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Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure

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Science China(Life Sciences) 2024年第2期67卷 360-378页

作者： Hongxia ruan Xuejuan Li Lina Zhou Zihan Zheng Rulin Hua Xu Wang Yuan Wang Yujie Fan Shuwen Guo Lihua Wang Shafiq ur Rahman Ziwei Wang Yuyuan Wei Shuangyan Yu Rongzhi Zhang Qian Cheng Jie Sheng Xue Li Xiaoyan Liu Ruqiang Yuan Xiaoyan Zhang Lihong Chen Guowang Xu Youfei Guan Jing Nie Hongqiang qin Feng Zheng Advanced Institute for Medical Sciences Dalian Medical UniversityDalian 116044China Department of Nephrology Second HospitalDalian Medical UniversityDalian 116023China CAS key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Chongqing International Institute for Immunology Chongqing 401320China Department of Nephrology Shenzhen HospitalSouthern Medical UniversityShenzhen 518101China Wuhu Hospital and Health Science Center East China Normal UniversityShanghai 200241China Peking University First Hospital Peking UniversityBeijing 100034China

Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis *** cell loss is an initiating event for peritoneal *** find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E,driving downstream inflammatory responses,including the activation of ***,pyroptosis is associated with elevated vascular endothelial growth factor A and C,two key factors in vascular angiogenesis and lymphatic vessel *** deficiency mice are protected from high glucose induced peritoneal fibrosis and ultrafiltration *** of melatonin abrogates mesothelial cell pyroptosis through a MT1R-mediated action,and successfully reduces peritoneal fibrosis and angiogenesis in an animal model while preserving dialysis ***,melatonin treatment maintains mitochondrial integrity in mesothelial cells,meanwhile activating m TOR signaling through an increase in the glycolysis product dihydroxyacetone *** effects together with quenching free radicals by melatonin help mesothelial cells maintain a relatively stable internal environment in the face of high-glucose ***,Melatonin treatment holds some promise in preserving mesothelium integrity and in decreasing angiogenesis to protect peritoneum function in patients undergoing peritoneal dialysis.

关键词： melatonin mitochondria pyroptosis GSDME peritoneal fibrosis mTOR

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基于改进麻雀优化PID的波浪补偿控制方法

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工程科学与技术 2024年第1期56卷 22-34页

作者：张琴蔡慧茹兰明东浦克胡雄上海海事大学物流工程学院上海201306

随着海上风电“十四五”规划的不断推动,在深远海域对兆瓦级大功率海上风机的需求量随之增加,其规模也在不断扩大。但是,在吊运、安装等海上工作过程中,复杂海浪对船舶产生的持续影响导致风机安装的精度和效率大幅下降,甚至会对人员安... 详细信息

随着海上风电“十四五”规划的不断推动,在深远海域对兆瓦级大功率海上风机的需求量随之增加,其规模也在不断扩大。但是,在吊运、安装等海上工作过程中,复杂海浪对船舶产生的持续影响导致风机安装的精度和效率大幅下降,甚至会对人员安全以及财产造成重大损失。在深远海域复杂海况下对工程船舶进行有效的波浪补偿,可提供稳定的作业环境以保证精准高效地完成各项工作,因此,本文提出了一种基于改进麻雀优化PID的波浪补偿控制方法并将其应用于Stewart补偿平台。首先,建立波浪补偿平台动力学以及运动学反解模型,并设计正解模型迭代求解算法。随后,使用PID进行波浪补偿控制,并通过麻雀搜索算法优化参数。接着,采用Circle混沌映射对其进行初始化分布,以解决初始化不均匀的问题;并采用动态自适应加权、柯西突变以及反向学习以提升算法全局寻优能力。最后,生成4~6级海况下的某工程船运动数据作为系统输入,利用MATLAB和Simulink软件平台搭建模型进行补偿控制验证,并在Stewart硬件平台上做补偿试验。结果表明,改进麻雀搜索算法具有较快的收敛速度、较高的精度和更好的寻优能力,优化后的PID控制方法更适合用于复杂海况下波浪补偿平台的控制优化,可为大功率海上风机安装的补偿平台控制系统设计提供参考。

关键词：波浪补偿平台 3自由度补偿比例积分微分控制器改进麻雀搜索算法

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Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2024年

