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典型钢铁行业铊污染问题现状及防治对策研究

现代化工 2024年第5期44卷 7-10,14页

作者：黄进孙映竹令狐兴兵向仁军湖南省生态环境事务中心湖南长沙410014

通过研究湖南省钢铁行业涉铊现状,整理了湖南省钢铁行业铊转化途径及污染现状、铊污染物处理处置及再利用情况、监控管控现状,分析了湖南省钢铁冶炼行业铊污染问题及成因,并从源头削减、控制污染途径、加强监管、强化科研攻关等方面为... 详细信息

通过研究湖南省钢铁行业涉铊现状,整理了湖南省钢铁行业铊转化途径及污染现状、铊污染物处理处置及再利用情况、监控管控现状,分析了湖南省钢铁冶炼行业铊污染问题及成因,并从源头削减、控制污染途径、加强监管、强化科研攻关等方面为典型钢铁行业铊污染防治提供参考对策与建议。

关键词：钢铁行业铊污染问题对策

肠道非免疫细胞及其在炎症性肠病中的作用研究进展

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解放军医学杂志 2024年第5期49卷 594-601页

作者：王泽瑞焦艳梅令狐恩强解放军总医院第一医学中心消化内科医学部北京100853 解放军总医院第五医学中心感染病医学部北京100039

炎症性肠病(IBD)是免疫性疾病,虽然免疫细胞及相关的免疫学反应在IBD的发病过程中起主导作用,但是非免疫细胞,如肠道上皮细胞、间质细胞、内皮细胞等也参与了这一过程。近年来研究表明,肠道非免疫细胞在维持肠道上皮稳态、基质重塑、免... 详细信息

炎症性肠病(IBD)是免疫性疾病,虽然免疫细胞及相关的免疫学反应在IBD的发病过程中起主导作用,但是非免疫细胞,如肠道上皮细胞、间质细胞、内皮细胞等也参与了这一过程。近年来研究表明,肠道非免疫细胞在维持肠道上皮稳态、基质重塑、免疫反应及炎症过程中发挥着重要作用。有关肠道非免疫细胞的构成、基因表达特点及细胞功能,以及它们在IBD发生发展过程中的作用成为研究热点,尤其单细胞RNA测序(scRNA-seq)技术初步阐明了肠道细胞不同亚群的基因表达特征及细胞功能,以及这些变化与IBD发生发展的关系。本文针对肠道非免疫细胞在IBD中作用的相关进展进行综述。

关键词：炎症性肠病溃疡性结肠炎克罗恩病单细胞RNA测序上皮细胞间充质细胞

Burden of pancreatitis and associated risk factors in China,1990 to 2019:a systematic analysis for the Global Burden of Disease Study 2019

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Chinese Medical Journal 2022年第11期135卷 1340-1347页

作者： ke Han Shimin Chen Yang Song Chen Du Fei Gao Shaohua Liu Yao He Ningli Chai Enqiang linghu Miao Liu Department of Gastroenterology First Medical Center of Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China Institute of Geriatrics Beijing Key Laboratory of Aging and GeriatricsNational Clinical Research Center for Geriatric DiseaseSecond Medical Center of Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China Graduate School Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China.

Background: Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces quality of life. However, national epidemiological data on pancreatitis in China are lacking. This study aimed to quantify the disease burden of pancreatitis in China from 1990 to ***: This study was based on the Global Burden of Disease Study 2019 dataset. Age-standardized rates of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) were used to describe the disease burden of pancreatitis, and estimated annual percentage change (EAPC) was used to indicate the average change in age-standardized rates. We also described the trend of pancreatitis-related mortality and DALYs, which are attributable to alcohol use by age and ***: From 1990 to 2019, the ASIR, ASPR, ASMR, and age-standardized DALYs of pancreatitis in China decreased by 10.90, 1.50, 0.49, and 15.54 per 100,000, respectively, with EAPCs of -1.35 (95% uncertainty interval [UI]: -1.67, -1.02) and -0.37 (95% UI: -0.43, -0.31), -2.01 (95% UI: -2.07, -1.94) and -2.32 (95% UI: -2.37, -2.28), respectively. Recently, the numbers of incident and prevalent cases have risen, with estimates of 380,018 (95% UI: 308,669-462,767) and 493,765 (95% UI: 416,705-578,675), respectively, in 2019. Among men, the disease burden of pancreatitis was more severe than among women, and with variances in the distribution among different age groups. Age-standardized DALYs caused by alcohol-related pancreatitis have gradually worsened in the past decade, accounting for 34.09% of the total in ***: The disease burden of pancreatitis in China has declined in the past 30 years, but the exacerbation of population aging poses a challenge to prevention and control of pancreatitis. Alcohol use has gradually become an important factor in the disease burden of pancr

