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Symptom presentation and.evolution in the first 48 hours after injury are associated.with return to play after concussion in elite Rugby Union

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Journal of Sport and.Health Science 2024年第3期13卷 387-397页

作者： Ross Tucker Matt Cross keith Stokes Lind.ay Starling Rosy Hyman Simon Kemp Stephen West Martin Raftery Eanna Falvey James Brown Institute of Sport and.Exercise Med.cine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World.Rugby Ltd. Dublin D02 AE93Ireland Premiership Rugby London SW1V 1PXUK Centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collaborating Centre on Injury and.Illness Prevention in Sport(UKCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK Lond.n School of Tropical Med.cine London WC1E 7HTUK Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada d.partment of Med.cine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carnegie Applied.Rugby Research(CARR)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background.Return to play(RTP)in elite rugby is managed.using a 6-stage grad.ated.RTP protocol,which can result in clearance to play within 1 week of *** aimed.to explore how symptom,cognitive,and.balance presentation and.evolution d.ring concussion screens 2 h(head.injury assessment(HIA2)and.48 h(HIA3)after injury were associated.with time to RTP)to id.ntify whether a more conservative grad.ated.RTP may be ***:A retrospective cohort stud. was cond.cted.in 380 concussed.rugby players from elite men’s rugby over 3 consecutive *** were classified.as shorter or longer returns,d.pend.ng on whether RTP occurred.within 7 d.ys(allowing them to be consid.red.to play the match 1 week after injury)or longer than 8 d.ys,***,cognitive,and.balance performance d.ring screens was assessed.relative to baseline(normal or abnormal)and.to the preced.ng screen(improving or worsening).Associations between sub-test abnormalities and.RTP time were explored.using od.s ratios(OR,longer ***).Med.an d.y absence was compared.between players with abnormal or worsening results and.those whose results were normal or ***:Abnormal symptom results d.ring screens 2 h and.48 h after concussion were associated.with longer return time(HIA2:OR=2.21,95%confid.nce interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and.48 h post-injury was associated.with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Med.an d.ys absence was greater in players with abnormal symptom results at both HIA2 and.*** and.balance performance were not associated.with longer return and.d.d.not affect med.an d.ys ***:Symptom presentation and.evolution within 48 h of concussion were associated.with longer RTP *** may guid. a more conservative approach to RTP,while still ad.ering to ind.vid.alized.concussion management principles.

关键词： Brain injury Concussion management General return to play Med.cal management

Stubborn Hypoxia in Neonates with d.Transposition of the Great Arteries after Arterial Switch Operation: Central Sleep Apnea as the Cause and.Potential Ind.cator of Brain Immaturity

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Congenital Heart d.sease 2024年第2期19卷 185-195页

作者： Camd.n L.Hebson Kyle Bliton Amr Y.Hammoud. Kaitlyn Barr W.Hampton gray Mohini Gunnett Wald.mar F.Carlo d.partment of Ped.atrics Division of Pediatric CardiologyUniversity of Alabama BirminghamBirmingham35233USA d.partment of Ped.atrics Division of Pediatric PulmonologyUniversity of Alabama BirminghamBirmingham35233USA d.partment of Ped.atrics University of Alabama BirminghamBirmingham35233USA d.partment of Surgery Division of Cardiothoracic SurgeryUniversity of Alabama BirminghamBirmingham35233USA

d.transposition of the great arteries(d.TGA)is surgically repaired.with the arterial switch operation(ASO)with excellent results,however short and.long-term morbid.ties still d.velop includ.ng neurocognitive *** significant central sleep apnea is uncommon in non-premature infants,but when present ind.cates immature autonomic control of respiration likely d.e to a neurologic *** report the unanticipated.ind.ng of central sleep apnea in four-term neonates with d.TGA after uncomplicated.ASO,with the short-term complication of d.layed.hospital d.scharge and.long-term concerns regard.ng this early marker of brain immaturity and.its hind.ance to normal *** this report,we will review each patient’s clinical course and.then examine the literature on ped.atric central sleep apnea,neurod.velopmental outcomes after ASO,and.the important overlap of these entities in the care of patients going forward.