作者： Can Zhu Yiyang Wang Lei Meng Beibei Qiu Jing Li Shucheng qin ke Hu Xin Jiang Wenbin Lai Minchao Liu Zhe Liu Chenxing Lu Jinyuan Zhang Yongfang Li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information EngineeringZhejiang Normal University key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of ChemistryChemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials(HTMs) in the n-i-p perovskite solar cells(pero-SCs) is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride(QxMACl),as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, QxMACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, QxMACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/QxMACl treatment showed a higher power conversion efficiency(PCE) of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at85 °C, respectively. To further enhance the PCE of the PBQ12/QxMACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/QxMACl-based devices reached 25.24%(the calibrated PCE of 24.55% by the National Institute of Metrology, China).

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创新生态系统不确定性条件下后发企业何以实现颠覆性创新——基于SOR模型的动态能力中介作用

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科技进步与对策 2024年第8期41卷 44-54页

作者：侯珂李鑫浩阮添舜西安石油大学经济管理学院陕西西安710065 西北大学经济管理学院陕西西安710069

创新生态系统被视为培养颠覆性创新的沃土,其日益增加的不确定性为后发企业提供了实现颠覆性创新的机会窗口。将动态能力细分为认知性动态能力与非认知性动态能力两个维度,利用SOR模型构建“条件刺激—能力构建—颠覆行为”的理论框架,... 详细信息

创新生态系统被视为培养颠覆性创新的沃土,其日益增加的不确定性为后发企业提供了实现颠覆性创新的机会窗口。将动态能力细分为认知性动态能力与非认知性动态能力两个维度,利用SOR模型构建“条件刺激—能力构建—颠覆行为”的理论框架,试图打开创新生态系统不确定性条件下后发企业实现颠覆性创新的“黑箱”。基于创新生态系统中376份后发企业的样本数据,研究发现:①创新生态系统不确定性不仅对颠覆性创新有显著正向影响,而且对认知性动态能力和非认知性动态能力也有显著正向影响;②认知性动态能力与非认知性动态能力对颠覆性创新有显著正向影响,并且分别在创新生态系统不确定性与颠覆性创新关系中起部分中介作用;③创新生态系统开放度能够正向调节创新生态系统不确定性与认知性动态能力关系。研究有助于指导面对不确定性的后发企业实现“弯道超车”,并且为创新生态系统突破创新迟滞困境提供新思路。

关键词：创新生态系统不确定性条件动态能力颠覆性创新 SOR模型

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Unloading and successful treatment with bioresorbable stents during percutaneous coronary intervention:A case report

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World Journal of Cardiology 2024年第8期16卷 484-490页

作者： Tao Sun Ming-Xue Zhang Yan Zeng Li-Hua ruan Yi Zhang Cheng-Long Yang Zhang qin Jing Wang Hai-Mei Zhu Yun Long Department of Cardiology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Teaching and Research Section of Chinese Internal Medicine The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Pain The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND With the development of percutaneous coronary intervention(PCI),the number of interventional procedures without implantation,such as bioresorbable stents(BRS)and drug-coated balloons,has increased *** drug-eluting stent unloading is one of the most common clinical ***,BRS detachment is more concealed and harmful,but has yet to be reported in clinical *** this study,we report a case of BRS unloading and successful *** is a case of a 59-year-old male with the following medical history:“Type 2 diabetes mellitus”for 2 years,maintained with metformin extended-release tablets,1 g PO BID;“hypertension”for 20 years,with long-term use of metoprolol sustained-release tablets,47.5 mg PO QD;“hyperlipidemia”for 20 years,without regular *** was admitted to the emergency department of our hospital due to intermittent chest pain lasting 18 hours,on February 20,2022 at 15:*** results showed sinus rhythm,ST-segment elevation in leads I and avL,and poor R-wave progression in leads V1–***-sensitivity troponin I level was 4.59 ng/mL,indicating an acute high lateral wall myocardial *** patient’s family requested treatment with BRS,without *** PCI,the BRS became unloaded but was successfully *** patient was followed up for 2 years;he had no episodes of angina pectoris and was in generally good *** We describe a case of a 59-year-old male experienced BRS unloading and successful *** analyzing images,the causes of BRS unloading and the treatment plan are discussed to provide insights for BRS release *** discuss preventive measures for BRS unloading.

