检索结果-南通市图书馆

Activation of DNA Damage Signaling Components by Diagnostic Computed Tomography (CT) Scans Detected in patient Samples Using an Electrochemiluminescence-Based Assay platform

引用

Advances in Bioscience and Biotechnology 2017年第7期8卷 228-247页

作者： Yiching Hseih Ulrike Begley Lauren Endres James keith Antonietta F. Hansen Laurence Kaminsky Brian McCandless Thomas J. Begley Colleges of Nanoscale Science and Engineering State University of New York Polytechnic Institute Albany NY USA College of Arts and Sciences Stratton Veterans Administration Medical Center State University of New York Polytechnic Institute Albany NY USA

Technologies that measure activation of components of the DNA damage response (DDR) have applications in exposure assessment and personalized medicine. The DDR and associated DNA repair pathways encompass hundreds of proteins, making detailed measurement of activation technically challenging and laborious. The purpose of our study was to develop protein-specific assays for certain DDR components on a high-throughput electrochemiluminescence (ECL)-based platform. We developed five working assay pairs for ataxia telangiectasia mutated (ATM), checkpoint kinase 2 (CHK2), phosphorylated-ATM S1981, phosphorylated-CHK2 T68 and phosphorylated-tumor protein p53 (p53) S15. We validated the ECL results against traditional immunoblot and γ-H2AX foci measures in cell and cancer models. In an effort to test the ECL-based technology in a clinical setting, we utilized peripheral blood mononuclear cells (pBMCs) from patients undergoing computed tomography (CT) scans. CT scans represent both a valuable medical imaging diagnostic and a controlled environmental exposure to ionizing radiation for research studies, as they deliver ~2 to 31 millisieverts (mSv) and are known to activate DDR components. In this study, we show that ECL-based technology can measure the basal and damage-induced levels of DDR components in patient pBMC samples. Using a blinded study design and patient matched pre- and post CT scan samples, we show that ECL-derived data can consistently (94% of the time, 15/16 patients) identify pBMCs that have been exposed to low dose ionizing radiation associated with CT scans. Ultimately, the results of our pilot clinical study support the idea that ECL-based technology is applicable for use in clinical and population cohorts that study components of the DDR.

关键词： DNA Damage Response Ionizing Radiation Diagnostic CT-Scan Clinical Samples ATM CHK2 p53

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高结晶度羟基磷灰石涂层牙科种植体:5年前瞻性临床研究

引用

中国口腔种植学杂志 2012年第4期17卷 196-203页

作者： Todd Thierer John p.Davliakos J.Daulton keith Jr John J.Sanders Dennis p.Tarnow James A.Rivers 王小容刘朴张艳纽约州罗彻斯特市罗彻斯特大学医疗中心南卡罗来纳州查尔斯顿市南卡罗来纳医科大学医学院南卡罗来纳州查尔斯顿市南卡罗来纳医科大学牙周学研究生院纽约州纽约市纽约大学牙科学院牙周学和牙科种植学系南卡罗来纳州查尔斯顿市南卡罗来纳医科大学修复牙科学系四川大学华西口腔医院成都市第一人民医院口腔科中国杰美公司

提高HA涂层的晶体含量能够使得它们在体内的耐降解能力比低结晶度的HA涂层高很多,但更高的结晶度也降低了表面可浸润性,这可能对组织附着和长期临床结果有不利的影响。本前瞻性研究的开展是为了确定在之前报道的浸润性降低的前提下,是... 详细信息

提高HA涂层的晶体含量能够使得它们在体内的耐降解能力比低结晶度的HA涂层高很多,但更高的结晶度也降低了表面可浸润性,这可能对组织附着和长期临床结果有不利的影响。本前瞻性研究的开展是为了确定在之前报道的浸润性降低的前提下,是否高结晶度HA涂层种植体能够符合最低85%的5年种植体成功率标准。研究对象是在3家大学牙科诊所和1家私人牙科诊所就诊,上颌和/或下颌有1或多个缺失牙齿的连续病人,共有120位病人按方案进行了治疗并且成功的用种植体支持修复体进行了修复。3位病人的4个种植体失败并从此研究中排除。没有出现其他无法解决的不良事件。5年时的累积成功率是97%(n=88位病人的184个种植体),超过了5年临床使用后种植体成功率85%的标准。

