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Shexiang Baoxin Pill Regulates Intimal Hyperplasia,Migration,and Apoptosis after Platelet-Derived Growth Factor-BB-Stimulation of Vascular Smooth Muscle Cells via miR-451

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Chinese Journal of Integrative Medicine 2022年第9期28卷 785-793页

作者： LI yi-ping QIANG Ting-ting WANG ke-yan WANG Xiao-long Department of Cardiology Shuguang Hospital of Shanghai University of Traditional Chinese MedicineShanghai201203China

Objective:To investigate the regulatory roles of Shexiang Baoxin Pill(SXBXW)in neointimal formation and vascular smooth muscle cells(VSMCs)invasion and apoptosis as well as the potential molecular mechanisms using cultured VSMCs model of vascular injury(platelet-derived growth factor(PDGF)-BBstimulated)in ***:VSMCs were randomly assigned to 5 groups:blank,PDGF-BB(20 ng/mL+0.1%DMSO),SXBXW-L(PDGF-BB 20 ng/mL+SXBXW low dose 0.625 g/L),SXBXW-M(PDGF-BB 20 ng/mL+SXBXW medium dose 1.25 g/L)and SXBXW-H(PDGF-BB 20 ng/mL+SXBXW high dose 2.5 g/L)*** proliferation was assessed using cell counting kit-8(CCK-8)assay and bromodeoxyuridine(BrdU)incorporation assay,the migration effects were detected by Transwell assay,cell apoptosis rate was measured by the Annexin V/propidium iodide(PI)apoptosis *** markers of contractile phenotype of VSMCs were detected with immunofluorescent *** validate the effects of miR-451 in regulating proliferation,migration and apoptosis treated with SXBXW,miR-451 overexpression experiments were performed,the VSMCs were exposed to PDGF-BB 20 ng/mL+0.1%DMSO and later divided into 4 groups:mimic-NC(multiplicity of infection,MOI=50),SXBXW(1.25 g/L)+mimic-NC,mimic-miR451(MOI=50),and SXBXW(1.25 g/L)+mimic-miR451,and alterations of proteins related to the miR-451 pathway were analyzed using Western ***:PDGF-BB induced VSMCs injury causes acceleration of proliferation and *** inhibited phenotypic switching,proliferation and migration and promoted cell apoptosis in PDGF-BB-induced *** addition,miR-451 was shown to be down-regulated in the VSMCs following PDGF-BB *** treatment enhanced the expression of miR-451 in PDGF-BB-induced VSMCs(P<0.05).Compared with SXBXW+mimic-NC and mimicmiR451 groups,the expression of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta(Ywhaz)and p53 was further reduced in SXBXW+mimic-miR451 group,while activating transcription factor 2(ATF2)was

关键词： Shexiang Baoxin Pills miR-451 platelet-derived growth factor-BB-stimulated vascular smooth muscle cells proliferation apoptosis

Design of manganese ion coated Prussian blue nanocarrier for the therapy of refractory diffuse large B-cell lymphoma based on a comprehensive analysis of ferroptosis regulators from clinical cases

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Nano Research 2023年第4期16卷 5265-5278页

作者： Yulu Yang Rui Chen ke Li Pengfei Gao yi Gong Weihu Yang Kaiyong Cai key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityChongqing 400044China Department of Pathology Chongqing University Cancer HospitalChongqing 400030China Department of Phase I Clinical Trial Ward Chongqing University Cancer HospitalChongqing 400030China

Diffuse large B-cell lymphoma(DLBCL)is a prevalent human malignancy,and understanding its biology will help identify problems in refractory patients and customize alternative therapies for *** found that DLBCL can be stratified into two independent subtypes with different clinical characteristics and outcomes by consensus clustering of expression of ferroptosis regulatory genes,which proves that ferroptosis is effective in treating refractory *** this work,we constructed a novel ferroptosis nanocarrier(PBPMn@PEG)by coating Prussian blue nanoparticles with manganese ions and encapsulating them with poly(ethyleneglycol).The low efficiency of the Fenton reaction of Prussian blue nanoparticles can be improved greatly by manganese coating,and can effectively generate hydroxyl radicals,and induce ferroptosis of lymphoma cells(SU-DHL-10 cells)by down-regulating ferroptosis suppressor genes and up-regulating ferroptosis driver *** also induces effective cell apoptosis,which is synergistic with ferroptosis for DLBCL *** vivo experiments also prove that PBPMn@PEG achieved a better anti-tumor effect by up-regulating COX2,HO-1/hemeoxygenase-1(HMOX1),and NADPH oxidase-4(NOX4),and downregulating FSP1 and GPX4,with lower *** a novel and potential DLBCL drug carrier,our discovery served as a foundation for the treatment of the refractory DLBCL by inducing ferroptosis for DLBCL treatment in addition to the therapeutic effect of drugs.

