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Wave Propagation Simulation Using the CIP Method of Characteristic Equations

Communications in Computational Physics 2008年第1期3卷 121-135页

作者： kazuya shiraishi Toshifumi Matsuoka Department of Civil&Earth Resources Engineering Kyoto University Kyotodaigaku-Katsura Nishikyo-kuKyoto 615-8540Japan

We apply the CIP(Cubic Interpolated Profile)scheme to the numerical sim-ulation of the acoustic wave propagation based on characteristic *** CIP scheme is based on a concept that both the wavefield and its spatial deriv ative propa-gate along the same characteristic curves derived from a hyperbolic differential *** describe the derivation of the characteristic equations for the acoustic waves from the basic equations by means of the directional splitting and the diagonaliza-tion of the coffcient matrix,and establish geophysical boundary *** the CIP scheme calculates both the wavefield and its spatial derivatives,it is easy to realize the boundary conditions *** also show some numerical simula-tion examples and the CIP can simulate acoustic w ave propagation with high stability and less numerical *** method of characteristics with the CIP scheme is a very powerful technique to deal w ith the wave propagation in complex geophysical problems.

关键词： Acoustic wave characteristi cequa tion CIP

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Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C

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World Journal of Gastroenterology 2004年第5期10卷 733-736页

作者： Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki Department of Internal Medicine Division of GastroenterologyTokai University School of MedicineBohseidaiIsehara 259-1193Japan

AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to ***:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively ***: Twenty-five patients completed IFN *** patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy *** vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C.

关键词： Adult Antiviral Agents dosage Drug Resistance, Viral Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interferon-beta Leukocytes, Mononuclear Male Middle Aged Predictive Value of Tests RNA, Viral

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