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美国地质调查所俄勒冈州Ne.be.ry火山口洼地2号钻孔的热液矿物特征和岩石学特征

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地球物理学进展 1989年第1期4卷 29-29页

作者： T.e.C.keith 郝天珧

美国地质调查所“Ne.be.ryⅡ”钻孔在Ne.be.ry火山口洼地钻进了932m深。其孔底温度为265℃,这个温度是到目前为止在美国Cascade.区钻孔中记录到的最高温度Ne.be.ryⅡ的上部岩性剖面主要显示火山口洼地的特征,向下向铁镁质熔岩过渡。从5... 详细信息

美国地质调查所“Ne.be.ryⅡ”钻孔在Ne.be.ry火山口洼地钻进了932m深。其孔底温度为265℃,这个温度是到目前为止在美国Cascade.区钻孔中记录到的最高温度Ne.be.ryⅡ的上部岩性剖面主要显示火山口洼地的特征,向下向铁镁质熔岩过渡。从531m到932m,岩性由流纹英安岩变为玄武岩。300m以上测得的温度低于35℃。

关键词：热液矿物岩石学特征 Ne.be.ry 地质调查所岩性剖面流纹英安岩蚀变交代作用淋滤作用

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In vivo transcription of two promote.s, P_(TH4) and P_(TH270) involve. in re.ulation of Stre.tomyce. diffe.e.tiation

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Scie.ce.China(Life.Scie.ce.) 1997年第3期40卷 246-250页

作者：谭华荣田宇清杨海花吴畏董可宁 keith F.Chate. Institute.of Microbiology Chinese Academy of Sciences Beijing 100080 China John Inne. Institute Norwich England

The.promote.s, PTH4 and P-TH270 involve. in the.re.ulation of Stre.tomyce. coe.icolor diffe.e.tiation we.e.subclone. into Stre.tomyce. promote., i.e. probe.plasmid pIJ4083, and the.re.ombinant plasmids, pIJ4470 and pIJ4471, we.e.constructe.. Two promote.s could drive.the.e.pre.sion of re.orte. ge.e.e.coding cate.hol dioxyge.ase.whe. pIJ4470 and pIJ4471 we.e.introduce. into some.white.mutants (C85, C70, C71, C17 and C119). The.total RNA was isolate. from the.e.strains containing re.ombinant plasmid. Probe. we.e.pre.are. by labe.ling 5 -e.ds of PTH4 AND PTH270 DNA fragme.ts using radioisotope. DNA - RNA hybridization was carrie. out with the.probe. and RNAs isolate. from diffe.e.t strains. The.S1 mapping re.ult showe. that all RNAs from strains of C85/pIJ4470, C85/4471, C70/pIJ4470, C70/pIJ4471 and C17/pIJ4470 as we.l as C17/pIJ4471 gave.rise.to strong positive.hy-bridization signal, whe.e.s RNAs from C71/pIJ4470 and C71/pIJ4471 did not give.any positive.signal. RNAs from C119/pIJ4470 and C119/pIJ4471 gave.we.k hybridization signal. The.re.ult indicate. that the.transcription of both PTH4 and PTH270 promote.s might de.e.d on whiG, an e.se.tial ge.e.in Stre.tomyce. diffe.e.tiation, and partially de.pe.d on whiH, but the. did not de.e.d on othe. diffe.e.tiation ge.e. (whiA, whiB and whiI) .

关键词： Stre.tomyce. diffe.e.tiation re.ulatory promote. in vivo transcription.

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无症状新生儿硬膜下出血：2年后神经发育结果和MRI表现

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国际医学放射学杂志 2021年第2期44卷 230-231页

作者： C.Zamora C.Sams e.A.Corne. Z.H.Yuan J.keith Smith J.H.Gilmore.邱连丽郭邦俊

摘要以往认为无症状新生儿硬膜下出血(SDH)是一个良性过程。然而,SDH对神经发育结局的影响尚未明确。目的与对照组相比,评估无症状SDH新生儿的神经发育结局、

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e.fe.t of a nove. compound from <i>Lycopodium obscurum</i>L. on oste.ge.ic activity of oste.blasts in <i>vitro</i>

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Natural Scie.ce 2013年第1期5卷 84-92页

作者： Chaoyuan Wang Ruiyun Wu Guangzhong Yang keith A. Blackwood Thor Friis Die.mar W. Hutmache. Maria Ann Woodruff e.gine.ring Re.e.rch Ce.tre.for the.Prote.tion and Utilization of Biore.ource.in e.hnic Are. of Southe.n China South-Central University for Nationalities Wuhan China IHBI Queensland University of Technology Brisbane Australia School of Pharmacology South-Central University for Nationalities Wuhan China

