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A PERSONAL MEMOIR OF WEIMIN ZHENG-“A MAN FOR ALL SEASONS”

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Journal of Systems Science and Systems Engineering 2013年第4期22卷 499-504页

作者： keith W.HIPEL Department of Systems Design Engineering University of Waterloo

In 1951 Professor Weimin Zheng returned to the People＇s Republic of China from the United Kingdom to assist in building his country into a modern nation. Rather than pursue a doctoral degree at the California Institute of Technology, or Caltech as it is popularly called, Professor Zheng, unselfishly and patriotically, decided that he would devote his many talents to providing a first-class education to Chinese students within a strong university system. In particular,

关键词： A MAN FOR ALL SEASONS A PERSONAL MEMOIR OF WEIMIN ZHENG

Prostate-associated gene 4 （PAGE4）, an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer

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Asian Journal of Andrology 2016年第5期18卷 695-703页

作者： Prakash Kulkarni A keith Dunker keith Weninge John Orban Institute for Bioscience and Biotechnology Research University of Maryland Rockville MD 20850 USA Center for Computational Biology and Bioinformatics Department of Biochemistry and Molecular Biology Indiana University School of Medicine and Informatics Indianapolis IN 46202 USA Department of Physics North Carolina State University Raleigh NC 27695 USA Department of Chemistry and Biochemistry University of Maryland College Park MD 20742 USA.

Prostate-associated gene 4 （PAGE4） is a remarkably prostate-specific Cancer/Testis Antigen that is highly upregulated in the human fetal prostate and its diseased states but not in the adult normal gland. PAGE4 is an intrinsically disordered protein （IDP） that functions as a stress-response protein to suppress reactive oxygen species as well as prevent DNA damage. In addition, PAGE4 is also a transcriptional regulator that potentiates transactivation by the oncogene c-Jun, c-Jun forms the AP-1 complex by heterodimerizing with members of the Fos family and plays an important role in the development and pathology of the prostate gland, underscoring the importance of the PAGE4/c-Jun interaction. HIPK1, also a component of the stress-response pathway, phosphorylates PAGE4 at T51 which is critical for its transcriptional activity. Phosphorylation induces conformational and dynamic switching in the PAGE4 ensemble leading to a new cellular function. Finally, bioinformatics evidence suggests that the PAGE4 mRNA could be alternatively spliced resulting in four potential isoforms of the polypeptide alluding to the possibility of a range of conformational ensembles with latent functions. Considered together, the data suggest that PAGE4 may represent the first molecular link between stress and prostate cancer （PCa）. Thus, pharmacologically targeting PAGE4 may be a novel opportunity for treating and managing patients with PCa, especially patients with low-risk disease.

关键词： prostate-associated Gene 4 cancer/testis antigen intrinsically disordered protein prostate cancer c-Jun AP-1 proteininteraction networks homeodomain-interacting protein 1

Effects of novel vaccines on weight loss in diet-induced-obese(DIO) mice

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Journal of Animal Science and Biotechnology 2012年第3期3卷 136-142页

作者： keith N Haffer Braasch Biotech LLC 421 Rose AvenueGarrestonSD 570303-0430USA

The purpose of the study was to test the therapeutic effects of novel vaccines for reducing weight gain and increasing weight loss in diet induced obesity （DIO） model. Male C57BL/6 J mice, fed a 60% Kcal fat diet for 8 weeks prior to the start of the study, were vaccinated via the intraperitoneal route with two formulations （JH17 ＆ JH]8） of chimeric-somatostatin vaccines at 1 and 22 days of the study. Control mice were injected with PBS. All mice continued to be feed the 60% Kcal fat diet for the week and food intake was measured weekly. At week 6 6 week study. Body weights were measured two times a mice were euthanized and a terminal bleed was made and antibody levels to somatostatin and levels of insulin-like growth factor 1 （IGF-1） were determined. Vaccination with both vaccine formulations induced a statistically significant body weight change over the study period, as compared with PBS controls. Percentage of baseline body weight was also significantly affected by vaccination during the study period. Vaccinates finished the study at 104% and 107% of baseline weight, JHI7 ＆ JH18 respectively, while untreated controls reached 115% of baseline weight. Food intake per mouse was similar in all mouse groups during the entire study. Control mice did not demonstrate any antibody titers to somatostatin, while all vaccinated mice had measurable antibody responses （〉 1：500,000 titer）. IGF-1 levels were not statistically significant among the groups, but were elevated in the JH18 vaccinates （mean 440.4 ng/mL） when compared with PBS controls （mean 365.6 ng/mL）. Vaccination with either JH17 or JH18 chimeric -somatostatin vaccines produced a statistically significant weight loss as compared with PBS controls （P 〈 0.0001）, even though the DIO mice with continually fed a 60% Kcal fat diet. The weight loss/lower weight gain observations were even more significant, as all mice consumed similar amounts of food for the entire study. The presence of high levels of anti-somatostatin

