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Characteristics and prognosis of synchronous multiple early gastric cancer

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World Journal of Gastroenterology 2013年第41期19卷 7154-7159页

作者： Taro Isobe Kousuke Hashimoto Junya Kizaki Naotaka Murakami Keishiro Aoyagi Kikuo Koufuji Yoshito Akagi kazuo shirouzu Department of Surgery Kurume University School of MedicineFukuoka 830-0011Japan

AIM:To assess the clinicopathologic characteristics,risk factors,and prognosis for synchronous multiple early gastric cancer(SMGC).METHODS:A total of 146 patients with SMGC and1194 patients with single gastric cancer who had undergone gastrectomy between 1989 and 2008 were retrospectively analyzed to determine their clinicopathologic characteristics and postoperative *** were classified into groups on the basis of location and *** habits were evaluated using the Brinkman *** and pathological factors were compared using either Fisher’s exact test or Pearson’sχ*** regression analysis was performed to identify independent risk *** rate was calculated using the Kaplan-Meier ***:SMGCs accounted for 10.9%of gastric cancer cases and occurred predominantly in elderly male patients with a family history of gastric cancer who were both smokers and *** tumors were typically macroscopically elevated and histologically *** were no significant differences between SMGC and single gastric cancer patients with respect to tumor location,tumor size,lymph node metastasis,the number of metastatic lymph nodes,venous invasion,or tumor stage(P=0.052,P=0.347,P=0.595,P=0.805,P=0.559,and P=0.408,respectively).Further,there was no significant difference in postoperative survival between the patient groups(P=0.200).Of the 146SMGC patients,a single patient had remnant ***:A careful preoperative endoscopy is necessary for patients who are at high risk of SMGC,and minimally invasive treatment may be indicated in some cases.

关键词： Gastric cancer Synchronous Multiple Endoscopy Prognosis

Prognosis of metastatic splenic hilum lymph node in patients with gastric cancer after total gastrectomy and splenectomy

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World Journal of Hepatology 2010年第2期2卷 81-86页

作者： Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Takuya Imaizumi Junya Kizaki kazuo shirouzu Department ofSurgery Kurume University School of MedicineFukuoka830-0011Japan

AIM:To clarify the significance of combined resection of the spleen to dissect the No.10 lymph node(LN). METHODS:We studied 191 patients who had undergone total gastrectomy with splenectomy,excluding non-curative cases,resection of multiple gastric cancer, and those with remnant stomach *** clinico-pathological factors were evaluated for any independent contributions to No.10 LN metastasis,usingχ 2 test. Significant factors were extracted for further analysis, carried out using a logistic regression ***,lymph node metastasis was evaluated for any independent contribution to No.10 LN metastasis,using the same *** cumulative survival rate was calculated using the Kaplan-Meier *** significance of any difference between the survival curves was determined using the Cox-Mantel test,and any difference was considered significant at the 5%level. RESULTS:From the variables considered to be potentially associated with No.10 LN metastasis,age, depth,invasion of lymph vessel,N factor,the numberof lymph node metastasis,Stage,the number of sites, and location were found to differ significantly between those with metastasis(the Positive Group)and those without(the Negative Group).A logistic regression analysis showed that the localization and Stage were significant parameters for No.10 LN *** was no case located on the lesser curvature in the Posi-tive *** numbers of No.2,No.3,No.4sa,No. 4sb,No.4d,No.7,and No.11 LN metastasis were each found to differ significantly between the Positive Group and the Negative Group.A logistic regression analysis showed that No.4sa,No.4sb,and No.11 LN metastasis were each a significant parameter for No.10 LN *** was no significant difference in survival curves between the Positive Group and the Negative Group. CONCLUSION:Splenectomy should be performed to dissect No.10 LN for cases which have No.4sa,No. 4sb or No.11 LN ***,in cases where the tumor is located on th

关键词： Gastric cancer Lymph node metastasis Lymphadenectomy,Splenectomy Total gastrectomy

Relevance of Surgery in Stage IV Gastric Carcinoma

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Journal of Cancer Therapy 2013年第1期4卷 6-15页

作者： Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Junya Kizaki Taro Isobe Kousuke Hashimoto kazuo shirouzu Department of Surgery Kurume University School of Medicine Kurume Japan.

