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Health 2024年第6期16卷 561-564页

作者： Fumihiko yasuma Junichiro Hayano Department of Biomedical Sciences College of Life and Health Sciences Chubu University Kasugai Japan Heart Beat Science Lab. Co. Nagoya Japan

Letter to the Editor.

关键词： Letter to the Editor

Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5723-5731页

作者： Akihiro Yoshihara Kota Nishihama Chisa Inoue Yuko Okano Kazuhito Eguchi Soichiro Tanaka Kanako Maki Valeria Fridman D'Alessandro Atsuro Takeshita Taro yasuma Mei Uemura Toshinari Suzuki Esteban C Gabazza Yutaka Yano Department of Diabetes and Endocrinology Japan Community Health care Organization Yokkaichi Hazu Medical CenterYokkaichi 510-0016MieJapan Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie UniversityTsu 514-8507MieJapan Department of Immunology Faculty and Graduate School of MedicineMie UniversityTsu 514-8507MieJapan Department of Immunology and Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan

BACKGROUND Ectopic adrenocorticotropic hormone(ACTH)-secreting neuroendocrine tumors are rare *** with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor *** and coagulopathies have been reported as the cause of ***,detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been *** SUMMARY A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric *** analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol *** enhanced computed tomography(CT)scan revealed a 3-cm tumor in the pancreatic *** cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTHsecreting pancreatic neuroendocrine *** Ki-67 index was 40%.She was transferred to Mie University Hospital for surgical *** patient was diagnosed with urinary tract infection,cytomegalovirus hepatitis,esophageal candidiasis,pulmonary infiltrates suspicious for Pneumocystis carinii pneumonia,peripheral deep vein thrombosis,pulmonary embolism,and disseminated intravascular *** multiple organ infections and thromboses responded well to antimicrobial and anticoagulant *** studies disclosed a pancreatic tumor and a metastatic lesion in the liver,whereas somatostatin receptor scintigraphy showed negative findings,suggesting the primary and metastatic tumors were poorly differentiated.A CT scan before admission showed no metastatic liver lesion,suggesting that the pancreatic tumor was rapidly *** of surgery,antitumor chemotherapy was *** patient was transferred to another hospital to initiate ***,she died four months later due to the rapidly progressive *** ACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor ***

关键词： Neuroendocrine tumors Cushing's syndrome Ectopic adrenocorticotropic hormone syndrome Pneumocystis pneumonia Pulmonary embolism Infections Case report

Sodium-glucose co-transporter-2 inhibitor-associated euglycemic diabetic ketoacidosis that prompted the diagnosis of fulminant type-1 diabetes:A case report

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World Journal of Clinical Cases 2021年第13期9卷 3163-3169页

作者： Taro yasuma Yuko Okano Soichiro Tanaka Kota Nishihama Kazuhito Eguchi Chisa Inoue Kanako Maki Akihiro Uchida Mei Uemura Toshinari Suzuki Corina N D'Alessandro-Gabazza Esteban C Gabazza Yutaka Yano Department of Diabetes Metabolismand Endocrinology and ImmunologyMie UniversityTsu 514-8507Japan Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507Japan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507Japan Department of Immunology Mie University Faculty and Graduate School of MedicineTsu 514-8507Japan Department of Diabetes Mie University Graduate School of MedicineTsu 514-8507Japan

Fulminant type 1 diabetes mellitus(FT1DM)is a subtype of type 1 diabetes mellitus characterized by an abrupt onset and a rapid and complete functional loss of isletβ*** is a very rare disease generally associated with ketoacidosis and the absence of circulating pancreatic islet-related *** ketoacidosis with normal blood glucose levels has been reported during sodiumglucose co-transporter 2(SGLT2)inhibitor *** SUMMARY The patient was a 43-year-old woman that consulted a medical practitioner for malaise,thirst,and *** analysis showed high blood glucose levels(428 mg/dL),a mild increase of hemoglobin A1c(6.6%),and increased ketone bodies in *** patient was diagnosed with type 2 diabetes *** patient was initially treated with insulin,which was subsequently changed to an oral SGLT2 *** to glutamic acid decarboxylase were *** days after receiving oral SGLT2 inhibitor,she consulted at Mie University Hospital,complaining of fatigue and *** analysis revealed diabetic ketoacidosis with almost normal blood glucose *** endogenous insulin secretion was markedly low,and the serum levels of islet-related autoantibodies were *** made the diagnosis of FT1DM with concurrent SGLT2 inhibitor-associated euglycemic diabetic *** patient's general condition improved after therapy with intravenous insulin and withdrawal of oral *** was discharged on day 14 with an indication of multiple daily insulin *** This patient is a rare case of FT1DM that developed SGLT2 inhibitor-associated diabetic ketoacidosis with almost normal blood glucose *** case report underscores the importance of considering the diagnosis of FT1DM in patients with negative circulating autoantibodies and a history of hyperglycemia that subsequently develop euglycemic diabetic ketoacidosis following treatment with a SGLT2 inhibitor.