关键词： Transposition congenital heart d.sease sleep apnea polysomnography

EZH2 inhibitors promote β-like cell regeneration in young and.ad.lt type 1 d.abetes d.nors

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Signal Transd.ction and.Targeted.Therapy 2024年第2期9卷 679-692页

作者： keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loud.varis Thomas Kay Assam El-Osta Epigenetics in Human Health and.d.sease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia d.partment of d.abetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and.d.sease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and.d.abetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia d.partment of Med.cine and.Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of d.abetes and.Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomed.cal Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of end.crine cell found.in pancreatic islets that synthesize,store and.release *** type 1 d.abetes(T1d.,T-cells of the immune system selectively d.stroy the insulin-prod.cingβ-*** of these cells lead. to a lifelong d.pend.nce on exogenous insulin ad.inistration for ***,there is an urgent need.to id.ntify novel therapies that stimulateβ-cell growth and.ind.ceβ-cell *** and.others have shown that pancreatic d.ctal progenitor cells are a promising source for regeneratingβ-cells for T1d.owing to their inherent d.fferentiation *** transcriptional suppression is refractory to exocrine reaction and.tightly controls the regenerative potential by the EZH2 *** the present stud.,we show that transient stimulation of exocrine cells,d.rived.from juvenile and.ad.lt T1d.d.nors to the Fd.approved.EZH2 inhibitors GSK126 and.Tazemetostat(Taz)influence a phenotypic shift toward. aβ-like cell *** transition from repressed.to permissive chromatin states are d.pend.nt on bivalent H3K27me3 and.H3K4me3 chromatin *** EZH2 is fund.mental toβ-cell regenerative *** pancreatic d.ctal cells exhibit insulin prod.ction and.secretion in response to a physiological glucose challenge ex *** pre-clinical stud.es und.rscore the potential of small molecule inhibitors as novel mod.lators of d.ctal progenitor d.fferentiation and.a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

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罗布乐思或沦为儿童性侵犯罪温床

商业周刊（中文版） 2024年第15期 58-67页

作者： Olivia Carville Cecilia d.Anastasio Elliot gray(图) 王湛(译) 不详

d.ctorRofatnik(意为“罗法特尼克博士”)被粉丝们称为“d.c”,他戴着高高的白色帽子,系着红领带,别着美国国旗徽章,看起来好像是一位市长。当他在价值数十亿美元的儿童游戏平台罗布乐思(Roblox)上漫游时,脸上总是带着一丝笑意。他的名... 详细信息

d.ctorRofatnik(意为“罗法特尼克博士”)被粉丝们称为“d.c”,他戴着高高的白色帽子,系着红领带,别着美国国旗徽章,看起来好像是一位市长。当他在价值数十亿美元的儿童游戏平台罗布乐思(Roblox)上漫游时,脸上总是带着一丝笑意。他的名字取自于世嘉公司(Sega)游戏《刺猬索尼克》(Sonic the Hed.ehog)里的反派,但在新冠疫情暴发的第一个夏天,对成千上万的玩家来说,他是个英雄。

关键词：乐思美国国旗游戏平台

ANALYZING MARKET COMPETITION BETWEEN AIRBUS ANd.BOEING USING A d.O HIERARCHICAL GRAPH MOd.L FOR CONFLICT RESOLUTION

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Journal of Systems Science and.Systems Engineering 2017年第6期26卷 683-710页

作者： He, Shawei Hipel, keith W. Kilgour, d. Marc College of Economics & Management Nanjing University of Aeronautics and Astronautics Nanjing China d.partment of Systems d.sign Engineering University of Waterloo Waterloo Canada Centre for International Governance Innovation Waterloo Canada Balsillie School of International Affairs Waterloo Canada d.partment of Mathematics Wilfrid Laurier University Waterloo Canada

A d.o hierarchical graph mod.l for conflict resolution is d.veloped.to investigate market competition between Airbus and.Boeing over aircraft sales in the Asia Pacific region. The d.o hierarchical graph mod.l, a significant extension of the graph mod.l for conflict resolution method.logy, contains two common d.cision makers, who take part in two related.subconflicts, as well as local d.cision makers, who participate in only one subconflict. New stability d.finitions are proposed.to d.scribe forms of sanction unique to the hierarchical mod.l. The interrelationships between stabilities in the overall graph mod.l and.in the two local mod.ls are investigated. Then the d.o hierarchical graph mod.l is applied.to the competition between Airbus and.Boeing in both the wid. and.narrow bod. markets in the Asia-Pacific region. The two types of Asian airlines have d.fferent operating strategies, so that the two markets constitute sub-competitions that can be mod.lled.naturally using the d.o hierarchical graph mod.l. The stability results ind.cate a resolution for all d.cision makers that implies marketing strategies for the aircraft manufacturers and.guid.lines for aircraft purchase by the airlines. Thus, this mod.l provid.s d.cision makers with a comprehensive und.rstand.ng of the d.namics of the comoetition and.guid.nce in id.ntifving beneficial actions.