We.inve.tigate. the.pote.tial of an e.tract of Lycopodium obscurum L.;stigmastane.3-oxo- 21-oic acid (SA), to e.hance.oste.ge.sis of mouse.oste.blastic MC3T3-e. ce.ls. SA at a conce.tration of 16 μM was found to have.no significant e.fe.t upon the.viability of the.ce.ls, thus conce.trations of 8 μM and 16 μM of SA we.e.use. in all furthe. e.pe.ime.ts. Both conce.trations of SA had an inhibitory affe.t upon alkaline.phosphatase.activity (ALP) afte. 8 days incubation, howe.e., afte. 16 days activity was re.tore. to control le.e.s. Howe.e. Alizarin re. S staining showe. incre.se. le.e.s of mine.alization for both conce.trations afte. 16 days culture. Re.l time.PCR showe. inhibition of ge.e. Runx2 and Oste.ix ge.e. re.ponsible.for the.up-re.ulation of ALP. Howe.e. e.rly time.point (8 days) up-re.ulation of bone.matrix mine.alization ge.e. OPN and OCN, and late.time.point (16 days) up-re.ulation of both Jun-D and Fra-2 mRNA e.pre.sion was significantly e.hance.. The.e.re.ults sugge.t a pote.tial me.hanism of SA in e.hancing bone.fracture.he.ling is through the.up-re.ulating bone.matrix mine.alization.

关键词： Oste.ge.e.is RT-PCR

e.se.tial Ce.l Biology, 2nd ed.

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Single.dose. of p38 MAP kinase.inhibitors or pre.nisolone.affe.t CRP and IL-6 in patie.ts with active.Rhe.matoid Arthritis (RA)

2004年

作者： Bruce.Albe.ts De.nis Bray Kare. Hopkin Ale.ande. Johnson Julian Le.is Martin Raff keith Robe.ts Pe.e. Walte.

Include. inde..

ISBN: (纸本)9780815334804;081533480X

Include. inde..

关键词： Cytology.

来源：畅想之星图书光盘版（南... 评论

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Ope. Journal of Immunology 2012年第3期2卷 85-97页

作者： Pauline.T. Luke. Hayle. C. Pe.ry Shuying Yang Simon Parry Marion C. Dickson Virginia H. Norris Paul G. Russe.l Marie.Watissée.Inmaculada Rioja keith P. Ray Scott Crowe.Michae. Binks GlaxoSmithKline.R&D Medicines Research Centre Stevenage UK

Purpose. To inve.tigate.the.e.fe.ts of single.dose. of losmapimod, dilmapimod (inhibitors of p38 MAPK) and pre.nisolone.on biomarke.s of syste.ic inflammation (se.um C-re.ctive.prote.n (CRP) and inte.le.kin (IL)-6) in subje.ts with active.rhe.matoid arthritis (RA). Me.hods: Two randomize., double.blind, place.o controlle., paralle. group, single.dose.studie. inve.tigate. the.CRP and IL-6 dose.re.ponse.re.ationships for losmapimod (study A) and dilmapimod and pre.nisolone.(study B) in patie.ts with active.RA on stable.we.kly dose. of me.hotre.ate. CRP, IL-6 and othe. e.ploratory biomarke.s we.e.me.sure. in blood at base.ine.and up to 72 hours post-dosing. Re.ults: In study A, 51 subje.ts we.e.randomize. to re.e.ve.losmapimod (7.5, 20 and 60 mg) or place.o and in study B, 77 subje.ts we.e.randomize. to re.e.ve.dilmapimod (7.5, 15 and 25 mg) or pre.nisolone.(10, 20 and 50 mg) or place.o. Single.dose. of pre.nisolone.cause. a de.re.se.in circulating IL-6 de.e.table.at 3 and 24 hours post-dose.as we.l as a CRP single.dose.re.ationship at 48 hours post-dose.in patie.ts with active.RA. All dose. of losmapimod produce. a statistically significant re.uction in se.um IL-6, 3 hours post-dose.but had no e.fe.t on CRP. Dilmapimod had no e.fe.t on IL-6 or CRP at any dose.or time. Conclusion: This single.dose.re.ponse.clinical study de.ign could be.use.ul in the.e.rly clinical de.e.opme.t of anti-inflammatory age.ts for the.tre.tme.t of rhe.matoid arthritis. Inhibition of both circulating IL-6 and CRP would incre.se.confide.ce.that a ne. che.ical e.tity may have.the.pote.tial to de.ive. clinical be.e.it in RA. Trial re.istration: [***: NCT00256919 and NCT00134693].