关键词： Euglycemic diabetic ketoacidosis Sodium-glucose cotransporter 2 inhibitors Fulminant type 1 diabetes Case report

Intravenous immune globulin suppresses angiogenesis in mice and humans

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Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc ***,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human Fcγ***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of IVIg on blood vessels.

关键词： doses inhibited degeneration

Sleep Fragmentation and Risk of Automobile Accidents in Patients with Obstructive Sleep Apnea—Sleep Fragmentation and Automobile Accidents in OSA

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Health 2019年第2期11卷 171-181页

作者： Akiko Noda Fumihiko yasuma Seiko Miyata Kunihiro Iwamoto Yoshinari Yasuda Norio Ozaki Chubu University Graduate School of Life and Health Sciences Kasugai Japan Department of Internal Medicine National Hospital Organization Suzuka National Hospital Suzuka Japan Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan Department of CKD Initiatives Nagoya University Graduate School of Medicine Nagoya Japan

Objectives: Automobile accidents related to obstructive sleep apnea (OSA) represent an important public health concern. Frequent arousal response during sleep is responsible for the symptoms of daytime sleepiness and an increased risk of automobile accidents in patients with OSA. We therefore investigated the potential relationships between the intensity of arousal and occurrence of automobile accidents in OSA. Methods: We determined the incidence of automobile accidents in the past 5 years among 51 men with OSA (age, 58.5 ± 10.4 years) using a questionnaire. Daytime sleepiness was rated with the Epworth Sleepiness Scale (ESS). We calculated an automobile accident score, with two points per automobile accident causing damage and one point per near miss. Standard polysomnography was performed for all patients, and arousals were classified as electroencephalographic (EEG) arousal of an abrupt shift in EEG frequency alone and Movement arousal, which was defined as EEG arousal with increased electromyographic activity persisting for ≥3 s. The number of EEG or Movement arousals per hour (arousal index) was determined. Results: The Movement arousal index was significantly greater in the 27 patients who experienced at least one automobile accident causing damage than in the resting 24 patients who had no history of automobile accidents. Multiple regression analysis including age, body mass index, and sleep parameters revealed that the Movement arousal index was the most significant factor of risk for automobile accidents (β = 0.563, P = 0.017) as well as the ESS score (β = 0.417, P = 0.022). Conclusion: Movement arousal during sleep contributes to daytime sleepiness and the resulting frequent involvement of OSA patients in automobile accidents.

关键词： Sleep Apnea Arousal Automobile Accidents Daytime Sleepiness

Complete withdrawal of glucocorticoids after dupilumab therapy in allergic bronchopulmonary aspergillosis:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6922-6928页

作者： Tadashi Nishimura Tomohito Okano Masahiro Naito Chikashi Tsuji Soichi Iwanaka yasumasa Sakakura Taro yasuma Hajime Fujimoto Corina N D'Alessandro-Gabazza Yasuhiro Oomoto Tetsu Kobayashi Esteban C Gabazza Hidenori Ibata Department of Pulmonary Medicine Mie Chuo Medical CenterTsu 514-1101MieJapan Department of Pulmonary and Critical Care Medicine Mie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan Department of Pulmonary and Critical Care Medicine Graduate School of Medicine MieMie UniversityTsu 514-8507MieJapan

BACKGROUND Allergic bronchopulmonary aspergillosis(ABPA)is an allergic reaction to Aspergillus species that aggravates bronchial *** studies demonstrated the glucocorticoid-sparing effect of dupilumab in patients with *** is no report of complete withdrawal of glucocorticoids after *** SUMMARY The patient was a 54-year-old woman with bronchial asthma treated with inhaled corticosteroids and a long-acting beta-2 *** consulted our institution for productive cough and fever in March *** computed tomography scan revealed mucoid impaction,and the bronchial lavage fluid culture was positive for Aspergillus *** diagnosis was *** patient was treated with oral glucocorticoids from April 2017 to November *** January 2019,she had bronchial asthma exacerbation,and a chest computed tomography scan showed recurrent mucoid *** was treated with oral glucocorticoids and *** February 2020,during tapering of oral glucocorticoid,she had the third episode of bronchial asthma exacerbation and a mucoid *** patient was treated with dupilumab in addition to oral glucocorticoid and *** clinical response improved,and oral glucocorticoid was discontinued in June *** This is the first case of ABPA in which complete withdrawal of glucocorticoid was possible after treatment with dupilumab.

关键词： Allergic bronchopulmonary aspergillosis Dupilumab Asthma Interleukin-13 Interleukin-4 Case report

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

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Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Istituto di Biostrutture e Bioimmagini CNRNaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory Medicine University of Western AustraliaCrawleyWAAustralia Division of Immunology Department of PathologyUniversity of CambridgeCambridgeUK Department of Immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Institut National de la Santéet de la Recherche Médicale(INSERM)U1222 ParisFrance Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly Department of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s *** most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human *** bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in *** we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage *** approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRI exhibited increased developmental and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： CD64 angiogenesis antibodies