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Neurite Orientation Dispersion and Density Imaging of Rat Brain Microstructural Changes due to Middle Cerebral Artery Occlusion at a 3T MRI

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Current Medical Science 2021年第1期41卷 167-172页

作者： Zhen-xiong WANG Wen-zhen ZHU Shun ZHANG Mehran Shaghaghi ke-jia CAi Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Radiology Department of Bioengineeringand the Center for MR ResearchUniversity of Illinois at ChicagoChicago60612USA

The purpose of this work was to demonstrate the feasibility of neurite orientation dispersion and density imaging(NODDI)in characterizing the brain tissue microstructural changes of middle cerebral artery occlusion(MCAO)in rats at 3T MRI,and to validate NODDI metrics with histology.A multi-shell diffusion MRI protocol was performed on 11 MCAO rats and 10 control rats at different post-operation time points of 0.5,2,6,12,24 and 72 *** orientation dispersion index(ODI)and intracellular volume fraction(V_(ic))metrics were compared between MCAO group and control *** evolution of NODDI metrics was characterized and validated by *** was consistent with significantly increased ODI and V_(ic)in comparison to control tissues at all time points(Pke periods(Pke in translational research and clinical practice.

关键词： diffusion magnetic resonance imaging neurite orientation dispersion and density imaging middle cerebral artery occlusion model stroke rats

An Evaluation of Genotoxicity and Cytotoxicity of Melamine in Combination with Cyanuric Acid at Three Mass Ratios

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Biomedical and Environmental Sciences 2014年第8期27卷 641-645页

作者： LIU Xin HUANG Da Wei WU ke jia WU Yong Ning jia Xi Wu GONG Zhi Yong Institute of Food Science and Engineering Wuhan Polytechnic University Hubei Collaborative Innovation Center for Processing of Agricultural Products Wuhan Polytechnic University China National Center for Food Safety Risk Assessment Chaoyang District

Melamine in combination with cyanuric acid has been considered to be more toxic than either melamine or cyanuric acid alone. The objective of this study was designed to evaluate the combined genotoxicity and cytotoxicity of melamine （M） and cyanuric acid （C） at three mass ratios （1：1, 1：2, 2：1）. MC （1：1）, MC （1：2）, and MC （2：1） were evaluated for their potential genotoxic risk, at gene level by Ames test, and at chromosomal level by micronucleus test. In order to evaluate cytotoxicity in HEK-293 cells, the MTT assay was included. Western blot was also employed to investigate the renal injury molecule-1 （Kim-1） expression in HEK-293 cells exposed to MC. Neither genotoxicity at gene level nor at chromosomal level was observed for MC （1：1）, MC （1：2）, and MC （2：1）. Based on MTT assay, three ratios of MC at 82.5 and 165 μg/mL slightly inhibited viability of HEK-293 cells （P〈0.05）. MC （1：1） at 41.25 and 82.50 IJg/mL could elevate the Kim-1 expression in HEK-293 cells.

关键词： An Evaluation of Genotoxicity and Cytotoxicity of Melamine in Combination with Cyanuric Acid at Three Mass Ratios TA

SC79 promotes efficient entry of GDNF liposomes into brain parenchyma to repair dopamine neurons through reversible regulation of tight junction proteins

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Nano Research 2023年第2期16卷 2695-2705页

作者： Xiaomei Wu Li Wang Kai Wang jia ke Sufen Li Tingting Meng Hong Yuan Qirui Zhang Fuqiang Hu College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China College of Pharmaceutical Science Shenyang Pharmaceutical UniversityShenyang 110016China

Glial cell line-derived neurotrophic factor(GDNF),a disease-modifying drug for Parkinson’s disease(PD)is in Phase 2 clinical trials(EudraCT number:2011-003866-34),however it is administered by direct intrastriatal delivery via stereotaxy,which is accompanied with intracranial infection,brain tissue damage,and other *** addition,because of complex administration routes,clinical trials of GDNF have yielded contrary results,largely due to differences in dose and concentration brought by intracranial ***,a small molecular agonist SC79 was screened to open blood-brain barrier(BBB)and promote GDNF liposomes to get into ***79 reversibly reduces the expression of claudin-5,one of dominant tight junctions of *** study showed SC79 promoted liposomes to enter into brain parenchyma 2.43 times more than that of the *** deficits of PD mice receiving SC79 and brain-targeted GDNF liposomes were recovered by 36.70%and tyrosine hydroxylase positive neurons in striatum were restored by 39.90%.Our combination therapy effectively avoids the side effects such as secondary infection and uneven delivery caused by intracranial injection,improving patients’compliance and providing valuable research ideas for the clinic.

