检索结果-南通市图书馆

Analysis of stress fractures in athletes based on our clinical experience

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2011年第1期2卷 7-12页

作者： Jun Iwamoto Yoshihiro Sato Tsuyoshi takeda Hideo Matsumoto Institute for Integrated Sports Medicine Keio University School of MedicineTokyo 160-8582Japan Department of Neurology Mitate HospitalFukuoka 826-0041Japan

AIM:To analyze stress fractures in athletes based on experience from our sports medicine ***:We investigated the association between stress fractures and age,sex,sports level,sports activity,and skeletal site in athletes seen at our sports medicine clinic between September 1991 and April *** fractures of the pars interarticularis were excluded from this ***:During this period(18 years and 8 mo),14276 patients(9215 males and 5061 females)consulted our clinic because of sports-related injuries,and 263 patients(1.8%)[171 males(1.9%)and 92 females(1.8%)]sustained stress *** average age of the patients with stress fractures was 20.2 years(range 10-46 years);112 patients(42.6%)were 15-19 years of age and 90(34.2%)were 20-24 years of ***,90 patients(34.2%)were active at a high recreational level and 173(65.8%)at a competitive *** highest proportion of stress fractures was seen in basketball athletes(21.3%),followed by baseball(13.7%),track and field(11.4%),rowing(9.5%),soccer(8.4%),aerobics(5.3%),and classical ballet(4.9%).The most common sites of stress fractures in these patients were the tibia(44.1%),followed by the rib(14.1%),metatarsal bone(12.9%),ulnar olecranon(8.7%)and pelvis(8.4%).The sites of the stress fractures varied from sport to *** ulnar olecranon was the most common stress fracture site in baseball players,and the rib was the most common in *** and classical ballet athletes predominantly sustained stress fractures of the tibia and metatarsal *** and field and soccer athletes predominantly sustained stress fractures of the tibia and pubic *** athletes predominantly sustained stress fractures of the *** and long distance female runners who sustained multiple stress fractures had the female athlete ***:The results of this analysis showed that stress fractures were seen in high-level young athletes,with similar proportions for males and females

关键词： Athletes Bone mineral density Female athlete triad Stress fracture Vitamin D insufficiency

KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2021年第7期48卷 618-630页

作者： Kevin Christian Montecillo Gulay keisuke Aoshima Yuki Shibata Hironobu Yasui Qin Yan Atsushi Kobayashi Takashi Kimura Laboratory of Comparative Pathology Department of Clinical SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Laboratory of Radiation Biology Department of Applied Veterinary SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Department of Pathology Yale School of MedicineNew HavenCT 06510USA

Epigenetic regulators have been implicated in tumorigenesis of many types of cancer;however,their roles in endothelial cell cancers such as canine hemangiosarcoma(HSA)have not been *** this study,we find that lysine-specific demethylase 2 b(KDM2 B)is highly expressed in HSA cell lines compared with normal canine endothelial *** of KDM2 B in HSA cells results in increased cell death in vitro compared with the scramble control by inducing apoptosis through the inactivation of the DNA repair pathways and accumulation of DNA ***,doxycycline-induced KDM2 B silencing in tumor xenografts results in decreased tumor sizes compared with the ***,KDM2 B is also highly expressed in clinical cases of *** hypothesize that pharmacological KDM2 B inhibition can also induce HSA cell death and can be used as an alternative treatment for *** treat HSA cells with GSK-J4,a histone demethylase inhibitor,and find that GSK-J4 treatment also induces apoptosis and cell *** addition,GSK-J4 treatment decreases tumor ***,we demonstrate that KDM2 B acts as an oncogene in HSA by enhancing the DNA damage ***,we show that histone demethylase inhibitor GSK-J4 can be used as a therapeutic alternative to doxorubicin for HSA treatment.

关键词： DNA repair Epigenetics Hemangiosarcoma KDM2B Oncogene

Missing flux from the ocean: isotope revealed an important NOx flux mediated by microbial processes

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第9期9卷 139-139页

作者： keisuke Koba Center for Ecological Research Kyoto University

NOxin the atmosphere can affect human health and economic development as well as atmospheric chemistry and ***, it is crucial to deeply understand the dynamics of NOxincluding its sources and sinks. However, as in the cases of other nitrogen compounds such as nitrous oxide, it is quite difficult to trace the fate of NOx, then close its budget.

