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A new diagnostic feasibility for cardiomyopathy utilizing acoustic microscopy

World Journal of Cardiovascular Diseases 2013年第1期3卷 22-30页

作者： Yoichi Nakamura Kengo Fukushima Kusano Kazufumi Nakamura kazuto kobayashi Naohiro Hozumi Yoshifumi Saijo Tohru Ohe Biomedical Imaging Laboratory Graduate School of Biomedical Engineering Tohoku University Sendai Japan Department of Cardiology Sakakibara Heart Institute of Okayama Okayama Japan Department of Cardiovascular Medicine Matsuyama Shimin Hospital Matsuyama Japan Department of Research and Development Honda Electronics Co. Ltd. Toyohashi Japan epartment of Cardiovascular Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan Toyohashi University of Technology International Cooperation Center for Engineering Education Development Toyohashi Japan

Aims: Dilated cardiomyopathy often shows left ventricular systolic dysfunction, although histologically it always exhibits non-specific abnormality. We hypothesized that myocyte sound speed might be altered due to incomplete protein accumulation in cells. Methods and Results: Ninety eight biopsied samples were obtained from 49 patients comprising 43 with clinical dilated cardiomyopathy and 6 with hypertrophic cardiomyopathy. Sound speed was evaluated in deparaffinized 10 μm thick sections using an acoustic microscope (frequency range: 50 - 105 MHz). Conventional histology revealed 7 cases of persistent myocarditis derived from clinical dilated cardio- myopathy samples. Histology of the remaining dilated cardiomyopathy patients indicated non-specific abnormality. All hypertrophic cardiomyopathy cases exhibited myocardial disarray. Ten normal autopsied hearts were compared as controls. The sound speed of controls was 1627 ± 30m/sec. The sound speed in dilated cardiomyopathy samples (1700 ±51m/sec) was 1.045-fold faster compared to controls. The sound speed in hypertrophic cardiomyopathy samples (1734 ±51m/sec, 1.066-fold compared to controls) was faster than that of the myocarditis group (1672 ±30m/sec, 1.028-fold) (P = 0.0218). Furtheremore, desmin expression was evaluated as extent of emergence (grading 0 - 4). The desmin expression score in hypertrophic cardiomyopathy samples (2.7 ± 0.8) was significantly higher than in other groups (dilated 2.0 ± 1.4, myocarditis 1.6 ± 1.5 vs., controls 0, P ≤ 0.0001, 0.0001, 0.0129, respectively). Conclusion: Cardio-myopathy enhanced the sound speed, which correlated with the elasticity of myocytes, following the impaired compliance of left ventricle, despite the absence of histological changes. The elevation of sound speed of myocytes may be linked to cytoskeletal changes. Myocyte sound speed may be a new diagnostic tool for diagnosis of idiopathic cardiomyopathy independently of conventional histological diagnosis.

关键词： Cardiomyopathy Acoustic Microscopy Heart Failure Myocytes Sound Speed Diagnosis

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Application of Scanning Acoustic Microscopy for Detection of Dental Caries Lesion

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Open Journal of Stomatology 2023年第1期13卷 12-24页

作者： Yukihiro Naganuma Kouki Hatori Masahiro Iikubo Masatoshi Takahashi Yoshihiro Hagiwara kazuto kobayashi Atsushi Takahashi Kumi Hoshi Yoshifumi Saijo Keiichi Sasaki Clinics of Dentistry for Disabled Tohoku University Hospital Sendai Japan Department of Prosthetic Dentistry Ohu University School of Dentistry Koriyama Japan Division of Dental Informatics and Radiology Tohoku University Graduate School of Dentistry Sendai Japan Division of Dental Biomaterials Tohoku University Graduate School of Dentistry Sendai Japan Department of Orthopaedic Surgery Tohoku University School of Medicine Sendai Japan Honda Electronics Co. Ltd. Toyohashi Japan Biomedical Imaging Laboratory Graduate School of Biomedical Engineering Tohoku University Sendai Japan Division of Advanced Prosthetic Dentistry Tohoku University Graduate School of Dentistry Sendai Japan