关键词： Coronary artery diseases Percutaneous coronary intervention Bioresorbable stents Stent unloading Stent release Intravascular ultrasound Case report

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不利天气下考虑公司利他偏好的农产品供应链补贴机制

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系统科学与数学 2024年第4期44卷 962-980页

作者：覃燕红王珂刘力重庆理工大学管理学院重庆400054 重庆理工大学绿色供应链创新研究中心重庆400054

在不利天气影响农产品产量的情况下,考虑财政预算约束和公司利他偏好,构建无政府补贴、产出补贴、收购补贴、一次性补贴公司和一次性补贴农户五种情形下的博弈模型,比较不同政府补贴方式对农产品供应链最优决策的影响,并从改善消费者剩... 详细信息

在不利天气影响农产品产量的情况下,考虑财政预算约束和公司利他偏好,构建无政府补贴、产出补贴、收购补贴、一次性补贴公司和一次性补贴农户五种情形下的博弈模型,比较不同政府补贴方式对农产品供应链最优决策的影响,并从改善消费者剩余和社会福利、提高资金使用效率三方面分析政府的最优补贴策略.研究表明:每种补贴方式都能提高农产品供应链系统利润、改善社会整体福利,且政府补贴能有效增强利他偏好对农户努力水平的提升作用.进一步,当补贴资金不受财政预算约束时,收购补贴和产出补贴都能发挥资金杠杆作用;且从改善消费者剩余和社会整体福利角度,收购补贴为最优补贴策略;从补贴资金使用效率角度,产出补贴为最优补贴策略.当补贴资金受财政预算约束时,仅一次性补贴公司能发挥资金杠杆作用,且一次性补贴公司总是优于一次性补贴农户.

关键词：农产品供应链政府补贴财政预算约束利他偏好不利天气

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玻璃微区钙钛矿纳米晶发光调控与应用

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硅酸盐学报 2024年第8期52卷 2643-2658页

作者：阮超孙轲李昕阔邱建荣谭德志浙江大学材料科学与工程学院杭州310058 之江实验室杭州311121 浙江大学光电科学与工程学院杭州310027

钙钛矿纳米晶玻璃由于其在可见光波段发光波长可调、超高稳定性、光致发光量子效率高、单色性良好等独特优势,被广泛应用于光存储、微型发光二极管(Micro-LED)、超高分辨显示等前沿领域。本文探讨了钙钛矿纳米晶的独特光学特性,综述了... 详细信息

钙钛矿纳米晶玻璃由于其在可见光波段发光波长可调、超高稳定性、光致发光量子效率高、单色性良好等独特优势,被广泛应用于光存储、微型发光二极管(Micro-LED)、超高分辨显示等前沿领域。本文探讨了钙钛矿纳米晶的独特光学特性,综述了近年来通过B位取代、热处理和玻璃组成改性等方法优化钙钛矿纳米晶的晶体质量,进而提高其量子效率的各项研究。深入分析了热处理、超快激光直写等方式调控钙钛矿晶体组分和发光波长的根本机制。最后总结并展望了钙钛矿纳米晶玻璃在LED和光存储等领域的潜在应用和发展前景。

关键词：钙钛矿纳米晶玻璃优化量子效率调控发光波长光存储发光二极管显示

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AcWRKY28 mediated activation of AcCPK genes confers salt tolerance in pineapple(Ananas comosus)

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Horticultural Plant Journal 2024年第2期10卷 398-412页

作者： Qiao Zhou Samaranayaka Vidana Gamage Nirosha Priyadarshani Rongjuan qin Han Cheng Tiantian Luo Myat Hnin Wai Mohammad Aqa Mohammadi Yanhui Liu Chang Liu Hanyang Cai Xiaomei Wang Yeqiang Liu Yuan qin Lulu Wang Guangxi key Lab of Sugarcane Biology State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesCollege of AgricultureGuangxi UniversityNanningGuangxi 530004China State key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Life ScienceCollege of Plant ProtectionCollege of AgricultureCollege of HorticultureFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyCenter for Genomics and BiotechnologyFujian Agriculture and Forestry UniversityFuzhouFujian 350002China Pingtan Science and Technology Research Institute of Fujian Agriculture and Forestry University PingtanFujian 350400China National Education Commission BMICHColombo00700Sri Lanka Fishery Multiplication Management Station of Lijiang River Water Supply Hub Project GuilinGuangxi 541001China Horticulture Research Institute Guangxi Academy of Agricultural SciencesNanning Investigation Station of South Subtropical Fruit TreesMinistry of AgricultureNanningGuangxi 530007China

