检索结果-南通市图书馆

ADSORPTION OF CO ON Sm-Ni MODEL CATALYSTS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 1996年第4期17卷 6-7页

作者：Ｓｈｅｎｇ　ＳｈｉｓｈａｎＹａｏ　ＬｉｊｕｎＺｈｕ　ＸｉａｏｌｅｉＸｉｏｎｇ　ＧｕｏｘｉｎｇＺｈｕａｎｇ　ＳｈｕｘｉａｎＺｈｕ　ＪｕｎｆａＣｈｉｎｅｓｅ　Ａｃａｄｅｍｙ　ｏｆ　ＳｃｉｅｎｃｅｓＤａｌｉａｎ　Ｉｎｓｔｉｔｕｔｅ　ｏｆ　Ｃｈｅｍｉｃａｌ　ＰｈｙｓｉｃｓＤｅｐａｒｔｍｅｎｔ　ｏｆ　Ｃｈｅｍｉｃａｌ　ＰｈｙｓｉｃＳｔａｔｅ　Ｋｅｙ　Ｌａｂｏｒａｔｏｒｙ　ｏｆ　Ｃａｔａｌｙｓｉｓ

ＡＤＳＯＲＰＴＩＯＮＯＦＣＯＯＮＳｍ／ＮｉＭＯＤＥＬＣＡＴＡＬＹＳＴＳ＊ＳｈｅｎｇＳｈｉｓｈａｎ，ＹａｏＬｉｊｕｎ，ＺｈｕＸｉａｏｌｅｉ，ＸｉｏｎｇＧｕｏｘｉｎｇ（ＳｔａｔｅＫｅｙＬａｂｏｒａｔｏｒｙｏｆＣａｔａｌｙ... 详细信息

ＡＤＳＯＲＰＴＩＯＮＯＦＣＯＯＮＳｍ／ＮｉＭＯＤＥＬＣＡＴＡＬＹＳＴＳ＊ＳｈｅｎｇＳｈｉｓｈａｎ，ＹａｏＬｉｊｕｎ，ＺｈｕＸｉａｏｌｅｉ，ＸｉｏｎｇＧｕｏｘｉｎｇ（ＳｔａｔｅＫｅｙＬａｂｏｒａｔｏｒｙｏｆＣａｔａｌｙｓｉｓ，ＤａｌｉａｎＩｎｓｔｉｔｕ...

关键词： Hydrogen adsorption Samarium nickel model catalyst Thermal desorption spectroscopy

同方期刊数据库

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity of tumor cells

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2009年第1期3卷 26-29页

作者： Liang zhuang Shiying YU Xiaoyuan HUANG Yang CAO Huihua xiong Cancer Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Cancer Biology Research Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

DNA double-strand break(DSB)is generally regarded as the most lethal of all DNA lesions after ***80,DNA-PK catalytic subunit(DNA-PKcs)and ataxia telangiectasia mutated(ATM)proteins are major DSB repair *** this study,survival fraction at 2Gy(SF2)values of eight human tumor cell lines(including four human cervical carcinoma cell lines HeLa,SiHa,C33A,Caski,three human breast carcinoma cell lines MCF-7,MDA-MB-231,MDA-MB-453,and one human lung carcinoma cell line A549)were acquired by clone formation assay,and western blot was applied to detect the expressions of Ku80,DNA-PKcs and ATM *** correlativity of protein expression with SF2 value was analyzed by Pearson linear correlation *** found that the expression of the same protein in different cell lines and the expression of three proteins in the same cell line had a signiﬁcant *** SF2 values were also different in eight tumor cell lines and there was a positive correlativity between the expression of DNA-PKcs and SF2(r=0.723,P=0.043),but Ku80 and ATM expression had no correlation with SF2(P>0.05).Theseﬁndings suggest that the expression level of DNA-PKcs protein can be an indicator for predicting the radiosensitivity of tumor cells.