关键词： blood-brain barrier brain delivery facilitation tight junction glial cell line-derived neurotrophic factor disease-modifying Parkinson’s disease

Molecular Evolution of Protein Sequences and Codon Usage in Monkeypox Viruses

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 89-97页

作者： ke-jia Shan Changcheng Wu Xiaolu Tang Roujian Lu Yaling Hu Wenjie Tan jian Lu State key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Sinovac Biotech Ltd. Beijing 100085China NHC key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 100052China

The monkeypox virus(mpox virus,MPXV)epidemic in 2022 has posed a significant public health ***,the evolutionary principles of MPXV remain largely ***,we examined the evolutionary patterns of protein sequences and codon usage in *** first demonstrated the signal of positive selection in OPG027,specifically in the CladeⅠlineage of ***,we discovered accelerated protein sequence evolution over time in the variants responsible for the 2022 ***,we showed strong epistasis between amino acid substitutions located in different *** codon adaptation index(CAI)analysis revealed that MPXV genes tended to use more non-preferred codons compared to human genes,and the CAI decreased over time and diverged between clades,with CladeⅠ>Ⅱa andⅡb-A>Ⅱ*** the decrease in fatality rate among the three groups aligned with the CAI pattern,it remains unclear whether this correlation was coincidental or if the deoptimization of codon usage in MPXV led to a reduction in fatality *** study sheds new light on the mechanisms that govern the evolution of MPXV in human populations.

关键词： Mpox virus Positive selection OPG027 Accelerated evolution Codon usage bias

Entropy engineering in CaZn_(2)Sb_(2)-YbMg_(2)Sb_(2)Zintl alloys for enhanced thermoelectric performance

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Rare Metals 2022年第9期41卷 2998-3004页

作者： ke-jia Liu Zong-Wei Zhang Chen Chen Li-Hua Wei Huo-Lun He Jun Mao Qian Zhang School of Materials Science and Engineering and Institute of Materials Genome&Big DataHarbin Institute of TechnologyShenzhen518055China Department of Mechanical Engineering The University of Hong KongHong Kong999077China State key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China

The significant atomic disorder induced by entropy engineering can effectively suppress lattice thermal conductivity and improve thermoelectric *** variety of compositions of Zintl phases offers a wide range of possibilities for entropy *** we successfully prepared a five-component solid solution(CaZn_(2)Sb_(2))_(0.5)(YbMg_(2)Sb_(2))_(0.5) with a configurational entropy of~1.40R,whereR is the gas *** a result,the room-temperature lattice thermal conductivity was only~0.68 W·m^(-1)·K^(-1),which is lower than that of all AM_(2)Sb_(2) Zintl phases.

关键词： alloys entropy performance

High-Efficient Numeric Simulation of Spontaneous Potential Log in Complex Beds

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石油地球物理勘探 2009年第3期44卷 118-124页

作者： Pan ke-jia Tan Yong-ji School of Mathematical Sciences and Computing Technology Central South University Changsha 410075 China School of Mathematical Sciences Fudan University Shanghai 200433 China

自然电位测井是石油勘探中探测地层物理参数的重要手段.针对近年来出现的侵入带电阻率渐变和水淹层等复杂地层模型,本文建立了基于连续侵入的自然电位测井的数学模型,提出了一种捕捉交界面电位跳跃的有限差分方法.该方法非常简单,易于... 详细信息

自然电位测井是石油勘探中探测地层物理参数的重要手段.针对近年来出现的侵入带电阻率渐变和水淹层等复杂地层模型,本文建立了基于连续侵入的自然电位测井的数学模型,提出了一种捕捉交界面电位跳跃的有限差分方法.该方法非常简单,易于计算机编程实现.利用该方法定量分析了目的层电阻率、地层厚度、井径、侵入带和水淹层等因素对自然电位测井响应的影响,取得了满意的结果.复杂地层自然电位测井数值模拟的实现为测井解释提供了依据,对实际测井工程具有一定的指导意义.