关键词：羟基磷灰石 HA 牙种植体结晶度浸润性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

陆相层序地层学的展望

引用

地质科学译丛 1994年第4期11卷 40-48,53页

作者： keith W.Shanley 覃建雄曾允孚 Shell Development Company Geology Research P. O. Box481 Houston Texas 77001-0481

该报告是1991年在加拿大班夫召开的NUNA会议上组建的陆相层序地层学工作组几年研究的总结。尽管人们早已发现,在陆相盆地中分布有不整合限定的地层单元,但目前层序地层学概念主要应用于海相地层的研究中。要成功地将层序地层学的概念应... 详细信息

该报告是1991年在加拿大班夫召开的NUNA会议上组建的陆相层序地层学工作组几年研究的总结。尽管人们早已发现,在陆相盆地中分布有不整合限定的地层单元,但目前层序地层学概念主要应用于海相地层的研究中。要成功地将层序地层学的概念应用于陆相地层,有必要对控制基准面及沉积物供应的因素作深入的研究。正如浅海环境一样,相对海平面可视为海岸陆相环境地层及地貌的基准面。不断地向内陆方向,决定容纳空间的地层基准面变得更为复杂,并表现为各种型式,如河流地层的均衡剖面、风成地层潜水面和山间沉积物的湖水面等。由于陆相盆地接近物源区,故其中沉积物供给比海洋环境丰富和复杂。在许多陆相沉积物中,可以明显看出沉积物供应受气候和构造作用影响。气候、构造作用及海平面升降的主要控制因素多少有些互相影响的事实,以及一种参数的变化很可能在其它方面有所反映的事实,在陆相地层中也颇易识别。即便在层序地层学的初期,它的概念就已应用于各类陆相环境,以试图解释各种相格架的变化。其中最具意义的研究是把海岸平原的河流相格架与同期海相地层指示的相对海平面变化相连系,以及研究高水位期和低水位期沉积之间有明显相变的湖泊环境。随着层序地层学在陆相地层研究中的应用,必将促进地层对比方法和模式的发展,从而更精确地预测河流及风成储集层的位置和性质。

关键词：地层层序地层学陆相

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

复合微量营养素补充剂对北京市成人血和尿营养素水平的影响

引用

中华临床营养杂志 2011年第4期19卷 227-231页

作者：李可基元香南杜芳伟 Yumei LIN Mei LI 黄晓明 Randolph R. keith 北京大学公共卫生学院营养与食品卫生系 100191 安利（中国）研发中心北京100191 美国纽崔莱健康研究所广州510730

目的探讨复合微量营养素补充剂对健康成人体内营养素水平的影响。方法选择北京市152名推荐食谱问卷得分低于12分的健康成年人作为研究对象，采用随机数字表法分为安慰剂组和补充剂组，每组76名。两组分别服用安慰剂和复合微量营养素补... 详细信息

目的探讨复合微量营养素补充剂对健康成人体内营养素水平的影响。方法选择北京市152名推荐食谱问卷得分低于12分的健康成年人作为研究对象，采用随机数字表法分为安慰剂组和补充剂组，每组76名。两组分别服用安慰剂和复合微量营养素补充剂。8周后检测受试者血浆及尿液中营养素浓度的变化情况。并于研究第56天同时给两组受试者服用复合微量营养素补充剂，观察服药前和服药后2 h血浆营养素水平变化。结果安慰剂组有3例失访，失访率为5.7%。服用复合微量营养素补充剂8周后，补充剂组的血浆α-生育酚［（18.23±0.82）比（14.55±0.73）μmol/L］、β-胡萝卜素［（4.28±0.29）比（2.38±0.24）μmol/L］、维生素C［（42.65±2.11）比（27.49±1.76）μmol/L］、B6［（323.51±15.88）比（69.43±10.47）nmol/L］和B12浓度［（1005.27±23.00）比（796.85±35.57）pmol/L］，尿维生素B1［（899.24±70.73）比（174.42±13.38）μg/g·Cr］和B2水平［（3227.68±330.04）比（259.10±33.33）μg/g·Cr］，及红细胞叶酸水平［（720.09±21.33）比（633.17±28.75）nmol/L］均明显高于安慰剂组（p均=0.0000），血浆γ-生育酚浓度明显低于安慰剂组［（2.18±0.13）比（2.87±0.26）μmol/L，p=0.0001］。服用复合微量营养素补充剂2 h后，补充剂组的血浆维生素C水平明显高于安慰剂组［（54.53±2.43）比（23.02±1.77）μmol/L，p=0.0000］。结论服用复合微量营养素补充剂可改变健康成人体内的营养素水平，但其意义有待进一步研究探讨。

