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Stick–slip behavior of Indian gabbro as studied using a NIED large-scale biaxial friction apparatus

Earthquake Science 2015年第2期28卷 97-118页

作者： Tetsuhiro Togo Toshihiko Shimamoto Futoshi Yamashita Eiichi Fukuyama kazuo Mizoguchi Yumi Urata State Key Laboratory of Earthquake Dynamics Institute of Geology China Earthquake Administration Geological Survey of Japan AIST Tsukuba Central 7 National Research Institute for Earth Science and Disaster Prevention (NIED) Central Research Institute of Electric Power Industry

This paper reports stick-slip behaviors of Indian gabbro as studied using a new large-scale biaxial friction apparatus, built in the National Research Institute for Earth Science and Disaster Prevention （NIED）, Tsukuba, Japan. The apparatus consists of the existing shaking table as the shear-loading device up to 3,600 kN, the main frame for holding two large rectangular prismatic specimens with a sliding area of 0.75 m^2 and for applying normal stresses an up to 1.33 MPa, and a reaction force unit holding the stationary specimen to the ground. The shaking table can produce loading rates v up to 1.0 m/s, accelerations up to 9.4 m/s^2, and displacements d up to 0.44 m, using four servocontrolled actuators. We report results from eight preliminary experiments conducted with room humidity on the same gabbro specimens at v = 0.1-100 mm/s and an = 0.66-1.33 MPa, and with d of about 0.39 m. The peak and steady-state friction coefficients were about 0.8 and 0.6, respectively, consistent with the Byerlee friction. The axial force drop or shear stress drop during an abrupt slip is linearly proportional to the amount of displacement, and the slope of this rela- tionship determines the stiffness of the apparatus as 1.15 × 10^8 N/m or 153 MPa/m for the specimens we used. This low stiffness makes fault motion very unstable and the overshooting of shear stress to a negative value was recognized in some violent stick-slip events. An abrupt slip occurred in a constant rise time of 16-18 ms despite wide variation of the stress drop, and an average velocity during an abrupt slip is linearly proportional to the stress drop. The use of a large-scale shaking table has a great potential in increasing the slip rate and total displacement in biaxial friction experiments with large specimens.

关键词： Stick-slip in gabbro - Biaxial frictionapparatus - Shaking table Friction experiment Faultmechanics

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Key Events in the Formation of Present-Day English

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Language and Semiotic Studies 2016年第2期2卷 141-148页

作者： kazuo Koike J.F.Oberlin University Japan

The English language has a history of about one thousand and five hundred years since it began to be spoken from around the middle of the fi fth century in England. During that time many internal and external events which are associated with the history, the culture, and society of England infl uenced the language at each stage. These events have brought changes to the system of the language and qualitative improvement directly or indirectly in every stage of the history of the English language. This paper focuses on the period stretching from Old English to Early Modern English, and its purpose is to discuss what sort of events were involved in the forming of Present-day English.

关键词： Old English Middle English Early Modern English history

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SOA Direct Modulation in Wavelength-Selectable Laser Array Light Sources

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光学学报 2003年第S1期23卷 431-432页

作者： kazuo Kasaya Ken Tsuzuki Hiroaki Sanjoh Yasuo Shibata Yuichi Tohmori NTT Photonics Laboratories NTT Corporation 3-1 Morinosato Wakamiya Atsugi-shi Kanagawa Pref 243-0198 Japan

We demonstrated, for the first time, 2.5-Gb/s SOA direct modulation in the wavelength-selectable DFB laser array. The SOA direct modulation was achieved in the wide tuning range of 22.7nm by selecting arrayed laser an... 详细信息

关键词： DFB laser range of

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Effectiveness of entecavir in preventing hepatocellular carcinoma development is genotype-dependent in hepatitis B virus-associated liver cirrhosis

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World Journal of Hepatology 2021年第1期13卷 144-150页

作者： kazuo Tarao Akito Nozaki Makoto Chuma Masataka Taguri Shin Maeda Department of Gastroenterology Tarao’s Gastroenterological ClinicYokohama City 241-0821Japan Gastroenterological Center Yokohama City University Medical CenterYokohama 232-0024Japan Department of Data Science Yokohama City University School of Data ScienceYokohama 236-0004Japan Division of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND The oral nucleos(t)ide analogue,entecavir(ETV)was demonstrated to reduce the rate of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)-associated liver ***,the reduction of HCC differs in various regions of the *** To investigate the reduction of HCC development due to ETV therapy by *** We surveyed the differences in HCC development following ETV treatment based on published articles using PubMed(2004-2019).RESULTS The regions with the most marked reduction in HCC development due to ETV therapy were Spain(1.0%/year)and Canada(Southern part,1.3%/year),and the most ineffective areas were South Korea(3.6%-3.8%/year),China(3.3%/year),Taiwan(2.4%-3.1%/year),and Hong Kong(2.8%/year).Following ETV administration,the incidence of HCC in genotype D regions(1.89%±0.28%/year,mean±SE)was significantly lower than that in genotype C regions(2.91%±0.24%/year,P<0.01).With regard to the initial HBV-DNA level,in genotype C patients(average:5.61 Log10IU/mL)this was almost the same as that in genotype D patients(average:5.46 Log10IU/mL).Moreover,there was no association between the prevalence ratio of HBV and the incidence of HCC on ETV *** The effectiveness of ETV in preventing HCC development in HBV-associated liver cirrhosis is genotype-dependent.