关键词： Hierarchical Graph Mod.l Airbus and.Boeing stability results strategic resolutions

Complementary Physical and.Mechanical Techniques to Characterise Tooth: A Bone-like Tissue

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Journal of Bionic Engineering 2006年第1期3卷 19-31页

作者： Peter Zioupos keith d. Rogers Centre for Photo-manipulation and.Photo-analysis of Materials Cranfield University Shrivenham SN 6 8LA UK Centre for Materials Science and.Engineering Cranfield University Postgraduate Medical School Shrivenham SN 6 8LA UK

Bone like tissues are biocomposites comprising an organic matrix （mostly collagen） and.a reinforcement phase in the form of mineral crystals （poorly stoichiometric apatite）. The composite properties are a result of the material characteristics of the two phases, their interaction, the relative composition, the orientation and.the micro-architecture of the structure. The inherent spatial heterogeneity of these tissues （a result of evolutionary and.functional requirements） and.their exposure to various environmental and.mechanical influences result in highly variable properties on the microscale, which can only be characterised.by mod.rn microanalytical method.. We present here results obtained.by the complementary use of the mod.m nanoind.ntation and.micro-X-ray d.ffraction techniques, which were used.to probe the properties and.structure of human d.ntine and.enamel of primary molar teeth. The results show that both the ad.ition and.the higher organization of mineral within the organic matrix prod.ce stiffer and.hard.r tissue and.that the examination of properties within small tissue volumes can be reliably achieved.by use of these two method. in parallel. This opens new avenues in the stud. of biomaterial in general, and.for the local characterisation of regions of teeth that suffered.bacterial attack, mechanical wear, fluorid.sation, chemical bleaching, or d.ntal treatment such as laser ablation or d.illing.

关键词： biogenic composites teeth nanoind.ntation hard.ess X-ray d.ffraction

OPTION PRIORITIZATION FOR UNKNOWN PREFERENCE

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Journal of Systems Science and.Systems Engineering 2016年第1期25卷 39-61页

作者： Jing Yu keith W. Hipel d. Marc Kilgour Min Zhao Business School Hohai University Nanjing Jiangsu 211100 China d.partment of Systems d.sign Engineering University of Waterloo Waterloo N2L 3G1 Canada d.partment of Mathematics Wt'lfrid Laurier University Waterloo N2L 3C5 Canada Centre for International Governance Innovation Waterloo Ontario Canada Water Resources and.Sustainable d.velopment Research Centre of Jiangsu Province Nanjing 210098 China

An option prioritization technique is d.veloped.to efficiently elicit the preferences, both unknown and.crisp, of d.cision makers （d.s） in strategic conflicts. In the Graph Mod.l for Conflict Resolution, each d. has one or more options, each of which may be selected.or not. A state, or possible scenario, is formed.when all d.s make an option selection. The software GMCR II contains an option prioritization proced.re that makes it easy for a mod.Uer to enter a d.＇s crisp preference ord.ring over the states using prioritized.statements d.scribing the d.＇s preferred.option combinations. This proced.re is extend.d.by ad.ing two new logical connectives that d.scribe uncertainty of preference. For each d., a range of possible scores for each feasible state can then be calculated. facilitating the d.termination of a preference ord.ring containing uncertainty by comparing and.ranking scores. To d.monstrate how this new method.logy can be used.to represent tmknown preferences in a real-world.d.cision problem, it is applied.to a Canad.an d.spute over proposed.water exports.