关键词： Alcohol use Global disease burden Incidence Mortality DALYs Pancreatitis China

Expression of bcl-2 oncogene in gastric precancerous lesions and its correlation with syndromes in traditional Chinese medicine

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World Journal of Gastroenterology 2005年第21期11卷 3293-3296页

作者： linghu Shao-XianLao Chun-ZhiTang InstituteoftheSpleenandStomach GuangzhouUniversityofTraditionalChineseMedicineGuangzhou510405GuangdongProvinceChina

AIM: To observe the protein and mRNA expression of bcl-2 oncogene in gastric precancerous lesions (GPL) and to analyze its correlation with syndromes in traditional Chinese medicine (TCM). METHODS: Sixty-seven patients with GPL confirmed by gastroscopy and pathology were studied,including 39 cases of moderate gastric mucosal dysplasia,19 cases of severe gastric mucosa dysplasia, 9 cases of incomplete colon metaplasia. In syndrome differentiation of TCM,17 cases belonged to the syndrome of qi and yin deficiency of the spleen and stomach complicated by qi stagnation, 21 cases belonged to the syndrome of qi and yin deficiency of the spleen and stomach complicated by stomach heat, 29 cases belonged to the syndrome of qi and yin deficiency of the spleen and stomach complicated by blood stasis. Protein and mRNA expression of bcl-2 oncogene were detected by labeled streptavidin biotin (LSAB) immunohist-ochemistry and in situ hybridization respectively. RESULTS: Abnormal expression of protein and mRNA on bcl-2 oncogene was found in GPL,which increased gradually with the course of lesions. In moderate and severe gastric mucosal dysplasia and incomplete colon metaplasia,there was no difference in the expression of bcl-2 oncogene (P>0.05).In different accompanying syndromes, the expression of protein and mRNA on bcl-2 oncogene increased gradually in the following order: deficiency of both qi and yin of the spleen and stomach accompanying qi stagnation→stomach heat→blood stasis. In GPL, compared with accompanying blood stasis, there was an obvious difference in the expression of bcl-2 oncogene between the syndrome of qi and yin deficiency of the spleen and stomach and accompanying stomach heat, so did accompanying qi stagnation (the level of protein: X2=8.45, P<0.05;the level of mRNA: X2=7.35, P<0.05). CONCLUSION: Apoptosis-associated bcl-2 oncogene is abnormally expressed in GPL,which correlates with different accompanying syndromes in TCM.

关键词： Stomach neoplasm/genetics Stomach neoplasm/ therapy of TCM Precancerous condition/pathology Oncogene bcl-2 Syndrome of TCM

艾滋病患者肠道免疫细胞和肠道菌群的变化及其临床意义

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中国艾滋病性病 2024年第4期30卷 414-419页

作者：王泽瑞焦艳梅洪卫国令狐恩强解放军总医院第一医学中心消化内科医学部北京100853 解放军总医院第五医学中心感染病医学部北京100039

cART能够有效抑制艾滋病患者体内(HIV-1)复制,提高感染者外周血CD4细胞数量,显著降低HIV-1相关疾病的发病率和病死率。不过,目前仍然有约20%的患者接受cART后并不能实现免疫重建。虽然后者发生的确切机制尚不完全清楚,但是慢性HIV-1感... 详细信息