关键词：

Endoscopic submucosal dissection as excisional biopsy for anorectal malignant melanoma:A case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第13期7卷 1652-1659页

作者： Shigeo Manabe Yoshio Boku Michiyo takeda Fumitaka Usui Ikuhiro Hirata Shuji Takahashi Department of Gastroenterology Kouseikai Takeda Hospital Kyoto 600-8558 Japan Fujita Clinic 67 Gokiya-cho Oomiya-dori Shichijo-kudaru Shimogyo-ku Kyoto 600-8267 Japan

BACKGROUND Anorectal malignant melanoma(AMM)is a rare disorder with an extremely poor *** there is currently no consensus on the treatment methods for AMM,surgical procedures have been the most common treatment methods used until *** recently encountered a case of AMM that we diagnosed using endoscopic submucosal dissection(ESD).To our knowledge,this is the first case of ESD for AMM,suggesting that ESD can potentially be a diagnostic and treatment method for *** S UMA/MARY A 77-year-old woman visited our hospital with a chief complaint of anal bleeding and a palpable rectal *** revealed a 20-mm protruded lesion in the lower *** obtaining biopsy specimens from the lesion,although a malignant rectal tumor was suspected,a definitive diagnosis was not *** ultrasonography revealed tumor invasion into the submucosal layer but not the muscular ***,we performed an excisional biopsy using *** examination of the ESD-resected specimen revealed tumor cells positive for Human Melanin Black-45,Melan-A,and ***,the tumor cells lacked melanin pigment;thus,a diagnosis of amelanotic AMM was *** the AMM had massively invaded the submucosal layer and both lymphatic and venous invasion were present,we closely monitored the patient without any additional therapy on the basis of her *** months after ESD,local recurrence was detected,and the patient consented to wide local *** USION It is suggested that ESD is a potential diagnostic and treatment method for AMM.

关键词： Endoscopic submucosal dissection Anorectal malignant melanoma Endoscopic mucosal resection Case report

Characteristics of gas evolution profiles during coal pyrolysis and its relation with the variation of functional groups

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Coal Science & Technology 2018年第4期5卷 452-463页

作者： Lu Zhang Shichao Qi Norihiro takeda Shinji Kudo Junichiro Hayashi Koyo Norinaga Department of Applied Science for Electronics and Materials Kyushu University6-1Kasuga KoenKasugaFukuoka 816-8580Japan Institute for Materials Chemistry and Engineering Kyushu University6-1Kasuga KoenKasugaFukuoka 816-8580Japan

Strict relation between the substituents or functional groups attached to the coal macromolecules and the generation of the volatile products, e.g., CH4 H2O, CO, CO2, etc., during the coal pyrolysis is an important but confusing subject. In this paper, quadrupole mass spectronletry, gas chromatography, and ^l3C nuclear magnetic resonance are applied to real-time monitoring the formations of volatile products, off-line quantitative determination of the total products from the pyrolysis of a sub-bituminous coal (SC), and the changes of diverse substitents in the SC along with coke foamation, respectively. These measurements are also performed for the pyrolysis of a caking coal to contrast SC. The qualitative and quantitative data reveal that, during coal pyrolysis, the functional groups related with the formation of CO, i.e., ether, carbonyl, and anhydride, can directly gen erate CO via bond breaking, or take a detour of the formation of other intermediates via condensation and recombination firstly. Moreover, the formations of CO2 and CH4 are related to the direct removal of -COO- and -CH3,respectively.

关键词： Light gas evolution Carbonization QMS GC ^13C NMR

Morphological changes of doxorubicin-loaded liposomes observed by atomic force microscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 60-61页

作者： Naoki Takahashi keisuke Ueda Kenjirou Higashi Keiji Yamamoto Kunikazu Moribe Graduate School of Pharmaceutical Sciences Chiba University

Liposomes, closed vesicles composed of lipid bilayers, have been widely used as pharmaceutical carriers. Liposomal formulations containing doxorubicin (DOX) of an anticancer drug are developed to reduce toxic side effects and to improve drug accumulation at tumor tissues. An encapsulation of DOX into the inner water phase of liposomes results in the formations of fibrous DOX bundles and the elongation of the liposomes [1].In this study, atomic force microscopy (AFM).

