检索结果-南通市图书馆

Frontiers of physics 2018年第3期13卷 29-35页

作者： Jun-Chi Wu Xu Peng Yu-Qiao Guo Hao-Dong Zhou Ji-Yin Zhao ke-qin ruan Wang-Sheng Chu Changzheng Wu Hefei National Laboratory for Physical Sciences at the Microscale iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) CAS Center for Excellence in Nanoscience and CAS Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of China Hefei 230026 China National Synchrotron Radiation Laboratory University fff Science and Technology of China Hefei 230026 China

Two-dimensional （2D） materials with robust ferromagnetism have played a key role in realizing next- generation spin-electronic devices, but many challenges remain, especially the lack of intrinsic ferro- magnetic behavior in almost all 2D materials. Here, we highlight ultrathin Mn3O4 nanosheets as a new 2D ferromagnetic material with strong magnetocrystalline anisotropy. Magnetic measurements along the in-plane and out-of-plane directions confirm that the out-of-plane direction is the easy axis. The 2D-confined environment and Rashba-type spin-orbit coupling are thought to be responsible for the magnetocrystaUine anisotropy. The robust ferromagnetism in 2D MnaO4 nanosheets with magne- tocrystalline anisotropy not only paves a new way for realizing the intrinsic ferromagnetic behavior in 2D materials but also provides a novel candidate for building next-generation spin-electronic devices.

关键词： 2D ferromagnetic material topochemical conversion magnetocrystalline anisotropy

Dominant negative effect as a novel mechanism of SPAST gene mutation in a large family with hereditary spastic paraplegia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 74-77页

作者： ke Deng Haibo ruan Feifei Yu Zhenle Pei Congjian Xu Shuo Zhang Shanghai Ji Ai Genetics&IVF Institute Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200000China Shanghai key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200000China The First People’s Hospital of Wenling WenlingZhejiang 317500China Rushan Hospital of Traditional Chinese Medicine RushanShandong 264599China Department of Obstetrics and Gynecology Fudan UniversityShanghai 200000China.

Hereditary spastic paraplegia(HSP)is a group of disorders with genetic heterogeneity,lower-extremity weakness,and spasticity are the most common signs and *** is the most frequently disease-causing *** is a microtubule-severing enzyme encoded by SPAST that cleaves long microtubules into short fragments by interacting with other proteins or *** spastic paraplegia type 4(SPG4),which is autosomal dominant,is the clinical subtype associated with SPAST ***4 accounts for up to one-third of all HSP cases and usually presents with isolated lower extremity spasticity,with or without bladder or sensory dysfunction.1 The main cause of SPG4 is believed to be spastin haploinsufficiency,which results from mutations in the SPAST gene.

关键词： bladder insufficiency clinical

Interfacial oxidized Pd species dominate catalytic hydrogenation of polar unsaturated bonds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第1期17卷 228-234页

作者： Pengyao You Shaoqi Zhan Pengpeng ruan Ruixuan qin Shiguang Mo Yazhou Zhang Kunlong Liu Lansun Zheng Nanfeng Zheng State key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsand Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Department of Chemistry BMCUppsala UniversityBMC Box 576Uppsala S-75123Sweden Department of Chemistry University of OxfordOxford OX13QZUK

The determination of catalytically active sites is crucial for the design of efficient and stable catalysts toward desired ***,the complexity of supported noble metal catalysts has led to controversy over the locations of catalytically active sites(e.g.,metal,support,and metal/support interface).Here we develop a structurally controllable catalyst system(Pd/SBA-15)to reveal the catalytic active sites for the selective hydrogenation of ketones to alcohol using acetophenone hydrogenation as model *** investigations demonstrated that unsupported Pd nanocrystals have no catalytic activity for acetophenone ***,oxidized Pd species were catalytically highly active for acetophenone *** catalytic activity decreased with the decreased oxidation state of *** work provides insights into the hydrogenation mechanism of ketones but also other unsaturated compounds containing polar bonds,e.g.,nitrobenzene,N-benzylidene-benzylamine,and carbon dioxide.