cART能够有效抑制艾滋病患者体内(HIV-1)复制,提高感染者外周血CD4细胞数量,显著降低HIV-1相关疾病的发病率和病死率。不过,目前仍然有约20%的患者接受cART后并不能实现免疫重建。虽然后者发生的确切机制尚不完全清楚,但是慢性HIV-1感染对肠道组织和黏膜免疫微环境的破坏可能是一个重要原因。肠道组织富含免疫细胞,容易受HIV-1攻击,造成肠道黏膜组织损伤和通透性增加,继而发生肠道菌群紊乱和肠道菌群移位。这些变化不仅可以造成患者体内整体的免疫激活和系统性慢性炎症,而且还影响病毒潜伏和cART后的免疫重建。因此,解析HIV-1慢性感染、肠道免疫损伤和肠道菌群失调之间存在的复杂关系,对于阐明艾滋病患者免疫重建失败的机制、发现新型的治疗靶点以及创建新型的治疗策略,都具有重要的参考价值。为此,本文针对慢性HIV-1感染者肠道免疫细胞和肠道菌群改变的特点及其临床意义进行综述。

关键词：肠道免疫细胞 1型艾滋病病毒肠道菌群紊乱肠道菌群移位免疫重建系统性免疫激活慢性炎症

Clinical efficacy and prognostic risk factors of endoscopic radiofrequency ablation for gastric low-grade intraepithelial neoplasia

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 724-733页

作者： Nan-Jun Wang Ning-Li Chai Xiao-Wei Tang Long-Song Li Wen-gang Zhang En-Qiang linghu Department of Gastroenterology and Hepatology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND The use of radiofrequency ablation(RFA)has been reported in the treatment of gastric low-grade intraepithelial neoplasia(LGIN).However,its efficacy and prognostic risk factors have not been well *** To explore the efficacy and prognostic risk factors of RFA for gastric LGIN in a large,long-term follow-up clinical *** The clinical data of 271 consecutive cases from 198 patients who received RFA for treatment of gastric LGIN at the Chinese PLA General Hospital from October 2014 to October 2020 were reviewed in this retrospective *** on operative parameters,complications,and follow-up outcomes including curative rates were recorded and *** The curative rates of endoscopic RFA for gastric LGIN at 3 mo,6 mo,and 1-5 years after the operation were 93.3%,92.8%,91.5%,90.3%,88.5%,85.7%,and 83.3%,*** analyses revealed that Helicobacter pylori(***)infection and disease duration>1 year had a significant effect on the curative rate(P1 year may be the main risk factors for relapse of LGIN after RFA.

关键词： Endoscopic radiofrequency ablation Gastric low-grade intraepithelial neoplasia Clinical efficacy Prognostic risk factors

绝经后骨质疏松小鼠骨髓间充质干细胞免疫相关因子抗体芯片检测及关键差异基因分析

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中国组织工程研究 2024年第25期28卷 3947-3954页

作者：杨杉杉欧阳仁俊田佳令狐敏王振杨晓红遵义医科大学附属口腔医院口腔修复科贵州省遵义市563006 遵义医科大学基础药理教育部重点实验室贵州省遵义市563006

背景:近年来,绝经后骨质疏松症骨骼与免疫系统之间相互作用机制的研究已成为热点,但关键免疫相关因子表达改变对绝经后骨质疏松症的影响尚不明确,仍需进一步探索。目的:通过生物信息学方法探讨绝经后骨质疏松症小鼠骨髓间充质干细胞免... 详细信息

背景:近年来,绝经后骨质疏松症骨骼与免疫系统之间相互作用机制的研究已成为热点,但关键免疫相关因子表达改变对绝经后骨质疏松症的影响尚不明确,仍需进一步探索。目的:通过生物信息学方法探讨绝经后骨质疏松症小鼠骨髓间充质干细胞免疫相关因子差异化表达情况。方法:通过卵巢切除手术构建绝经后骨质疏松症小鼠模型,采用全骨髓贴壁法获取骨髓间充质干细胞并稳定传代至第2代,使用RayBio L-Series Mouse Antibody Array 308 Glass Slide Kit免疫相关因子抗体芯片检测卵巢切除组及假手术组小鼠骨髓间充质干细胞中存在差异表达的蛋白,对检测结果进行GO、keGG富集分析及PPI网络分析,通过MCC、EPC及MNC算法所得值筛选共同的Hub基因。结果与结论:共获得68个差异表达基因。GO分析发现差异表达基因富集于免疫系统过程、胞外区、信号受体结合等条目。keGG分析发现差异基因主要富集于细胞因子-细胞因子受体的相互作用、肿瘤坏死因子信号通路和趋化因子信号通路等条目。通过对68个差异表达基因构建PPI网络分析进一步筛选得到了8个Hub基因,绘制小提琴图和相关性矩阵发现8个Hub基因的表达水平在卵巢切除组均较假手术组显著下调。结果显示,绝经后骨质疏松症小鼠骨髓间充质干细胞存在差异性表达的免疫相关因子,筛选得到其中的关键基因主要涉及细胞因子-细胞因子受体的相互作用、免疫系统相关过程等具有潜在靶向的信号通路及细胞生物学过程,为绝经后骨质疏松症的诊治和预防提供新的靶点。