Introduction: A scanning acoustic microscope (SAM) is an apparatus for imaging acoustic properties. This apparatus can non-invasively and rapidly evaluate the hardness of materials in the elastic region. This device shows great potential for the diagnosis of dental caries in the clinical setting. However, since the tissue elastic modulus measured using a SAM is a property of the elastic region and the Knoop hardness is a property of the plastic region, the hardness properties differ completely. Therefore, we investigated whether the acoustic impedance measured using a SAM is related to the Knoop hardness, which is used as the standard for removal of carious dentin. Method: Polished sections were prepared from 20 extracted carious wisdom teeth. The acoustic impedance and Knoop hardness were measured for each section. In addition to comparing carious and healthy dentin in SAM images, we evaluated the difference between the carious and healthy dentin in terms of the acoustic impedance and Knoop hardness. We also evaluated the correlation between the Knoop hardness and acoustic impedance. Results: The SAM images were visualized as two-dimensional color images based on the acoustic impedance values. The mean acoustic impedance of carious dentin was significantly lower than that of healthy dentin, showing a similar trend as Knoop hardness. A strong correlation was observed between the two. Discussion: The acoustic impedance values obtained through acoustic microscopy differed significantly between carious and sound dentin. Both types of dentins were visualized using two-dimensional color images. A strong correlation was observed between the acoustic impedance value, which indicates the hardness of the elastic region, and the Knoop hardness, which indicates the hardness of the plastic region. The results of the present study indicate that acoustic impedance accurately reflects the hardness of dentin.

关键词： Scanning Acoustic Microscope Acoustic Impedance Caries Knoop Hardness

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Fabrication of MEMS Diaphragm Transducer Array Based on Epitaxial PZT Thin Film for 2-D Hydrophone Application

Fabrication of MEMS Diaphragm Transducer Array Based on Epit...

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2008 IEEE International Ultrasonics Symposium

作者： Nagaya Okada Kazuki Higuchi Yoshiyuki Asakura kazuto kobayashi Mikinori Ito Masashi Takabe Mikito Otonari Ikuo Kanja Daisukc Akai Kazuaki Sawada Makoto Ishida HONDA ELECTRONICS CO. LID. Toyohashi University of Technology

＜正＞Background,Motivation and Objective The increasing interest in 3-D imaging and high frequency applications leads to investigate new solutions for transducer *** an adequate signal-to-noise ratio with piezoelectr...

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Comparison of incidence of acute kidney injury after robot-assisted radical prostatectomy with that after open retropubic and extraperitoneal laparoscopic radical prostatectomies in patients with prostate cancer

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Current Urology 2024年第2期18卷 139-143页

作者： Shunsuke Sato Toshiaki Tanaka Takeshi Maehana Kohei Hashimoto Ko kobayashi Naoya Masumori Department of Urology Sapporo Medical UniversitySapporoJapan

Background:We retrospectively evaluated the postoperative renal function in patients who had undergone radical prostatectomy to compare the incidences of postoperative acute kidney injury(AKI)among the patients who had undergone robot-assisted radical prostatectomy(RARP),retropubic radical prostatectomy(RRP),and extraperitoneal laparoscopic radical prostatectomy(exLRP).Materials and methods:Patients with prostate cancer who had undergone radical prostatectomy at our institution between 2008 and 2014 were ***-assisted radical prostatectomy was performed using an intraperitoneal approach in a 25-degree Trendelenburg position,whereas other procedures were performed with the patient in the supine *** evaluated the serum creatinine levels and estimated glomerular filtration rates immediately after surgery and on postoperative day *** evaluated the incidence of AKI after prostatectomy using the Acute Kidney Injury Network criteria of the Kidney Disease:Improving Global Outcomes ***:A total of 150 consecutive patients were included,with each of the 3 groups(RARP,RRP,and exLRP)comprising 50 *** AKI was observed in 15(30.0%),1(2.0%),and 3(6.0%)patients in the RARP,RRP,and exLRP groups,*** 1 AKI was observed in all the patients except *** incidence of AKI in RARP group was significantly higher than that in the other groups(p<0.001).In the RARP group,the serum creatinine level was significantly elevated immediately after the surgery;however,it returned to baseline on postoperative day *** procedures were the only independent factor associated with AKI ***:This study suggest that compared with RRP and exLRP,RARP is associated with a higher incidence of postoperative AKI,although most patients recover ***-abdominal pneumoperitoneum may contribute to AKI onset.

