检索结果-南通市图书馆

Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics

World Journal of Gastroenterology 2022年第18期28卷 1996-2007页

作者： Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam keith Roberts Manuel Abradelo David C Bartlett Bobby V Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias HPB and Liver transplant Unit Queen Elizabeth HospitalBirmingham B152GWUnited Kingdom Department of HPB and Liver transplantation Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152THUnited Kingdom

BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer *** are conflicting on the role of IGBC diagnosis in oncological *** studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others *** to investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative *** Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary *** comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was *** analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank *** analysis was performed with univariable and multivariable Cox regression *** the cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced t stage and required more extensive resections than IGBC *** was longer in patients with IGBC in the whole cohort(29 vs 4 mo,Pthe non-surgical(14 vs 2 mo,Pter surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and *** diagnosis was identified as an independent predictor of *** IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour *** studies are required to further investigate this,including detailed

关键词： Gallbladder cancer Incidental gallbladder cancer Non-incidental gallbladder cancer Gallbladder cancer survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Robust fiber-based frequency synchronization system immune to strong temperature fluctuation

引用

Chinese Optics Letters 2018年第1期16卷 25-29页

作者：朱玺王波郭倚辰袁一博 Romeo Gamatham Bruce Wallace keith Grainge Lijun Wang State Key Laboratory of Precision Measurement technology and Instruments Department of Precision Instrument Tsinghua University Department of Physics Tsinghua University SKA South Africa Blend on Baker Jodrell Bank Centre for Astrophysics Alan Turing Building School of Physics & AstronomyThe University of Manchester

In order to make the fiber-based frequency synchronization system suitable for the use of large-scale scientific and engineering projects in which the ambient temperature of the fiber links change dramatically, we design a non-harmonic frequency dissemination system immune to strong temperature fluctuation. After the lab tests, in which the ambient temperature of the fiber fluctuates 40°C/day and 20°C/h, respectively, the relative frequency stabilities of this system reaches 4.0 × 10-14∕s and 3.0 × 10-16∕104 s. It is demonstrated that the proposed non-harmonic scheme shows a strong robustness to complicated working environment with strong temperature fluctuation.

关键词： Diode lasers Fiber optic couplers Light beams Optical circulators temperature Wavelength division multiplexers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

耕作和混合农业体系未来植物养分利用的前景和挑战

引用

AMBIO－人类环境杂志 2005年第4期34卷 277-281页

作者： Lars Bergstrm keith W.t.Goulding 张秋英乌普萨拉瑞典农业大学土壤科学系 Rothamsted研究所农业和环境部门

在不污染环境的情况下生产足量的健康食品对未来世界农业是一个严重挑战。瑞典"21世纪的食物"研究计划已经研究了可持续耕作体系的经济的、环境的以及社会的各个方面,本文列举了瑞典"21世纪的食物"研究计划以及其它相关的国际研究计划... 详细信息

在不污染环境的情况下生产足量的健康食品对未来世界农业是一个严重挑战。瑞典"21世纪的食物"研究计划已经研究了可持续耕作体系的经济的、环境的以及社会的各个方面,本文列举了瑞典"21世纪的食物"研究计划以及其它相关的国际研究计划中注重改善养分利用效率的一些研究,特别是氮和磷。它表明有许多可持续性解决养分利用效率的方法,有些很复杂,但有些就很简单。政府政策包括津贴、研究和技术以及公众对耕作方式的认可,所有这些都与制定这些解决方法结合在一起。需要知识转让的参与式途径,这样科学家、政策决策者、农场主、顾问以及消费者们可以交流信息,一起构建可持续的耕作体系。

关键词：养分利用效率耕作体系农业体系植物混合国际研究计划可持续性污染环境 21世纪政府政策

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Benchmarking the performance of Bayesian optimization across multiple experimental materials science domains