关键词： diffuse large B-cell lymphoma(DLBCL) ferroptosis Prussian blue nanoparticles manganese ion tumor therapy

Research on a combinatorial control method for coaxial rotor aircraft based on sliding mode

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Defence Technology（防务技术） 2022年第2期18卷 280-292页

作者： yi-ran Wei Hong-bin Deng Zhen-hua Pan ke-wei Li Han Chen School of Mechatronical Engineering Beijing Institute of TechnologyBeijingChina School of Automation Beijing Institute of TechnologyBeijingChina Beijing Institute of Computer and Electronics Application BeijingChina Hong Kong Polytechnic University Hong KongChina

Aiming at the position and attitude tracking of coaxial rotor aircraft(CRA),this paper proposes a combinatorial control method of sliding mode control(SMC)coupled with proportional-integralderivative control(PIDC).Considering the complete description of flight dynamics,aerodynamics and airflow interference,the dynamical model of CRA is *** dynamical model is simplified according to the actual flight,then the simplified dynamical model is divided into two subsystems:a fully-actuated subsystem and an under-actuated *** controller of the fully-actuated subsystem consists of a SMC controller coupled with a rate bounded PIDC controller,while the controller of the under-actuated subsystem is composed of a SMC *** sliding manifold is defined by combining the position and velocity tracking errors of the state variables for each *** stability theory is used to verify the stability of the sliding mode controller,which ensures that all state trajectories of the system can reach and stay on the sliding mode surface,the uncertainty and external interference of the model are *** and experiment compared with the conventional PIDC are carried out,the results demonstrate the effectiveness and the robustness of the proposed control method of this paper.

关键词： Coaxial rotor aircraft Sliding mode control Position and attitude tracking Simulation Experiment

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

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Nano-Micro Letters 2021年第2期13卷 74-109页

作者： Yuanyuan Jin Haixia Wang ke yi Shixian Lv Hanze Hu Mingqiang Li Yu Tao Laboratory of Biomaterials and Translational Medicine The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630People’s Republic of China Department of Bioengineering University of WashingtonSeattleWA 98195USA Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA

Acute liver failure(ALF),a fatal clinical disease featured with overwhelming hepatocyte necrosis,is a grand challenge in global ***,a satisfactory therapeutic option for curing ALF is still absent,other than liver *** are currently being developed for the diagnosis and treatment of *** liver can sequester most of nanoparticles from blood circulation,which becomes an intrinsic superiority for nanobiomaterials targeting hepatic *** can enhance the bioavailability of free drugs,thereby significantly improving the therapeutic effects in *** can also increase the liver accumulation of therapeutic agents and enable more effective targeting of the liver or specific liver *** addition,stimuli-responsive,optical,or magnetic nanomaterials exhibit great potential in the therapeutical,diagnostic,and imaging applications in ***,therapeutic agents in combination with nanobiomaterials increase the specificity of ALF therapy,diminish adverse systemic effects,and offer a multifunctional theranostic *** holds excellent significance and prospects in ALF *** this review,we summarize the therapeutic mechanisms and targeting strategies of various nanobiomaterials in *** highlight recent developments of diverse nanomedicines for ALF therapy,diagnosis,and ***,the challenges and future perspectives in the theranostics of ALF are also discussed.

关键词： Acute liver failure Nanomaterials Drug/gene/cytokines delivery Targeted therapy Imaging

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying Sun Zhen-Ni Guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Strength, strain capacity and toughness of five dual-phase pipeline steels

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Journal of Iron and Steel Research International 2021年第6期28卷 752-761页

作者： yi Ren Xian-bo Shi Zhen-guo Yang yi-yin Shan Wei Ye Gui-xi Cai ke Yang State key Laboratory of Metal Material for Marine Equipment and Application Anshan 114009LiaoningChina CAS key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina Institute of Metal Research Chinese Academy of SciencesShenyang 110016LiaoningChina

The effect of microstructures on strength,strain capacity and low temperature toughness of a micro-alloyed pipeline steel was *** various dual-phase microstructures,namely,acicular ferrite and a small amount of(around 2 vol.%)polygonal ferrite(AF+PF),polygonal ferrite and bainite(PF+B),polygonal ferrite and martensite/austenite islands(PF+M/A),polygonal ferrite and martensite(PF+M)and elongated polygonal ferrite and martensite(ePF+M),have been *** results show that AF+PF microstructure has high yield strength and excellent low temperature toughness,whereas its yield ratio is the *** ferrite-based dual-phase steels,PF+B,PF+M/A and PF+M microstructures show better strain capacity and low temperature *** strain capacity and low temperature toughness of ePF+M microstructure are the worst due to its high *** relationship between microstructure,strength,strain capacity and toughness has been *** on the results,the optimum microstructure for a better combination of strength,strain capacity and toughness is suggested to be the one having appropriate polygonal ferrite as second phase in an acicular ferrite matrix.