关键词：复合微量营养素补充剂营养素中国成人

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Feasibility, acceptability, and effectiveness of non-pharmaceutical interventions against infectious diseases among crisis-affected populations: a scoping review

引用

Infectious Diseases of poverty 2022年第1期11卷 8-26页

作者： Jonathan A.polonsky Sangeeta Bhatia keith Fraser Arran Hamlet Janetta Skarp Isaac J.Stopard Stéphane Hugonnet Laurent Kaiser Christian Lengeler Karl Blanchet paul Spiegel World Health Organization GenevaSwitzerland Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland MRC Centre for Global Infectious Disease Analysis Department of Infectious Disease EpidemiologyImperial College LondonLondonUK Abdul Latif Jameel Institute for Disease and Emergency Analytics Imperial College LondonLondonUK Swiss Tropical and public Health Institute BaselSwitzerland University of Basel BaselSwitzerland Geneva Centre of Humanitarian Studies University of GenevaGenevaSwitzerland Center for Humanitarian Health Johns Hopkins Bloomberg School of Public HealthBaltimoreUSA

Background:Non-pharmaceutical interventions(NpIs)are a crucial suite of measures to prevent and control infectious disease *** being particularly important for crisis-affected populations and those living in informal settlements,who typically reside in overcrowded and resource limited settings with inadequate access to healthcare,guidance on NpI implementation rarely takes the specific needs of such populations into *** therefore conducted a systematic scoping review of the published evidence to describe the landscape of research and identify evidence gaps concerning the acceptability,feasibility,and effectiveness of NpIs among crisis-affected populations and informal ***:We systematically reviewed peer-reviewed articles published between 1970 and 2020 to collate available evidence on the feasibility,acceptability,and effectiveness of NpIs in crisis-affected populations and informal *** performed quality assessments of each study using a standardised *** analysed the data to produce descriptive summaries according to a number of categories:date of publication;geographical region of intervention;typology of crisis,shelter,modes of transmission,NpI,research design;study design;and study ***:Our review included 158 studies published in 85 peer-reviewed *** research used low quality study *** acceptability,feasibility,and effectiveness of NpIs was highly context *** general,simple and cost-effective interventions such as community-level environmental cleaning and provision of water,sanitation and hygiene services,and distribution of items for personal protection such as insecticide-treated nets,were both highly feasible and ***,financial,and human resource constraints affected both the implementation and sustainability of *** engagement emerged as a strong factor contributing to the effectiveness of ***,measures that involve po

关键词： Disease outbreaks Communicable disease control prevention & control Vulnerable populations Warfare and armed conflicts Disasters Relief work poverty areas

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High school sports programs differentially impact participation by sex

引用

Journal of Sport and Health Science 2015年第3期4卷 282-288页

作者： keith M. Drake Meghan R. Longacre Todd MacKenzie Linda J. Titus Michael L. Beach Andrew G. Rundle Madeline A. Dalton Hood Center for Children and Families Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA Department of pediatrics Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA Department of Community and Family Medicine Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA Department of Medicine Dartmouth-Hitchcock Medical Center Lebanon NH 03756 USA Department of Anesthesiology Dartmouth--Hitcheock Medical Center Lebanon NH 03756 USA Department of Epidemiology Mailman School of Public Health Columbia University New York NY 10032 USA

