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Eosinophilic enteritis requiring differentiation from chronic enteropathy associated with SLCO2A1 gene:A case report

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World Journal of Gastroenterology 2023年第11期29卷 1757-1764页

作者： Kantaro Kimura keisuke jimbo Nobuyasu Arai Masamichi Sato Mitsuyoshi Suzuki Takahiro Kudo Tomonori Yano Toshiaki Shimizu Department of Pediatrics Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of Medicine Jichi Medical UniversityTochigi 329-0498Japan

BACKGROUND Eosinophilic gastrointestinal disease(EGID)is a disorder characterized by infiltration of eosinophils causing mucosal damage and dysfunction of the gastrointestinal *** endoscopic findings of eosinophilic enteritis(EoN),an EGID variant,are nonspecific and occasionally difficult to *** contrast,chronic enteropathy associated with SLCO2A1(CEAS)is a chronic persistent small intestinal disorder characterized by endoscopic findings such as multiple oblique and circular *** SUMMARY We report the case of a 10-year-old boy who had suffered abdominal pain and fatigue for the preceding 6 *** was referred to our institute for investigation of suspected gastrointestinal bleeding because of severe anemia with hypoproteinemia and positive fecal human *** upper and lower gastrointestinal endoscopic findings were normal;however,double-balloon small bowel endoscopy showed multiple oblique and circular ulcers with discrete margins and mild constriction of the intestinal lumen in the *** findings were highly consistent with CEAS,but urine prostaglandin metabolites were within normal limits,and no previously reported mutations in the SLCO2A1 gene were *** evaluation demonstrated moderate to severe eosinophilic infiltration localized to the small intestine suggesting a diagnosis of *** remission was maintained with montelukast and a partial elemental diet,but emergent surgery for bowel obstruction due to small intestinal stenosis was performed two years after the initial *** EoN should be considered in the differential diagnosis of CEAS-like small intestinal ulcerative lesions and normal urinary prostaglandin metabolite levels.

关键词： Anemia Chronic enteropathy associated with SLCO2A1 Double-balloon endoscopy Eosinophilic gastrointestinal disease Hypoproteinemia Case report

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A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of <i>Helicobacter pylori</i>Infection in Children

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Advances in Microbiology 2017年第4期7卷 253-264页

作者： Tamaki Ikuse Takahiro Kudo Naho Obayashi keisuke jimbo Yo Aoyagi Yoshikazu Ohtsuka Thomas G. Blanchard Steven J. Czinn Toshiaki Shimizu Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan Department of Pediatrics University of Maryland School of Medicine Baltimore USA

Proper diagnosis in the pediatric population is required to eradicate Helicobacter pylori (H. pylori) and prevent gastric cancer. Our aim was to assess the performance of non-invasive tests to diagnose H. pylori infection in pediatric patients. A retrospective analysis was performed on 141 pediatric patients requiring endoscopic evaluation and diagnostic tests for H. pylori infection to define the cause of abdominal symptoms. Non-invasive tests included the 13C-urea breath test (UBT), a monoclonal stool antigen test using enzyme-linked immuno-sorbent assay (mSAT), and a serum immunoglobulin G antibody test using antigens derived from Japanese individuals (S-Ab). This study investigated sensitivity, specificity, likelihood ratios for a positive and a negative test (LR+ and LR-), and accuracy of non-invasive tests, in comparison with invasive tests. Eighty two of 141 patients (58%) were recognized as H. pylori positive by invasive methods. When UBT, mSAT or S-Ab were analyzed, all were found to be effective over 94% accurate. Specificity ranged between 86.7% and 95.8%, and sensitivity ranged between 93.8% and 97.1%. When subjects were stratified into three distinct age groups, the best performance was achieved for 1-6 years old with mSAT at 100% for sensitivity, specificity, and accuracy. S-Ab yielded the best results for children 7-12 years old and the UBT test performed best for 13-18 years old. These results demonstrate the utility of UBT, mSAT, and S-Ab non-invasive tests in diagnosing H. pylori but suggest that certain tests may be optimal for children of distinct ages. Three non-invasive tests, UBT, mSAT and S-Ab showed sufficient sensitivity, specificity and accuracy for the initial diagnosis of H. pylori infection among pediatric patients. Non-invasive tests may contribute to achieving minimum invasive diagnosis with combining with a histological test and a culture test in children.

关键词： Accuracy Non-Invasive Tests Urea Breath Test Stool Antigen Test Serum Antibody Test

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Antibiotic Resistance of <i>Helicobacter pylori</i>and Eradication Rate in Japanese Pediatric Patients

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Advances in Microbiology 2017年第4期7卷 241-252页

作者： Tamaki Ikuse Yo Aoyagi Naho Obayashi keisuke jimbo Takahiro Kudo Yoshikazu Ohtsuka Thomas G. Blanchard Steven J. Czinn Toshiaki Shimizu Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan Department of Pediatrics University of Maryland School of Medicine Baltimore USA