引用

npj Computational Materials 2021年第1期7卷 1742-1751页

作者： Qiaohao Liang Aldair E.Gongora Zekun Ren Armi tiihonen Zhe Liu Shijing Sun James R.Deneault Daniil Bash Flore Mekki-Berrada Saif A.Khan Kedar Hippalgaonkar Benji Maruyama keith A.Brown John Fisher III tonio Buonassisi Massachusetts Institute of technology CambridgeMAUnited States Boston University BostonMAUnited States Singapore-MIt Alliance for Research and technology SingaporeSingapore Air Force Research Laboratory DaytonOhioUnited States Agency for Science Technology and Research(A*STAR)SingaporeSingapore National University of Singapore SingaporeSingapore Present address:Aalto University EspooFinland Present address:Northwestern Polytechincal University(NPU) Xi’anShaanxi P.R.China

Bayesian optimization(BO)has been leveraged for guiding autonomous and high-throughput experiments in materials ***,few have evaluated the efficiency of BO across a broad range of experimental materials *** this work,we quantify the performance of BO with a collection of surrogate model and acquisition function pairs across five diverse experimental materials *** defining acceleration and enhancement metrics for materials optimization objectives,we find that surrogate models such as Gaussian Process(GP)with anisotropic kernels and Random Forest(RF)have comparable performance in BO,and both outperform the commonly used GP with isotropic *** with anisotropic kernels has demonstrated the most robustness,yet RF is a close alternative and warrants more consideration because it is free from distribution assumptions,has smaller time complexity,and requires less effort in initial hyperparameter *** also raise awareness about the benefits of using GP with anisotropic kernels in future materials optimization campaigns.

关键词： optimization performance acceleration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

重性抑郁症首发未用药患者的枕叶GABA波谱研究

引用

生物医学工程学杂志 2012年第2期29卷 233-236页

作者：宋哲黄沛钰邱丽华吴杞柱龚启勇张必达 Heberlein keith 谢鹏重庆医科大学神经科学研究中心重庆400016 重庆市神经生物学重点实验室重庆400016 四川大学华西医院放射科华西磁共振研究中心成都610041 西门子中国有限公司医疗系统集团深圳518057

在中枢神经系统中,γ-氨基丁酸(GABA)是主要的抑制性神经递质。由于GABA在普通磁共振波谱(MRS)上为低谱峰信号,且与其他物质的波峰重叠,因此难以准确得出其在脑内感兴趣区的含量。为观察抑制性神经递质GABA在首发未用药重性抑郁症(MDD)... 详细信息

在中枢神经系统中,γ-氨基丁酸(GABA)是主要的抑制性神经递质。由于GABA在普通磁共振波谱(MRS)上为低谱峰信号,且与其他物质的波峰重叠,因此难以准确得出其在脑内感兴趣区的含量。为观察抑制性神经递质GABA在首发未用药重性抑郁症(MDD)患者枕叶的含量改变,本研究采用了J-耦合编辑点分辨波谱(MEGA-PRESS)技术检测18例首发未用药重性MDD(17项HAMD评分>18分)患者和23名健康对照被试枕叶皮层的GABA含量。采用双样本t检验及相关分析进行统计学处理。结果表明,病例组枕叶GABA含量(11.35±3.26)显著低于对照组(27.30±8.87),P<0.001。病例组枕叶GABA含量与汉密尔顿抑郁量表及贝克抑郁自评量表相关性均不显著。首发未用药重性MDD患者的枕叶GABA含量降低,可能导致其视觉功能下降。

关键词：抑郁症枕叶 γ-氨基丁酸磁共振波谱

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

信号转导的欠缺——是HIV感染时细胞功能障碍的普遍途径吗?