New anticancer drugs are being increasingly used for advanced and recurrent gastric cancer in many institutions. Therefore, the relative importance of surgery may have changed, and there may also be controversy as to whether patients with stage IV gastric cancer should or not undergo surgical resection. The relevance of surgery in this population was studied. The relevance of surgery was studied in 304 cases of stage IV gastric cancer who were treated at KurumeUniversityHospitalfrom 1995 to 2009. Multivariate analysis showed that distant organ metastasis was significantly correlated with surgery. In stage IV cases, chemotherapy and the number of stage IV factors were independent prognostic factors. In surgery cases, venous invasion, chemotherapy, and residual tumor were independent prognostic factors. R0 was significantly higher in the surgery with chemotherapy group than in the chemotherapy alone group, but there was no significant difference in R1 or R2 cases between the surgery with chemotherapy group and the chemotherapy alone group. In R2 cases, use of a new drug was an independent prognostic factor. The rate of R0 was significantly higher in the preoperative chemotherapy group than in the surgery alone group. In preoperative chemotherapy cases, the S-1/cisplatin (CDDP) group had a 50% 2-year survival rate, and these cases underwent postoperative chemotherapy using the S-1 regimen. A multimodal treatment is considered most effective for stage IV gastric cancer, where this includes preoperative chemotherapy, surgery, and postoperative chemotherapy using the new anti-cancer drugs.

关键词： Gastric Cancer Stage IV Surgery Chemotherapy Multimodal Treatment

Molecular targeting therapy using bevacizumab for peritoneal metastasis from gastric cancer

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World Journal of Critical Care Medicine 2013年第4期2卷 48-55页

作者： Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Junya Kizaki Taro Isobe Kousuke Hashimoto kazuo shirouzu Department of Surgery Kurume University School of Medicine Kurume Fukuoka 830-0011 Japan

AIM: To clarify the significance of vascular endothelial growth factor(VEGF) in peritoneal metastasis from gastric cancer, using the gastric cancer cell line MKN-45 compared with the high potential peritoneal dissemination gastric cancer cell line MKN-45 P. METHODS: The supernatant of culture medium of MKN-45 cells or MKN-45 P cells was collected and the concentrations were measured of various cytokines, matrix metalloproteinases, growth factor and angiogenic factors, including VEGF. We performed an initial pilot study to explore whether bevacizumab, a humanized monoclonal antibody against VEGF, had any suppressive effect on the peritoneal dissemination from gastric cancer in an experimental nude mouse modelof peritoneal metastasis. RESULTS: The concentrations of interleukin-6(IL-6), IL-8, VEGF and matrix metalloproteinase-2 protein in the culture supernatant were each significantly higher than each of those for MKN-45. In the in vivo study, the volume of ascites and the mitotic index were significantly lower in the therapy group than in the nontherapy group. The survival curve of the therapy group was significantly higher than that of the non-therapy group. These results suggested that VEGF was correlated with peritoneal metastasis from gastric cancer. CONCLUSION: Findings suggested that bevacizumab for inhibiting VEGF could suppress peritoneal dissemination from gastric cancer.

