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检索条件"作者=kazuyuki Aihara"
47 条 记 录,以下是1-10 订阅
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Energy landscape decomposition for cell differentiation with proliferation effect
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National Science Review 2022年 第8期9卷 144-152页
作者: Jifan Shi kazuyuki aihara Tiejun Li Luonan Chen Research Institute of Intelligent Complex Systems Fudan University International Research Center for Neurointelligence The University of Tokyo Institutes for Advanced Study The University of Tokyo Key Laboratory of Mathematics and Its Applications (LMAM) and School of Mathematical Sciences Peking University Key Laboratory of Systems Biology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University Guangdong Institute of Intelligence Science and Technology
Complex interactions between genes determine the development and differentiation of cells. We establish a landscape theory for cell differentiation with proliferation effect, in which the developmental process is mode... 详细信息
来源: 同方期刊数据库 同方期刊数据库 评论
Dynamics-based data science in biology
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National Science Review 2021年 第5期8卷 16-18页
作者: Jifan Shi kazuyuki aihara Luonan Chen International Research Center for Neurointelligence The University of Tokyo Institutes for Advanced StudyThe University of Tokyo Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University Key Laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of Sciences
Life science has long been a rich subject for research, and continues to develop at high speed. One of the major aims of life science is to study the mechanisms of various biological processes on the basis of biologic...
来源: 同方期刊数据库 同方期刊数据库 评论
Mathematically modelling and controlling prostate cancer under intermittent hormone therapy
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Asian Journal of Andrology 2012年 第2期14卷 270-277页
作者: Yoshito Hirata Gouhei Tanaka Nicholas Bruchovsky kazuyuki aihara Institute of Industrial Science University of Tokyo Tokyo 153-8505 Japan Vancouver Prostate Centre Vancouver General Hospital Vancouver BC V6H 3Z6 Canada
In this review, we summarize our recently developed mathematical models that predict the effects of intermittent androgen suppression therapy on prostate cancer (PCa). Although hormone therapy for PCa shows remarkab... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
Detection for disease tipping points by landscape dynamic network biomarkers
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National Science Review 2019年 第4期6卷 775-785页
作者: Xiaoping Liu Xiao Chang Siyang Leng Hui Tang kazuyuki aihara Luonan Chen Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences School of Mathematics and Statistics Shandong University at Weihai Institute of Industrial Science the University of Tokyo Institute of Statistics and Applied Mathematics Anhui University of Finance & Economics School of Life Science and Technology Shanghai Tech University Center for Excellence in Animal Evolution and Genetics Research Center for Brain Science and Brain-Inspired Intelligence
A new model-free method has been developed and termed the landscape dynamic network biomarker(l-DNB) methodology. The method is based on bifurcation theory, which can identify tipping points prior to serious disease d... 详细信息
来源: 同方期刊数据库 同方期刊数据库 评论
Dynamical network biomarkers for identifying critical transitions and their driving networks of biologic processes
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Frontiers of Electrical and Electronic Engineering in China 2013年 第2期8卷 105-114页
作者: Rui Liu kazuyuki aihara Luonan Chen Department of Mathematics South China University of Technology Guangzhou 510640 China Collaborative Research Center for Innovative Mathematical Modeling Institute of Industrial Science University of Tokyo Tokyo 153-8505 Japan Key Laboratory of Systems Biology SIBS-Novo Nordisk Translational Research Centre for PreDiabetes Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China
Non-smooth or even abrupt state changes exist during many biological processes, e.g., cell differentiation processes, proliferation processes, or even disease deterioration processes. Such dynamics generally signals t... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Predicting future dynamics from short-term time series using an Anticipated Learning Machine
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National Science Review 2020年 第6期7卷 1079-1091页
作者: Chuan Chen Rui Li Lin Shu Zhiyu He Jining Wang Chengming Zhang Huanfei Ma kazuyuki aihara Luonan Chen School of Data and Computer Science Sun Yat-sen University Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences School of Mathematical Sciences Soochow University Institute of Industrial Science The University of Tokyo International Research Center for Neurointelligence The University of Tokyo Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Key Laboratory of Systems Biology Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences
