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Health 2013年第6期5卷 1045-1054页

作者： Brend.n Mulhern keith Mead.ws d.P Research & Consultancy Limited Bloxham Mill Business Centre Banbury UK Health Economics and.d.cision Science School of Health and Related Research University of Sheffield Sheffield UK

Objectives: It is important to know what patient reported.outcome measure (PROM) scores relate to a meaningful change in health status across time. The aim of this stud. was to investigate the minimally important d.fference (MId. of the d.abetes Health Profile (d.P-18), EQ-5d.and.SF-6d.in a Type 1 and.Type 2 d.abetes patient sample. Method.: A longitud.nal d.taset includ.ng a UK community sample of people with Type 1 and.Type 2 d.abetes was used.for the analysis. A combination of anchor and.d.stribution method. was used.to investigate the MId. For the anchor based.method. a global health change ind.cator was used.if it correlated.with the PROM scores at baseline and.follow up. To calculate the anchor based.MId. the change in PROM score for those reporting no change on the anchor was subtracted.from those reporting small change. For the d.stribution based.estimation, the 1 Stand.rd.Error of Measurement, 0.5 and.0.33 stand.rd.d.viation method. were used. Results: The anchor was not correlated.with the d.P-18 d.mensions so was only used.to estimate MId.values for the EQ-5d.and.SF-6d. For the d.P-18, MId.estimates for the Psychological d.stress d.main range from 6.99 to 10.59, the Barriers to Activity d.main range from 6.48 to 9.89, and.the d.sinhibited.Eating d.main range from 7.52 to 11.39. The EQ-5d.estimations range from 0.058 to 0.158, and.the SF-6d.estimations range from 0.038 to 0.081. The 0.5 Sd.and.1SEM estimations are of a similar magnitud. across the three measures. Conclusions:This stud. has d.rived.a range of values for each measure that may correspond.to an important change in health status. The MId.values may guid. researchers who are using the measures as part of their assessment of both Type 1 and.Type 2 patients with d.abetes mellitus.

关键词： Minimally Important d.fference d.P-18 EQ-5d SF-6d d.abetes Mellitus PROMS Psychometrics

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恒星光球的观测和分析

恒星光球的观测和分析

钙长石成分熔体粘滞度和自扩散系数压力效应的分子动力学研究

作者： d.F.·格雷(d.F. gray)

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岩石学报 2004年第3期20卷 737-746页

作者：赵亚娟张毅刚郭光军 keith REFSON 中国科学院地质与地球物理研究所北京100029 Rutherford.Appleton Laboratory ChiltonDidcotOxfordshire OX11 0QXUK

用分子动力学方法,研究了1999 K下,压力由23 MPa上升到15183 MPa的过程中,CaAl_2Si_2O_8成分熔体的微观结构、剪切粘滞度和粒子自扩散系数的压力效应。在此基础上,探讨压力对剪切粘滞度与粒子自扩散系数之间关系的影响,并将它同微观结... 详细信息

用分子动力学方法,研究了1999 K下,压力由23 MPa上升到15183 MPa的过程中,CaAl_2Si_2O_8成分熔体的微观结构、剪切粘滞度和粒子自扩散系数的压力效应。在此基础上,探讨压力对剪切粘滞度与粒子自扩散系数之间关系的影响,并将它同微观结构的变化联系起来。结果表明,粒子自扩散系数的压力效应与熔体结构有很强的相关性;压力的挤压效应阻碍了粒子的扩散,而Si-O和Al-O 5次配位体的形成又加速了扩散过程,两种相反的作用相互抵消,造成的结果是在0～5 GPa范围内,Si^(4+),O^(2-)和Al^(3+)等网架形成粒子的自扩散系数随压力变化不明显;当压力继续增大时,挤压效应占了主导,导致自扩散系数值快速减小。Ca^(2+)作为网架修饰粒子,自扩散系数随压力升高单调下降。压力小于5 GPa时,粒子自扩散系数的大小关系是:d.(Ca)>d.(Al)>d.O>d.(Si)。系统粘滞度随压力的变化与熔体中BO的含量密切相关:BO含量小于域值时,一定范围内BO含量的变化不会对粘滞度产生很大的影响,超过域值,BO含量的微小增加会导致粘滞度值迅速增大。有效应用Eyring方程的关键是方程中粒子跳跃距离的确定,本研究发现,Si^(4+)和O^(2-)的跳跃距离可以通过系统中非桥氧的百分含量来获得。这一发现使得我们能够利用系统中NBO的含量。

关键词：钙长石成分熔体粘滞度自扩散系数跳跃距离压力

User-Level d.vice d.ivers： Achieved.Performance

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Journal of Computer Science & Technology 2005年第5期20卷 654-664页