关键词： Hepatocellular carcinoma Entecavir Genotype of hepatitis B virus Oral nucleos(t)ide analogue

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Amidine-bearing lipoplex targeting to hepatocyte cells

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Chinese Chemical Letters 2008年第9期19卷 1115-1118页

作者： Yasuya Kudo Kazunori Koiwai Kazuhiro Shimizu Shota Kusuki Mina Sakuragi Naohiko Shimada Yoichi Takeda kazuo Sakurai Department of Chemical Process & Environments Faculty of Environmental EngineeringThe University of Kitakyushu1-1HibikinoWakamatsu-kuKitakyushuFukuoka 808-0135Japan TERUMO Corporation R & D Center 1500 InokuchiNakai-machiAshigarakami-gun Kanagawa 259-0151Japan

A lipoplex （i.e., pDNA#1/lipid complex and transfection reagent for pDNA delivery） containing galactosylceramide （GalCer） and an amidine-bearing lipid （TRX） was examined whether the bound pDNA was specifically ingested by hepatocyte via asialoglycoprotein receptor （ASGPR） and then expressed protein. Gel electrophoresis and small-angle X-ray scattering （SAXS） confirmed that the TRX-GalCer liposome#2 complexed with pDNA and the resultant lipoplex took a hexagonally packed inverted cylinder structure when the GalCer composition was less than 20 wt.% of the total lipid. When the lipoplex carrying pGL3 （luciferase-cording pDNA） was administrated to HepG2, the luciferase activity was increased with increasing the GalCer composition until it reached 3 wt.% and then decreased upon further addition of GalCer. When we added galactose itself as a competitor, the luciferase activity was decreased, while glucose did not show such decrease, suggesting that HepG2 ingested the lipoplex via ASGPR-mediated endocytosis. This paper indicated that the hexagonally packed inverted cylinder structures of lipoplex may not always provide excellent transfection and presented a possibility that the TRX lipoplex#3 can obtain a cellulartargeting ability through the receptors for oligosaccharide.

关键词： Gene theraphy Amidine Galactosylceramide Targeting

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Brief history of the Asian International Seminars on Atomic and Molecular Physics

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原子与分子物理学报 2006年第6期23卷 1162-1163页

作者： TAKAYANAGI kazuo Institute of Space and Astronatucial Science Professor Emeritus University of Tokyo

中日原子与分子物理讨论会是由中国著名学者清泉教授与日本著名学者高柳和夫教授共同发起创办的。第一次会议于1985年8月在成都举行。第二次会议于1988年10月在日本富士山北面脚下会议中心举行。第三次会议于1990年10月在山东泰安举... 详细信息

中日原子与分子物理讨论会是由中国著名学者清泉教授与日本著名学者高柳和夫教授共同发起创办的。第一次会议于1985年8月在成都举行。第二次会议于1988年10月在日本富士山北面脚下会议中心举行。第三次会议于1990年10月在山东泰安举行。第四次会议于1992年10月在日本东京举行。此次会议又称为第一届亚洲国际原子与分子物理讨论会。从此以后,会议规模扩大了,改称为亚洲国际原子分子论坛。现将高柳和夫教授所写的会议发展简史发表在本学报。供大家参考。

关键词：亚洲国际原子与分子物理 Brief history of the Asian International Seminars on Atomic and Molecular Physics 会议

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Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients

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Asian Journal of Andrology 2012年第4期14卷 580-583页

作者： Toshinobu Miyamoto Aldra Tsujimura Yasushi Miyagawa Eitetsu Koh Mikio Namiki Michiharu Horikawa Yasuaki Saijo kazuo Sengoku Department of Obstetrics and Gynecology Asahikawa Medical University Asahikawa Hokkaido 078-8510 Japan Department of Urology Osaka University Graduate School of Medicine Suita 565-0871 Japan Department of Integrated Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-1192 Japan Division of Community Medicine and Epidemiology Department of Health Science Asahikawa Medical University Asahikawa 078-8510 Japan