Predicting time series has significant practical applications over different disciplines. Here, we propose an Anticipated Learning Machine(ALM) to achieve precise future-state predictions based on short-term but high-... 详细信息
来源: 同方期刊数据库 同方期刊数据库 评论
System identification and parameter estimation in mathematical medicine: examples demonstrated for prostate cancer
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Frontiers of Electrical and Electronic Engineering in China 2016年 第1期4卷 13-19页
作者: Yoshito Hirata Kai Morino Taiji Suzuki Qian Guo Hiroshi Fukuhara kazuyuki aihara Institute of Industrial Science The University of Tokyo Tokyo 153-8505 Japan Graduate School of Information Science and Technology The University of Tokyo Tokyo 113-8656 Japan Department of Mathematical and Computing Sciences Graduate School of Information Science and Engineering Tokyo Institute of Technology Tokyo 152-8552 Japan Department of Mathematics Shanghai Normal University Shanghai 200234 China Department of Urology Graduate School of Medicine The University of Tokyo Tokyo 113-8655 Japan
We review our studies on how to identify the most appropriate models of diseases, and how to determine their parameters in a quantitative manner given a short time series of biomarkers, using intermittent androgen dep... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Hunt for the tipping point during endocrine resistance process in breast cancer by dynamic network biomarkers
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Journal of Molecular Cell Biology 2019年 第8期11卷 649-664页
作者: Rui Liu Jinzeng Wang Masao Ukai Ki Sewon Pei Chen Yutaka Suzuki Haiyun Wang kazuyuki aihara Mariko Okada-Hatakeyama Luonan Chen School of Mathematics South China University of Science and Technology Guangzhou 510640 China Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming 650223 China School of Life Science and Technology ShanghaiTech University Shanghai 200031 China Shanghai Research Center for Brain Science and Brain-Inspired Intelligence Shanghai 201210 China School of Life Sciences and Technology Tongji University Shanghai 200092 China National Research Center for Translational Medicine (Shanghai) Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Graduate School of Medical Life Science Yokohama City University Yokohama 230-0045 Japan Laboratory for Integrated Cellular Systems RIKEN Center for Integrative Medical Sciences (IMS) Yokohama 230-0045 Japan Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai 200031 China Department of Medical Genome Sciences Graduate School of Frontier Sciences The University of Tokyo Chiba 277-8562 Japan Institute of Industrial Science The University of Tokyo Tokyo 153-8505 Japan Laboratory of Cell Systems Osaka University Osaka 565-0871 Japan
Acquired drug resistance is the major reason why patients fail to respond to cancer *** is a challenging task to *** the tipping point of endocrine resistance and detect the associated *** from new systems biology the... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
Predicting local COVID-19 outbreaks and infectious disease epidemics based on landscape network entropy
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Science Bulletin 2021年 第22期66卷 2265-2270,M0003页
作者: Rui Liu Jiayuan Zhong Renhao Hong Ely Chen kazuyuki aihara Pei Chen Luonan Chen School of Mathematics South China University of TechnologyGuangzhou 510640China Pazhou Lab Guangzhou 510330China Stanford University Stanford 94305USA International Research Center for Neurointelligence The University of TokyoTokyo 113-8654Japan State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Key Laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China
新型冠状病毒肺炎(COVID-19)的迅速传播对全人类构成了巨大的威胁.为了及时采取相应的控制措施,制定有效的策略来检测COVID-19疫情的预警信号是非常必要的.然而,与时间序列预测不同,流行病的暴发事件通常是高度非线性的,具有从缓慢变化... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
A MIXED ANALOG/DIGITAL CHAOTIC NEURO-COMPUTER HARDWARE SYSTEM AND ITS APPLICATIONS
A MIXED ANALOG/DIGITAL CHAOTIC NEURO-COMPUTER HARDWARE SYSTE...
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The Second International Conference on Dynamics Vibration and Control
作者: Yoshihiko Horio kazuyuki aihara Department of Electronic Engineering Tokyo Denki University Chiyoda-kuTokyo101-8457Japan aihara Complexity Modeling Project ERATO JSTShibuya-ku151-0064.Japan and Institute of Industrial ScienceUniversity of TokyoMeguro-kuTokyo153-8505Japan
<正>We construct a 400-neuron chaotic neuro-computer hardware system with analog integrated circuits. The analog circuitry can handle real numbers, so that our system physically implements the real number processing...
来源: cnki会议 评论