引用

国外医学（免疫学分册） 1991年第1期14卷 32-34页

作者： Anthony J Pinching keith E Nye 郑珊珊

为研究免疫系统或神经系统的HIV 感染和HIV 病的主要致病机制已做了许多研究。HIV 包膜糖蛋白(gp 120)和CD4抗原之间相互作用的显著特异性为HIV 对免疫系统的某些影响,特别是CD4^+t 细胞和抗原提呈细胞的感染已提供了清楚的根据。t、B ... 详细信息

为研究免疫系统或神经系统的HIV 感染和HIV 病的主要致病机制已做了许多研究。HIV 包膜糖蛋白(gp 120)和CD4抗原之间相互作用的显著特异性为HIV 对免疫系统的某些影响,特别是CD4^+t 细胞和抗原提呈细胞的感染已提供了清楚的根据。t、B 细胞和抗原提呈细胞功能缺陷的发病机理争议较多。我们的推测有所不同,认为HIV 能影响细胞内信号传输并以此解释其对细胞功能的影响。

关键词：艾滋病 HIV 信号转导

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

trizivir (Abacavir/Lamivudine/Zidovudine) plus Lopinavir/Ritonavir Induction therapy Followed by trizivir-Alone Maintenance for HIV-1-Infected Patients: A 96-Week Pilot treatment Simplification Study

引用

World Journal of AIDS 2012年第3期2卷 245-251页

作者： Joseph C. Gathe Dean t. Martin M. keith Rawlings Benjamin Daquioag John E. Fuchs Vanessa C. Williams Katrina L. Oie Gary E. Pakes Cigna Healthcare Corp. Phoenix USA Glaxo-SmithKline Research Triangle Park Durham USA Peabody Clinic Dallas USA therapeutic Concepts P.A. Houston USA

Objective: the purpose of this study was to investigate whether switching HIV-infected patients stabilized on trizivir (abacavir 300 mg/lamivudine 150 mg/zidovudine 300 mg) plus lopinavir/ritonavir 400 mg/100mg twice daily to trizivir alone affects clinical efficacy and tolerability. Methods: this phase 4, open-label, pilot study was conducted over 96 weeks in 23 antiretroviral-na?ve, HIV-infected patients. Initially, these patients received induction therapy with trizivir plus lopinavir/ritonavir 400 mg/100mg twice daily. Patients who achieved a viral load 3. Nineteen patients completed induction;of the four who did not, three were lost to follow-up and one withdrew due to gastrointestinal adverse events. In 14 induction completers who had viral load measurements taken at week 48, intent-to-treat: observed analysis showed a week 48 viral load 3 higher than the baseline count. twelve patients completed the subsequent 48-week trizivir-alone maintenance phase, of whom 11 (92%) achieved viral loads of both 3 above baseline. trizivir-only maintenance was associated with fewer adverse events than the trizivir-lopinavir/ritonavir induction phase and with improvement in total cholesterol, LDL-cholesterol, and triglycerides. Conclusions: trizivir-alone maintenance after trizivir-lopinavir/ritonavir induction maintained virologic and CD4+ cell response, and was associated with an improved adverse event and lipid profile.

关键词： Abacavir/Lamivudine/Zidovudine HIV-1 Infection Induction-Maintenance Strategy Kaletra Lopinavir/Ritonavir trizivir

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas

引用

World Journal of Gastrointestinal Surgery 2014年第7期6卷 136-141页

作者： Ioannis t Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo keith D Lillemoe Andrew L Warshaw Cristina R Ferrone Departments of Surgery Massachusetts General HospitalBoston MA 02114 United States Department of Surgery University of ArizonaTucson AZ 85724 United States Departments of Radiology Massachusetts General Hos-pitalBoston MA 02114 United States Department of Radiology University of Napoli80138 Napoli Italy Departments of Pathology Massachusetts General HospitalBoston MA 02114 United States Departments of Gastroenterology Massachu-setts General HospitalBoston MA 02114 United States

AIM: to identify their diagnostic and prognostic clinical characteristics in a large ***: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General ***: twelve patients were identified between 1/1/1997 and 8/1/2007. their median age was 55.5 years(range 19-78 years), and 6 were females. the le-sion was incidentally discovered in half of the *** enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. the median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions ***: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided.