Helicobacter pylori (H. pylori) eradication rates achieved with a proton pump inhibitor (PPI), amoxicillin and clarithromycin have recently decreased to about 75% because of the increase in clarithromycin resistance in Japan. In the present study, H. pylori resistance rates against clarithromycin, amoxicillin and metronidazole were investigated in pediatric patients and eradication rates were evaluated when tailored antibiotics regimens based on antibiotic sensitivity data were used. We isolated H. pylori endoscopically from 77 pediatric patients suffering from abdominal symptoms. The susceptibility tests of H. pylori strains to clarithromycin, amoxicillin and metronidazole were examined and eradication therapy was tailored using the appropriate antibiotics. Seventy-seven patients were treated with a mean age of 12.16 ± 3.34 years (range, 4.92-19.75) consisting of 40 males and 37 females. The average resistance rates between 1998 and 2016 to clarithromycin, amoxicillin and metronidazole were 54.5% (42 of 77), 6.5% (5 of 77) and 5.2% (4 of 77) respectively. The prevalence of clarithromycin resistance increased significantly over time to reach 88.9% by 2013-2016. Successful eradication rates using tailored antibiotic treatment was 93.8% (61 of 65). Clarithromycin-based eradication therapy rate reached 92.6% against clarithromycin-sensitive strains. Metronidazole-based initial eradication therapy also had a high successful rate (97.0%) to clarithromycin-resistant strains. Although high rates of clarithromycin resistant H. pylori reaching about 90% were observed in Japanese children, tailored eradication therapy using the appropriate antibiotic agents were highly successful. H. pylori sensitivity testing and eradication therapy with appropriate antibacterial agents may contribute to accomplishment of high initial eradication rates and consequently reducing the incidence of developing gastric cancer.

关键词： Resistance Eradication Rate Susceptibility Test Clarithromycin Metronidazole

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Containerless Solidification from Undercooled Melt of Intermetallic Compounds with Strong Anisotropy

Containerless Solidification from Undercooled Melt of Interm...

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The 7th China-Japan Workshop on Microgravity Sciences

作者： Tomohiro Yamazaki Kiyoshi Nozaki keisuke Morita Kazuhiko Kuribayashi Itaru jimbo Department of Materials Science Tokai UniversityHiratsukaKanagawaJapan Institute of Space and Astronautical Science(ISAS) Japan Aerospace Exploration Agency(JAXA)SagamiharaKanagawaJapan Materials and Advanced Research Laboratory Nikon CorporationSagamiharaKanagawaJapan

＜正＞*** In samples solidified from undercooled metals,it has been reported that the grain-size strongly depends on the levels of *** means that,in order to modify the microstructures,the undercooling of the melt has to be precisely *** this point of view,a lot of experiments on the relationships between solidification velocities and the

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Numerical Simulation of Unsteady Shock Waves Using HGA Method

Numerical Simulation of Unsteady Shock Waves Using HGA Metho...

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The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational Mechanics

作者： Tomohiko jimbo Takahiko Tanahashi Department of Mechanical Engineering Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama Kanagawa 223-8522 Japan Department of Mechanical Engineering Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama Kanagawa 223-8522 Japan

In recent large-scale numerical simulations, efficiency of grid generation and efficient use of limited computer resources are demanded. Various solution-algorithms have been proposed to solve them. In problems of especially unsteady high-speed compressible flows, discontinuity of physical quantity like Shock Waves is dealt with, changing in the location at every moment. In order to obtain higher resolutions, high-resolution schemes and fine grids are needed. As refining whole domain by fine grids, much computer memory is needed and it causes computational speed to be late. Therefore, in order to use limited computer resources efficiently, AMR (Adaptive Mesh Refinement) Method [1] is used, which obtains higher resolutions with minimum requirement computer memory by collecting fine grids only in the location where the change of the physical quantity is intense. As analysis objects are complex in recent numerical simulations, efficiency of grid generation is demanded. Therefore, it is very important to generate grids easily constructed by cells that are not distortion around complex objects.

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Production Technology for Thin-film Lithium Secondary Battery

Production Technology for Thin-film Lithium Secondary Batter...

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2011 2nd International Conference on Advances in Energy Engineering(ICAEE)

作者： Takehito jimbo Poong Kim Koukou Suu ULVAC Inc.Institute of Semiconductor and Electronics Technologies

Production technology such as production tools,methods and processes for thin-film lithium secondary battery will be ***-film lithium secondary batteries that are produced by thin-film deposition technology have special advantages thanks to their unique thin-film *** are not only safe to use as a result of their being allsolid-state,but are also thin,lightweight and *** can be employed in small electronic devices and biomedical *** thin-film lithium secondary batteries are mass-produced for the market,their demand will increase rapidly,thereby accelerating market *** we can establish and provide a mass-production technology for thin-film lithium secondary batteries,we will be able to contribute to the growth of markets for these batteries and products that use them.

