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Berberine mitigates nonalcoholic hepatic steatosis by downregulating SIRT1-FoxO1-SREBP2 pathway for cholesterol synthesis

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Journal of Integrative Medicine 2021年第6期19卷 545-554页

作者： Meng-ya Shan Ying Dai Xiao-dan Ren Jing Zheng ke-bin zhang bin Chen Jun Yan Zi-hui Xu Department of Integrative Medicine Xinqiao HospitalArmy Medical UniversityChongqing 400037China National Drug Clinical Trail Institution Xinqiao HospitalArmy Medical UniversityChongqing 400037China Department of Biochemistry and Molecular Biology Army Medical UniversityChongqing 400038China Department 1 Research Institute of Surgery&Daping HospitalArmy Medical Center of Chinese People’s Liberation ArmyArmy Medical UniversityChongqing 400042China

Objective:To investigate effects of berberine(BBR)on cholesterol synthesis in HepG2 cells with free fatty acid(FFA)-induced steatosis and to explore the underlying ***:A steatosis cell model was induced in HepG2 cell line fed with FFA(0.5 mmol/L,oleic acid:-palmitic acid=2:1),and then treated with three concentrations of BBR;cell viability was assessed with cell counting kit-8 *** accumulation in cells was observed through oil red O staining and total cholesterol(TC)content was detected by TC *** effects of BBR on cholesterol synthesis mediators were assessed by Western blotting and quantitative polymerase chain *** addition,both silent information regulator 1(SIRT1)and forkhead box transcription factor O1(FoxO1)inhibitors were employed for ***:FFA-induced steatosis was successfully established in HepG2 *** accumulation and TC content in BBR groups were significantly lower(Pbinding protein 2(SREBP2)and 3-hydroxy 3-methylglutaryl-Co A reductase levels(Pked the BBR-mediated therapeutic *** showed that the increased SIRT1 expression increased FoxO1 deacetylation,and promoted its nuclear ***:BBR can mitigate FFA-induced steatosis in HepG2 cells by activating SIRT1-FoxO1-SREBP2 signal *** may emerge as a potential drug candidate for treating nonalcoholic hepatic steatosis.

关键词： Berberine Nonalcoholic fatty liver disease Lipid metabolism SIRT1-FoxO1-SREBP2

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电解铝用高效感应滤波整流供电系统分析

电机与控制学报 2017年第7期21卷 78-86页

作者：王灿宁志毫张可人张斌罗潇左剑国网湖南省电力公司电力科学研究院湖南长沙410007

电解铝整流供电系统会产生大量的谐波与无功,不仅造成严重的电能质量问题,同时影响系统的运行效率。针对电解铝整流供电系统供电电压高、容量超大、整流变压器阀侧绕组电压低电流超大等特点,提出了一种适用于电解铝的新型感应滤波整流... 详细信息

电解铝整流供电系统会产生大量的谐波与无功,不仅造成严重的电能质量问题,同时影响系统的运行效率。针对电解铝整流供电系统供电电压高、容量超大、整流变压器阀侧绕组电压低电流超大等特点,提出了一种适用于电解铝的新型感应滤波整流供电系统。相比传统整流供电系统,新系统在改善电能质量的同时,能够有效地缩短谐波及无功的流通路径,从而达到节能降耗的目的。新系统具有特殊的拓扑结构,并且为实现感应滤波技术,整流变压器的滤波绕组等值漏阻抗设计为零。理论分析了新系统的谐波传递特性和无功补偿特性。给出了样机试验分析,测试结果验证了理论分析的正确性,说明新型电解铝整流供电系统在谐波抑制、无功补偿以及节能等方面所具有的优势。

关键词：整流谐波抑制感应滤波无功补偿节能

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong Yang Haochen Shen Xiaoming Xiao Zhichao Li Qi Zhou Wei Yang bin Jiang Yongli Sun Luhong zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

基于模糊c-means与自适应粒子群优化的模糊聚类算法

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计算机科学 2016年第8期43卷 267-272页

作者：耿宗科王长宾张振国河北师范大学数学与信息科学学院石家庄050024

已有的粒子群模糊聚类算法需要设置粒子群参数并且收敛速度较慢,对此提出一种基于改进粒子群与模糊c-means的模糊聚类算法。首先,使用模糊c-means算法生成一组起始解,提高粒子群演化的方向性;然后,使用改进的自适应粒子群优化方法对数... 详细信息

已有的粒子群模糊聚类算法需要设置粒子群参数并且收敛速度较慢,对此提出一种基于改进粒子群与模糊c-means的模糊聚类算法。首先,使用模糊c-means算法生成一组起始解,提高粒子群演化的方向性;然后,使用改进的自适应粒子群优化方法对数据进行训练与优化,训练过程中自适应地调节粒子群参数;最终,采用模糊c-means算法进行模糊聚类过程。对比实验结果表明,所提方法大幅度提高了计算速度,并获得了较高的聚类性能。

关键词：粒子群优化参数调节模糊聚类算法自适应调节收敛速度

42例原发性胃腺鳞癌的临床病理特征与预后分析

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中华胃肠外科杂志 2017年第2期20卷 207-212页

作者：李斌孙琳王晓娜邓靖宇丁学伟王学军柯彬张李张汝鹏梁寒天津医科大学肿瘤医院胃部肿瘤科国家肿瘤临床医学研究中心天津市“肿瘤防治”重点实验室天津市恶性肿瘤临床医学研究中心天津300060 天津医科大学肿瘤医院胃部肿瘤科国家肿瘤临床医学研究中心天津市"肿瘤防治"重点实验室病理科天津300060