关键词： Ku80 DNA-PK(cs)-binding protein,human ataxia telangiectasia mutated protein tumor cell lines radiosensitivity

Fragmentation Mechanism of Fullerenes in the Positive and Negative Ion Channels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2001年第8期18卷 1056-1059页

作者： KONG Qing-Yu ZHAO Li zhuang Jun QIAN Shi-xiong LI Yu-Fen State key Joint Laboratory for Materials Modification by Laser Ion and Electron Beamsand Department of PhysicsFudan UniversityShanghai 200433

The authors have performed the photofragmentation studies of pristine C_(60) and C_(60)/C_(70) composites on the reflectron time-of-flight mass spectrometer(RTOF MS)in the positive and negative ion *** mechanism of the formation of daughter fullerenes in the negative ion channel and the enhancement of fullerene coalescence reactions have been discussed compared to our previous studies on the linear *** 5 cm free expansion path in the RTOF experiments provides sufficient time and favorable environment for the electrons to attach to the neutral daughter species,so it is thought to play a key role for the appearance of strong mass peaks of anionic fragmentation and aggregation fullerene *** appearance of odd-numbered“fullerene”fragments is briefly discussed.

关键词： fragmentation (MS) neutral

Bacterial resistance to lead: Chemical basis and environmental relevance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2019年第11期31卷 46-55页

作者： Qiying Nong ke Yuan zhuang Li Ping Chen Yongshun Huang Ligang Hu Jie Jiang Tiangang Luan Baowei Chen Southern Marine Science and Engineering Guangdong Laboratory School of Marine Sciences Sun Yat-Sen University Zhuhai 519082 China School of Life Sciences Sun Yat-Sen University Guangzhou 510275 China State key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences P.O.Box 2871 Beijing 100085 Guangdong Provincial Hospital for Occupational Diseases Prevention and Treatment Guangzhou 510300 China School o/Enuironmental Science and Engineering Sim Yat-sen University Guangzhou 510275 PR China Shenzhen Center for Disease Control and Prevention Shenzhen 518055 China

Natural bacterial isolates from heavily contaminated sites may evolve diverse tolerance strategies,including biosorption,efflux mechanism,and intracellular precipitation under the continually increased stress of toxic lead (Pb) from anthropogenic *** strategies utilize a large variety of functional groups in biological macromolecules (e.g.,exopolysaccharides (EPSs) and metalloproteins) and inorganic ligands,including carboxyl,phosphate and amide groups,for capturing *** amount and type of binding sites carried by biologically originated materials essentially determines their performance and potential for Pb removal and *** factors,e.g.,metal ion radius,electronegativity,the shape of the cell surface sheath,temperature and pH,are thought to exert significant influences on the abovementioned interactions with ***,understanding the chemical basis of Pb-binding in these bacteria can allow for the development of effective microbial Pb remediation technologies and further elucidation of Pb cycling in the environment.

关键词： Lead Resistance mechanisms Bacteria Biosorption Immobilization Remediation

维普期刊数据库

Expression of albumin, IGF-1, IGFBP-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma patients with cirrhosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第27期11卷 4272-4276页

作者： Shi-Min Luo Wei-Min Tan Wei-xiong Deng Si-Min zhuang Jian-Wei Luo Department of Cadre Surgery The First Municipal People's Hospital of Guangzhou Guangzhou 510180 Guangdong Province China

