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High concentrations of human β-defensin 2 in gastric juice of patients with Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第31期11卷 4782-4787页

作者： Hajime Isomoto Hiroshi Mukae Hiroshi Ishimoto Yoshito Nishi Chun-Yang Wen Akihiro Wad Ken Ohnita Toshiya hirayama Masamitsu Nakazato Shigeru Kohno Second Department of Internal Medicine Nagasaki University School of Medicine Sakamoto 1-7-1Nagasaki Japan Department of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School of MedicineSakamoto 12-4 Nagasaki Japan Department of Bacteriology Institute of Tropical Medicine Nagasaki University School of Medicine Sakamoto 12-4 Nagasaki Japan Third Department of Internal Medicine Miyazaki Medical College Kiyotake Miyazaki Japan

AIM: Human β-defensin (HBD)-1 and HBD-2 are endogenous antimicrobial peptides. Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice duringH pylori ***: HBD-1 and HBD-2 concentrations were measured by radioimmunoassay in plasma and gastric juice of 49 H pylori-infected and 33 uninfected subjects and before and after anti-H pyloritreatment in 13 patients with H pylori-associated gastritis. Interleukin (IL)-1β and IL-8 concentrations in gastric juice were measured by enzyme-linked immunosorbent assay (ELISA). Histological grades of gastritis were determined using two biopsy specimens taken from the antrum and corpus. Reverse phase high performance liquid chromatography (RP-HPLC)was used to identify ***: HBD-2 concentrations in gastric juice, but not in plasma, were significantly higher in H pylori-positive than -negative subjects, albeit the post-treatment levels were unchanged. Immunoreactivity for HBD-2 was exclusively identified in H pylori-infected mucosa by RPHPLC. HBD-2 concentrations in gastric juice correlated with histological degree of neutrophil and mononuclear cell infiltration in the corpus. IL-1β levels correlated with those of IL-8, but not HBD-2. Plasma and gastric juice HBD-1concentrations were similar in H pylori-infected and uninfected ***: Our results place the β-defensins, especially HBD-2, in the front line of innate immune ***, HBD-2 may be involved in the pathogenesis of H pylori-associated gastritis, possibly through its function as immune and inflammatory mediator.

关键词： β-防御素2 胃液胃疾病幽门螺杆菌细菌感染

Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis

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World Journal of Gastroenterology 2013年第17期19卷 2718-2722页

作者： Hideo Suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki hirayama Ichinosuke Hyodo Department of Gastroenterology Institute of Clinical Medicine University of Tsukuba Graduate School Center of Integrative Medicine Tsukuba University of Technology

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation.

关键词： Qing Dai Herbal medicine Ulcerative colitis Hydroxyl radical Electron spin resonance

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电阻式核磁共振测量的最新进展

物理学报 2012年第14期61卷 366-378页

作者：刘洪武杨凯锋 T.D.Mishima M.B.Santos K.Nagase Y.hirayama 吉林大学超硬材料国家重点实验室原子与分子物理研究所长春130012 ERATO Nuclear Spin Electronics Project-JST SendaiMiyagi 980-8578Japan Homer L.Dodge Department of Physics and Astronomy University of OklahomaNormanOklahoma 73019-2061USA Department of Physics Tohoku UniversitySendaiMiyagi 980-8578Japan

电阻式核磁共振(RDNMR)测量是1988年由德国马普所的von Klitzing研究小组针对GaAs二维电子气中少量核自旋的探测而提出的一种具有超高灵敏度的实验技术.目前,RDNMR已经成为研究单层或双层GaAs二维电子气核自旋和电子自旋特性的重要手段... 详细信息

电阻式核磁共振(RDNMR)测量是1988年由德国马普所的von Klitzing研究小组针对GaAs二维电子气中少量核自旋的探测而提出的一种具有超高灵敏度的实验技术.目前,RDNMR已经成为研究单层或双层GaAs二维电子气核自旋和电子自旋特性的重要手段.由于为实现电阻式核磁共振测量所建立的动态核极化方法强烈依赖于GaAs特有的材料属性,至今这一技术一直没有扩展应用到其他半导体低维系统中.最近,本研究小组发展了一种动态核极化新方法,成功实现了对典型窄带半导体锑化铟(InSb)二维电子气的电阻式核磁共振测量.本文在介绍电阻式核磁共振测量工作原理及已建立的典型动态核极化方法的基础上,着重讨论所提出的动态核极化新方法的机理、实验结果以及对今后研究的展望.