目的探讨原发性胃腺鳞癌的临床病理特征、诊治及预后的特点。方法天津医科大学肿瘤医院2001年1月至2011年1月期间共收治胃部肿瘤患者5562例，其中原发性胃腺鳞癌患者42例，占同期胃部肿瘤患者的0．76％。收集该组胃腺鳞癌患者临床病理... 详细信息

目的探讨原发性胃腺鳞癌的临床病理特征、诊治及预后的特点。方法天津医科大学肿瘤医院2001年1月至2011年1月期间共收治胃部肿瘤患者5562例，其中原发性胃腺鳞癌患者42例，占同期胃部肿瘤患者的0．76％。收集该组胃腺鳞癌患者临床病理及随访资料进行回顾性队列研究，采用Cox比例风险模型分析胃腺鳞癌的预后影响因素。结果42例原发性胃腺鳞癌患者中男32例，女10例，男女比例3．2：1．0，平均年龄63（46～77）岁。5例（11．9％）术前病理确诊为腺鳞癌，其余37例术前病理均认为腺癌。根据AJCC第7版关于胃腺癌的TNM分期标准，Ⅱ期5例（11．9％），Ⅲ期30例（71．4％），1V期7例（16．7％）；肿瘤最大径〉5cm者18例（42．9％）；Borrmann分型为Ⅲ～Ⅳ者29例（69．0％），低（或未）分化肿瘤者32例（76．2％）。31例（73．8％）行根治性手术治疗，未行根治性手术治疗者包括3例原发肿瘤侵犯胰腺、1例侵犯横结系膜根部和7例Ⅳ期患者；有37例患者行淋巴结清扫，其中83．8％（31／37）有淋巴结转移。排除7例Ⅳ期患者和10例拒绝辅助化疗的患者，本组25例患者接受辅助化疗方案治疗。全组平均生存时间36．4月，中位生存时间28．0月，术后1、3、5年生存率分别为82．2％、42．3％和18．2％。单因素分析结果显示，肿瘤最大径（x2=4．039，P=0．044）、Borrmann分型（x2=18．728，P=0．000）、肿瘤分化程度（x2=19．612，P=0．000）、手术根治程度（X2=41．452，P=0．000）、是否有淋巴结转移（x2=9．689，P=0．002）及肿瘤分期（x2=26．277，P=0．000）与患者预后有关；多因素分析结果显示，肿瘤分化程度（HR=10．560，95％CI：2．263～49．281，P=0．003）、手术根治程度（HR=4．309，95％CI：1．311—14．168，P=0．016）和肿瘤分期（HR=2．392，95％CI：1．022～5．600，P=0．044）是影响患者预后独立因素。结论原发性胃腺鳞癌罕见且预后差，应优先推荐手术治疗，肿瘤分化程度、手术根治程度及肿瘤分期是评估原发性腺鳞癌患者预后的重要指标。

关键词：胃肿瘤腺鳞癌临床病理学预后

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming zhang bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang Dai Guoyao Yue Yiman zhang Lulu Li Zhong-Zhen Yu Peng Min Hao-bin zhang 21 State key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

A mechanical reinforced and antifreezing polyacrylate hydrogel electrolyte for high-performance zinc-ion batteries

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Nano Research 2025年第1期18卷 341-350页

作者： Zili zhang Ruolin Wang Hongfei Lu Di zhang Yu Zhao Jing Xu bin Sun Zhi-Min Dang Yang Jin School of Electrical and Information Engineering Zheng Zhou UniversityZhengzhou 450001China State key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The operation of aqueous zinc-ion batteries in flexible energy storage field is plagued by the uncontrollable growth of Zn-dendrite and inevitable freeze of water below 0 ℃.Therefore,it is necessary to design a hydrogel electrolyte with good mechanical property and freezing resistance to uniform the Zn-deposition and resist flexibility loss at low *** find that the mechanical property(strength and toughness)of hydrogel electrolyte has a significant impact on the suppression of dendrite growth and the uniform deposition of zinc ***,a polyacrylate hydrogel is prepared in one step by ultraviolet(UV)curing method with Zn(CF_(3)SO_(3))_(2)salt and polyvinyl alcohol(PVA)addition to increase the antifreezing ability and mechanical *** adsorption of water molecules by 2-hydroxyethyl acrylate(HEA)and PVA reduces the freezing point of the hydrogel,which is beneficial for enhancing the electrochemical stability at low *** this basis,the Zn-symmetrical battery with hydrogel electrolyte has a long lifespan of 4710 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2)at room ***,the hydrogel electrolyte exhibits an outstanding stability at low temperature of^(-2)0 ℃,the lifespan of symmetrical battery reaches to 4000 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2).The assembled full cell with NaV3O8·1.5H_(2)O(NVO)cathode and hydrogel electrolyte possesses a high capacity retention ratio of 77%after 10,000 cycles at^(-2)0 ℃.The flexible cell can power light-emitting diode(LED)lamp under bending,warping and cutting without liquid leakage and an electronic watch at the operating temperature of^(-2)0 ℃.

关键词： zinc ion battery hydrogel electrolyte mechanical enhancement freezing resistance

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo ke Gao key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management