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Annual advances of integrative pharmacology in 2019

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Traditional Medicine Research 2020年第2期5卷 74-82页

作者： ke-wu zeng Ming-Yao Gu State key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Cell Biology and Medical Genetics School of Basic Medical SciencesShenzhen University Health Science CenterShenzhen 51801China

Representative studies concerning the pharmacology of traditional medicine and active herbal products have been summarized over the past 12 *** annual integrative pharmacology review encompasses research articles published during 2019 on the bioactive compounds and extracts used in traditional *** highlighting the pharmacology progress of traditional medicine were specifically introduced,including artemisinin for cancer cell sensibility and induction to ferroptosis,rutin for neuroinflammation suppression,Ginseng Radix et Rhizoma for gut microbiota regulation against obesity,green tea and Pu-erh tea for metabolic syndrome,and marine-derived oligosaccharide(GV-971)from brown algae for ***,novel TCM molecular targets and pharmacological mechanisms were trialed against different human diseases,including cancers,cardiovascular,cerebrovascular diseases,diabetes,and metabolic ***,herb-derived bioactive products have become important treatment alternatives for cancer research in *** and cerebrovascular diseases,together with diabetes and metabolic diseases,are ongoing research areas for traditional ***,inflammation and infectious disease are also attracting more attention by researchers,which might have been influenced by seasonal influenza or HIV/Ebola viral *** traditional medicine investigations are required in neurodegenerative diseases,depression,and mental *** together,the findings of the integrative pharmacology review in 2019 provide a vast number of novel lead compounds or drug candidates for future clinical agent development and also details a novel series of attractive therapeutic targets and molecular mechanisms for human diseases.

关键词： Traditional medicine Natural product Pharmacology Cancer Inflammation Infectious diseases

Annual advances of integrative pharmacology in 2020

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Traditional Medicine Research 2021年第4期6卷 1-12页

Major studies on the pharmacology of traditional herbs as well as active compounds have been introduced in this review over the previous 12 *** annual integrative pharmacology review includes the reports published in 2020 on bioactive herbal extracts and novel compounds in traditional *** reports on traditional herbs as well as their active compounds for anticancer,inflammation,and metabolic diseases occupy dominant *** medicines are still widely reported as a crucial treatment to exhibit anticancer efficacy in numerous human cancer ***,the focus on the discovery of bioactive compounds from traditional medicines against mental disorders and neurodegenerative diseases seems to *** reports on bone loss and organ fibrosis treatments have notably gradually ***,studies of traditional herbs on cardiovascular and cerebrovascular diseases show a declining *** pharmacological reports in 2020 collectively show several crucial therapeutic targets and promising candidate compounds from traditional medicines for human diseases.

关键词： Traditional medicine Natural product Pharmacology Cancer Inflammation Infectious diseases

Advances in anti-inflammatory and immunoregulatory mechanisms of sinomenine

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Traditional Medicine Research 2021年第1期6卷 40-47页

作者： Xiao-Qing Zhou ke-wu zeng State key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Sinomenine,a major active ingredient from traditional Chinese medicine Qingfengteng(Sinomenium acutum(Thunb.)*** Wils.),has been proven to have anti-inflammatory,analgesic,anti-tumor,immunomodulatory and other pharmacological effects,and is clinically used for various inflammatory and autoimmune ***,due to complex molecular mechanisms and pathological characteristics in inflammatory and immune responses,the precise anti-inflammatory and immunological mechanisms of sinomenine are still *** review summarizes the anti-inflammatory and immunoregulatory mechanisms of sinomenine during recent years in rheumatoid arthritis,respiratory system,nervous system,digestive system and organ transplant *** molecular pharmacological mechanisms of sinomenine responsible for anti-inflammatory and immunosuppressive effects were in detail introduced based on 3 aspects including cytokines induction,signal pathways modulation and immune cells function ***,this review also raises some concerns and challenges in future sinomenine study,which will contribute to crucial theoretical and practical significance for in-depth development and utilization of sinomenine as medicinal resource.

关键词： Sinomenine Sinomenium acutum(Thunb.)Rehd.et Wils. Anti-inflammatory Immunosuppression Molecular mechanism Immunocyte

The role of natural products in regulating pyroptosis

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Traditional Medicine Research 2020年第3期5卷 167-177页

作者： Yi-Zhen Bai ke-wu zeng State key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

In recent years,large numbers of novel cell death types have been reported such as autophagic death,paraptosis,mitosis,oncosis and *** a new type of proinflammatory programmed cell death,pyroptosis has attracted increasing attentions gradually,and its morphological characteristics and molecular mechanisms are significantly different from other cell death types such as necrosis and *** research groups have demonstrated the association between pyroptosis and various human diseases including immunological disease,cancer,atherosclerosis,infectious disease,and cardiovascular and cerebrovascular *** products are small molecules synthetized in organisms including primary and secondary *** products are important sources of modern innovative drugs discovery and can be used as key tools to explore the molecular mechanism of cell *** aim of this study is to review the molecular mechanisms and pathways of pyroptosis,and to categorize and conclude research results on the correlation between different natural products and pyroptosis in recent *** this study,a total of 39 papers were enrolled in *** molecular pathways and mechanisms of pyroptosis were clearly *** types of natural products,their sources,effects,mechanisms and therapeutic potentials are categorized and *** is showed that a variety of natural products and pyroptosis have close *** negatively or positively affect or act on different positions of pyroptosis inflammatory pathways,indicating that they may have certain potential therapeutic effects on pyroptosis-related ***,a relatively new way of cell death,is closely associated with a variety of *** products can have obvious effects on the process of pyroptosis as potential sources of new ***-depth studies using natural products to investigate pyroptosis will help to enhance our understandings of human diseases and establish effec

关键词： Natural products Pyroptosis Programmed cell death Gasdermin-D Inflammasome.