关键词：半导体二维电子气电阻式核磁共振测量动态核极化窄带半导体

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Histopathological Examination and Literature Review of Orthokeratinized Odontogenic Cyst

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Open Journal of Stomatology 2019年第5期9卷 125-135页

作者： Hirotoshi Iwai Takehiro Suzuki Tomoko Suzuki Juri Muramori Hiroyuki Seto Mitsuko Nakayama Tadahiko Utsunomiya Masaaki Suemitsu Kayo Kuyama Satoshi hirayama Department of Operative Dentistry Nihon University School of Dentistry at Matsudo Chiba Japan Department of Pathology Nihon University School of Dentistry at Matsudo Chiba Japan

Background: With transitions in the disease concept of orthokeratinized odontogenic cyst (OOC), the pathogenesis and etiology have not been sufficiently elucidated. Objectives: OOC cases were reclassified and observed to understand the clinico-histopathological characteristics. In addition, literature review of OOC was performed to better organize the pathology. Materials and methods: Subjects with jawbone cysts lined by keratinized stratified squamous epithelium from 2005 to 2018 were reclassified, and clinico-histopathological findings were analyzed. Previous reports of OOC/orthokeratinized-type odontogenic keratocyst (OKC) from 1980 to 2019 were organized. Results: Five cases of OOC were diagnosed, representing 2.1% of odontogenic developmental cysts (total, 239 cases). Mean age was 37.6 years, with a female predominance. The mandibular molar area was the frequent site, and all cysts were solitary. Sixty percent involved an impacted tooth. Mean maximum diameter of the cyst was 2.2 cm. Histopathologically, 4 cases were unilocular, and partial palisading of the basal layer and scattered epithelial islands were observed in 2 cases each and formation of daughter cysts was noted in 3 cases. Previous papers described that most were unilocular and related to impacted teeth. Mean age ranged between 20 and 40 years, and the mandibular molar region was dominant. Recurrence rates were low. Conclusion: OOC shows a different biological attitude to OKC and is closer to dentigerous cyst. Meanwhile, OOC shows a similar histology of epidermoid cysts accompanying the granular layer. We thus surmised that OCC represents an independent concept as an odontogenic developmental cyst.

关键词： Orthokeratinized Odontogenic Cyst (OOC) Odontogenic Developmental Cyst Literature Review

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“朱鹮再次翱翔在佐渡的天空中! ”

中国报道 2021年第8期 29-31,V0034-V0037页

作者：平山征夫为新潟国际情报大学

我希望东北亚之间的交流不仅限于经济领域,更要深化环保、文化等多领域的交流。因此,我十分期待三国围绕朱鹮开展的交流能够成为良好的示范。值此日中韩合作秘书处成立10周年之际,能为纪念特刊撰稿,介绍三国合作保护朱鹮的历程,我感到... 详细信息

我希望东北亚之间的交流不仅限于经济领域,更要深化环保、文化等多领域的交流。因此,我十分期待三国围绕朱鹮开展的交流能够成为良好的示范。值此日中韩合作秘书处成立10周年之际,能为纪念特刊撰稿,介绍三国合作保护朱鹮的历程,我感到十分荣幸。此外,也要对秘书处就围绕朱鹮开展的的三国合作提供大力支持,特别是举办两届朱鹮国际论坛,表示衷心的感谢。

关键词：中韩合作朱鹮纪念特刊秘书处东北亚三国

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Anaplastic Lymphoma Kinase (ALK) and p53 Are Potentially Useful Markers to Distinguish Inflammatory Myofibroblastic Tumor