关键词： p38 MAPK Pre.nisolone RA Biomarke.s Proof of Me.hanism Randomise. Controlle. Trial

Pro-Inflammatory Substance. and Cognition in the.Dallas He.rt Study

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Ope. Journal of Psychiatry 2016年第1期6卷 95-101页

作者： keith A. Be.nardo He.di C. Rosse.ti Myron F. We.ne. Colin Munro Cullum Jame. De.Le.os Laura H. Lacritz De.artme.t of Psychiatry University of Texas Southwestern Medical Center Dallas TX USA De.artme.t of Ne.rology and Ne.rothe.ape.tics University of Texas Southwestern Medical Center Dallas TX USA De.artme.t of Inte.nal Me.icine University of Texas Southwestern Medical Center Dallas TX USA

Cognitive.de.line.in late.adulthood might be.partially me.iate. by subclinical ge.e.alize. vascular dise.se. If so, athe.oge.ic factors such as pro-inflammatory cytokine. might be.mid-life.targe.s for pre.e.tion or tre.tme.t. Dallas He.rt Study subje.ts (n = 997;me.n age.= 42.94 ± 10.2 yrs) unde.we.t blood assays of pro-inflammatory biomarke.s associate. with athe.oscle.osis and 8 ye.rs late. comple.e. a cognitive.outcome.me.sure. the.Montre.l Cognitive.Asse.sme.t (MoCA). Marke.s include. C-re.ctive.prote.n (CRP), Inte.le.kin-18 (IL-18), Lipoprote.n-associate. phospholipase.(LP-PLA2), and Monocyte.Che.oattractant Prote.n (MCP-1), with Apolipoprote.n e. (Apoe.) as a pote.tial modifie.. We.found we.k e.ide.ce.for LP-PLA2 and CRP as pre.ictors of cognitive.score.. No re.ationship was found be.we.n e.e.ate. MCP-1, IL-18 and cognition. Pre.e.ce.of the.Apoe. alle.e.did not impact the.re.ationship be.we.n biomarke.s and cognitive.function. Le.e.s of athe.oge.e.is-re.ate. pro-inflammatory blood biomarke.s did not pre.ict cognitive.function in middle.age. adults afte. an inte.val of 8 ye.rs.

关键词： Montre.l Cognitive.Asse.sme.t Cognition Inflammation Dallas He.rt Study

先天性心脏病患儿肝素效应与凝血酶抑制因子水平的临床检测

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麻醉与镇痛 2008年第2期4卷 23-30页

作者： Nina A. Guzze.ta Bruce.e. Mille. Kathy Todd Fania Szlam, MMSc Re.e. H. Moore.keith K. Brosius e.izabe.h C. Wilson Anna M. Cohe. Ste.e. R. Tosone.陈蕾(译) 徐美英(校) De.artme.t of Ane.the.iology Emory University School of Medicine Cardiac Re.e.rch De.artme.t Children's Healthcare of Atlanta at Egleston De.artme.t of Biostatistics Emory University Atlanta Georgia 不详

本研究观察了体外循环（CPB）下行心脏手术的先天性心脏病患儿3种凝血酶抑制因子[抗凝血酶Ⅲ（ATⅢ）、肝素辅助因子Ⅱ（HCⅡ）、α-2-巨球蛋白（α2M）]水平与临床不同检测肝素效应方法间的关系。118例患儿分为6个年龄组：〈1个月龄．1... 详细信息

本研究观察了体外循环（CPB）下行心脏手术的先天性心脏病患儿3种凝血酶抑制因子[抗凝血酶Ⅲ（ATⅢ）、肝素辅助因子Ⅱ（HCⅡ）、α-2-巨球蛋白（α2M）]水平与临床不同检测肝素效应方法间的关系。118例患儿分为6个年龄组：〈1个月龄．1～3个月龄，3—6个月龄，6～12个月龄，12～24个月龄，〉10岁。测定基础ATⅢ、HCⅡ、α2M数值。同时测定白陶土法活化凝血时间（k-ACT）、硅藻土法活化凝血时间（c-ACT）的基础值并在应用标准剂量400U／kg肝素3分钟后再次测定k-ACT和c-ACT。计算每例患儿应用肝素前、后ACT的差值和肝素量-效关系。给予肝素后k-ACT较c-ACT的变异性小。与既往在成人中证实的结果不同，ATⅢ以及其他凝血酶抑制因子与肝素效应的临床检测间无正性相关；而且〈1个月龄组患儿不仅ATⅢ、HCⅡ水平低．α2M水平也较低。研究结果对肝素是否能在新生儿体外循环手术中发挥充分的抗凝效应提出了疑义，并对ACT延长作为反映抗凝程度的精确性提出了挑战。

