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Gene-activated matrix harboring a miR20a-expressing plasmid promotes rat cranial bone augmentation

Regenerative Biomaterials 2021年第2期8卷 34-42页

作者： Rena Shido Yoshinori Sumita Masahito Hara Mayumi Iwatake Shun Narahara Mayumi Umebayashi kei-ichiro miura Yukinobu Kodama Izumi Asahina Department of Regenerative Oral Surgery Unit of Translational MedicineNagasaki University Graduate School of Biomedical Sciences1-7-1 SakamotoNagasaki 852-8588Japan Basic&Translational Research Center for Hard Tissue Disease Unit of Translational MedicineNagasaki University Graduate School of Biomedical Sciences1-7-1 SakamotoNagasaki 852-8588Japan Laboratory of Craniofacial Tissue Engineering and Stem Cells Faculty of DentistryMcGill University3640 University StreetM43MontrealQuebec H3A 2B2Canada Department of Hospital Pharmacy Nagasaki University Hospital1-7-1 SakamotoNagasaki 852-8501Japan

Gene-activated matrix(GAM)has a potential usefulness in bone engineering as an alternate strategy for the lasting release of osteogenic proteins but efficient methods to generate non-viral GAM remain to be *** this study,we investigated whether an atelocollagen-based GAM containing naked-plasmid(p)DNAs encoding microRNA(miR)20a,which may promote osteogenesis in vivo via multiple pathways associated with the osteogenic differentiation of mesenchymal stem/progenitor cells(MSCs),facilitates rat cranial bone ***,we confirmed the osteoblastic differentiation functions of generated pDNA encoding miR20a(pmiR20a)in vitro,and its transfection regulated the expression of several of target genes,such as Bambi1 and PPARc,in rat bone marrow MSCs and induced the increased expression of ***,when GAMs fabricated by mixing 100 ll of 2%bovine atelocollagen,20mg b-TCP granules and 0.5mg(3.3 lg/ll)AcGFP plasmid-vectors encoding miR20a were transplanted to rat cranial bone surface,the promoted vertical bone augmentation was clearly recognized up to 8 weeks after transplantation,as were upregulation of VEGFs and BMP4 expressions at the early stages of ***,GAM-based miR delivery may provide an alternative non-viral approach by improving transgene efficacy via a small sequence that can regulate the multiple pathways.

关键词： gene-activated matrix in vivo gene transfer bone augmentation atelocollagen mir20a

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Cell-Based Microfluidic Device Utilizing Cell Sheet Technology

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Cyborg and Bionic Systems 2022年第1期2022卷 35-42页

作者： Katsuhisa Sakaguchi kei Akimoto Masanori Takaira Ryu-ichiro Tanaka Tatsuya Shimizu Shinjiro Umezu Department of Integrative Bioscience and Biomedical Engineering Graduate School of Advaneed Science and Enginring TWInsWaseda University2-2 Wakamatsu-ChoShinju-KuTokyo 162-8480Japan Department of Modern Mechanical Engineering Graduate School of Creative Science and Engineering Waseda University 1-104 Totsuka-ChoShinju-KuTokyo 169-8555Japan Insttute of Advanced BiomedicalEngineering and Seience TWIns Tokyo Women's Medical University8-1 Kawada-ChoShinju-KuTokyo 162-8666Japan

The developmentof microelectromechanical systems hasresulted in the rapid development of polydimethylpolysiloxane(PDMS)microfluidic devices for drug screening *** cell functions,such as the response of endothelial cells to fluids,have beenelucdated using microuidic ***,organon-achip systems that includeorgans that are importantfor biologicalcirculation,such as the heart,liver,pancreas,kidneys,and brain,have been *** organs realize the biologicalcirculation system in a manner that cannot be reproduced by artificial organs;however,the flow channels between the organsare often artifically created by *** this study,we developeda microfluidic device consisting only of cels,by combiningcell sheet technology with microtitanium *** were placed between stacked fibroblast cellsheets,and the celisheets adhered to each other,afer which the microwires were removed leaving a luminal structure with a size approximatelyequal to the arteriolar *** lumen structure was constructed using wires with diameters of 50,100,150,and 200μm,which were approximations of the arteriole *** using a perfusion device,we successfully perfused theluminal structure created inside the *** results revealed that a aulture solution can be supplied toa cellsheet witha very high cell *** biofabrication technology proposed in this study can contribute to the development of organ-on-a-chip systems.