关键词： Obesity Treatment Vaccines Weight loss Weight management

MODEL, GUESS, CHECK: Wordle as a primer on active learning for materials research

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npj Computational Materials 2022年第1期8卷 937-939页

作者： keith A.Brown Department of Mechanical Engineering Physics Departmentand Division of Materials Science&EngineeringBoston UniversityBostonMAUSA

Research and games both require the participant to make a series of *** learning is a process borrowed from machine learning for algorithmically making choices that has become increasingly used to accelerate materials *** this process may seem opaque to researchers outside the field of machine learning,examining active learning in games provides an accessible way to showcase the process and its ***,we examine active learning through the lens of the game Wordle to both explain the active learning process and describe the types of research questions that arise when using active learning for materials research.

关键词： Wordle learning outside

EMDS 3.0:A modeling framework for coping with complexity in environmental assessment and planning

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Science China(Technological Sciences) 2006年第z1期49卷 63-75页

作者： keith M.Reynolds U.S.Dept.Agriculture Forest ServicePacific Northwest Research Station3200 SW Jefferson WayCorvallisOR 97331USA

The Ecosystem Management Decision Support (EMDS) system is an application framework for knowledge-based decision support of ecological assessments at any geographic scale. The system integrates state-of-the-art geographic information system (GIS) as well as knowledge-based reasoning and decision modeling technologies to provide decision support for a substantial portion of the adaptive management process of ecosystem management. EMDS 3.0 is implemented as an ArcMap extension and integrates the logic engine of NetWeaver to perform landscape evaluations, and the decision modeling engine of Criterium DecisionPlus for evaluating management priorities. Key features of the system's evaluation component include abilities to (1) reason about large, abstract, multi-faceted ecosystem management problems, (2) perform useful evaluations with incomplete information, (3) evaluate the influence of missing information, and (4) determine priorities for missing information. A key feature of the planning component is the ability to determine priorities for management activities, taking into account not only ecosystem condition, but also criteria that account for the feasibility and efficacy of potential management actions. Both components include powerful and intuitive diagnostic features that facilitate communicating the explanation of modeling results to a broad audience.

关键词： natural resources, modeling, assessment, analysis, planning, software, ecosystem management.

Can Engineers Lead Again?

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Engineering 2016年第1期2卷 19-20页

作者： keith Clarke Swansea Bay Tidal Lagoon Future Cities Catapult Forum for the Future

The industrial revolution which transformed Europe, and Britain in particular-was led by engineers. From James Watt to Isambard Kingdom Brunel, the finest engineers combined a whole host of skills and disciplines. They were entrepreneurs, developers, lobbyists, financiers, contractors, designers, manufac- turers, and project managers-all rolled into one. And, above all, they were leaders.

关键词：工程师工业革命项目经理企业家开发商承包商设计者制造者

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

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Particuology 2019年第6期17卷 10-21页

作者： Ahmad Baroutaji Sandra Lenihan keith Bryan School of Engineering Faculty of Science and EngineeringUniversity of WolverhamptonTelfordUK School of Mechanical Electrical and Process EngineeringCork Institute of TechnologyCorkIreland

Capping failure,edge chipping,and non-uniform mechanical properties of convex-faced pharmaceutical tablets are common problems in the pharma *** this paper,the finite element method(FEM)and design of experiment techniques are used to determine the optimal shape of convex-faced(CF)pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping *** effects of different geometrical parameters and friction on the compaction responses of convex-faced pharmaceutical tablets were first identified and *** FEM model of the tabletting process was generated using the implicit code ABAQUS and validated against experimental *** surface methodology was used to establish the relationship between the design variables,represented by the geometrical parameters and friction coefficient,and compaction responses of interest including residual die pressure,relative density variation within a tablet,and relative shear stress at the edge of a tablet.A statistical-based optimisation approach was then used to optimise the shape of CF *** obtained results demonstrated how the geometrical parameters and friction coefficient of CF pharmaceutical tablets strongly affect their compaction behaviour and quality.

关键词： Capping failure Edge chipping Tabletting FEM Optimisation Residual radial pressure