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A case of EGFR mutation-positive lung adenocarcinoma in which the T790M allele fraction was increased by repeated EGFR-TKI treatment

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Cancer Communications 2019年第1期39卷 593-597页

作者： Hideharu Kimura Yoshiaki Amino Hayato Koba Yuichi Tambo Noriyuki Ohkura Johsuke Hara Takashi Sone kazuo kasahara Department of Respiratory Medicine Kanazawa University HospitalTakara-machi 13-1KanazawaIshikawa 920-8641Japan Regional Respiratory Symptomatology Kanazawa University Graduate School of Medical ScienceKanazawaIshikawa 920-8641Japan Respiratory Medicine Institute of MedicalPharmaceutical and Health SciencesKanazawa University Faculty of MedicineKanazawaIshikawa 920-8641Japan

Dear editor,The current treatment strategy for advanced non-small cell lung cancer(NSCLC)patients harboring epider-mal growth factor receptor(EGFR)mutations involves EGFR-tyrosine kinase inhibitors(EGFR-TKIs).Several reports on EGFR-TKI resistance have shown that the T790M mutation within the EGFR gene is present in approximately half of the patients who develop resist-ance to a first-or second-generation EGFR-TKI[1,2].In Japan,osimertinib monotherapy is the standard therapy for patients harboring the EGFR T790M mutation arising after the development of resistance to a first-or second-generation EGFR-TKI[3,4].Herein,we report the case of a patient who underwent four tumor biopsies over the treatment *** no detection of this mutation after developing resistance to the first-line EGFR-TKI,in the fourth biopsy specimen,which was collected after progression following EGFR-TKI re-challenge,EGFR T790M mutation was detected using the cobas®EGFR mutation test(Roche Molecular Systems,Pleasanton,CA,USA).Additionally,we analyzed the T790M allele frequency(AF)in longitudinal biopsy samples obtained at four different time points using droplet digital PCR(ddPCR)(PrimePCR™,Bio-Rad Laboratories,Inc.,Her-cules,CA,USA).We discuss the clinical usefulness of longitudinal assessment of the EGFR T790M AF,espe-cially for deciding the appropriate treatment(e.g.,osi-mertinib)in patients with EGFR mutations.

关键词： TKI treatment Roche

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Long-lasting responses after discontinuation of nivolumab treatment for reasons other than tumor progression in patients with previously treated,advanced non-small cell lung cancer

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Cancer Communications 2019年第1期39卷 665-669页

作者： Hideharu Kimura Tomoyuki Araya Taro Yoneda Hiroki Shirasaki Koji Kurokawa Tamami Sakai Hayato Koba Yuichi Tambo Shingo Nishikawa Takashi Sone kazuo kasahara Respiratory Medicine Kanazawa University HospitalTakara-machi 13-1KanazawaIshikawa 920-8641Japan Respiratory Medicine National Hospital Organization Kanazawa Medical CenterKanazawaIshikawa 920-8650Japan Respiratory Medicine Komatsu Municipal HospitalKomatsuIshikawa 923-8560Japan Respiratory Medicine Fukui-ken Saiseikai HospitalFukuiFukui 918-8503Japan Respiratory Medicine Ishikawa Prefectural Central HospitalKanazawaIshikawa 920-8530Japan Internal Medicine Keiju Medical CenterNanaoIshikawa 926-8605Japan Regional Respiratory Symptomatology Kanazawa University Graduate School of Medical ScienceKanazawaIshikawa 920-8641Japan

Dear Editor,Nivolumab,an inhibitor of programmed cell death 1(PD-1),is an immune checkpoint inhibitor(ICI)that enhances T cell functions by preventing negative regulation of cancer immunity,and it has shown clinically significant efficacy and tolerability in various types of *** on the results of randomized phase III trials comparing nivolumab with docetaxel[1,2],nivolumab is now used in clinical practice for patients with previously treated advanced non-small cell lung cancer(NSCLC).Fur-thermore,the most recent Japan Lung Cancer Society guidelines include nivolumab monotherapy in the sys-temic treatment strategy for previously treated,locally advanced or metastatic NSCLC[3].However,ICIs induce characteristic immune-related adverse events(irAEs),which are not seen with conventional cytotoxic agents or molecular targeted *** can occur in any organ system,most typically the skin,lung,and gastrointesti-nal,hepatic,and endocrine systems.

关键词： nivolumab patients lung

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Measurement of Ion Cyclotron Emissions by Using High-Frequency Magnetic Probes in the LHD

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Plasma Science and Technology 2013年第3期15卷 209-212页

作者： Kenji SAITO Ryuhei KUMAZAWA Tetsuo SEKI Hiroshi kasahara Goro NOMURA Fujio SHIMPO Hiroe IGAMI Mitsutaka ISOBE Kunihiro OGAWA kazuo TOI Masaki OSAKABE Masaki NISHIURA Tsuguhiro WATANABE Satoshi YAMAMOTO Makoto ICHIMURA Takashi MUTOH National Institute for Fusion Science Graduate School of Engineering Nagoya University Institute of Advanced Energy Kyoto University Tsukuba University Plasma Research Center

Two pairs of high-frequency magnetic probes were installed in the Large Helical Device （LHD）. During the injection of a perpendicular neutral beam, ion cyclotron emissions （ICEs） with the fundamental frequency corresponding to the ion cyclotron frequency at the plasma edge were detected, which are the same type of ICE as measured with the former spare ion cyclotron range of frequencies （ICRF） heating antennas. This type of ICE was further investigated with regard to the phase and intensity of signals. Another type of ICE was found in the LHD, and these ICEs were synchronized with bursts of toroidicity induced Alfv^n eigenmodes （TAE） and the rise of intensity of lost ion flux. Therefore the source of these ICEs was thought to be the particles transferred from the core to the outer region of plasma by the TAE bursts. The frequency of ICEs induced by the TAE bursts increases linearly with the magnetic field strength, since the ion cyclotron frequency increases with the magnetic field strength.

关键词： LHD ICE TAE lost particle high-frequency magnetic probe

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