关键词： Liposome Doxorubicin Atomic force microscopy

Stabilization mechanism of nitrazepam supersaturated state in nitrazepam/Eudragit~?EPO/saccharin solution revealed by NMR measurements

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 58-59页

作者： Harunobu Kanaya keisuke Ueda Kenjirou Higashi Keiji Yamamoto Kunikazu Moribe Graduate School of Pharmaceutical Science Chiba University

Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug ***,the improvement of the drug dissolution by the drug/EPO solid dispersion is limited only in acidic solution due to the pHdependant solubility of basic EPO with its tertiary amino *** previously reported that the blending of saccharin(SAC)in the drug/EPO solid dispersion led to the supersaturation formation of drug even at neutral pH[1].

关键词： Solid dispersion Supersaturation NMR relaxation time 2D-NOESY

A spectroscopic study on the effect of ultra-violet solar radiation in Antarctica on the human skin fbroblast cells

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2013年第6期4卷 647-653页

作者： Tatsuyuki Yamamoto Hideo Akiyoshi keisuke Yoshikiyo Tetsuya Takahashi Yukiko Tanabe Sakae Kudoh Satoshi Imurad Naoyuki Yamamoto Faculty of Life and Environmental Science Shimane University Faculty of Education Shimane University Graduate School of Frontier Sciences The University of Tokyo National Institute of Polar Research Graduate School of Bioagricultural Sciences Nagoya University

A study on the effect of the solar ultra-violet radiation on the human skin fibroblast cells revealed that the production of matrix metalloproteinase-2 was inhibited by the radiation.A CO2 incubator connected by optical fibers to a reflector telescope for collecting the solar light was built at Syowa station by the 49th Japanese Antarctica Research *** direction of the telescope was continuously controlled by a sun-tracker to follow the movement of the Sun *** intensity of the collected light was monitored by a portable spectrophotometer housed *** human skin fibroblast cells were incubated in the CO2 chamber to investigate the effect of the solar radiation at Syowa station and were compared with those reference experiments at a laboratory in *** results showed cell damage by strong UV *** production of matrix metalloproteinase-2 was prompted by the moderate UV-B,but was inhibited by the strong UV-B radiation,as studied under laboratory conditions in *** effect of strong solar radiation at Syowa station involving the radiation of UV-B region was estimated to be of the same extent of the radiation caused by an artificial UV-B light with the intensity more than 50 mJ/cm2.

关键词： Antarctica Geobiology Ultra-violet radiation Human skin fibroblast cells Matrix metalloproteinase

Rare case of fecal impaction caused by a fecalith originating in a large colonic diverticulum: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第2期9卷 416-421页

作者： Hiroki Tanabe Kazuyuki Tanaka Mitsuru Goto Tomonobu Sato keisuke Sato Mikihiro Fujiya Toshikatsu Okumura Division of Gastroenterology and Hematology/Oncology Department of MedicineAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Department of Gastroenterology Asahikawa Kousei HospitalAsahikawa 078-8211HokkaidoJapan Department of Pathology Asahikawa Kousei HospitalAsahikawa 078-8211HokkaidoJapan

BACKGROUND Fecal impaction is defined as a large mass of compacted feces in the colon and has the potential to induce a serious medical condition in elderly *** impaction is generally preventable,and early recognition of the typical radiological findings is important for making an early *** factors that lead to fecal impaction are usually similar to those causing *** cases with fecal impaction associated with a diverticulum have been *** SUMMARY We present the case of a 62-year-old woman who suffered from abdominal pain and vomiting,had a medical history of repeated acute abdomen and was diagnosed with fecal impaction in the descending colon based on X-ray and computed tomography(CT)*** examination by gastrografinenhanced colonography following colonoscopy and CT colonography,the fecalith was suspected to have been produced at the site of a large diverticulum in the transverse *** fecalith was surgically resected,and a histological diagnosis of pseudodiverticulum was *** was no recurrence during 33 mo of *** This case highlights the importance of accurate identification and treatment of a fecal *** case indicated that the endoscopic evacuation and subsequent colonography were effective for identifying a diverticulum that might have caused fecal impaction.A fecal impaction was associated with the ***,the planned diverticulectomy was *** emergency medical treatment and maintenance treatments should be selected in such cases to prevent recurrence.

关键词： Colonic ileus Constipation Acute abdomen Computed tomography colonography Case report Colonoscopy