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A Novel Biomaterial for Cartilage Repair Generated by Self-Assembly: Creation of a Self-Organized Articular Cartilage-Like Tissue

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Journal of Biomaterials and Nanobiotechnology 2012年第2期3卷 125-129页

作者： kazuo Yudoh Rie Karasawa Institute of Medical Science St. Marianna University School of Medicine Kawasaki Japan Institute of Medical Science St. Marianna University School of Medicine Kawasaki Japan.

Recently, attention has been drawn to tissue engineering and other novel techniques aimed at reconstruction of the joint. Regarding articular cartilage tissue engineering, three-dimensional materials created in vitro by cultivation of autologous chondrocytes or mesenchymal stem cells with a collagen gel have been implanted to replace defective parts of the articular cartilage in limited cases with the diseases such as trauma or arthritis. However, several passages of chondrocyte culture are required to obtain a sufficient number of cells for tissue engineering. Additionally, several other problems arise including dedifferentiation of chondrocytes during cell culture, which need to be solved from a viewpoint of cellular resources. The purpose of our study is to create a novel biomaterial possessing functions and structures comparable to native hyaline articular cartilage by utilizing the physicochemical properties of the cartilage matrix components themselves, in other words, employing a self-assembly technique instead of using chondrocytes to produce cartilage matrices eventually leading to articular cartilage tissue formation. We verified the conditions and accuracy of the self-organization process and analyzed the resulting micro structure using electron beam microscopy in order to study the technique involved in the self-organization which would be applicable to creation of cartilage-like tissue. We demonstrated that self-assembly of several cartilage components including type II collagen, proteoglycan and hyaluronic acid could construct self-assembled cartilage-like tissues characterized by nano composite structures comparable to human articular cartilage and by low friction coefficients as small as those of native cartilage.

关键词： Self Assembly Articular Cartilage Tissue Engineering Chondrocyte

Nutritional supplement drink reduces inflammation and postoperative depression in patients after off-pump coronary artery bypass surgery

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World Journal of Cardiology 2021年第8期13卷 348-360页

作者： Satoshi Matsushita Akie Shimada Taira Yamamoto kazuo Minematsu Hirotaka Inaba Kenji Kuwaki Atsushi Amano Department of Cardiovascular Surgery Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of School Health Graduate School of EducationNagasaki UniversityNagasaki 852-8521Japan Department of Cardiovascular Surgery Juntendo University Urayasu HospitalChiba 279-0021Japan Department of Cardiovascular Surgery Tokai University Hachioji HospitalTokyo 192-0032Japan

BACKGROUND Coronary artery bypass grafting is a surgical treatment for ischemic heart *** development in surgical technique and improvement of perioperative management reduced the postoperative complications,some patients still delayed in progress of postoperative *** this study,we aimed to investigate the effect of daily intake of an herbal medicine-containing drink for rehabilitation after surgery in patients with ischemic heart *** To investigate the effect of taking an herbal medicine-containing,commercially available drink for postoperative rehabilitation in those *** Patients who underwent isolated off-pump coronary artery bypass(OPCAB)surgery were divided into two groups depend on the timing of the admission to the hospital:the Yunker(YKR)group,that consumed one bottle of a caffeine-free nutritional supplement drink on a daily basis and the control group(CTL)that underwent regular *** A total of 229 patients(CTL=130,YKR=99)were *** significant differences were observed in the baseline characteristics between the two *** YKR group had a significantly increased number of daily steps postoperatively(P<0.05)and had significantly lower postoperative serum tumor necrosis factor-alpha levels(P<0.01),while no significant differences were observed in the levels of other inflammatory or stress-related cytokines(interleukin-6,adiponectin,superoxide dismutase,and urine 8-hydroxy-2′-deoxyguanosine)between the two ***,the YKR group showed a significant improvement in the Hospital Anxiety and Depression Score(P<0.05).Moreover,there were no differences in postoperative complications and the duration of postoperative hospital stay between the two *** Our results demonstrated that the daily intake of an herbal medicine-containing drink after OPCAB surgery may have beneficial effects on cardiac rehabilitation by reducing inflammation markers and depression.

