLT,另外一侧腱束起于近端FDLT止于远端FHLT占3.1%(2/64)。单切口切取FHLT的平均长度为(5.08±1.09)cm;双切口切取FHLT的平均长度为(6.72 ± 1.02)cm;小切口切取FHLT的平均长度为(17.49 ± 1.80)cm,3种术式统计学分析差异有统计学意义(p<0.01)。所有患者都获得随访,随访时间12～36个月,平均13.7个月。术后12个月根据AOFAS踝与后足疗效评价标准评分为(93.28 ± 3.72)分,与术前[(63.04±7.75)分]比较有统计学意义;其中优6例,良3例,可1例。随访期间均未见胫神经、腓肠神经和足底内、外侧神经损伤。结论超过96%的标本腱束联合从FHLT发出至FDLT,切取FHLT后残端不与FDLT腱缝合将丧失趾跖屈功能。切取FDLT腱后残端不做腱固定,余趾仍能保留跖屈功能;双切口切取FHLT转移修复慢性跟腱病具有肌腱固定强度高、保留趾跖屈功能以及并发症少的优点。

关键词：长屈肌趾长屈肌跟腱病变肌腱移植

Trizivir (Abacavir/Lamivudine/Zidovudine) plus Lopinavir/Ritonavir Induction Therapy Followed by Trizivir-Alone Maintenance for HIV-1-Infected patients: A 96-Week pilot Treatment Simplification Study

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World Journal of AIDS 2012年第3期2卷 245-251页

作者： Joseph C. Gathe Dean T. Martin M. keith Rawlings Benjamin Daquioag John E. Fuchs Vanessa C. Williams Katrina L. Oie Gary E. pakes Cigna Healthcare Corp. Phoenix USA Glaxo-SmithKline Research Triangle Park Durham USA peabody Clinic Dallas USA Therapeutic Concepts p.A. Houston USA

Objective: The purpose of this study was to investigate whether switching HIV-infected patients stabilized on Trizivir (abacavir 300 mg/lamivudine 150 mg/zidovudine 300 mg) plus lopinavir/ritonavir 400 mg/100mg twice daily to Trizivir alone affects clinical efficacy and tolerability. Methods: This phase 4, open-label, pilot study was conducted over 96 weeks in 23 antiretroviral-na?ve, HIV-infected patients. Initially, these patients received induction therapy with Trizivir plus lopinavir/ritonavir 400 mg/100mg twice daily. patients who achieved a viral load 3. Nineteen patients completed induction;of the four who did not, three were lost to follow-up and one withdrew due to gastrointestinal adverse events. In 14 induction completers who had viral load measurements taken at week 48, intent-to-treat: observed analysis showed a week 48 viral load 3 higher than the baseline count. Twelve patients completed the subsequent 48-week Trizivir-alone maintenance phase, of whom 11 (92%) achieved viral loads of both 3 above baseline. Trizivir-only maintenance was associated with fewer adverse events than the Trizivir-lopinavir/ritonavir induction phase and with improvement in total cholesterol, LDL-cholesterol, and triglycerides. Conclusions: Trizivir-alone maintenance after Trizivir-lopinavir/ritonavir induction maintained virologic and CD4+ cell response, and was associated with an improved adverse event and lipid profile.

关键词： Abacavir/Lamivudine/Zidovudine HIV-1 Infection Induction-Maintenance Strategy Kaletra Lopinavir/Ritonavir Trizivir

对急性卒中介入治疗组织的欧洲推荐（EROICAS）

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国际脑血管病杂志 2017年第9期25卷 769-781页

作者： Jens Fiehler Christophe Cognard Mauro Gallitelli Olav Jansen Adam Kobayashi Heinrich p MaRie keith W Muir Mikael Mazighi Karl Schaller peter D Schellinger 阳勇毕薪然马爱军潘旭东不详青岛大学附属医院神经内科 266100

1引言最近发表的5项随机对照试验（randomized controlled trial，RCT）和多项汇总分析明确证实，对于经恰当选择的颈动脉近端闭塞[即大血管闭塞（large vessel occlusion，LVO）]所致急性缺血性卒中患者，血管内血栓切除术（endovascul... 详细信息

1引言最近发表的5项随机对照试验（randomized controlled trial，RCT）和多项汇总分析明确证实，对于经恰当选择的颈动脉近端闭塞[即大血管闭塞（large vessel occlusion，LVO）]所致急性缺血性卒中患者，血管内血栓切除术（endovascular thrombectomy，EVT）联合最佳药物治疗（best medical treatment，BMT），

关键词：介入治疗急性卒中急性缺血性卒中欧洲组织随机对照试验血管闭塞 vessel