检索结果-南通市图书馆

Back to the drawing board:Overview of the next generation of combination therapy for inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第25期30卷 3182-3184页

作者： Jeffrey A Lowell Michael J Farber keith Sultan Department of Medicine Zucker School of Medicine at HofstraNorth Shore University Hospital-Long Island Jewish Medical CenterManhassetNY 11030United States Preclinical Studies New York Institute of Technology College of Osteopathic MedicineGlen HeadNY 11545United States Division of Gastroenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States

Inflammatory bowel disease(IBD)is entering a potentially new era of combined *** et al provide an insightful review of the current state of combination therapy,with a focus on the use of a combined biologic and immunomodulator,as well as emerging data on the future potential of dual-biologic therapy(DBT).While current evidence for DBT is limited,encouraging safety profiles and ongoing trials suggest a brighter future for this *** importance of controlled trials should be stressed in establishing new treatment *** prospective randomized trials of DBT and perhaps future combinations of biologics and small molecule therapies will hopefully guide the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Immunomodulators Dual-therapy combination therapy

Matt cutts: Try something new for 30 days

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新世纪智能 2024年第40期 17-19页

作者： keith

当你开始感叹生活枯燥，每天的生活除上学放学、吃饭看书、洗漱睡觉之外再无乐趣可言时，不妨试着改变你的生活方式：培养一种新的爱好，每天做一件你喜欢做的事情，或者培养一种新的生活习惯。每天只需努力一点点，你的生活就会因此而...

当你开始感叹生活枯燥，每天的生活除上学放学、吃饭看书、洗漱睡觉之外再无乐趣可言时，不妨试着改变你的生活方式：培养一种新的爱好，每天做一件你喜欢做的事情，或者培养一种新的生活习惯。每天只需努力一点点，你的生活就会因此而大不相同。A few years ago, I felt like I was stuck in a rut,

关键词：

Embracing the Year of the Dragon

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

china Today 2024年第2期73卷 30-32页

作者： keith BENNETT Friends of Socialist china based in London

The Lunar New Year has increasingly become a common festival of people throughout the *** people,and people throughout the world,are looking forward to welcoming the Year of the Dragon,which falls on February 10,*** Dragon is considered the most auspicious of the 12 signs in the chinese zodiac and this year is specifically the Year of the Wood Dragon,the first since *** to Lifestyle Asia,“Wood Dragons enjoy fulfilling ***’re likely to materialize all their ambitions into actions,coming up with truly revolutionary ideas.”

关键词： looking has likely

Five Principles as Relevant Today as 70 Years Ago

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

china Today 2024年第8期73卷 18-19页

作者： keith BENNETT 不详

The chinese initiative has become an international consensus with productive actions.A conference marking the 70th anniversary of the Five Principles of Peaceful coexistence,a cornerstone of chinese foreign policy,was held in Beijing on June 28,attracting attendees from around the world,including former political leaders from some 20 *** the conference,President Xi Jinping made an important speech in which he said that the Five Principles“marked a groundbreaking and epoch-making achievement in the history of international relations.”

关键词： corners attracting Peace

Symptom presentation and evolution in the first 48 hours after injury are associated with return to play after concussion in elite Rugby Union

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 387-397页

作者： Ross Tucker Matt cross keith Stokes Lindsay Starling Rosy Hyman Simon Kemp Stephen West Martin Raftery Eanna Falvey James Brown Institute of Sport and Exercise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland Premiership Rugby London SW1V 1PXUK centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK collaborating centre on Injury and Illness Prevention in Sport(UKccIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of Tropical Medicine London WC1E 7HTUK Sport Injury Prevention Research centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Department of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland carnegie Applied Rugby Research(cARR)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Return to play(RTP)in elite rugby is managed using a 6-stage graduated RTP protocol,which can result in clearance to play within 1 week of *** aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RTP)to identify whether a more conservative graduated RTP may be ***:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive *** were classified as shorter or longer returns,depending on whether RTP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,***,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RTP time were explored using odds ratios(OR,longer ***).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or ***:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%cI):1.39-3.50;HIA3:OR=3.30,95%cI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%cI:1.36-4.58;HIA3:OR=3.34,95%cI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and *** and balance performance were not associated with longer return and did not affect median days ***:Symptom presentation and evolution within 48 h of concussion were associated with longer RTP *** may guide a more conservative approach to RTP,while still adhering to individualized concussion management principles.