关键词： Herbal medicine Inflammation Cardiac rehabilitation Moderate-to-vigorous intensity physical activity Off-pump coronary artery bypass

Usefulness of Radiofrequency Ablation with the PVT-350BTP Probe for the treatment of Hepatocellular Carcinoma

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Open Journal of Medical Imaging 2011年第1期1卷 9-13页

作者： Naoki Hotta kazuo Masuko 不详

Radiofrequency ablation (RFA) has been clinically employed in Japan, and its usefulness in the treatment of hepatocellular carcinoma (HCC) has been reported by many researchers. In the present study, the convex puncture probe PVT-350BTP, rather than a conventional convex probe, was used for RFA for the treatment of HCC and its usefulness was assessed. At the same time, evaluation of the therapeutic effect using ultrasound contrast agent was investigated. The subjects were 20 patients (16 men and 4 women) with 20 HCC nodules as confirmed by contrast CT or abdominal angiography. No nodules were ≤1.0 cm in diameter, 12 were 1.1 cm - 2.0 cm, and 8 were 2.1 cm - 3.0 cm. An Aplio diagnostic ultrasound system (Toshiba Medical Systems, Tokyo, Japan) and the PVT-350BTP probe (Toshiba) were employed for RFA. The PVT-350BTP supports puncture angles of 55, 70, 85, and 100 degrees. By mounting various types of puncture adapters on the probe, 13 G to 22 G puncture needles can be used. The needle can easily be attached and detached by operating a lever. Contrast echo studies with Levovist were performed before and after RFA, and the results were evaluated using the Advanced Dynamic Flow (ADF) imaging technique. Puncture was performed successfully using this probe for 20 cases with 20 nodules. It was confirmed that RFA with the PVT-350BTP permits percutaneous treatment to be performed more reliably than with a conventional probe.

关键词： Ultrasound RFA HCC PVT-350BTP

How to Reduce Cancer Incidences and Deaths in Asia UICC Strategic Direction for "Cancer Prevention and Early Detection"

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How to Reduce Cancer Incidences and Deaths in Asia UICC Stra...

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： kazuo Tajima Director Aichi Cancer Center Research Institute Nagoya Japan

＜正＞In Asian countries, an epidemic pattern of cancer by site is very characteristic due to various geographic condition and different cultural background. From the current international cancer statistics of the WHO, a number of annual deaths in the world were estimated at 7 million and more than 50% are found in Asian Pacific region. To establish strategic direction for cancer controls in Asia, first we need epidemiological evidences on risk and protective factors of cancers obtained from well designed epidemiological studies to promote the primary prevention. Furthermore a well designed cancer screening system should be established to reduce cancer deaths as a secondary prevention.

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THE RELATIONSHIP BETWEEN LYSOSOMAL WRAPPING MECHANISM（LWM） AND THE HETEROPHAGOLYSOSOMES SEEN IN RAT SPLEEN MACROPHAGES AFTER γ-RAY IRRADIATION

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THE RELATIONSHIP BETWEEN LYSOSOMAL WRAPPING MECHANISM（LWM）...

The Second Chinese-Japanese Electron Microscopy Seminar

作者： kazuo Ogawa Department of Anatomy Kyoto University Faculty of MedicineJapan

＜正＞Mayahara and Ogawa（1）first discovered the lysosomal wrap- ping mechanism（LWM）in histiocytes in the subcutaneous tissue of mice injected with horseradish *** then,in many researches the LWM has been found fre...

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基于多项Logit模型的游客组合出行方式选择行为研究

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综合运输 2024年第5期46卷 100-106,113页

作者：孙轶琳黄佩汤心怡董轶男赵志健西井和夫浙江大学建筑工程学院浙江杭州310058 浙江大学建筑设计研究院有限公司浙江杭州100000 浙江大学工程师学院浙江杭州310015 浙江大学平衡建筑中心浙江杭州310028 流通科学大学政策研究学部日本神户651-2188

交通与旅游融合发展已成为新趋势,单方式出行无法满足旅游出行需求,研究旅游的组合出行方式选择,对扩大旅游公共交通服务、提升旅游交通管理水平十分重要。为剖析个人属性、家庭属性、出行特征对游客组合出行方式选择的影响,以京江浙居... 详细信息