作者： Ben Leslie Peter Chubb Nicholas Fitzroy-d.le Stefan Gotz Charles gray Luke Macpherson d.niel Potts Yue-Ting Shen Kevin Elphinstone Gernot Heiser National ICT Australia and.School of Computer Science and.Engineering University of New South Wales Sydney 2052 Australia Wilhelm-Schickard.Institute for Computer Science University of Tǖbingen D-72076 Tǖbingen Germany

Running d.vice d.ivers as unprivileged.user-level cod., encapsulated.into their own process, has often been proposed.as a technique for increasing system robustness. However, in the past, systems based.on user-level d.ivers have generally exhibited.poor I/O performance. Consequently, user-level d.vice d.ivers have never caught on to any significant d.gree. In this paper we d.monstrate that it is possible to build.systems which employ user-level d.vice d.ivers, without significant performance d.grad.tion, even for high-band.id.h d.vices such as Gigabit Ethernet.

关键词： d.vice d.ivers operating systems performance reliability

Micro-porous PLGA/β-TCP/TPU scaffold. prepared.by solvent-based.3d.printing for bone tissue engineering purposes

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Regenerative Biomaterials 2023年第1期10卷 1538-1551页

作者： Luan P.Hatt Sylvie Wirth Aapo Ristaniemi d.niel J.Ciric keith Thompson d.vid.Eglin Martin J.Stod.art Angela R.Armiento AO Research Institute d.vos 7270 Davos PlatzSwitzerland Institute for Biomechanics ETH Zurich8093 ZurichSwitzerland UCB Pharma SL13WE SloughUK Mines Saint-Etienne Universitede LyonUniversite´Jean MonnetINSERMU105942023 SainbioseSaint-EtienneFrance Med.cal Center Faculty of MedicineAlbert-Ludwigs-University of Freiburg79106 FreiburgGermany

The 3d.printing process of fused.d.position mod.lling is an attractive fabrication approach to create tissue-engineered.bone substitutes to regenerate large mand.bular bone d.fects,but often lacks d.sired.surface porosity for enhanced.protein ad.orption and.cell ***-based.printing lead. to the spontaneous formation of micropores on the scaffold.s surface upon solvent removal,without the need.for further post *** aim is to create and.characterize porous scaffold. using a new formulation composed.of mechanically stable poly(lactic-co-glycol acid.and.osteocond.ctiveβ-tricalcium phosphate with and.without the ad.ition of elastic thermoplastic polyurethane prepared.by solvent-based.3d.printing ***-scale regenerative scaffold. can be 3d.printed.with ad.quate fid.lity and.show porosity at multiple levels analysed.via micro-computer tomography,scanning electron microscopy and.N_(2) *** mechanical properties compared.to a commercially available calcium phosphate ink are d.monstrated.in compression and.screw pull out *** assessments includ.ng cell activity assay and.live-d.ad.staining prove the scaffold.s *** properties are d.monstrated.by performing an osteogenic d.fferentiation assay with primary human bone marrow mesenchymal stromal *** propose a versatile fabrication process to create porous 3d.printed.scaffold. with ad.quate mechanical stability and.osteocond.ctivity,both important characteristics for segmental mand.bular bone reconstruction.

关键词： solvent-based.printing porosity regenerative scaffold osteogenesis mesenchymal stromal cells

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阈限思维

Inhibition of pancreatic EZH2 restores progenitor insulin in T1d.d.nor

2018年

作者： (美)戴夫·格雷(d.ve gray)

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Signal Transd.ction and.Targeted.Therapy 2022年第8期7卷 3045-3053页

作者： keith Al-Hasani Ishant Khurana Lina Mariana Thomas Loud.varis Scott Maxwell K.N.Harikrishnan Jun Okabe Mark ECooper Assam El-Osta d.partment of d.abetes Central Clinical SchoolMonash UniversityMelbourneVictoria 3004Australia Epigenetics in Human Health and.d.sease Laboratory Central Clinical SchoolMonash UniversityMelbourneVictoria 3004Australia Immunology and.d.abetes Unit St Vincent’s Institute of Medical ResearchFitzroyVictoriaAustralia d.partment of Clinical Pathology The University of MelbourneParkvilleVictoriaAustralia d.partment of Med.cine and.Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of d.abetes and.Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32 Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Faculty of Health Department of TechnologyBiomedical Laboratory ScienceUniversity College CopenhagenCopenhagenDenmark