关键词：自然电位数值模拟登录水电阻率有限差分法计算机编程物理参数石油勘探

Terahertz coherent detection via two-color laser pulses of various frequency ratios

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Chinese Physics B 2019年第9期28卷 391-398页

作者： Xin-Yang Gu ke-jia Wang Zhen-Gang Yang Jin-Song Liu Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China

The mechanism of terahertz(THz) pulse coherent detection via two-color laser pulses of various frequency ratios in gas plasma is theoretically *** investigations demonstrate that except for the commonly used frequency ratio of 2, other uncommon frequency ratios can also be utilized to detect THz pulse, such as 2 n, n + 1/2(n ≤ 3, n is a positive integer).The well-developed transient photocurrent model is extended to our terahertz detection *** on this model, our simulation results can be explained by analyzing the process of asymmetric electron ionization and electron acceleration.

关键词： terahertz gas plasma coherent detection photoionization

Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome

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World Journal of Gastroenterology 2018年第8期24卷 894-904页

作者： Lei-Min Yu ke-jia Zhao Shuang-Shuang Wang Xi Wang Bin Lu Department of Gastroenterology First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina First Clinical Medical College of Zhejiang Chinese Medical University Hangzhou 310053Zhejiang ProvinceChina key Laboratory of Digestive Pathophysiology of Zhejiang Province First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

AIM To study the role of microbial metabolites in the modulation of biochemical and physiological processes in irritable bowel syndrome(IBS).METHODS In the current study, using a metabolomic approach, we analyzed the key metabolites differentially excreted in the feces of control mice and mice with IBS, with or without Clostridium butyricum(C. butyricum) treatment. C57 BL/6 mice were divided into control, IBS, and IBS + C. butyricum groups. In the IBS and IBS + C. butyricum groups, the mice were subjected to water avoidance stress(WAS) for 1 h/d for ten days. Gas chromatography/mass spectrometry(GC-MS) together with multivariate analysis was employed to compare the fecal samples between groups. RESULTS WAS exposure established an appropriate model of IBS in mice, with symptoms of visceral hyperalgesia and diarrhea. The differences in the metabolite profiles between the control group and IBS group significantly changed with the progression of IBS(days 0, 5, 10, and 17). A total of 14 differentially excreted metabolites were identified between the control and IBS groups, and phenylethylamine was a major metabolite induced by stress. In addition, phenylalanine metabolism was found to be the most relevant metabolic pathway. Between the IBS group and IBS + C. butyricum group, 10 differentially excreted metabolites were identified. Among these, pantothenate and coenzyme A(Co A) biosynthesis metabolites, as well as steroid hormone biosynthesis metabolites were identified as significantly relevant metabolic *** The metabolic profile of IBS mice is significantly altered compared to control mice. Supplementation with C. butyricum to IBS mice may provide a considerable benefit by modulating host metabolism.

关键词： Irritable bowel syndrome Metabolite Gas chromatography/mass spectrometry Clostridium butyricum

Effect of powder mixing process on the microstructure and thermal conductivity of Al/diamond composites fabricated by spark plasma sintering

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Rare Metals 2010年第1期29卷 86-91页

作者： CHU ke, jia Chengchang, LIANG Xuebing, and CHEN Hui School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China School of Materials Science and Engineering University of Science and Technology Beijing Beijing China

Two powder mixing processes, mechanical mixing （MM） and mechanical alloying （MA）, were used to prepare mixed Al/diamond powders, which were subsequently consolidated using spark plasma sintering （SPS） to produce bulk Al/diamond composites. The effects of the powder mixing process on the morphologies of the mixed powders, the microstructure and the thermal conductivity of the composites were investigated. The results show that the powder mixing process can significantly affect the microstructure and the thermal conductivity of the composites. Agglomerations of the particles occurred in mixed powders using MM for 30 min, which led to high pore content and weak interfacial bonding in the composites and resulted in low relative density and low thermal conductivity for the composites. Mixed powders of homogeneous distribution of diamond particles could be obtained using MA for 10 min and MM for 2 h. The composite prepared through MA indicated a high relative density but low thermal conductivity due to its defects, such as damaged particles, Fe impurity, and local interfacial debonding, which were mainly introduced in the MA process. In contrast, the composite made by MM for 2 h demonstrated high relative density and an excellent thermal conductivity of 325 W.m^-1.K^-1, owing to its having few defects and strong inter-facial bonding.

关键词： metal matrix composites thermal properties sintering powder mixing