Unfavorable environmental cues severely affect crop productivity resulting in significant economic losses to farmers. In plants, multiple regulatory genes, such as the WRKY transcription factor (TF) family, modulate the expression of defense genes. However, the role of the pineapple WRKY genes is poorly understood. Here, we studied the pineapple WRKY gene, AcWRKY28, by generating AcWRKY28 over-expressing transgenic pineapple plants. Overexpression of AcWRKY28 enhanced the salt stress resistance in transgenic pineapple lines. Comparative transcriptome analysis of transgenic and wild-type pineapple plants showed that “plant-pathogen interaction” pathway genes, including 9calcium-dependent protein kinases (CPKs), were up-regulated in AcWRKY28 over-expressing plants. Furthermore, chromatin immunoprecipitation and yeast one-hybrid assays revealed AcCPK12, AcCPK3, AcCPK8, AcCPK1, and AcCPK15 as direct targets of AcWRKY28. Consistently, the study of AcCPK12 over-expressing Arabidopsis lines showed that AcCPK12 enhances salt, drought, and disease resistance. This study shows that AcWRKY28 plays a crucial role in promoting salt stress resistance by activating the expression of AcCPK genes.

关键词： Pineapple AcWRKY AcCPK Transcription factor Salt stress ChIP

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Clinical and genetic characteristics of a child with Sotos syndrome and attention-deficit/hyperactivity disorder:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5131-5139页

作者： Ya-Jing Yang Bei-Yi Li ke-Xin Gan Jing Liu Xiu-qin Lv Dong-Mei Zhang Hui-Juan Ma Department of Internal Medicine North China University of Science and TechnologyTangshan 063000Hebei ProvinceChina Department of Internal Medicine Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Department of Endocrinology Hebei General HospitalShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of Hebei Medical UniversityShijiazhuang 050023Hebei ProvinceChina

BACKGROUND Sotos syndrome is an autosomal dominant disorder,whereas attention-deficit/hyperactivity disorder(ADHD)is a neurodevelopmental *** report aimed to summarize the clinical and genetic features of a pediatric case of Soros syndrome and ADHD in a child exhibiting precocious *** SUMMARY The patient presented with accelerated growth and advanced skeletal maturation;however,she lacked any distinct facial characteristics related to specific genetic *** analyses revealed a paternally inherited heterozygous synonymous mutation[c.4605C>T(***1535Arg)].Functional analyses suggested that this mutation may disrupt splicing,and bioinformatics analyses predicted that this mutation was likely *** an initial diagnosis of Sotos syndrome,the patient was diagnosed with ADHD during the follow-up period at the age of 8 years and 7 *** The potential for comorbid ADHD in Sotos syndrome patients should be considered to avoid the risk of a missed diagnosis.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Nuclear receptor binding SET domain protein 1 Case report Developmental disabilities Diagnosis Como rbidity Management

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人文观照下儿童美术生活化教学实践探讨

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当代教研论丛 2024年第6期10卷 45-48页

作者：柯钦莆田市荔城区第二实验小学福建莆田351100

文章以人文观照为出发点,探讨儿童美术生活化教学的实践方法,并以创意徽章教学为例,分析如何将美术教育与儿童的生活实际相结合,以提高儿童的综合素质和创新能力。文章力图通过对创意徽章教学的实践研究,为儿童美术教育提供一种新的教... 详细信息

文章以人文观照为出发点,探讨儿童美术生活化教学的实践方法,并以创意徽章教学为例,分析如何将美术教育与儿童的生活实际相结合,以提高儿童的综合素质和创新能力。文章力图通过对创意徽章教学的实践研究,为儿童美术教育提供一种新的教学思路和方法,促进儿童美术教育的创新发展。

关键词：人文观照儿童生活美术创意徽章

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