关键词： organs fluid diameters

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Heterogeneous Round-Trip Trading and the Emergence of Volatility Clustering in Speculation Game

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Journal of Systems Science & Complexity 2022年第1期35卷 221-244页

作者： KATAHIRA kei CHEN Yu Faculty of Engineering Information and SystemsUniversity of TsukubaTennodai 1-1-1TsukubaIbaraki 305-8573Japan Research Fellow of Japan Society for the Promotion of Science Japan. Graduate School of Frontier Sciences The University of Tokyo5-1-5 KashiwanohaKashiwa-shiChiba-ken 277-8563Japan.

This study is a detailed analysis of Speculation Game,a simple agent-based model of financial markets,in which the round-trip trading and the dynamic wealth evolution with variable trading volumes are *** of herding behavior,the authors find that the heterogeneous holding periods in round-trip trades can contribute to the emergence of volatility *** particular,the spontaneous redistribution of market wealth through repetitions of round-trip trades with non-uniform horizons can widen the wealth disparity and establish the Pareto distribution of the capital *** a result,the intermittent placements of relatively big orders from endogenously emerged rich traders can bring on large fluctuations in price *** data are used to support the scenario derived from the model.

关键词： Financial stylized facts heterogeneity Pareto’s law round-trip trading wealth distribution

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Rational double points on Enriques surfaces

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Science China Mathematics 2021年第4期64卷 665-690页

作者： ichiro Shimada Department of Mathematics Graduate School of ScienceHiroshima UniversityHigashi-Hiroshima 739-8526Japan

We classify,up to some lattice-theoretic equivalence,all possible configurations of rational double points that can appear on a surface whose minimal resolution is a complex Enriques surface.

关键词： Enriques surface rational double points hyperbolic lattice

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Dual ultracontractivity and its applications

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Frontiers of Mathematics in China 2014年第4期9卷 899-928页

作者： ichiro SHIGEKAWA Department of Mathematics Kyoto University Kyoto 606-8502 Japan

The ultracontractivity is well studied and several equivalent conditions are known. In this paper, we introduce the dual notion of the ultracontractivity, which we call the dual ultracontractivity. We give necessary and sufficient conditions for the dual ultracontractivity. As an application, we discuss one-dimensional diffusion processes. We can write the conditions for the dual ultracontractivity in terms of speed measures.

关键词： Dual ultracontractivity one-dimensional diffusion processes Nashinequality interpolation

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An overview of the contribution of acupuncture to thyroid disorders

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Journal of Integrative Medicine 2018年第6期16卷 375-383页

作者： Fung-kei Cheng Hong Kong China

Thyroid dysfunction, affecting people of all ages, not only damages human growth and energy metabo- lism but is also comorbid with other illnesses such as cardiovascular disease, kidney disease and gastroin- testinal disorders. With the increasing acceptance of alternative and complementary therapies, acupuncture, a traditional Chinese medical practice, has also been employed to address this problem. Analysing 29 clinical projects that were retrieved from 29 major digital databases and include 1757 patients aged 7-79 years from China, Italy, Korea, Macedonia and Russia, this narrative review offers an overview of the efficacy, and evaluated the safe and cost-effective use of acupuncture against hyper- thyroidism, hypothyroidism and thyroid-relevant illnesses. Findings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination ther- apy. In addition to showing the role of acupuncture as an alternative and complementary medicine or as an adjunctive therapy for curative and rehabilitative purposes, more well-designed researches are needed to achieve reliable data.