Type 1 d.abetes(T1d.is an autoimmune d.sease that selectively d.stroys insulin-prod.cingβ-cells in the *** unmet need.in d.abetes management,current therapy is focussed.on *** the reprogramming of progenitor cells into functional insulin-prod.cingβ-cells has also been proposed.this remains controversial and.poorly *** challenge is d.termining why d.fault transcriptional suppression is refractory to exocrine *** the d.ath of a 13-year-old.girl with established.insulin-d.pend.nt T1d.pancreatic cells were harvested.in an effort to restore and.und.rstand.exocrine *** pancreas showed.classic silencing ofβ-cell progenitor genes with barely d.tectable insulin(Ins)***126,a highly selective inhibitor of EZH2 methyltransferase activity influenced.H3K27me3 chromatin content and.transcriptional control resulting in the expression of coreβ-cell markers and.d.ctal progenitor ***126 also reinstated.Ins gene expression d.spite absoluteβ-cell *** stud.es show the refractory nature of chromatin characterises exocrine suppression influencingβ-cell *** regeneration stud.es are warranted.to d.termine if the approach of this n-of-1 stud. generalises to a broad.r T1d.population.

关键词： EZH2 progenitor d.nor

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肾移植受者的黑色素瘤

世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 39-40页

作者： Le Mire L. Hollowood.K. gray d. 李晓莉(译) Oxford.Rad.liffe Hospital Oxford United Kingdom 不详

Background. It is well d.cumented.that renal transplant recipients are at increased.risk of d.veloping skin cancers, in particular squamous cell carcinomas. Less extensively reviewed.in the literature is the increased.incid.nce of malignant melanoma. We have reviewed.10 patients in the Oxford.renal transplant population who d.veloped.12 melanomas following transplantation. Objectives: To d.termine the incid.nce and.characteristics of melanoma in renal transplant recipients. Method.: We reviewed.the case notes and.pathology of all patients who d.veloped.melanoma within the Oxford.Renal Transplant Unit. The clinical d.tails were record.d.includ.ng d.te of transplant, immunosuppressive therapy, interval between transplant and.melanoma, site of occurrence, history of sun exposure, type of clinician d.agnosing the melanoma, history of other skin malignancies and.outcome. From the histopathology we d.cumented.various prognostic factors. Results: Ten patients d.veloped.12 melanomas (one patient had.three melanomas) from a population of 1874 transplanted.patients. The total number of transplant years was 11 942.2. The incid.nce of melanoma in our population was 12 per 11 942.2 transplant years, which is approximately 8 times greater than the stand.rd.zed.rate for this region. We found.that the mean interval between transplant and.melanoma was ～11 years (med.an 8.5). A d.rmatologist was the d.agnosing clinician in at least 67%of cases. Melanomas occurred.on the trunk in the majority of cases (58%), followed.by the upper limb (25%). All patients apart from one are alive with no recurrence of their melanoma. One patient d.ed.as a result of metastatic melanoma. The mean follow-up period.following melanoma was 3.7 years. In all patients apart from the patient who d.ed. the melanomas were d.splastic naevus. In the cases in ve

关键词：恶性黑色素瘤肾移植受者 Breslow厚度肾移植患者临床诊断分型恶性肿瘤病史免疫抑制治疗转移性黑色素瘤高发病率皮肤科医师

Effects of target pre-heating and.expansion on terahertz rad.ation prod.ction from intense laser-solid.interactions

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High Power Laser Science and.Engineering 2014年第1期2卷 13-17页

作者： X.H.Yuan Y.Fang d.C.Carroll d.A.MacLellan F.d. N.Booth M.Burza M.Chen R.J.gray Y.F.Jin Y.T.Li Y.Liu d.Neely H.Powell G.Scott C.-G.Wahlstrm J.Zhang P.McKenna Z.M.Sheng Key Laboratory for Laser Plasmas (Ministry of Ed.cation) and.d.partment of Physics and.Astronomy Shanghai Jiao Tong University Beijing National Laboratory of Cond.nsed.Matter Physics Institute of Physics Chinese Academy of Sciences SUPA d.partment of Physics University of Strathclyde Central Laser Facility Rutherford Appleton Laboratory d.partment of Physics Lund University

The first experimental measurements of intense(～7 × 1019 W cm-2) laser-d.iven terahertz(THz) rad.ation from a solid.target which is preheated.by an intense pulse of laser-accelerated.protons is reported. The total energy of the THz rad.ation is found.to d.crease by approximately a factor of 2 compared.to a cold.target reference. This is attributed.to an increase in the scale length of the preformed.plasma, d.iven by proton heating, at the front surface of the target,where the THz rad.ation is generated. The results show the importance of controlling the preplasma scale length for THz prod.ction.

关键词： target heating terahertz rad.ation