关键词： oxidized Pd metal/oxide interface constant particle size Pd/SBA-15 acetophenone hydrogenation

Liquefaction susceptibility and deformation characteristics of saturated coral sandy soils subjected to cyclic loadings-a critical review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2024年第1期23卷 261-296页

作者： Chen Guoxing qin You Ma Weijia Liang ke Wu Qi C.Hsein Juang Institute of Geotechnical Engineering Nanjing Tech UniversityNanjing 210009China Civil Engineering and Earthquake Disaster Prevention Center of Jiangsu Province Nanjing 210009China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 210016China Glenn Department of Civil Engineering Clemson UniversityClemsonSC 29634USA

Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical *** to the unique marine depositional environment of coral sandy soils,the engineering characteristics and responses of these soils subjected to monotonic and cyclic loadings have been a subject of intense interest among the geotechnical and earthquake engineering *** paper critically reviews the progress of experimental investigations on the undrained behavior of coral sandy soils under monotonic and cyclic loadings over the last three *** focus of coverage includes the contractive-dilative behavior,the pattern of excess pore-water pressure(EPWP)generation and the liquefaction mechanism and liquefaction resistance,the small-strain shear modulus and strain-dependent shear modulus and damping,the cyclic softening feature,and the anisotropic characteristics of undrained responses of saturated coral sandy *** particular,the advances made in the past decades are reviewed from the following aspects:(1)the characterization of factors that impact the mechanism and patterns of EPWP build-up;(2)the identification of liquefaction triggering in terms of the apparent viscosity and the average flow coefficient;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefaction resistance and the number of cycles required to reach liquefaction;(4)the establishment of the invariable form of the predictive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effects of stress-induced anisotropy on liquefaction susceptibility and dynamic deformation *** gained through the critical review of these advances in the past decades offer a perspective for future research to further resolve the fundamental issues concerning the liquefaction mechanism and responses of coral sandy sites subjecte

关键词： liquefaction susceptibility dynamic deformation characteristics coral sandy soil cyclic loading review and prospect

Weak interaction-steered evolution of polyoxovanadate-based metal-organic polyhedra from transformation via interlock to packing

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 527-533页

作者： Yan-Hu Wang ke-Wei Tong Chao-qin Chen Jing Du Peng Yang College of Chemistry and Chemical Engineering Advanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha 410082China College of Chemistry and Materials Science Testing and Analysis CenterHebei Normal UniversityShijiazhuang 050024China

A bottleneck in biomimetic synthesis consists in the full copy of,for example,the hierarchical structure of proteins directed by weak *** contrast with covalent bonds bearing definite orientation and high stability,weak intermolecular forces within a continuous dynamic equilibrium can be hardly tamed for molecular *** this endeavor,a ligand-dominated strategy that embodies tunable electrostatic repulsion andπ···πstacking was first employed to shape polyoxovanadate-based metal-organic polyhedra(VMOPs).Structural evolution involving transformation,interlock,and discovery of an unprecedented prototype of the Star of David was hence *** only as a handy tool for the primary structural control over VMOPs,these weak forces allow for an advanced management on the spatial distribution of such manmade macromolecules as well as the associated physicochemical behaviors,representing an ideal model for simulating and interpreting the conformation-function relationship of proteins.