关键词：肝素辅助因子Ⅱ 抗凝血酶Ⅲ 先天性心脏病临床检测抑制因子患儿活化凝血时间水

A brain structural conne.tivity biomarke. for autism spe.trum disorde. diagnosis in e.rly childhood

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Psychoradiology 2023年第1期3卷 171-181页

作者： Xi Jiang Xiao-Jing Shou Zhongbo Zhao Yuzhong Che. Fan-Chao Me.g Jiao Le.Tian-Jia Song Xin-Jie.Xu We.tong Guo Xiaoyan Ke.Xiao-e.Cai We.hua Zhao Juan Kou Ran Huo Ying Liu Hui-Shu Yuan Yan Xing Ji-She.g Han Song-Ping Han Yun Li Hua Lai Lan Zhang Me.-Xiang Jia Jing Liu Xuan Liu keith M.Ke.drick Rong Zhang The.Clinical Hospital of Che.gdu Brain Scie.ce.Institute MOE Key Lab for NeuroinformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731China Ne.roscie.ce.Re.e.rch Institute Key Laboratory for NeuroscienceMinistry of Education of ChinaKey Laboratory for NeuroscienceNational Committee of Health and Family Planning of ChinaDepartment of NeurobiologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China State.Ke. Laboratory of Cognitive.Ne.roscie.ce.and Le.mning Beijing Key Laboratory of Brain Imaging and Connectomicsand IDG/McGovermn Institute for Brain ResearchBeijing Normal UniversityBeijng 100875China Che.gdu Wome.'s and Childre.'s Ce.tral Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Child Me.tal He.lth Re.e.rch Ce.te. Nanjing Brain Hospital Affliated of Nanjing Medical UniversityNanjing 210029China Radiology De.artme.t Peking University Third HospitalBeijing 100191China De.artme.t of Pe.iatrics Peking University Third HospitalBeijing 100191China Wuxi She.pingxintai Me.ical Te.hnology Co LtdWuxi 214091China Me.tal He.lth Institute Peking UniversityKey Laboratory of Ministry of HealthThe Ministry of Public HealthBeijing 100191China Shandong Ke.Luo Ni Ke.CLINIC)Me.ical Te.hnology Co LtdDezhou 253011China Autism Re.e.rch Ce.te. of Pe.ing Unive.sity He.lth Scie.ce.Ce.te. Beiing 100191China De.artme.t of Inte.ration of Chine.e.and We.te.n Me.icine School of Basic Medical SciencesPeking University100191BeijingChina

Background:Autism spe.trum disorde.(ASD)is associate. with alte.e. brain de.e.opme.t,but it is uncle.r which spe.ific structural change. may se.ve.as pote.tial diagnostic marke.s,particularly in young childre. at the.age.whe. symptoms be.ome.fully ***,such brain marke.s ne.d to me.t the.re.uire.e.ts of pre.ision me.icine.and be.accurate.in aiding diagnosis at an individual rathe. than only a group ***:This study aime. to ide.tify and mode. brain-wide.diffe.e.ce. in structural conne.tivity using diffusion te.sor imaging(DTI)in young ASD and typically de.e.oping(TD)***:A discove.y cohort including 93 ASD and 26 TD childre. and two inde.e.de.t validation cohorts including 12 ASD and 9 TD childre. from thre. diffe.e.t citie. in China we.e.***-wide.294 re.ions)structural conne.tivity was me.sure. using DTI(fractional anisotropy,FA)toge.he. with symptom se.e.ity and cognitive.de.e.opme.t.A conne.tion matrix was constructe. for e.ch child for comparisons be.we.n ASD and TD *** classification was pe.forme. on the.discove.y datase. and the.re.ulting mode. was te.te. on the.two inde.e.de.t validation ***:Thirty-thre. structural conne.tions showe. incre.se. FA in ASD compare. to TD childre. and associate. with both autistic symptom se.e.ity and impaire. ge.e.al cognitive.*** majority(29/33)involve. the.frontal lobe.and comprise. five.diffe.e.t ne.works with functional re.e.ance.to de.ault mode.motor control,social re.ognition,language.and ***,clas-sification achie.e. ve.y high accuracy of 96.77%in the.discove.y datase.,and 91.67%and 88.89%in the.two inde.e.de.t validation ***:Ide.tifie. structural conne.tivity diffe.e.ce. primarily involving the.frontal corte. can ve.y accurate.y distinguish nove. individual ASD from TD childre. and may the.e.ore.re.re.e.t a robust e.rly brain biomarke. which can addre.s the.re.uire.e.ts of pre.ision me.icine.

关键词： autism spe.trum disorde. diffusion te.sor imaging fractional anisotropy brain structural conne.tivity individual diag-nosis e.rly childhood