关键词： Pipeline steel Dual-phase microstructure Strength Strain capacity Toughness

Inorganic arsenic contamination of rice from Chinese major rice-producing areas and exposure assessment in Chinese population

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Science China Chemistry 2015年第12期58卷 1898-1905页

作者： Xiaowei Li ke Xie Bing Yue Yunyun Gong yi Shao Xiaohong Shang Yongning Wu key Laboratory of Food Safety Risk Assessment Ministry of Health China National Center for Food Safety Risk Assessment 3. Food Science and Engineering Department Wuhan Polytechnic University 4. Institute for Global Food Security School of Biological Sciences Queen's University of Belfast

This study examined the total arsenic(Ast) and inorganic arsenic(Asi) content in the main rice growing area of China. The results were compared with other countries and then used for dietary exposure assessment. A total of 446 rice samples from 15 main rice-growing provinces and autonomous regions of China were collected and then divided into unpolished and polished rice. Total arsenic and arsenic species were analyzed in a total of 892 subsamples using inductively coupled plasma-mass spectrometry(ICP-MS) and high performance liquid chromatography(HPLC) coupled ICP-MS, respectively. National Ast means were 255 μg/kg of unpolished rice and 143 μg/kg of polished rice. Asi was found to be the predominant species and mean levels were 209 μg/kg of unpolished rice and 108 μg/kg of polished rice, respectively. Exposure assessment to Asi in polished rice has been calculated for the margin of exposure(MOE), which highlights the fact that Asi levels in the Chinese rice should arouse public health concern.

关键词： arsenic speciation exposure assessment inorganic arsenic rice

Arylation of pyridine N-oxides via a ligand-free Suzuki reaction in water

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Chinese Chemical Letters 2015年第1期26卷 55-57页

作者： Chun Liu Shao-ke Zhang yi-Xia Zhang Zi-Lin Jin State key Laboratory of Fine Chemicals Dalian University of Technology

We report a practical and highly efficient protocol for the arylation of pyridine N-oxides with arylboronic acid through palladium-catalyzed Suzuki reaction in *** ligand-free Suzuki reaction is performed in the presence of diisopropylamine and gives 2-or 3-arylated pyridyl N-oxide derivatives in good to excellent yields within 1 h.

关键词： Pyridine N-oxides Arylation Palladium Suzuki reaction Water

Down-regulation of histone deacetylase 7 reduces biological activities of retinal microvascular endothelial cells under high glucose condition and related mechanism

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1210-1217页

作者： Jia-yi Ning Han-yi Yang Ting-ke Xie yi-Xuan Chen Jing Han Xi’an Medical University Xi’an 710021Shaanxi ProvinceChina Department of Ophthalmology Tangdu Hospitalthe Air Force Military Medical UniversityXi’an 710038Shaanxi ProvinceChina

AIM:To investigate the expression and effect of histone deacetylase 7(HDAC7)in human retinal microvascular endothelial cells(HRMECs)under high glucose condition and related mechanism,and the expression of HDAC7 in the retinal tissue in diabetic ***:The expression of HDAC7 in HRMECs under high glucose and the retinal tissue from normal or diabetic rats were detected with immunohistochemistry and Western ***-shHDAC7 HRMECs were used to study the effect of HDAC7 on cell *** count kit-8(CCK-8),5-ethynyl2’-deoxyuridine(EdU),flow cytometry,scratch test,Transwell test and tube formation assay were used to examine the ability of cell proliferation,migration,and ***,a preliminary exploration of its mechanism was performed by Western ***:The expression of HDAC7 was both upregulated in retinal tissues of diabetic rats and high glucosetreated ***-regulation of HDAC7 expression significantly reduced the ability of proliferation,migration,and tube formation,and reversed the high glucose-induced high expression of CDK1/Cyclin B1 and vascular endothelial growth factor in high glucose-treated ***:High glucose can up-regulate the expression of HDAC7 in ***-regulation of HDAC7 can inhibit HRMECs ***7 is proposed to be involved in pathogenesis of diabetic retinopathy and a therapeutic target.

关键词： human retinal microvascular endothelial cells histone deacetylase 7 high glucose diabetic rat vascular endothelial growth factor