关键词： Brain injury concussion management General return to play Medical management

维普期刊数据库

How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel Olivia Galea Kirsten Holte caroline Luszawski Elizabeth Jenkins Jennifer O’Neil carolyn A Emery Rebekah Mannix Kathryn Schneider keith Owen Yeates Roger Zemek children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta children’s Hospital Research Institute University of calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency Medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency Medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RcTs)of non-pharmacological interventions following ***:We searched MEDLINE,Embase,PsycInfo,cINAHL,and Web of Science up to May *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),consensus on Exercise Reporting Template(cERT),and international consensus on Therapeutic Exercise aNd Training(i-cONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RcTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),cERT 17/19(89%;IQR=2;range:10-19),and i-cONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),cERT 24%(5/21),and i-cONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and cERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;cERT:r_(s)=-0.44;p=0.06;i-cONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;cERT:rs=0.04;p=0.86;i-cONTENT:rs=0.12;p=0.60).conclusion:RcTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and cERT publication,but p

关键词： concussion Intervention Randomized controlled trial Systematic review

维普期刊数据库

Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall Duncan Loader Santiago Gouveia Marta Burak James Halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari keith J Roberts Syed S Raza Michail Papamichail David c Bartlett Robert P Sutcliffe Nikolaos A chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom college of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

BAcKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dccA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dccA and present the experience of a highvolume tertiary-centre managing dccA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dccA who received *** patients from 2017 to 2022 who were referred for NAT for dccA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dccA was *** studies reported outcomes for 9 patients who received NAT for dccA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dccA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dccA is *** propose using the established National-comprehensive-cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1D owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1D donors to the FDAapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

cI-WGAN:融合临床指标和WGAN的孤独症个体化脑功能连接网络生成

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

数据采集与处理 2024年第4期39卷 813-826页

作者：孙海林严加栋张嵘 KENDRIcK keith 蒋希电子科技大学生命科学与技术学院成都611731 麦吉尔大学蒙特利尔神经研究所蒙特利尔H3A 2B4 北京大学基础医学院神经生物学系北京100191 北京大学神经科学研究所北京100191 神经科学教育部重点实验室北京100191 卫健委神经科学重点实验室北京100191 北京大学医学部孤独症研究中心北京100191

脑功能连接(Functional connectivity,Fc)网络作为潜在的脑影像标志物对孤独症谱系障碍(Autism spectrum disorder,ASD)的辅助诊疗研究具有重要作用。然而现有的Fc生成方法大多仅基于脑影像数据,未充分考虑个体的临床指标从而易丢失疾... 详细信息

脑功能连接(Functional connectivity,Fc)网络作为潜在的脑影像标志物对孤独症谱系障碍(Autism spectrum disorder,ASD)的辅助诊疗研究具有重要作用。然而现有的Fc生成方法大多仅基于脑影像数据,未充分考虑个体的临床指标从而易丢失疾病的特异性信息。而且,ASD作为一种谱系障碍,其临床指标存在显著的个体化差异。因此,仅基于脑影像数据的传统生成模型在生成准确的且能反映个体化临床指标的ASD个体Fc的任务上存在挑战。针对上述挑战,提出了个体化临床指标引导的沃瑟斯坦生成对抗网络模型(clinical-indicator-aware Wasserstein generative adversarial network,cI-WGAN),用于生成孤独症个体化Fc网络。该模型引入个体化临床指标引导机制,实现了高精度ASD患者Fc网络的生成。基于全世界最大孤独症脑影像公开数据集之一的ABIDE I数据集进行实验,cI-WGAN生成Fc与真实Fc的峰值信噪比(Peak signal-to-noise ratio,PSNR)、结构相似度(Structural similarity,SSIM)与平均绝对误差(Mean absolute error,MAE)分别达到19.037、0.236与0.178,相较于其他Fc生成模型分别提升了3%、12%与2%。此外基于生成Fc和独立临床验证指标的表征相似度分析(Representational similarity analysis,RSA),cI-WGAN生成的Fc相较其他模型生成Fc最少提高了0.1倍和3.7倍,证明了cI-WGAN生成的Fc包含更多的ASD个体特异性信息。本文提出的cI-WGAN模型实现了高质量个体化Fc的生成,为ASD的早期诊断和个性化治疗提供了有力的技术支持。

关键词：孤独症谱系障碍大脑功能连接生成对抗网络临床指标引导机制梯度惩罚机制

维普期刊数据库