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铁道学报 2009年第3期31卷 20-25页

作者：潘科石剑云大连交通大学土木与安全工程学院辽宁大连116028

针对《地铁运营安全评价标准》(GB/T50438-2007)及传统综合评价方法在指标分值、隶属度确定和指标权重上存在的不足,引入变权理论和相对差异函数。建立了地铁运营火灾风险评价指标体系及其指标分值,用变权方法调整已建立的指标常权,用... 详细信息

针对《地铁运营安全评价标准》(GB/T50438-2007)及传统综合评价方法在指标分值、隶属度确定和指标权重上存在的不足,引入变权理论和相对差异函数。建立了地铁运营火灾风险评价指标体系及其指标分值,用变权方法调整已建立的指标常权,用相对差异函数确定单因素对各安全等级的隶属度,以优化和显示某些因素在体系中的重要性。理论分析和实例计算表明,引入的这两种方法不仅可行,而且使评价结果更加合理。该项工作可为我国城市地铁运营安全评价的深入开展提供参考依据。

关键词：变权相对差异函数地铁运营安全评价火灾风险

TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis

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Cancer Communications 2019年第1期39卷 14-27页

作者： Dan-dan Wang Yi-bing Chen Jing-jing Zhao Xiao-fei Zhang Guang-chao Zhu De-sheng Weng ke pan Lin Lv Qiu-zhong pan Shan-shan Jiang Lei-lei Wang Jian-chuan Xia Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060GuangdongP.R.China Department of Biotherapy Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Shandong Medicinal Biotechnology Centre Back and Neck Pain HospitalShandong Academy of Medical SciencesJinan 250062ShandongP.R.China Genetic and Prenatal Diagnosis Center Department of Gynecology and ObstetricsFirst Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052HenanP.R.China key Laboratory for Applied Microbiology of Shandong Province Ecology Institute of Shandong Academy of SciencesJinan 250014ShandongP.R.China

Background: In our previous study, we identified a candidate tumor suppressor gene, testin LIM domain protein (TES), in primary gastric cancer (GC). TES contains three LIM domains, which are specific interacting regions for the cell adhesion and cytoskeleton regulatory proteins. Mena is a known cytoskeleton regulator that regulates the assembly of actin filaments and modulates cell adhesion and motility by interacting with Lamellipodin (Lpd). Therefore, we hypothesized that TES plays a role as tumor suppressor in GC through interacting with Mena. This study aimed to investigate the tumor suppressive functions of TES in GC. Methods: We explored the tumor suppressive effect of TES in GC by in vitro cell proliferation assay, colony formation assay, cell cycle analysis, Transwell assays, and in vivo tumorigenicity and metastasis assays. The interaction of TES and Mena was investigated through immunoprecipitation-based mass spectrometry. We also analyzed the expression of TES and Mena in 172 GC specimens using immunohistochemistry and investigated the clinicopathological and prog-nostic significance of TES and Mena in GC. Results: TES suppressed GC cell proliferation and colony formation, induced cell cycle arrest, and inhibited tumorigenicity in vitro. Additionally, it inhibited GC cell migration and invasion in vitro and suppressed metastasis in vivo. TES interacted with Mena, and inhibited the interaction of Mena with Lpd. Transwell assays suggested that TES suppressed migration and invasion of GC cells in a Mena-dependent fashion. In GC patients with high Mena expression, the expression of TES was associated with tumor infiltration (P = 0.005), lymph node metastasis (P = 0.003), TNM stage (P = 0.003), and prognosis (P = 0.010). However, no significant association was observed in GC patients with low Mena expression. Conclusions: We believe that TES functions as a Mena-dependent tumor suppressor. TES represents a valuable prog-nostic marker and potential target for GC

关键词： Gastric cancer TES Tumor suppressor Mena Lamellipodin

基于逐级加载的弯曲蠕变试验分析沥青混合料低温开裂性能

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中南大学学报（自然科学版） 2021年第7期52卷 2450-2458页

作者：李超潘科王岚内蒙古工业大学土木工程学院内蒙古呼和浩特010051 内蒙古自治区土木工程结构与力学重点实验室内蒙古呼和浩特010051

为了探究复合多聚磷酸改性沥青混合料低温流变性能,通过小梁弯曲试验和逐级加载的小梁弯曲蠕变试验方法,研究不同温度和蠕变荷载作用下,复合多聚磷酸改性沥青混合料低温流变性能的变化规律,并与SBS改性沥青混合料进行比较,评价其流变性... 详细信息