Three new eudesmane sesquiterpenes from Artemisia vestita

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Chinese Chemical Letters 2013年第9期24卷 797-800页

作者： Shuai-Hua Tian Xing-Yun Chai ke Zan ke-wu zeng Peng-Fei Tu State key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Health Science Center Modern Research Center for Traditional Chinese Medicine Beijing University of Chinese Medicine

Three eudesmane sesquiterpene lactones, namely artemivestinolides A-C （1-3）, along with three known 11-epimeric lactones （4-6）, were isolated from the aerial parts ofArtemisia vestim. Their structures were elucidated on the basis of extensive spectroscopic analyses （IR, HR-ESIMS, 1D NMR and 2D NMR）, and the absolute configurations were determined by single-crystal X-ray diffraction （with copper radiation）. Furthermore, in an in vitro assay, the three new compounds exhibited a moderate inhibition of the lipopolysaccharide （LPS）-induced nitric： oxide （NO） production in BV-2 microglial cells.

关键词： Artemisia vestita Eudesmane sesquiterpene Artemivestinolide X-ray diffraction

Three new phenanthrenes from Cremastra appendiculata (***) Makino

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Chinese Chemical Letters 2013年第8期24卷 737-739页

作者： Liang Liu Jun Li ke-wu zeng Ping Li Peng-Fei Tu State key Laboratory of Natural Medicines China Pharmaceutical University State key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science Center Medical College Yangzhou University Modern Research Center for Traditional Chinese Medicine Beijing University of Chinese Medicine

Three new phenanthrenes,along with one known phenanthrene,were isolated from the ethanolic extract of the tubers of Cremastra appendiculata（***） *** structures were elucidated on the basis of extensive spectroscopic *** 1-4 were tested for in vitro cytotoxic activities against human lung（A549）,colon（HCT-116）,liver（HepG2）,and breast（MCF-7 and MDA-MB-231） cancer cell lines.

关键词： Phenanthrene Cremastra appendiculata Chemical constituent Cytotoxicity

Annual advances of integrative pharmacology in 2018

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Traditional Medicine Research 2019年第2期4卷 56-67页

作者： ke-wu zeng State key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing China

A number of researches concerning pharmacology of traditional medicine and active natural products over the past 12 months have outlined the importance of reviewing the *** annual integrative pharmacology review evaluates researches published during 2018 in different diseases including cardiovascular and cerebrovascular diseases,cancers,diabetes and metabolic diseases,and so *** emphasis is on bioactive compounds and extracts from traditional herbs,as well as the novel molecular targets and ***,some traditional prescriptions in China and other geographical locations have also been included.

关键词： Traditional medicine Natural product Herb Cancer Inflammation Cardiovascular diseases

Natural products as a crucial source of anti-inflammatory drugs: recent trends and advancements

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Traditional Medicine Research 2019年第5期4卷 257-268页

作者： Yan-Hang Wang ke-wu zeng State key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing China

Natural active molecules are key sources of modern innovative drugs. Particularly, a great amount of natural active molecules have been reported to possess promising therapeutic effects on inflammatory diseases, including asthma, rheumatoid arthritis, hepatitis, enteritis, metabolic disorders and neurodegenerative diseases. However, these natural active molecules with various molecular structures usually exert anti-inflammatory effects through diversiform pharmacological mechanisms, which is necessary to be summarized systematically. In this review, we introduced the current major anti-inflammatory natural active molecules based on their chemical structures, and discussed their pharmacological mechanisms including anti-inflammatory molecular signaling pathways and potential target proteins, which providing a referential significance on the development of novel anti-inflammatory drugs, and also revealing new therapeutic strategies for inflammatory diseases.

关键词： Natural products Anti-inflammation Traditional Chinese medicine Mechanism of action Drug target

Targeting SARS-CoV-2 main protease for drug discovery

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Infectious Diseases Research 2020年第2期1卷 1-4页

作者： Yang Liu ke-wu zeng State key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Center of Basic Medicine Research Peking University Third HospitalBeijing 100191China

The unprecedented pandemic of Coronavirus Disease 2019(COVID-19)was first emerged in wuhan,China and has spread globally due to its high transmissibility and infectivity,which seriously threaten global *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a specific virus that can cause ***,more than 45 million cases have been confirmed according to data supplied by Johns Hopkins University,and at least 1.1 million people have died from ***,the number of infected cases continues to grow,while no specific drugs or vaccines are available for the treatment of ***,specific drugs against SARS-CoV-2 infection,offering efficacy and safety,are urgently needed.

关键词： drugs Hopkins acute