Background： Among numerous health benefits, sports participation has been shown to reduce the risk of overweight and obesity in children and adolescents. Schools represent an ideal environment for increasing sports participation, but it is unclear how access and choice influence participation and whether characteristics of the school sports program differentially influence boys＇ and girls＇ participation. The purpose of this study was to evaluate the characteristics of high school athletic programs and determine the extent to which these characteristics influenced boys＇ and girls＇ sports team participation. Methods： Longitudinal telephone surveys were conducted with 1244 New Hampshire and Vermont students. Students self-reported their sports team participation at baseline （elementary school） and follow-up （high school）. High school personnel were surveyed to assess sports oppor- tunities, which were defined for this analysis as the number of sports offered per 100 students （i.e., choice） and the percent of sports offered that did not restrict the number of players （i.e., access）. Results： Approximately 70% of children participated on at least one sports team, including 73% of boys and 66% of girls. We detected sta- tistically significant interactions between sex and two school opportunity variables： 1） the number of sports offered per 100 students （i.e., choice） and 2） the percent of sports offered that did not restrict the number of players （i.e., access）. After controlling for children＇s baseline sports participation and other covariates, boys were more likely to play on at least one sports team per year if their school did not restrict participation in the most popular sports （relative risk, RR = 1.12, p 〈 0.01）; in contrast, girls were more likely to play on at least one sports team per year if their school offered a wider variety of sports （RR = 1.47, p 〈 0.001）. Conclusion： Sports participation has previously been shown to confer a number of health benefits; as

关键词： Adolescents Gender equity High school students School athletic programs Sex differences Sports participation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

像素乐园

引用

建筑实践 2019年第11期 132-135页

作者： Marcial Jesús Javier González Stefanie Schramel Marta pinheiro Lara Broglio Mónica páez keith Gong Amey Kandalgaonkar 佰筑

"像素乐园"是一个公共空间美化项目,它将不同的户外设施组合在一个整体空间中,包括特色景观、儿童游乐设施、成人休闲设施等。这个项目的灵感来源于像素的数字概念。像素是具有自己RGB或CMYK颜色信息的图像的最小独立样本,也是任意给定... 详细信息

"像素乐园"是一个公共空间美化项目,它将不同的户外设施组合在一个整体空间中,包括特色景观、儿童游乐设施、成人休闲设施等。这个项目的灵感来源于像素的数字概念。像素是具有自己RGB或CMYK颜色信息的图像的最小独立样本,也是任意给定数字图像中众多像素的集合。为了将这个想法转化为项目实际运用中的空间组织,我们尝试通过添加、组合较小的独立功能像素来创建一个多功能的公共空

关键词：像素像元 CMYK

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A NEW AppROACH TO HOLISTIC NITROGEN MANAGEMENT IN CHINA

引用

Frontiers of Agricultural Science and Engineering 2022年第3期9卷 490-510页

作者： Xuejun LIU Zhenling CUI Tianxiang HAO Lixing YUAN Ying ZHANG Baojing GU Wen XU Hao YING Weifeng ZHANG Tingyu LI Xiaoyuan YAN keith GOULDING David KANTER Robert HOWARTH Carly STEVENS Jagdish LADHA Qianqian LI Lei LIU Wim DE VRIES Fusuo ZHANG Key Laboratory of plant-Soil Interactions of Ministry of Education National Academy of Agriculture Green DevelopmentCollege of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Environmental&Resource Sciences Zhejiang UniversityHangzhou 310058China College of Tropical Crops Hainan UniversityHaikou 570228China State Key Laboratory of Soil and Sustainable Agriculture Nanjing Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Department of Sustainable Agriculture Sciences Rothamsted ResearchHarpenden AL52JQUK Department of Environmental Studies New York UniversityNew YorkNY 10003USA Department of Ecology&Evolutionary Biology Cornell UniversityIthacaNY 14853USA Lancaster Environment Centre Lancaster UniversityLancasterLA14YQUK Department of plant Sciences University of CaliforniaDavisDavisCA 95616USA School of Life Sciences Jiangsu Normal UniversityXuzhou 221116China College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China Environmental Systems Analysis Group Wageningen University&ResearchPO Box 476700 AA Wageningenthe Netherlands.

Since the 1980s,the widespread use of N fertilizer has not only resulted in a strong increase in agricultural productivity but also caused a number of environmental problems,induced by excess reactive N emissions.A range of approaches to improve N management for increased agricultural production together with reduced environmental impacts has been *** 4R principles(right product,right amount,right time and right place)for N fertilizer application have been essential for improving crop productivity and N use efficiency while reducing N *** example,site-specific N management(as part of 4R practice)reduced N fertilizer use by 32%and increased yield by 5%in ***,it has not been enough to overcome the challenge of producing more food with reduced impact on the environment and *** paper proposes a new framework of food-chainnitrogen-management(FCNM).This involves good N management including the recycling of organic manures,optimized crop and animal production and improved human diets,with the aim of maximizing resource use efficiency and minimizing environmental *** could meet future challenges for food demand,resource sustainability and environmental safety,key issues for green agricultural transformation in China and other countries.