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Open Journal of Urology 2013年第2期3卷 71-74页

作者： Shinji Kurosaka Kazumasa Matsumoto Akira Irie Takahiro hirayama Morihiro Nishi Tetsuo Fujita Takefumi Satoh Yuichi Sato Masatsugu Iwamura Kazunari Yoshida Department of Molecular Diagnostics School of Allied Health Sciences Kitasato University Tokyo Japan Department of Urology School of Medicine Kitasato University Tokyo Japan

Aims: Inflammatory myofibroblastic tumor (IMT) of the urinary bladder is a clinically and histologically uncommon benign tumor that can be easily mistaken for a malignant neoplasm. We sought to determine whether immunohistochemical staining would be evaluated IMT of the urinary bladder. We have also shown the literatures that imminohistochemical staining of IMT was investigated to distinguish malignant lesions using PubMed data base. Methods: Immunohistochemical staining, including anaplastic lymphoma kinase (ALK), p53, cytokeratin, vimentin, desmin, alpha-smooth muscle actin, myoglobin, smooth muscle myosin and S100, was carried out on serial sections from archival specimens of three patients who underwent transurethral resection and partial cystectomy. Results: Immunohistchemical staining in all patients was positive for ALK and weak positive for p53 protein. In the literatures, positive rates of ALK and p53 inthe IMT of the urinary bladder were 60.9% and 53.1%, respectively. Sarcoma and carcinosarcoma were shown in the pathological specimens with negative ALK and strongly positive p53 inthe same data base. Conclusions: Both ALK and p53 were potentially useful protein markers to distinguish between IMT and sarcoma. However, this study was small sample size. Further study was warranted an investigation of the availability of these proteins in IMT.

关键词： Inflammatory Myofibroblastic Tumor Immunohistochemistry Bladder Cancer Anaplastic Lymphoma Kinase p53

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氧传输模式的研究

环境科学丛刊 1985年第8期 54-59页

作者： T.Matsuo K.hirayama 许廷玉

气—水界面氧传输速率对河流的自然净化过程是很重要的.Streeter和Phelps（1925）提出的河流氧平衡的表达方法中,他们用复氧系数K2来评价这个速率,然而,Dobbins（1964）提出用液膜系数KL评价氧传输速率比用复氧系数更合适.

关键词：紊流流体流动均方根速度粘滞性液膜方程

Bond Strength and Water Resistance of a Resin Composite Bonded to Glass Plates Treated with Commercial Ceramic Primers

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材料科学与工程（中英文B版） 2017年第3期7卷 99-106页

作者： Katsura OHASHI Kaori MIYAKE Tota SHIMIZU Akinori OHNO Tom SHIIYA Yoshiharu MUKAI Toshiyuki SUZUKI Ayako TERANAKA Hirotoshi IWAI Satoshi hirayama Katsuhiko KIMOTO Tomotaro NIHEI Division of Clinical Biomaterials Department of Oral Science Graduate School of Dentistry Kanagawa Dental University Yokosuka Kanagawa 238-8580 Japan Institute of Oral Regenerative Medicine Kanagawa Dental University 82 Inaoka-cho Yokosuka Kanagawa 238-8580 Japan Division of Prosthodontics and Oral Implantology Dentistry for Oral Interdisciplinary Medicine Graduate School of Dentistry Kanagawa Dental University Yokosuka Kanagawa 238-8580 Japan Division of Cariology and Restorative Dentistry Department of Oral Interdisciplinary Medicine Graduate School of Dentistry Kanagawa Dental University Yokosuka Kanagawa 238-8580 Japan Department of Operative Dentistry School of Dentistry at Matsudo Nihon University Matsudo Chiba 271-8587 Japan

THREE-DIMENSIONAL NUMERICAL ANALYSIS OF ROTARY ARC PLASMA DURING CURRENT INTERRUPTION PROCESS

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THREE-DIMENSIONAL NUMERICAL ANALYSIS OF ROTARY ARC PLASMA DU...