为了探究复合多聚磷酸改性沥青混合料低温流变性能,通过小梁弯曲试验和逐级加载的小梁弯曲蠕变试验方法,研究不同温度和蠕变荷载作用下,复合多聚磷酸改性沥青混合料低温流变性能的变化规律,并与SBS改性沥青混合料进行比较,评价其流变性能对路用性能的影响。研究结果表明:在低温条件下,复合多聚磷酸改性沥青混合料抵抗破坏的能力比SBS改性沥青混合料的强,破坏时产生应变比SBS改性沥青混合料产生的应变大,低温抗裂性能比SBS改性沥青混合料的好;复合多聚磷酸混合料较SBS改性沥青混合料应力松弛性能好,抵抗温度开裂的性能好。2种试验方法证明复合多聚磷酸沥青混合料低温抗裂性能比SBS改性沥青混合料的性能好。

关键词：多聚磷酸改性沥青混合料弯曲蠕变低温抗裂性

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储罐爆炸事故中抛射碎片初速度预测

东北大学学报（自然科学版） 2014年第7期35卷 1047-1050,1054页

作者：潘科许开立东北大学资源与土木工程学院辽宁沈阳110819

为合理确定爆炸事故中抛射物初速度,基于碎片穿透实验及理论分析建立了两种碎片初速度的预测方法.在理论估算中,建立了以爆炸总能量乘以能量转化效率因子确定碎片初动能的碎片初速度预测模型.在爆炸总能量的计算方法中,Baum方程可以估... 详细信息

为合理确定爆炸事故中抛射物初速度,基于碎片穿透实验及理论分析建立了两种碎片初速度的预测方法.在理论估算中,建立了以爆炸总能量乘以能量转化效率因子确定碎片初动能的碎片初速度预测模型.在爆炸总能量的计算方法中,Baum方程可以估算压缩气体物理爆炸、化学反应失控爆炸的总能量,而在BLEVE中,用液体过热能来估算爆炸能量更为准确.以Baum,Birk等实验的转化效率为基础,根据最大熵原理得出了碎片能量转化效率因子的概率密度符合伽马分布.由实例分析可知,BLEVE中基于过热能及效率因子的初速度预测方法可以有效地进行爆炸碎片危险的定量化评价.

关键词：爆炸碎片抛射碎片初速度 BLEVE事故最大熵原理概率密度函数伽马分布

Analysis of the causes of primary revision after unicompartmental knee arthroplasty: A case series

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World Journal of Clinical Cases 2024年第9期12卷 1560-1568页

作者： Jin-Long Zhao Xiao Jin He-Tao Huang Wei-Yi Yang Jia-Hui Li Ming-Hui Luo Jun Liu Jian-ke pan The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Chinese Medicine The First Affiliated HospitalJinan UniversityGuangzhou 510630Guangdong ProvinceChina The Second School of Clinical Medical Sciences Guangzhou University of Chinese MedicineGuangdong Academy of Traditional Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The Second Affiliated Hospital Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120Guangdong ProvinceChina The Affiliated TCM Hospital Guangzhou Medical UniversityGuangzhou 510405Guangdong ProvinceChina The Research Team on Bone and Joint Degeneration and Injury Guangdong Provincial Academy of Chinese Medical SciencesGuangzhou 510405Guangdong ProvinceChina

BACKGROUND Unicompartmental knee arthroplasty(UKA)has great advantages in the treatment of unicompartmental knee osteoarthritis,but its revision rate is higher than that of total knee *** To summarize and analyse the causes of revision after *** This is a retrospective case series study in which the reasons for the first revision after UKA are *** analysed the clinical symptoms,medical histories,laboratory test results,imaging examination results and treatment processes of the patients who underwent revision and summarized the reasons for primary revision after *** A total of 13 patients,including 3 males and 10 females,underwent revision surgery after *** average age of the included patients was 67.62 *** prosthesis was used for 3 d to 72 *** main reasons for revision after UKA were improper suturing of the surgical opening(1 patient),osteophytes(2 patients),intra-articular loose bodies(2 patients),tibial prosthesis loosening(2 patients),rheumatoid arthritis(1 patient),gasket dislocation(3 patients),anterior cruciate ligament injury(1 patient),and medial collateral ligament injury with residual bone cement(1 patient).CONCLUSION The causes of primary revision after UKA were gasket dislocation,osteophytes,intra-articular loose bodies and tibial prosthesis *** of these factors may greatly reduce the rate of revision after UKA,improve patient satisfaction and reduce medical burden.