关键词： Gastric cancer Peritoneal metastasis Vascular endothelial growth factor MKN-45P Bevacizumab

The Significance of the Expression of FBXO31 in Gastric Cancer

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Journal of Cancer Therapy 2013年第1期4卷 75-79页

作者： Tomoya Sudo Ryunosuke Kogo Naohiro Nishida Keisuke Takahahi Genta Sawada Masahisa Ishibashi Junji Kurashige Ryutaro Uchi Tae Matsumura Hiroki Ueo Kousuke Mima Sayuri Akiyoshi Keishi Sugimachi Kouhei Shibata Hiromasa Fujita kazuo shirouzu Masaki Mori Koshi Mimori Department of Surgery Kurume University School of Medicine Kurume Japan Department of Surgery Medical Institute of Bioregulation Kyushu University Beppu Japan Department of Surgery Medical Institute of Bioregulation Kyushu University Beppu Japan&Department of Surgery Kurume University School of Medicine Kurume Japan Department of Surgical Oncology Graduate School of Medicine Osaka University Osaka Japan.

Loss of Heterozygosity (LOH) is commonly considered to be one of a reason when some genes lose their function. Numbers of tumor suppressor genes are existing on the LOH lesion and chromosome 16q24 had been reported as a LOH region in gastric cancer. Little is known about what kind of tumor suppressor genes locates around the position. F-box protein, (FBXO31) is a candidate tumor suppressor gene encoded in chromosome 16q24.3 and LOH of the gene was reported in breast cancer, hepatocellular carcinoma and ovarian cancer but the status of FBXO31 was not analyzed in gastric cancer so far. One hundred twenty-seven pairs of tumor and corresponding normal tissue specimens collected from gastric cancer patients who underwent gastrectomy. Total RNAs were extracted from those samples and the expression of FBXO31 was investigated using real time quantitative RT-PCR analysis. Patients were classified into FBXO31 high expression group and low expression group. Clinicopahological factors were compared between the two groups and importance of FBXO31 was investigated. The standardized expression of FBXO31 was not significantly different between tumor (0.43 ± 0.46) and the corresponding 0.49 ± 0.55 in normal tissue (p = 0.39). Two years survival rate was 77% in FBXO31 high expression group and 54% in low expression group however the chance of survival rate of high expression group was dropped in 5 years (Wilcoxon p = 0.01). Clinicopathological factors were compared between the two groups and peritoneal dissemination was observed significantly higher in FBXO31 low expression group than did in high expression group (p = 0.0398). In order to predict existence of peritoneal dissemination of gastric cancer before surgery, FBXO31 may become a favorite marker for the low risk of peritoneal dissemination.

关键词： FBXO31 LOH Gastric Cancer

PREPARATION AND CHARACTERIZATION OF SHISH-KEBAB TYPE LIQUID CRYSTALLINE POLY(p-PHENYLENEVINYLENE)

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Chinese Journal of Polymer Science 2006年第4期24卷 353-361页

作者： kazuo Akagi 郑世军 Institute of Materials Science University of Tsukuba Tsukuba 305-8573Japan College of the Material Science and Engineering Zhengzhou University Zhengzhou 450052 China

Novel shish-kebab type liquid crystalline poly（p-phenylenevinylene） derivatives were synthesized by Stille coupling reaction from 2,5-bis[（4-n-alkoxyl）benzoyloxy]1,4-dibromobenzene （monomer l） and 1,2-bis（tributylstannyl） ethylene （monomer 2）. The polymers with alkoxy groups are soluble in common organic solvents and exhibit blue fluorescence. Both the cast film and the annealed film have large red-shifts in fluorescence spectra and show yellow fluorescence. The polymers with CN and NO2 groups show poor solubility and green fluorescence. All the polymers possess liquid crystalline smectic phases. The melting point （Tm） of the polymers decreases when the length of the alkoxy tails of the mesogenic units increases. The polymers are easily aligned under a magnetic field of 10 Tesla. It is found that the conjugated backbone and LC side chain are aligned perpendicular and parallel to the magnetic field, respectively. The polymers show optical dichroism in fluorescence spectra, suggesting that they are available for advance materials with linear optical polarization.

关键词： Liquid crystalline conjugated polymers Poly(p-phenylenevinylene) Shish-kebab Linearly polarized dichroism Fluorescence.