AIM： To explore the expression of albumin （ALB）, insulinlike growth factor （IGF）-I, and insulin-like growth factor binding protein （IGFBP）-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma （HCC） patients with ***： Twenty-four HCC patients with cirrhosis who underwent hepatectomy were studied. ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA in liver tissues （including tumor tissues and adjacent non-tumor tissues） were detected by reverse transcriptase-polymerase chain reaction（RT-PCR）. Liver Ki67 immunohistochemistry staining was studied. At the same time, 12 patients with cholelithiasis or liver angioma who underwent operation were segregated as normal ***： In HCC patients with cirrhosis, hepatic ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA of tumor tissues or adjacent non-tumor tissues were lower than the normal liver tissues, while in tumor tissues, hepatic ALB mRNA and IGFBP-3 mRNA were lower, hepatic IGF-1 mRNA was higher than in adjacent non-tumor tissues. Liver Ki67 labeling index （Ki67 LI） in tumor tissues or adjacent nontumor tissues were higher than that in the normal liver tissues, while in tumor tissues it was higher than that in adjacent non-tumor ***： Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients.

关键词： Hepatocellular carcinoma Insulin growth factor-i Insulin-like growth factor binding protein-3

Offsetting the thermal expansion mismatch:a new way to high-performance solid oxide fuel cell cathodes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2021年第6期64卷 877-878页

作者： Lin zhuang College of Chemistry and Molecular Sciences Hubei Key Lab of Electrochemical Power SourcesWuhan UniversityWuhan 430072China The Institute for Advanced Studies Wuhan UniversityWuhan 430072China

On the cutting-edge of developing high-performance solid oxide fuel cells(SOFC),high activity and durability cathodes are required[1,2].However,the thermo-mechanical mismatch between SOFC cathode and electrolyte is the most hindering disadvantage of traditional highly active cathode materials(cobalt-containing perovskites)which usually yield higher thermal-expansion coefficient(TEC)than electrolytes[3].

关键词： expansion mismatch performance

维普期刊数据库

考虑台风效应的金属屋面系统全寿命期疲劳损伤估计

在线全文

学校读者我要写书评

暂无评论

Nanoscale Precise Editing of Multiple Immune Stimulating Ligands on DNA Origami for T Cell Activation and Cell-Based Cancer Immunotherapy

工程力学 2025年第1期42卷 189-198页

作者：宣颖张乐乐谢壮宁华南理工大学亚热带建筑科学国家重点实验室广州510640 中国建筑第二工程局有限公司华南公司深圳518048

评估金属屋面设计使用寿命年限内的累积损伤程度是抗风设计的重要环节，该文提出一种用于台风多发区域金属屋面系统全寿命期风致疲劳损伤的估计方法，该方法结合风洞测压试验数据和基于台风Monte Carlo模拟所得风速风向分布模型，采用... 详细信息

评估金属屋面设计使用寿命年限内的累积损伤程度是抗风设计的重要环节，该文提出一种用于台风多发区域金属屋面系统全寿命期风致疲劳损伤的估计方法，该方法结合风洞测压试验数据和基于台风Monte Carlo模拟所得风速风向分布模型，采用有限元数值模拟方法进行荷载应力分析，提取金属屋面板块疲劳热点处荷载应力关系，从而获得应力时程数据，通过雨流计数法统计应力循环数，并根据Goodman应力修正法则和Miner疲劳线性累积损伤理论，计算得到金属屋面系统在全寿命期的疲劳累积损伤情况;利用台风等效序列进行加载，以动态物理压力箱试验验证数值模拟方法有效性为基础，将该文方法应用于位于东南沿海的某大跨度圆柱形金属屋面的疲劳累积损伤估计。结果显示：金属屋面全寿命期风致疲劳损伤不仅与风压分布存在一定相关性，也与建筑物所在地区的极值风速分布和主导风向存在相关性，评估全寿命期风致疲劳损伤应结合风洞测压试验结果和建筑物所在地风速风向分布模型进行综合分析;对于更易出现疲劳破坏的屋面角区和边缘部位的高负压区域，量化分析局部加密角区和边缘部位檩距对风致疲劳损伤的影响。

关键词：金属屋面板有限元分析风洞试验风致疲劳损伤台风模型

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第3期6卷 719-732页

作者： Lele Sun Fengyun Shen Zijian xiong Yu Chao Chunhai Fan zhuang Liu Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Lab Carbon Based Functional Materials and DevicesSoochow UniversitySuzhou 215123Jiangsu School of Life Sciences Shanghai UniversityShanghai 200444 School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 201240