关键词： Unicompartmental knee arthroplasty Total knee arthroplasty Causes Revision Case series

市场化改革对企业创新投入和创新效率的影响研究

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科研管理 2024年第2期45卷 127-136页

作者：潘珂江旭西安交通大学管理学院陕西西安710049 过程管理与效率工程教育部重点实验室陕西西安710049 电工材料电气绝缘全国重点实验室陕西西安710049

市场化改革一直被视为解决我国企业创新问题的一剂“良药”,然而越来越多的证据表明市场化改革对创新的积极效应并非一成不变,既有研究亦对此莫衷一是。基于此,本文从双重竞争逻辑入手,运用制度理论,研究市场化改革如何影响企业创新投... 详细信息

市场化改革一直被视为解决我国企业创新问题的一剂“良药”,然而越来越多的证据表明市场化改革对创新的积极效应并非一成不变,既有研究亦对此莫衷一是。基于此,本文从双重竞争逻辑入手,运用制度理论,研究市场化改革如何影响企业创新投入与创新效率。采用2008—2019年中国省级创新数据的实证结果表明:(1)市场化改革对创新投入产生正向影响,即市场化改革能够借助制度的革新与完善,加速市场竞争与政府竞争,促使企业投入更多的创新资源;(2)市场化改革对创新效率产生倒U型影响,即过度的市场化改革会阻碍企业创新投入转化为创新产出,致使企业创新效率因双重竞争的负面影响而受到抑制;(3)市场化改革对创新投入与创新效率产生差异化效应,其根源在于制度变革对创新与竞争的桥接作用。本文的研究结论有助于进一步理解市场化改革对企业创新的深层次影响机理,为企业合理配置创新投入、有效提升创新效率提供经验证据,也为政府把控市场化改革进程、理顺政企关系提供理论参考。

关键词：市场化改革创新投入创新效率市场竞争政府竞争

Two New r-process-enhanced Stars with [Fe/H] >-0.6 dex from the LAMOST-MRS Survey

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Research in Astronomy and Astrophysics 2022年第7期22卷 109-117页

作者： Xiao-Jin Xie Jian-Rong Shi Tian-Lu Chen Hong-Liang Yan Tian-Yi Chen Kai-ke pan Chun-Qian Li Shuai Liu Qi Gao Tai-Sheng Yan Ming-Yi Ding Department of Physics College of ScienceTibet UniversityLhasa 850000China key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Apache Point Observatory SunspotNew Mexico 88349USA Astronomy Department New Mexico State UniversityLas CrucesNew Mexico 88003USA

We report the discovery of two r-process-enhanced stars with [Fe/H]>-0.6 dex selected from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) *** candidate stars have been selected from the LAMOST medium-resolution(R~ 7500) spectroscopic survey,and the follo wed-up high signal-to-noise ratio and high-resolution(R~31,500) spectra are obtained with the ARC Echelle Spectrograph mounted on the3.5 m telescope at the Apache Point Observatory,which allow us for the determination of stellar atmospheric parameters and abundances of 20 *** these three r-process-enhanced candidate stars,TYC 1710-933-1 and TYC 2858-372-1 have [Eu/Fe] higher than 0.3 dex and [Ba/Eu] lower than 0.0 dex,thus,can be identified as new r-process-enhanced *** 2858-372-1 shows similar r+s-process pattern to the *** 1710-933-1 presents enhancement of the r-process elements of Nd and *** work indicates that the enrichment mechanisms of the heavy neutron-capture elements are complicated for metal-rich stars.

关键词： stars:abundances stars:chemically peculiar stars:fundamental parameters

A hybrid Pareto-based algorithm for multi-objective resource allocation problem

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A hybrid Pareto-based algorithm for multi-objective resource...

第26届中国控制与决策会议

作者： Jun-qing Li Quan-ke pan Kun Mao State key Laboratory of Synthetic Automation for Process Industries Northeastern University College of Computer Science Liaocheng University

This paper introduces a hybrid algorithm combining discrete harmony search（DHS） and iterated local search（ILS） for solving the multi-objective resource allocation problem（RAP）. Two objectives are considered simultaneously, i.e. minimization of the overall cost and overall efficiency. The harmony search algorithm is used to conduct the global exploration task, while the iterated local search performs the exploitation work. In addition, an external Pareto archive set was introduced to memory the non-dominated solutions found so far. Experimental results on the well-known benchmarks verify the efficiency and effectiveness of the propose algorithm.

关键词： Harmony search resource allocation problem Pareto archive set multi-objective optimization

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钙制剂在面粉营养强化中的应用技术

粮油加工 2008年第1期 78-80页

作者：潘珂中国农业大学

本文对面粉营养强化进行了阐述,对在面粉中使用钙制剂进行了技术分析。

关键词：钙面粉营养强化