关键词： Polyoxometalates Polyoxovanadates Metal-organic polyhedron Interlock Weak intermolecular forces

A machine learning-based strategy for predicting the mechanical strength of coral reef limestone using X-ray computed tomography

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2790-2800页

作者： Kai Wu qingshan Meng Ruoxin Li Le Luo qin ke ChiWang Chenghao Ma State key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China State key Laboratory of Water Resources and Hydropower Engineering Science Institute of Engineering Risk and Disaster PreventionWuhan UniversityWuhan430072China

Different sedimentary zones in coral reefs lead to significant anisotropy in the pore structure of coral reef limestone(CRL),making it difficult to study mechanical *** X-ray computed tomography(CT),112 CRL samples were utilized for training the support vector machine(SVM)-,random forest(RF)-,and back propagation neural network(BPNN)-based models,***,the machine learning model was embedded into genetic algorithm(GA)for parameter optimization to effectively predict uniaxial compressive strength(UCS)of *** indicate that the BPNN model with five hidden layers presents the best training effect in the data set of *** SVM-based model shows a tendency to overfitting in the training set and poor generalization ability in the testing *** RF-based model is suitable for training CRL samples with large *** of Pearson correlation coefficient matrix and the percentage increment method of performance metrics shows that the dry density,pore structure,and porosity of CRL are strongly correlated to ***,the P-wave velocity is almost uncorrelated to the UCS,which is significantly distinct from the law for homogenous *** addition,the pore tensor proposed in this paper can effectively reflect the pore structure of coral framework limestone(CFL)and coral boulder limestone(CBL),realizing the quantitative characterization of the heterogeneity and anisotropy of *** pore tensor provides a feasible idea to establish the relationship between pore structure and mechanical behavior of CRL.

关键词： Coral reef limestone(CRL) Machine learning Pore tensor X-ray computed tomography(CT)

27-Hydroxycholesterol/liver X receptor/apolipoprotein E mediates zearalenone-induced intestinal immunosuppression:A key target potentially linking zearalenone and cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第3期14卷 371-388页

作者： Haonan ruan Jing Zhang Yunyun Wang Ying Huang Jiashuo Wu Chunjiao He Tongwei ke Jiaoyang Luo Meihua Yang key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100193China

Zearalenone(ZEN)is a mycotoxin that extensively contaminates food and feed,posing a significant threat to public ***,the mechanisms behind ZEN-induced intestinal immunotoxicity remain *** this study,Sprague-Dawley(SD)rats were exposed to ZEN at a dosage of 5 mg/kg/day *** a duration of 14 *** results demonstrated that ZEN exposure led to notable pathological alterations and immunosuppression within the ***,ZEN exposure caused a significant reduction in the levels of apolipoprotein E(ApoE)and liver X receptor(LXR)(Pkers(P<0.05)and decreased the presence of 27-hydroxycholesterol(27-HC)in the intestine(P<0.05).It was observed that ApoE or LXR agonists were able to mitigate the immunosuppressive effects induced by ***,a bioinformatics analysis highlighted that the downregulation of ApoE might elevate the susceptibility to colorectal,breast,and lung *** findings underscore the crucial role of the 27-HC/LXR/ApoE axis disruption in ZEN-induced MDSCs proliferation and subsequent inhibition of T lymphocyte activation within the rat ***,ApoE may emerge as a pivotal target linking ZEN exposure to cancer development.

关键词： Zearalenone Intestinal immunosuppression Apolipoprotein E Bioinformatics analysis Cancer

Magnetic emission intensity enhancement for amorphous alloys by constructing a multi-phase structure withα-Fe nanocrystals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第7期17卷 6630-6637页

作者： ke Liu Zhi qin Jie Shen Zhi Cheng Shiyue You Liang Ma Jing Zhou Wen Chen State key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park Wuhan University of TechnologySanya 572024China Hubei Longzhong Laboratory Wuhan University of Technology Xiangyang Demonstration ZoneXiangyang 441000China

The perturbation in the magnetic field generated by the rotation or oscillation of magnetic domains in magnetic materials can emit low-frequency electromagnetic waves,which are expected to be used in low-frequency ***,the magnetic emission intensity,defined by the perturbation ability,of current commercially applied amorphous alloys,such as Metglas,cannot meet the application requirements for low-frequency antennas due to the domain motion energy ***,a multi-phase Metglas amorphous alloy was constructed by incorporatingα-Fe nanocrystals using rapid annealing to manipulate the domain *** was found that 3.89 times higher magnetic emission intensity is obtained compared to the pristine due to the synergism of the deformation and displacement ***,the low-frequency magnetic emission performance verification was carried out by preparing magnetoelectric composites as the antenna vibrator by assembling the alloy and macro piezoelectric fiber composites(MFC).Enhancements of magnetic emission intensity are found at 93.3%and 49.2%at the first and second harmonic frequencies compared with the unmodified alloy ***,the approach leads to the development of high-performance communication with a novel standard for evaluation.