关键词：骨质疏松绝经后骨质疏松症骨髓间充质干细胞卵巢切除免疫相关因子生物信息学

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影像组学列线图在卵巢肿瘤诊断中的应用

影像研究与医学应用 2024年第4期8卷 1-3页

作者：张嘉婧令狐华重庆医科大学附属第一医院妇科重庆400016

卵巢肿瘤病理类型繁多,异质性明显。影像学检查为诊断卵巢肿瘤提供了可靠的依据。影像组学在传统影像学技术的基础上,高通量地提取及分析特征,已被用于卵巢肿瘤的诊断、分期、预后分析等方面。列线图模型通过整合多方面的预测因素,量化... 详细信息

卵巢肿瘤病理类型繁多,异质性明显。影像学检查为诊断卵巢肿瘤提供了可靠的依据。影像组学在传统影像学技术的基础上,高通量地提取及分析特征,已被用于卵巢肿瘤的诊断、分期、预后分析等方面。列线图模型通过整合多方面的预测因素,量化具体临床事件的风险,被广泛应用于肿瘤学研究。本文就国内外基于影像组学的列线图模型应用于卵巢肿瘤诊断中的研究作一综述,并探讨该技术所面临的挑战及发展前景。

关键词：卵巢肿瘤上皮性卵巢癌诊断影像组学列线图

Application of gas wettability alteration to improve methane drainage performance:A case study

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International Journal of Mining Science and Technology 2021年第4期31卷 621-629页

作者： Lin Jia kewen Li Xiaohong Shi Lipeng Zhao Jianshe linghu School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism Ministry of EducationBeijing 100083China Department of Energy Resources Engineering Stanford UniversityStanfordCA 94305USA Huayang New Material Technology Group Co. Ltd.Yangquan 045000China School of Resources and Environment Henan Polytechnic UniversityJiaozuo 454000China

Hydraulic fracturing technique is widely used for methane drainage and has achieved good effects in numerous coal mines,but negative effects may occur as the fracturing fluids are absorbed into the coal *** wettability alteration(GWA)technology can be used as it can enhance the gas and water mobility during dewatering process as a result of capillary pressure ***,there have been few reported field tests in coal mines using GWA *** paper describes a pilot-scale field test in Xinjing coal mine,Yangquan,*** fluorocarbon surfactants perfluorooctyl methacrylate monomer-containing polymethacrylate(PMP)was used to alter the wettability of coal seam to strong gas-wetness during the hydraulic fracturing *** study focuses on the comparison of two boreholes(Boreholes#9 and#10)and one other borehole(Borehole#8)with and without using GWA approach.A well-defined monitoring program was established by measuring the dewatering volume of the fracturing fluid and the drainage volume of methane as well as the *** field test results showed that the average methane drainage rates of Boreholes#9(39.28 m^(3)/d)and#10(51.04 m^(3)/d)with GWA treatment exceeded that of Borehole#8(21.09 m^(3)/d)without GWA treatment,with an increase of 86.3%and 142.1%,*** average methane concentrations of Boreholes#9(4.05%)and#10(6.18%)were 64.6%and 151.2%higher than that of Borehole#8(2.46%),*** the other hand,the dewatering ratio of Boreholes#9(4.36%)and#10(3.11%)was almost 19 times and 13 times greater than that of Borehole#8(0.22%).These field test results were in agreement with the experimental *** significant increase in both methane concentration and dewatering ratio demonstrated that GWA technology could be applied for enhanced methane drainage in coal *** lessons learned at Xinjing coal mine might be applied to other coal mines in China and elsewhere.

关键词： Field test Hydraulic fracturing Wettability alteration to gas-wetness Drainage of methane