关键词： Lymphoepithelial cysts Cystic lymphangio-mas Pancreas Asymptomatic cysts Benign cystic le-sions of the pancreas

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and Ravaz index

引用

Horticulture Research 2023年第1期10卷 31-44页

作者： ZoëMigicovsky Michelle Y.Quigley Joey Mullins tahira Ali Joel F.Swift Anita Rose Agasaveeran Joseph D.Dougherty Brendan Michael Grant Ilayda Korkmaz Maneesh Reddy Malpeddi Emily L.McNichol Andrew W.Sharp Jackie L.Harris Danielle R.Hopkins Lindsay M.Jordan Misha t.Kwasniewski R.keith Striegler Asia L.Dowtin Stephanie Stotts Peter Cousins Daniel H.Chitwood Plant Foodand Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNova ScotiaB2N 5E3Canada Department of Horticulture Michigan State UniversityEast LansingMI48823USA College of Natural Science Michigan State UniversityEast LansingMI48823USA Department of Neuroscience Michigan State UniversityEast LansingMI48823USA Department of Biology Saint Louis UniversitySt.LouisMO63103USA Department of Physics and Astronomy Michigan State UniversityEast LansingMI48823USA Department of Computational Mathematics Science&EngineeringMichigan State UniversityEast LansingMI48823USA College of Engineering Michigan State UniversityEast LansingMI48823USA College of Social Science Michigan State UniversityEast LansingMI48823USA Department of Economics Michigan State UniversityEast LansingMI48823USA Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI48823USA College of Arts and Letters Michigan State UniversityEast LansingMI48823USA E.&J.Gallo Winery AcampoCA95220USA Current affiliation:Constellation Brands SoledadCA93960USA Department of Food Science The Pennsylvania State UniversityState CollegePA16803USA Department of Forestry Michigan State UniversityEast LansingMI48823USA Department of Agriculture Foodand Resource SciencesUniversity of Maryland Eastern ShorePrincess AnneMD21853USA Department of Natural Sciences University of Maryland Eastern ShorePrincess AnneMD21853USA E.&J.Gallo Winery ModestoCA95354USA Department of Biology Acadia UniversityWolfvilleNova ScotiaB4P 2R6Canada

Annual rings from 30 year old vines in a California rootstock trial were measured to determine the effects of 15 different rootstocks on Chardonnay and Cabernet Sauvignon *** traits measuring vegetative growth,yield,berry quality,and nutrient uptake were collected at the beginning(1995 to 1999)and end(2017 to 2020)of the lifetime of a vineyard initially planted in 1991 and removed in 2021.X-ray Computed tomography(Ct)was used to measure ring widths in 103 *** width was modeled as a function of ring number using a negative exponential *** and late wood ring widths,cambium width,and scion trunk radius were correlated with 27 *** of annual ring width shows that scions alter the width of the first rings but that rootstocks alter the decay of later rings,consistently shortening ring width throughout the lifetime of the *** index,juice pH,photosynthetic assimilation and transpiration rates,and instantaneous water use efficiency are correlated with scion trunk ***,our research indicates that rootstocks modulate secondary growth over years,altering physiology and agronomic *** act in similar but distinct ways from climate to modulate ring width,which borrowing techniques from dendrochronology,can be used to monitor both genetic and environmental effects in woody perennial crop species.

关键词： rings lifetime removed

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Increased hepcidin expression in colorectal carcinogenesis

引用

World Journal of Gastroenterology 2008年第9期14卷 1339-1345页

作者： Douglas G Ward keith Roberts Matthew J Brookes Howard Joy Ashley Martin tariq Ismail Robert Spychal tariq Iqbal Chris tselepis CRUK Institute for Cancer Studies University of Birmingham Birmingham B15 2THUnited Kingdom

AIM:to investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. MEtHODS: Mass spectrometry (MALDI-tOF MS and SELDI-tOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real time Rt-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULtS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing t-stage of colorectal cancer (P thermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. this was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism.

关键词： Iron Hepcidin Colon Cancer Anaemia Mass spectrometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：