关键词： multi-phase amorphous alloys magnetic emission intensity enhancing mechanism magnetic domain pinning theory Jiles-Atherton model analysis

Preparation of MXene-based hybrids and their application in neuromorphic devices

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Extreme Manufacturing 2024年第2期6卷 164-188页

作者： Zhuohao Xiao Xiaodong Xiao Ling Bing Kong Hongbo Dong Xiuying Li Bin He Shuangchen ruan Jianpang Zhai Kun Zhou qin Huang Liang Chu School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen 333403JiangxiPeople’s Republic of China School of Mechanical and Vehicle Engineering Linyi UniversityLinyi 276000ShandongPeople’s Republic of China College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118GuangdongPeople’s Republic of China School of Mechanical&Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Ningbo Institute of Materials Engineering and Technology Chinese Academy of ScienceNingbo 315201ZhejiangPeople’s Republic of China Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018ZhejiangPeople’s Republic of China

The traditional von Neumann computing architecture has relatively-low information processing speed and high power consumption,making it difficult to meet the computing needs of artificial intelligence(AI).Neuromorphic computing systems,with massively parallel computing capability and low power consumption,have been considered as an ideal option for data storage and AI computing in the ***,as the fourth basic electronic component besides resistance,capacitance and inductance,is one of the most competitive candidates for neuromorphic computing systems benefiting from the simple structure,continuously adjustable conductivity state,ultra-low power consumption,high switching speed and compatibility with existing CMOS *** memristors with applying MXene-based hybrids have attracted significant attention in recent ***,we introduce the latest progress in the synthesis of MXene-based hybrids and summarize their potential applications in memristor devices and neuromorphological *** explore the development trend of memristors constructed by combining MXenes with other functional materials and emphatically discuss the potential mechanism of MXenes-based memristor ***,the future prospects and directions of MXene-based memristors are briefly described.

关键词： MXene etching fabrication memristor neuromorphic

New clinical trial design in precision medicine:discovery,development and direction

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1293-1321页

作者： Xiao-Peng Duan Bao-Dong qin Xiao-Dong Jiao ke Liu Zhan Wang Yuan-Sheng Zang Department of Medical Oncology Changzheng HospitalNaval Medical UniversityShanghaiChina

In the era of precision medicine,it has been increasingly recognized that individuals with a certain disease are complex and different from each *** to the underestimation of the significant heterogeneity across participants in traditional"one-sizefits-all"trials,patient-centered trials that could provide optimal therapy customization to individuals with specific biomarkers were developed including the basket,umbrella,and platform trial designs under the master protocol *** recent years,the successive FDA approval of indications based on biomarker-guided master protocol designs has demonstrated that these new clinical trials are ushering in tremendous *** the rapid increase in the number of basket,umbrella,and platform trials,the current clinical and research understanding of these new trial designs,as compared with traditional trial designs,remains *** majority of the research focuses on methodologies,and there is a lack of in-depth insight concerning the underlying biological logic of these new clinical trial ***,we provide this comprehensive review of the discovery and development of basket,umbrella,and platform trials and their underlying logic from the perspective of precision ***,we discuss future directions on the potential development of these new clinical design in view of the"Precision Pro","Dynamic Precision",and"Intelligent Precision".This review would assist trial-related researchers to enhance the innovation and feasibility of clinical trial designs by expounding the underlying logic,which be essential to accelerate the progression of precision medicine.

关键词： clinical approval successive