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Open Journal of Fluid Dynamics 2014年第3期4卷 288-297页

作者： kazuya tsuboi Eiji Tomita Graduate School of Natural Science and Technology Okayama University Okayama Japan

The local burning velocity and the flame displacement speed are the dominant properties in the mechanism of turbulent premixed combustion. The flame displacement speed and the local burning velocity have been investigated separately, because the flame displacement speed can be used for the discussion of flame-turbulence interactions and the local burning velocity can be used for the discussion of the inner structure of turbulent premixed flames. In this study, to establish the basis for the discussion on the effects of turbulence on the inner structure of turbulent premixed flames, the indirect relationship between the flame displacement speed and the local burning velocity was investigated by the flame stretch, the flame curvature, and the tangential strain rate using DNS database with different density ratios. It was found that for the local tangential strain rate and the local flame curvature, the local burning velocity and the flame displacement speed had the opposite correlations in each density ratio case. Therefore, it is considered that the local burning velocity and the flame displacement speed have a negative correlation.

关键词： Local Burning Velocity Flame Displacement Speed Flame Stretch Rate Tangential Strain Rate Flame Curvature Turbulent Premixed Flame Direct Numerical Simulation

Evaluation of the Local Burning Velocity Using DNS Data of Turbulent Premixed Flames

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Natural Science 2014年第12期6卷 1030-1036页

作者： kazuya tsuboi Ryoji Matsugi Eiji Tomita Graduate School of Natural Science and Technology Okayama University Okayama Japan

The local burning velocity, which is based on the consumption rate of the unburned mixture, is one of the dominant parameters in turbulent premixed flames. In this study, the evaluating method of the local burning velocity was investigated using DNS data of turbulent premixed flames with different Lewis numbers. The local burning velocity was evaluated by integrating the chemical reaction rates along normal to the flame surface within three kinds of integration ranges that were defined as follows: the range which is defined by the half length of normal to the flame surface between its certain point and the other point crossing the flame surface (Range 1);the range which is defined by the reaction progress variable that the chemical reaction rate along normal to a planer flame surface takes a half of the maximum value (Range 2);the range which is defined by the length of normal to the flame surface between its certain point and the point which has the extreme value of the reaction progress variable (Range 3). As a result, Range 1 and Range 2 were affected by the flame shapes greatly, since the quantities of the integration ranges fluctuated widely dependent on the variations of turbulent premixed flames. Under the conditions of the turbulent combustion in this study, Range 3, which is hardly affected by a flame shape, is considered to be appropriate to the evaluation of the local burning velocity.

关键词： Local Burning Velocity Integration Range Reaction Progress Variable Turbulent Premixed Flame Direct Numerical Simulation

Consideration on the Flow Velocity in the Experimental Analysis of the Flame Displacement Speed Using DNS Data of Turbulent Premixed Flames with Different Lewis Numbers

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Open Journal of Fluid Dynamics 2014年第3期4卷 278-287页

作者： kazuya tsuboi Shingo Morishita Eiji Tomita Graduate School of Natural Science and Technology Okayama University Okayama Japan

The flame displacement speed is one of the major characteristics in turbulent premixed flames. The flame displacement speed is experimentally obtained from the displacement normal to the flame surface, while it is numerically evaluated by the transport equation of the flame surface. The flame displacement speeds obtained both experimentally and numerically cannot be compared directly because their definitions are different. In this study, two kinds of experimental flame displacement speeds—involving the mean inflow velocity and the local flow velocity—were simulated using the DNS data with the different Lewis numbers, and were compared with the numerical flame displacement speed. The simulated experimental flame displacement speed involving the mean inflow velocity had no correlation with the numerical flame displacement speed, while the simulated displacement speed involving the local flow velocity had a clear correlation with the numerical displacement speed in the cases of higher Lewis number than unity. The correlation coefficient of the simulated displacement speed involving the local flow velocity with the numerical displacement speed had a maximum value on the isosurface of the reaction progress variable with the maximum temperature gradient where the dilation effect of the flame is strongest.

关键词： Flame Displacement Speed Simulating Experimental Measurement and Analysis Lewis Number Dilation Effect Turbulent Premixed Flame Direct Numerical Simulation

EPH-EPHRIN in human gastrointestinal cancers

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World Journal of Gastrointestinal Oncology 2010年第12期2卷 421-428页

作者： Haruhiko Sugimura Hiroki Mori Masaru tsuboi Kiyoko Nagura Hisaki Igarashi Ritsuko Nakamura Hiroko Natsume Tomoaki Kahyo kazuya Shinmura Hiroyuki Konno Yasushi Hamaya Shigeru Kanaoka Hideki Kataoka Department of Pathology I Hamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Surgery II Hamamatsu Uni- versity School of MedicineHamamatsu431-3192Japan Department of Molecular Diagnostics Hamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Medicine I Hamamatsu University School of MedicineHamamatsu431-3192Japan

Ever since its discovery two decades ago,the erythro- poietin-producing hepatoma (EPH)-EPHRIN system has been shown to play multifaceted roles in human gastroenterological cancer as well as ***,amplif ication and point mutations have been found in many human cancers and many investigators have shown correlations between these up-regulationsand tumor ***,the genes in this family are considered to be potential targets of cancer *** the other hand,the down-regulation of some members as a result of epigenetic changes has also been reported in some ***,the correlation between altered expressions and clinical prognosis seems to be inconclusive.A huge amount of protein-protein interaction studies on the EPH-EPHRIN system have provided a basic scheme for signal transductions,especially bi-directional signaling involving EPH-ERPHRIN molecules at the cell *** information also provides a manipulative strategy for harnessing the actions of these *** this review,we summarize the known alterations of EPH-EPHRIN genes in human tumors of the esophagus,stomach,colorectum,liver and pancreas and present the perspective that the EPH-EPHRIN system could be a potential target of cancer therapy.

关键词： Erythropoietin-producing hepatoma EPH-EPHRIN Gastric cancer Colorectal cancer Methylation Secreted form