交通与旅游融合发展已成为新趋势,单方式出行无法满足旅游出行需求,研究旅游的组合出行方式选择,对扩大旅游公共交通服务、提升旅游交通管理水平十分重要。为剖析个人属性、家庭属性、出行特征对游客组合出行方式选择的影响,以京江浙居民RP调查数据为基础,构建多项logit模型。结果显示,年龄、职业、家庭结构和出行时间等属性对组合出行方式的选择有显著影响,学生、年轻及低收入群体市内游时更倾向于“公共交通为主的方式”,单人及跨市旅行时更偏好“城际铁路为主的方式”,江苏居民相对京浙居民有更高概率选择“停车换乘”。针对不同公共交通旅游出行群体,提出旅游公共交通服务的政策建议,为促进旅游公共交通服务水平的提升奠定理论基础。

关键词：旅游交通出行方式选择组合出行多项logit模型 RP调查

Ultrastructural and Cytochemical Observations on Phagocytosis Periods of Macrophage in Mouse Thymus

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Ultrastructural and Cytochemical Observations on Phagocytosi...

The Third Chinese-Japanese Electron Microscopy Seminar

作者： kazuo OGAWA Department of Anatomy Kyoto University Faculty of MedicineKyotoJapan.

Introduction Lysosome was discovered by de Duve in *** then,many studies have shown that lysosome was involved in heterophagy and autophagy *** 1960s,Li(1)) investigated the ability,pattern and consequence of the hete...

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Protracted anaphylaxis developed after peginterferon α-2a administration for chronic hepatitis C

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World Journal of Gastroenterology 2015年第9期21卷 2826-2829页

作者： Akihiko Sakatani Yoshinori Doi Takaaki Matsuda Yasutaka Sasai Naohiro Nishida Megumi Sakamoto Naoto Uenoyama Yoshiya Matsumoto kazuo Kinoshita Department of Gastroenterology and Hepatology Osaka University Graduate School of MedicineSuitaOsaka 565-0871Japan Department of Gastroenterology Otemae HospitalOsaka 540-0008Japan Department of Respiratory Medicine Otemae HospitalOsaka 540-0008Japan

Peginterferon is a key drug used to treat chronic viral hepatitis that is known for causing various side *** effects occurring immediately after administration include headache, nausea, and influenza-like symptoms, such as fever and joint ***, reports of anaphylactic shock are extremely *** we report a patient with protracted anaphylaxis who suffered shock symptoms after peginterferon α-2a administration for chronic hepatitis *** the patient improved temporarily with shock treatment, symptoms of anaphylaxis *** peginterferon is often administered on an outpatient basis, it is important to recognize life-threatening side effects that may develop in a protracted manner.

关键词： Peginterferon α-2a Anaphylaxis Anaphylactic shock

Pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion from an aortic intramural hematoma

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World Journal of Gastroenterology 2016年第16期22卷 4259-4263页

作者： Akihiko Sakatani Yoshinori Doi Toshiaki Kitayama Takaaki Matsuda Yasutaka Sasai Naohiro Nishida Megumi Sakamoto Naoto Uenoyama kazuo Kinoshita Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine Department of Gastroenterology Otemae Hospital Department of Radiology Otemae Hospital

Pancreaticoduodenal artery aneurysms are a rare type of visceral artery aneurysm, whose rupture is associated with high mortality. These aneurysms are of particular interest because local haemodynamic change caused by coeliac artery obstruction plays an important role in their development. However, the pathophysiological mechanism of coeliac artery obstruction is not completely understood. Pressure from the median arcuate ligament is most frequently reported cause. Although it is well-known that stenosis or occlusion of the visceral vessels may be caused by aortic syndrome, reports of pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion due to aortic syndrome are extremely rare. Our case indicates a new aetiology for a pancreaticoduodenal artery aneurysm and demonstrates the rapid deterioration of the patient affected.

关键词： Pancreaticoduodenal artery Coeliac artery Visceral artery aneurysm Aortic dissection