关键词： Thin-film lithium secondary battery Production techonlogy Magnetron sputtering"

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Synthesis of High-Density Vertically Aligned Carbon Nanotubes Using Ultrasonic Nebulizer

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Materials Sciences and Applications 2012年第4期3卷 213-217页

作者： Jianhui Zhang Wei Li Tetsuo Soga Takashi jimbo Takayoshi Tanji Department of Fron- tier Materials Nagoya Institute of Technology Nagoya Japan. EcoTopia Science Institute Nagoya University Nagoya Japan

Vertically aligned carbon nanotubes (VACNTs) array with high density have been synthesized from a mixture of ferrocene and ethanol using ultrasonic nebulizer techniques. Using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) as well as Raman spectroscopy, investigations reveal that the vertically aligned CNTs are multi-wall CNTs with well-ordered graphene sheets and are about 20 - 50 nm in diameter. We found that high density vertically aligned CNTs can be synthesized at 750℃ - 850℃ and that the length and density of vertically aligned CNTs increase with increasing growth temperatures. In addition, the single-walls CNTs have well-ordered graphene sheet and are about 2 nm in diameter on silicon substrates at 650℃.

关键词： Carbon Nanotubes Chemical Vapor Deposition Transmission Electron Microscope

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Growth and Improvement of ZnO Nanostructure Using Aged Solution by Flow Coating Process

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Advances in Materials Physics and Chemistry 2013年第3期3卷 194-200页

作者： Kasimayan Uma Solaiappan Ananthakumar Ramalinga Viswanathan Mangalaraja Tetsuo Soga Takashi jimbo Centre for Social Contribution and Collaboration Nagoya Institute of Technology Nagoya Japan Centre for Social Contribution and Collaboration Nagoya Institute of Technology Nagoya Japan Department of Frontier Materials Nagoya Institute of Technology Nagoya Japan Department of Frontier Materials Nagoya Institute of Technology Nagoya Japan Department of Materials Engineering University of Concepcion Concepcion Chile Materials and Minerals Division National Institute for Interdisciplinary Science and Technology (CSIR) Kerala India

ZnO nanostructures were prepared on corning glass substrate by flow coating process with different annealing temperature from 100?C to 600?C. Fresh and two days aged solutions were used to investigate the growth behavior and to evaluate the nanostructure of ZnO. The effect of preparation conditions on the deposition of ZnO nanostructure was investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), Raman, and photoluminescence spectroscopy (PL). The results indicated that the solution aging condition and annealing temperature have a strong influence on the morphology and structural properties of the ZnO nanostructure. The solution aged after two days shows the different morphologies compared with the freshly prepared solution.

关键词： ZnO Nanostructure Flow Coating Photo Luminescence (PL)

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POLYCRYSTALLINE GAAS THIN FILM ON QUARTZ SUBSTRATE BY MOLECULAR BEAM EPITAXY

POLYCRYSTALLINE GAAS THIN FILM ON QUARTZ SUBSTRATE BY MOLECU...

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第8届国际材联电子材料国际研讨会

作者： M. Mosaddequr Rahman Tetsuo Soga Takashi jimbo Dept. of Electrical Eng. King Fahd University of Petroleum and MineralsP.O. Box: 1412 Dhahran 31261 Saudi Arabia Dept. of Environmental Tech. and Urban Planning Nagoya Institute of Tech. Gokiso-cho Showa-ku Nagoya 466 Japan Dept. of Environmental Tech. and Urban Planning Nagoya Institute of Tech. Gokiso-cho Showa-ku Nagoya 466 Japan

＜正＞ Polycrystalline and amorphous Si thin films are being successfully used in electronic devices. However, little attention has been paid to amorphous or polycrystalline GaAs which is also a candidate material for optoelectronic devices, such as, solar cells and sensors. Here it can be mentioned that GaAs has a band gap of 1.42 eV which is very close to the optimum value （1.5 eV） of band gap energy for solar energy conversion. Deposition of high quality GaAs films on quartz or glass substrate can yield low cost solar cells which can be

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Novel Quantitative Approach for Predicting mRNA/Protein Counts in Living Cells

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Applied Mathematics 2017年第8期8卷 1128-1139页

作者： Henri C. jimbo Seraphin I. Ngongo Achille Mbassi Nicolas G. Andjiga Department of Applied Mathematics and Statistics Waseda University Tokyo Japan Department of Applied Mathematics University of Paris 1 Pantheon Sorbonne Paris France Department of Urology Central Medical Hospital CEMAC Region Yaounde Cameroon Department of Mathematics Higher National School (ENS) Yaounde Cameroon

One of the most complex questions in quantitative biology is how to manage noise sources and the subsequent consequences for cell functions. Noise in genetic networks is inevitable, as chemical reactions are probabilistic and often, genes, mRNAs and proteins are present in variable numbers per cell. Previous research has focused on counting these numbers using experimental methods such as complex fluorescent techniques or theoretical methods by characterizing the probability distribution of mRNAs and proteins numbers in cells. In this work, we propose a modeling based approach;we build a mathematical model that is used to predict the number of mRNAs and proteins over time, and develop a computational method to extract the noise-related information in such a biological system. Our approach contributes to answering the question of how the number of mRNA and proteins change in living cells over time and how these changes induce noise. Moreover, we calculate the entropy of the system;this turns out to be important information for prediction which could allow us to understand how noise information is generated and expanded.

关键词： Applied Mathematics Embedded Control System Genetic Algorithm Optimization Biodynamics Stochastic Modelling Simulations Stochasticity Bioengineering and Medicine

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