关键词： Acute kidney injury Renal function Prostatectomy

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Fundamental Study on Response Properties of Structures Constructed on Lunar Regolith

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Open Journal of Earthquake Research 2024年第1期13卷 27-40页

作者： Yuji Miyamoto Takaharu Nakano Toshio kobayashi Department of Architecture and Civil Engineering Fukui University of Technology Fukui Japan Graduate School of Engineering Osaka University Osaka Japan SANSEI Inc. Tokyo Japan

The Artemis Program, for constructing the lunar base, is in progress. How to design and construct architectural and civil engineering structures in the lunar environment has become an important issue. The lunar surface is covered with soft sand, called regolith, and it is required to protect lunar bases and structures, as well as internal precision equipment, against vibrational disturbances such as moonquakes and meteorite collisions. Therefore, in this study, the static and cyclic triaxial compression tests of the regolith simulant were conducted. The reference strain and equivalent damping factor of the regolith simulant were smaller compared to sandy soil on Earth. In addition, a shaking table test using model specimens was conducted on the response properties of regolith ground alone and structures set on regolith ground. The buried foundation and pile foundation notably suppressed the horizontal response attributed to the rocking component compared to a direct foundation.

关键词： Lunar Development Regolith Soil-Structure Interaction Triaxial Compression Test Shaking Table Test

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Application of Scanning Acoustic Microscopy for Detection of Dental Caries Lesion

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Open Journal of Stomatology（口腔学期刊） 2023年第1期

作者： Yukihiro Naganuma Kouki Hatori Masahiro Iikubo Masatoshi Takahashi Yoshihiro Hagiwara kazuto kobayashi Atsushi Takahashi Kumi Hoshi Yoshifumi Saijo Keiichi Sasaki

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TiO₂-PES Fibrous Composite Material for Ammonia Removal Using UV-A Photocatalyst

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Journal of Materials Science and Chemical Engineering 2024年第1期12卷 1-19页

作者： Anh Phuong Le Thi Masaru Ohshiro Takaomi kobayashi Department of Science and Technology Innovation Nagaoka University of Technology Nagaoka Japan Kasai Corporation Niigata Japan

This study focused on the development and characterization of TiO2-PES composite fibers with varying TiO2 loading amounts using a phase inversion process. The resulting composite fibers exhibited a sponge-like structure with embedded TiO2 nanoparticles within a polymer matrix. Their photocatalytic performance for ammonia removal from aqueous solutions under UV-A light exposure was thoroughly investigated. The findings revealed that PeTi8 composite fibers displayed superior adsorption capacity compared to other samples. Moreover, the study explored the impact of pH, light intensity, and catalyst dosage on the photocatalytic degradation of ammonia. Adsorption equilibrium isotherms closely followed the Langmuir model, with the results indicating a correlation between qm values of 2.49 mg/g and the porous structure of the adsorbents. The research underscored the efficacy of TiO2 composite fibers in the photocatalytic removal of aqueous under UV-A light. Notably, increasing the distance between the photocatalyst and the light source resulted in de-creased hydroxyl radical concentration, influencing photocatalytic efficiency. These findings contribute to our understanding of TiO2 composite fibers as promising photocatalysts for ammonia removal in water treatment applications.

关键词： Ammonia Removal Photocatalyst TiO2-PES Composite Fiber Fibrous Material

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Unroofing Technique for Anomalous Origin of the Left Coronary Artery from the Right Sinus of Valsalva: Report of a Case

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World Journal of Cardiovascular Surgery 2024年第6期14卷 69-77页

作者： Keisuke Morimoto Futoshi kobayashi Hiromu Horie Yuki Sakaguchi Einosuke Mizuta Department of Cardiovascular Surgery Sanin Rosai Hospital Yonago Japan Department ofCardiology Sanin Rosai Hospital Yonago Japan

Anomalous origin of the left coronary artery (AOLCA) from the right sinus of Valsalva constitutes a rare congenital coronary artery anomaly. Patients with an anomalous left main coronary artery face a significantly higher risk of sudden cardiac death compared to those with an anomalous right coronary artery. The anomalous coronary artery traversing between the ascending aorta and the pulmonary artery markedly heightens the risk of myocardial ischemia, arrhythmia, and sudden death. Symptomatic patients often exhibit a longer intramural course of the coronary artery, which may necessitate earlier intervention or influence the choice of surgical repair method. Surgical intervention is advocated for patients with this anomaly, even in the absence of symptoms. For anomalous aortic origin of a coronary artery from the opposite sinus of Valsalva with an intramural course, coronary unroofing is the preferred revascularization procedure. This report presents a case of AOLCA originating from the right sinus of Valsalva, treated surgically using the unroofing technique for the aortic intramural segment of the anomalous coronary artery traversing between the great vessels. The unroofing technique is recommended for treating AOLCA with an extensive intramural course that does not involve the commissure.