关键词： Acupuncture Alternative and complementary medicine Endocrine system Integrative medicine Traditional Chinese medicine Thyroidism

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Ultrasonic vibrating system design and tool analysis

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中国有色金属学会会刊：英文版 2009年第B09期19卷 225-231页

作者： kei-Lin KUO Department of Vehicle Engineering National Taip ei University of Technology

The applications of ultrasonic vibrations for material removal processes exist predominantly in the area of vertical processing of hard and brittle materials. This is because the power generated by vertical vibrating oscillators generates the greatest direct penetration, in order to conduct material removal on workpieces by grains. However, for milling processes, vertical vibrating power has to be transformed into lateral (horizontal) vibration to produce the required horizontal cutting force. The objective of this study is to make use of ultrasonic lateral transformation theory to optimize processing efficiency, through the use of the finite element method for design and analysis of the milling tool. In addition, changes can be made to the existing vibrating system to generate best performance under consistent conditions, namely, using the same piezoelectric ceramics.

关键词：超声振动系统分析工具设计有限元分析方法超声波振动材料去除垂直振动硬脆材料

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Using sorbents to control heavy metals and particulate matter emission during solid fuel combustion

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Particuology 2009年第6期7卷 477-482页

作者： Hong Yao ichiro Naruse State Key Laboratory of Coal Combustion Huazhong University of Science and Technology Wuhan 430074 China Department of Mechanical Science & Engineering Nagoya University Nagoya 464-8603Japan

Some of the heavy metals in coal and wastes vaporize during combustion, concentrate in fine particulates, and emit with the flue gas into the atmosphere, to produce adverse effect on environment and health. This study first investigates the fate of the heavy metal species, especially Pb, Cd and Cr, known as semi-volatile, in various flue gases, especially in the presence of HCI and SO2, by chemical equilibrium calculation, in which, Si and Ca were proposed as base sorbent materials to capture Pb, Cd and Cr. Then Si- and Ca-based compounds as well as waste materials used as sorbents were optimized to capture the heavy metals. Finally, the optimal sorbent was tested in actual burning of dried sewage sludge as solid fuel, to evaluate the effectiveness of the sorbent. Calculated results show that Cl increases the volatility of most heavy metals, while SO2 enhances formation of condensed phases. Among the sorbents tested, kaolin appears most efficient to capture Pb and Cd. For sludge combustion with kaolin addition, both Pb and Cd were shifted from sub-micron to macro-sized particles, and accompanied by considerable decrease of 0.1 μm particles.

关键词： Combustion Heavy metal Paniculate matter Sorbent

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Some Issues on the Strength of the Lithosphere

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Journal of Earth Science 2011年第2期22卷 131-136页

作者： Shun-ichiro Karato Department of Geology and Geophysics Yale University

The strength of the oceanic and continental lithosphere has important controls on some of the major geological processes on earth including the operation of plate tectonics and the long-term stability of the continental roots. However, explaining these major geological features from the experi- mental and theoretical studies on the strength of rocks is challenging and some of the existing models for the strength of the lithosphere do not explain these main geological observations. A brief review is provided to summarize recent progress in these areas with the emphasis on experimental studies.

关键词： lithosphere plate tectonics continent.

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The thermal conductivity of the Earth's core and implications for its thermal and compositional evolution

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National Science Review 2021年第4期8卷 18-20页

作者： Kenji Ohta kei Hirose Department of Earth and Planetary Sciences Tokyo Institute of Technology Earth-Life Science Institute Tokyo Institute of Technology Department of Earth and Planetary Science The University of Tokyo

The thermal conductivity of iron alloys is a key to understanding the mechanism of convection in the Earth’s liquid core and its thermal history. The Earth’s magnetic field is formed by a dynamo action that requires...

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