Threshold dynamics of reaction-diffusion partial differential equations model of Ebola virus disease

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International Journal of Biomathematics 2018年第8期11卷 235-264页

作者： kazuo Yamazaki University of Rochester Department of Mathematics Rochester NY 14627 USA

We study the reaction-diffusion Ebola PDE model that consists of equations that govern the evolution of susceptible, in fee ted, recovered and deceased human individuals, as well as Ebola virus pathogens in the environment, with diffusive terms in all except the equation of the deceased human individuals. Under the setting of a spatial domain that is bounded, we prove the global well-posedness of the system;in contrast to the previous work on similar models such as cholera, avian influenza, malaria and dengue fever, diffusion coefficients may be different. Moreover, we derive its basic reproduction number, and under the condition that the diffusion coefficients of the susceptible and infected hosts are same, we prove the global stability of the disease-free-equilibrium, and uniform persistence in cases when the basic reproduction number lies beneath and above one, respectively. Again, we do not require that the diffusion coefficients of the recovered hosts be the same as the diffusion coefficients of the susceptible and infected hosts, in contrast to previous work on other models of infectious diseases. Another technical difficulty in our model is that the solution semiflow is not compact due to the lack of diffusion in the equation of the deceased human individuals;we overcome this difficulty using functional analysis techniques concerning Kura to wski measure of non-compactness.

关键词： Basic reproduction number Ebola persistence stability

Concept of Intelligent Mechanical Design for Autonomous Mobile Robots

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Journal of Bionic Engineering 2007年第4期4卷 217-226页

作者： Amir A. F Nassiraei kazuo Ishii Kyushu Institute of Technology Kitakyushu Fukuoka 808-0196 Japan

The concept of Intelligent Mechanical Design （IMD） is presented to show how a mechanical structure can be designed to affect robot controllability, simplification and task performance. Exploring this concept produces landmarks in the territory of mechanical robot design in the form of seven design principles. The design principles, which we call the Mecha-Telligence Principles （MTP）, provide guidance on how to design mechanics for autonomous mobile robots. These principles guide us to ask the right questions when investigating issues concerning self-controllable, reliable, feasible, and compatible mechanics for autonomous mobile robots. To show how MTP can be applied in the design process we propose a novel methodology, named as Mecha-Telligence Methodology （MTM）. Mechanical design by the proposed methodology is based on preference classification of the robot specification described by interaction of the robot with its environment and the physical parameters of the robot mechatronics. After defining new terms, we investigate the feasibility of the proposed methodology to the mechanical design of an autonomous mobile sewer inspection robot. In this industrial project we show how a passive-active intelligent moving mechanism can be designed using the MTM and employed in the field.

关键词： mechanical design intelligent autonomous robot mobile robot

A Switching Controller System for a Wheeled Mobile Robot

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Journal of Bionic Engineering 2007年第4期4卷 281-289页

作者： Masanori Sato Atushi Kanda kazuo Ishii Department of Brain Science and Engineering Kyushu Institute of Technology Kitakyushu 808-0196 Japan

A wheeled mobile mechanism with a passive and/or active linkage mechanism for rough terrain environment is developed and evaluated. The wheeled mobile mechanism which has high mobility in rough terrain needs sophisticated system to adapt various environments. We focus on the development of a switching controller system for wheeled mobile robots in rough terrain. This system consists of two sub-systems： an environment recognition system using link angles and an adaptive control system. In the environment recognition system, we introduce a Self-Organizing Map （SOM） for clustering link angles. In the adaptive controllers, we introduce neural networks to calculate the inverse model of the wheeled mobile robot. The environment recognition system can recognize the environment in which the robot travels, and the adjustable controllers are tuned by experimental results for each environment. The dual sub-system switching controller system is experimentally evaluated. The system recognizes its environment and adapts by switching the adjustable controllers. This system demonstrates superior performance to a well-tuned single PID controller.

关键词： mobile robot rough terrain neural network Self-Organizing Map