关键词： Unroofing Technique Anomaly of Coronary Artery Anomalous Origin of Left Coronary Artery

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Conversion surgery after gemcitabine and cisplatin plus durvalumab for advanced intrahepatic cholangiocarcinoma:A case report

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World Journal of Clinical Cases 2024年第34期12卷 6721-6727页

作者： Yu Igata Masashi Kudo Motohiro Kojima Shota Kami Keishiro Aoki Tomoyuki Satake Tatsushi kobayashi Motokazu Sugimoto Shin kobayashi Masaru Konishi Naoto Gotohda Department of Hepatobiliary and Pancreatic Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research and Clinical Trial Center National Cancer CenterKashiwa 277-8577Japan Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Diagnostic Radiology National Cancer Center Hospital EastChiba 277-8577Japan

BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine and cisplatin plus durvalumab(GCD)regimen was recently approved as first-line therapy for patients with advanced ***,post-GCD conversion surgery has not been previously ***,we describe a case of advanced intrahepatic cholangiocarcinoma(ICC)successfully treated with radical surgery after *** SUMMARY A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD,followed by durvalumab maintenance treatment,with mild adverse *** response was ***,a conversion surgery with extended left hepatectomy and bile duct resection was *** resection margins were negative,and the pathological diagnosis was compatible with small duct type *** patient remained disease-free for 8 months without adjuvant *** We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.

关键词： Conversion surgery Intrahepatic cholangiocarcinoma Small duct type Immunotherapy Case report

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Static Stretching Combined with Conscious Slower Breathing May Increase Parasympathetic Activity and Reduce Stress in Adult Women

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Health 2024年第3期16卷 242-256页

作者： Mami Sakurai Yasushi Ikarashi Masahiro Tabuchi Ailing Hu Takuji Yamaguchi Hiroyuki kobayashi Department of Hospital Administration Juntendo University Graduate School of Medicine Tokyo Japan Department of Beauty & Wellness Professional University of Beauty & Wellness Yokohama Japan Department of Personalized Kampo Medicine Juntendo University Graduate School of Medicine Tokyo Japan

Background: Women are thought to be more susceptible to stress than men in a stressful society, and reducing stress is crucial for women to maintain their health. Static stretching (SST) is applied in various fields to not only increase muscle flexibility but also reduce stress. Additionally, conscious slower breathing (CSB) predominates parasympathetic activity, causing a relaxing effect. These results indicate that combining SST and CSB may be more useful in reducing stress. However, to the best of our knowledge, the effect of this combination remains unclear. Objective: This study aimed to elucidate the effects of the combination of SST and CSB on autonomic activity and stress in adult women. Methods: Eleven healthy Japanese adult female participants performed SST with nonconscious natural breathing for 20 min. The same participants performed SST in combination with CSB (2 s inspiratory and 4 s expiratory) for 20 min on another day. Salivary cortisol and chromogranin A levels were measured before and after stretching as stress markers of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system. The coefficient of variation of the R-R interval (CVR-R) and high-frequency component (HF), which reflect parasympathetic nerve activity, and heart rate and low-frequency component (LF)/HF ratio, which reflect sympathetic nerve activity, were measured before, during, and after stretching. Results: SST decreased cortisol levels but with no significant changes in chromogranin A, heart rate, CVR-R, HF, or LF/HF ratio. The combination of SST and CSB increased CVR-R and HF levels in addition to decreasing cortisol levels but with no significant changes in chromogranin A, heart rate, or LF/HF levels. Conclusion: These results indicate that the combination of SST and CSB may increase parasympathetic activity and reduce stress. However, future randomized controlled trials with larger sample sizes should support this conclusion.

关键词： Static Stretching Conscious Slower Breathing Autonomic Activity Heart Rate Variability Stress

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