Genetic mechanisms are implicated as a cause of some male infertility, yet are poorly understood. Meiosis is unique to germ cells and essential for reproduction. The synaptonemal complex is a critical component for chromosome pairing, segregation and recombination. Hormadl is essential for mammalian gametogenesis as knockout male mice are infertile. Hormadl-deficient testes exhibit meiotic arrest in the early pachytene stage and synaptonema! complexes cannot be visualized. To analyze the hypothesis that the human HORMAD1 gene defects are associated with human azoospermia caused by meiotic arrest, mutational analysis was performed in all coding regions by direct sequence analysis of 30 Japanese men diagnosed with azoospermia resulting from meiotic arrest. By the sequence analysis, three polymorphism sites, Single Nucleotide Polymorphism 1 （c. 163A〉G）, SNP2 （c. 501T〉G） and SNP3 （c. 918C〉T）, were found in exons 3, 8 and 10. The 30 patients with azoospermia and 80 normal pregnancy-proven, fertile men were analyzed for HORMAD1 polymorphisms. Both SNP1 and SNP2 were associated with human azoospermia caused by complete early meiotic arrest （P〈0.0S）. We suggest that the HORMAD1 has an essential meiotic function in human spermatogenesis.

关键词： azoospermia HORMAD1 male infertility male meiosis SNP

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Third-Order Optical Nonlinearities of Squarylium Dyes with Benzothiazole Donor Groups Measured Using the Picosecond Z-Scan Technique

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Chinese Physics Letters 2011年第8期28卷 126-129页

作者： LI Zhong-Yu XU Song CHEN Zi-Hui ZHANG Fu-Shi KASATANI kazuo College of Petrochemical Engineering Changzhou UniversityChangzhou 213164 Department of Chemistry Tsinghua UniversityBeijing 100084 Department of Advanced Materials Science and Engineering Faculty of EngineeringYamaguchi UniversityTokiwadaiUbe 755-8611Japan

Third-order optical nonlinearities of two squarylium dyes with benzothiazole donor groups(BSQ1 and BSQ2)in chloroform solution are measured by a picosecond Z-scan technique at 532 *** is found that the two compounds show the saturation absorption and nonlinear self-focus refraction *** molecular second hyperpolarizabilities are calculated to be 7.46×10^(−31) esu and 5.01×10^(−30) esu for BSQ1 and BSQ2,*** large optical nonlinearities of squarylium dyes can be attributed to their rigid and intramolecular charge transfer *** difference inγvalues is attributed to the chloro group of benzene rings of BSQ2 and the one−photon resonance *** is found that the third-order nonlinear susceptibilities of two squarylium dyes are mainly determined by the real parts ofχ(3),and the large optical nonlinearities of studied squarylium dyes can be attributed to the nonlinear refraction.

关键词： structure effect attributed

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Dynamic Gratings in Optical Fibers： Synthesis and Sensing Applications

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Photonic Sensors 2012年第1期2卷 60-64页

作者： Zuyuan HE kazuo HOTATE Department of Electrical Engineering and Information Systems School of Engineering The University of Tokyo Tokyo113-8656 Japan

We proposed two schemes of generating and localizing dynamic gratings in optical fibers： one is based on the gain saturation in erbium-doped fiber; the other is based on Brillouin scattering in the fiber. By using these dynamic gratings, fully distributed strain/temperature sensors have been demonstrated. In this presentation, we review the principles, basic schemes, and experimental demonstrations of the novel dynamic grating techniques.

关键词： Dynamic grating fiber-optic sensor distributed strain sensor temperature sensor

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Automatic &Safe Oxytocin Induction of Labor

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Open Journal of Obstetrics and Gynecology 2018年第9期8卷 812-815页

作者： kazuo Maeda Department of Obstetrics and Gynecology Tottori University Mdical School Yonago Japan

Aims: To prevent fetal damage by excess oxytocin administration of manually controlled infusion, by automatic and safe increasing infusion setting with monitoring uterine contraction and fetal heart rate. Methods: Starting infusion level was 2 milliU/ml, as oxytocin sensitivity of a pregnant uterus is unknown, to avoid hyper contraction and fetal bradycardia caused by unexpected excess oxytocin sensitivity. The infusion automatically increased with automatic monitoring of uterine contraction curve, then the increasing stopped when contraction reached to normal labor level, where the infusion level maintained, which continued until delivery, if there is no trouble. However, the infusion continued until expiring all fluid in case of insensitive uterus, where the induction was performed in another day. The infusion stopped automatically when contraction was too strong, or fetal heart rate is abnormal. Thus, oxytocin sensitive case is protected from excess contraction and fetal asphyxia. Results: Normal vaginal delivery was achieved in 28/33 cases (85%), which was more than manually controlled infusion. No case was abnormal in successful oxytocin infusion. Conclusion: The automated technique will be applied to oxytocin labor induction.

关键词： Labor Induction Oxytocin Automatic Infusion Monitoring of Fetal Heart Rate and Contraction Increasing Infusion

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