The spatial arrangement of activating ligands is known to have great influence on T cell ***,independently studying each ligand’s spatial organization parameter that affects T cell activation remains a great ***,with DNA origami,we precisely organized the CD3ɛantibodies simulating T cell receptor(TCR)ligands and CD28 antibodies simulating co-stimulatory ligands to interrogate the independent role of TCR-ligand spacing and local copy numbers as well as the spacing between TCR ligands and co-stimulatory ligands on T cell *** found that T cell activation benefited fromlocally concentrated TCR ligands with a shorter spacing and was maximized by an∼38 nm spacing between TCR ligands and co-stimulatory *** T cell expander constructed based on our findings could efficiently expand CD8+T cells for tumor ***,the DNA nanostructurebased ligands’precise arrangement can be a unique tool in studying immune cell activations and cellbased immunotherapies.

关键词： DNA origami T cell activation T cell receptor immune cancer immunotherapy

结直肠癌进展与抑制的十字路口:间充质干细胞治疗干预效果及难题

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第23期29卷 5022-5030页

作者：郭昭庄浩岩史学文山东中医药大学第一临床医学院山东省济南市250000 山东中医药大学附属医院肛肠科山东省济南市250000

背景:结直肠癌早期的治疗方法包括内镜和手术切除,但是术后并发症多,晚期多采用化疗方法,然而化疗会引起胃肠功能紊乱、骨髓抑制、肝肾功能损伤等不良反应,导致大多数患者不主动、不配合治疗。目的:综述间充质干细胞治疗结直肠癌的作用... 详细信息

背景:结直肠癌早期的治疗方法包括内镜和手术切除,但是术后并发症多,晚期多采用化疗方法,然而化疗会引起胃肠功能紊乱、骨髓抑制、肝肾功能损伤等不良反应,导致大多数患者不主动、不配合治疗。目的:综述间充质干细胞治疗结直肠癌的作用机制、最新治疗进展及目前存在的问题,为将来临床应用提供依据。方法:计算机检索Pub Med数据库、中国知网、万方数据库收录的相关文献。英文检索词为“mesenchymal stem cells,colorectal cancer,cancer stem cell,tumor microenvironment”,中文检索词为“间充质干细胞,结直肠癌,癌症干细胞,肿瘤微环境”,最终纳入119篇文献进行分析。结果与结论:(1)间充质干细胞对于结直肠癌具有促进和抑制的双面作用;(2)间充质干细胞的肿瘤归巢特性使其能够准确迁移到肿瘤位置并释放药物,基于这一特性,增加了治疗结直肠癌的安全性和有效性;(3)间充质干细胞衍生的外泌体作为良好的药物载体,在结直肠癌靶向治疗中显示出良好的应用前景;(4)使用病毒载体、非病毒载体或其他转染工具将具有成熟抗肿瘤作用的药物加载到间充质干细胞中,共同治疗结直肠癌;(5)间充质干细胞与化疗药物联合使用可以提高化疗药物疗效并降低化疗药物不良反应;(6)间充质干细胞促进结直肠癌的发展机制主要与结直肠癌细胞中的信号转导、趋化因子的表达状态及间充质干细胞向癌症相关成纤维细胞转化有关;(7)间充质干细胞可能具有驱动癌症干细胞的特性,促进肿瘤起始并提高肿瘤侵袭性;(8)间充质干细胞治疗结直肠癌还存在着不可避免的问题:缺乏标准化治疗方案及疗效评价方法、治疗成本高昂、间充质干细胞的保存与运输问题、间充质干细胞与化疗药物共同使用的比例等。

关键词：结直肠癌间充质干细胞癌症干细胞肿瘤微环境化疗外泌体

维普期刊数据库