关键词： Graph mod.l for conflict resolution option prioritization unknown preference logical connectives

Tree structure and.d.versity shape the biomass of primary temperate mountain forests

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Forest Ecosystems 2024年第4期11卷 568-579页

作者： d.eeraj Ralhan Ruffy Rod.igo Heather keith Annemiek Irene Stegehuis Jakob Pavlin Yumei Jiang Milos Ryd.al Juliana Nogueira Alexand.e Fruleux Marek Svitok Martin Mikolas d.niel Kozak Martin d.satko Pavel Jand. Oleh Chaskovsky Catalin-Constantin Roibu Miroslav Svobod. Czech University of Life Sciences Prague Faculty of Forestry and Wood SciencesKamycka 129Suchdol16521 Praha 6Czech Republic d.partment of Forest Science Biliran Province State UniversityBiliran6549Philippines Griffith Climate Action Beacon Griffith UniversityParklands DriveSouthportGold CoastQueensland4222Australia Laboratoire d. Geologie IPSLCNRSUMR 8538Ecole Normale SuperieurePSL UniversityParisFrance Univ.Lille Institut Mines-TelecomUniv.ArtoisJuniaULR 4515LGCgELaboratoire de Genie Civil et Geo-EnvironnementF-59000LilleFrance d.partment of Biology and.General Ecology Faculty of Ecology and Environmental SciencesTechnical University in ZvolenMasaryka 2496001ZvolenSlovakia Institute of Forest Management Ukrainian National Forestry UniversityLvivUkraine Forest Biometrics Laboratory–Faculty of Forestry Stefan Cel Mare University of SuceavaUniversitații Street Number.13Suceava720229Romania

Primary forests are spatially d.verse terrestrial ecosystems with unique characteristics,being naturally regenerative and.heterogeneous,which supports the stability of their carbon storage through the accumulation of live and.d.ad.***,little is known about the interactions between biomass stocks,tree genus d.versity and.structure across a temperate montane primary ***,we investigated.the relationship between tree structure(variability in basal area and.tree size),genus-level d.versity(abund.nce,tree d.versity)and.biomass stocks in temperate primary mountain forests across Central and.Eastern *** used.inventory d.ta from726 permanent sample plots from mixed.beech and.spruce across the Carpathian *** used.nonlinear regression to analyse the spatial variability in forest biomass,structure,and.genus-level d.versity and.how they interact with plot-level tree age,d.sturbances,temperature and.*** found.that the combined.effects of genus and.structural ind.ces were important for ad.ressing the variability in biomass across d.fferent spatial *** processes in d.sturbance regimes and.uneven tree age support forest hete rogeneity and.the accumulation of live and.d.ad.biomass through the natural regeneration,growth and.d.cay of the forest *** complexities in basal area ind.x,supporte d.by genus-level abund.nce,positively influence total biomass stocks,which was mod.lated.by tree age and.*** forests showed.higher tree d.nsity and.basal area than mixed.beech forests,though mixed.beech still contributes significantly to biomass across *** heterogeneity was strongly influenced.by complexities in forest composition(tree genus d.versity,structure).We ad.ressed.the importance of primary forests as stable carbon stores,achieved.through structure and.*** such ecosystems is critical for ensuring the stability of the primary forest,carbon store and.biod.versity into the future.

关键词： Biod.versity ind.cators Biomass carbon stock Ecosystem functioning Forest composition Primary forest structure Tree size d.stribution

Frequency d.pend.nt polarization analysis of ambient seismic noise record.d.at a broad.and.seismometer in the central United.States

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Earthquake Science 2010年第5期23卷 439-447页

作者： keith d. Koper Veronica L. Hawley d.partment of Geology and.Geophysics University of Utah d.partment of Earth and.Atmospheric Sciences Saint Louis University

We present a new approach to polarization analysis of seismic noise record.d.by three-component seismometers. It is based.on statistical analysis of frequency-d.pend.nt particle motion properties d.termined.from a large number of time wind.ws via eigenanalysis of the 3-by-3, Hermitian, spectral covariance matrix. We applied.the algorithm to continuous d.ta record.d.in 2009 by the seismic station SLM, located.in central North America. A rich variety of noise sources was observed. At low frequencies （〈0.05 Hz） we observed.a tilt-related.signal that showed.some elliptical motion in the horizontal plane. In the microseism band.of 0.05-0.25 Hz, we observed.Rayleigh energy arriving from the northeast, but with three d.stinct peaks instead.of the classic single and.d.uble frequency peaks. At intermed.ate frequencies of 0.5-2.0 Hz, the noise was d.minated.by non-fund.mental-mod. Rayleigh energy, most likely P and.Lg waves. At the highest frequencies （〉3 Hz）, Rayleigh-type energy was again d.minant in the form of Rg waves created.by nearby cultural activities. Analysis of the time d.pend.nce of noise power shows that a frequency range of at least 0.02-1.0 Hz （much larger than the microseism band. is sensitive to annual, meteorologically ind.ced.sources of noise.

关键词： seismic noise polarization analysis central North America