关键词： 4R technology food chain N management N use efficiency soil-crop system sustainable management

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

磁共振弥散张量成像对脊髓型颈椎病患者术后神经功能恢复的预测作用

引用

中国脊柱脊髓杂志 2019年第5期29卷 385-393页

作者：李翔陆瓞骥胡勇香港大学深圳医院骨科深圳市创伤骨科新技术重点实验室广东省深圳市518053 香港大学矫形及创伤外科学系香港特别行政区

目的:探讨磁共振弥散张量成像(diffusion tensor imaging,DTI)在预测脊髓型颈椎病(cervical spondylotic myelopathy,CSM)患者术后神经功能恢复中的作用。方法:前瞻性分析50例行手术治疗的CSM患者的临床资料,患者年龄43~86岁(64.3±11.2... 详细信息

目的:探讨磁共振弥散张量成像(diffusion tensor imaging,DTI)在预测脊髓型颈椎病(cervical spondylotic myelopathy,CSM)患者术后神经功能恢复中的作用。方法:前瞻性分析50例行手术治疗的CSM患者的临床资料,患者年龄43~86岁(64.3±11.2岁)。以19例年龄50~62岁(54.6±4.2岁)的健康志愿者作为对照组。应用3.0T磁共振DTI成像序列,观察患者术前各神经纤维束感兴趣区(包括整个颈髓、颈髓前束、侧束及后束)中的各向异性分数(fractional anisotropy,FA)、平均弥散率(mean diffusivity,MD)、轴向弥散系数(axial diffusivity,AD)及径向弥散系数(radial diffusivity,RD),将患者按术后神经功能日本骨科协会(Japanese Orthopedic Association,JOA)评分改善率(recovery rate,RR)分为3组:优良疗效组(RR>0.7)、中等疗效组(RR 0.4~0.7)和一般疗效组(RRp>0.05)。除优良疗效组整个颈髓的FA值外,3个患者组的FA、MD和RD值与对照组比较均存在显著性差异(pppppp<0.05)。脊髓侧束的FA值在预测CSM患者优良手术效果中最为准确。结论:CSM患者术前DTI参数值,尤其是脊髓后束及侧束FA值,在预测患者术后神经功能康复程度中表现出优于临床及传统影像学指标的特性,具有潜在的临床应用前景。

关键词：脊髓型颈椎病弥散张量成像手术预后

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

丝孢烟霉菌属Capnofrasera

引用

菌物研究 2020年第4期18卷 208-234页

作者： Stanley J.Hughes Toni J.Atkinson keith A.Seifert Biodiversity Mycology&Botany Agriculture&Agri-Food CanadaOttawa KIA 0C6Canada p.O.Box 20 WarringtonDunedinNew Zealand Department of Biology Carleton UniversityOttawa AIS 5b6Canada

新增单型丝孢烟霉菌属Capnofrasera 3个新种,分别为***、***和***。另外,Coccosporium aucupariae转移至该属中,后选模式基于其原始插图,并对其认定的有性型给出简要描述。这些物种在形成束丝趋势、分生孢子分支、共轴细胞相对优势、分... 详细信息

新增单型丝孢烟霉菌属Capnofrasera 3个新种,分别为***、***和***。另外,Coccosporium aucupariae转移至该属中,后选模式基于其原始插图,并对其认定的有性型给出简要描述。这些物种在形成束丝趋势、分生孢子分支、共轴细胞相对优势、分生孢子细胞及顶延伸、及顶延伸后遗留瘢痕特质以及分生孢子的分隔、大小等方面均有所不同。这个世界性属中的每个物种都有独特的地理分布,并且与特定的树种或灌木相关。本研究说明并描述了丝孢烟霉菌属中的已知物种,包括模式种***,并提供了一个检索表和关键词以便鉴定。

关键词：无性型分类学 Coccosporium aucupariae 分生孢子个体发育共无性型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：