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Effectiveness of antibiotic prophylaxis for acute esophageal variceal bleeding in patients with band ligation: A large observational study

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World Journal of Gastroenterology 2024年第3期30卷 238-251页

作者： Chikamasa Ichita Sayuri Shimizu Tadahiro Goto Uojima Haruki Naoya itoh Masao Iwagami Akiko Sasaki Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236-0027KanagawaJapan TXP Research TXP Medical Co.Ltd.Chiyoda-ku 101-0042TokyoJapan Department of Clinical Epidemiology and Health Economics School of Public HealthThe University of TokyoBunkyo-ku 113-0033TokyoJapan Department of Genome Medical Sciences Project Research InstituteNational Center for Global Health and MedicineIchikawa 272-8516ChibaJapan Division of Infectious Diseases Aichi Cancer CenterNagoya 464-8681AichiJapan Department of Health Services Research Institute of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan

BACKGROUND Esophageal variceal bleeding is a severe complication associated with liver cirrhosis and typically necessitates endoscopic *** current standard treatment is endoscopic variceal ligation(EVL),and Western guidelines recom-mend antibiotic prophylaxis following ***,given the impro-vements in prognosis for variceal bleeding due to advancements in the management of bleeding and treatments of liver cirrhosis and the global concerns regarding the emergence of multidrug-resistant bacteria,there is a need to reassess the use of routine antibiotic prophylaxis after *** To evaluate the effectiveness of antibiotic prophylaxis in patients treated for *** We conducted a 13-year observational study using the Tokushukai medical database across 46 *** were divided into the prophylaxis group(received antibiotics on admission or the next day)and the non-prophylaxis group(did not receive antibiotics within one day of admission).The primary outcome was composed of 6-wk mortality,4-wk rebleeding,and 4-wk spontaneous bacterial peritonitis(SBP).The secondary outcomes were each individual result and in-hospital mortality.A logistic regression with inverse probability of treatment weighting was used.A subgroup analysis was conducted based on the Child-Pugh classification to determine its influence on the primary outcome measures,while sensitivity analyses for antibiotic type and duration were also *** Among 980 patients,790 were included(prophylaxis:232,non-prophylaxis:558).Most patients were males under the age of 65 years with a median Child-Pugh score of *** composite primary outcomes occurred in 11.2%of patients in the prophylaxis group and 9.5%in the non-prophylaxis *** significant differences in outcomes were observed between the groups(adjusted odds ratio,1.11;95%confidence interval,0.61-1.99;P=0.74).Individual outcomes such as 6-wk mortality,4-wk rebleeding,4-wk onset of SBP,and in-hospital mo

关键词： Esophageal varices Endoscopic hemostasis Antibiotic prophylaxis Liver cirrhosis Inverse probability of treatment weighting

将骨SPECT的图像数据投射到三维容积再现CT图像上获得三维SPECT/CT融合图像:可行性及在骨转移性病变诊断上的作用

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中华核医学与分子影像杂志 2017年第12期37卷 827-827页

作者：唐军 Yuji Ogata Tadaki Nakahara Kenichi Ode Yohji Matsusaka Mari Katagiri Yu Iwabuchi kazunari itoh Akira Ichimura Masahiro Jinzaki 上海交通大学附属苏州九龙医院核医学科 Department of Diagrtostic Radiology School of MedicineKeio University

目的建立一种图像数据投影的方法,即把骨SPECT的图像数据投射到三维容积再现CT图像上,从而获得三维SPECT/CT融合图像。评价该方法的可行性和临床应用价值。方法对318例癌症患者进行全身骨显像和SPECT/CT骨显像。骨SPECT和CT的容积数据... 详细信息

目的建立一种图像数据投影的方法,即把骨SPECT的图像数据投射到三维容积再现CT图像上,从而获得三维SPECT/CT融合图像。评价该方法的可行性和临床应用价值。方法对318例癌症患者进行全身骨显像和SPECT/CT骨显像。骨SPECT和CT的容积数据进行融合得到二维SPECT/CT图像。经半自动骨图像提取后,骨SPECT的彩色体素数据被投射到相应部位的容积再现CT数据上,由此获得三维SPECT/CT图像。该三维图像融合了常规容积再现的CT图像,可在三维空间上反映出骨代谢和解剖之间的关系。全身显像和SPECT、二维SPECT/CT融合图像和三维SPECT/CT融合图像均由2位医师独立阅片,并作出是否有骨转移的诊断。阅片者间的差异和诊断准确性用4点诊断量表来评价。结果共在744个转移性病灶和1 002个良性病灶中发现骨代谢增高。就单个病灶而言,阅片者间诊断为骨转移的一致性分别是:全身显像和SPECT为0.72,二维SPECT/CT融合图像为0.90,三维SPECT/CT融合图像为0.89。对骨转移诊断准确性的受试者工作特征(ROC)分析结果表明:阅片者1全身显像和SPECT、二维SPECT/CT融合图像和三维SPECT/CT融合图像曲线下面积分别为0.800、0.983和0.983,阅片者2的相应参数分别为0.865、0.992和0.993,其中全身显像和SPECT与二维或三维SPECT/CT相比P<0.001,而二维与三维SPECT/CT相比差异无统计学意义。阅片者1阅读全身显像和SPECT、二维SPECT/CT融合图像和三维SPECT/CT融合图像所需的时间分别为(241±75)、(225±73)和(182±71)s,阅读者2的相应时间分别为(207±72)、(190±73)和(179±73)s。结果显示阅读三维SPECT/CT图像的时间较二维SPECT/CT或全身显像和SPECT所需时间短(均P<0.000 1)。结论与二维SPECT/CT融合图像相比,三维SPECT/CT融合图像的诊断准确性更好,且阅片时间更短。

关键词： SPECT/CT 容积再现三维图像融合骨转移

Need for pancreatic stenting after sphincterotomy in patients with difficult cannulation

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World Journal of Gastroenterology 2014年第26期20卷 8617-8623页

作者： kazunari Nakahara Chiaki Okuse Keigo Suetani Yosuke Michikawa Shinjiro Kobayashi Takehito Otsubo Fumio itoh Department of Gastroenterology and Hepatology St. Marianna University School of Medicine Department of Gastroenterological and General Surgery St. Marianna University School of Medicine

AIM: To investigate the need for pancreatic stenting after endoscopic sphincterotomy (EST) in patients with difficult biliary cannulation.

关键词： Pancreatic stenting Pancreatic guidewire placement Post-endoscopic retrograde cholangiopancreatography pancreatitis Endoscopic sphincterotomy Endoscopic retrograde cholangiopancreatography

Crowned dens syndrome developed after an endoscopic retrograde cholangiopancreatography procedure

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World Journal of Gastroenterology 2016年第39期22卷 8849-8852页

作者： Hiroyasu Nakano kazunari Nakahara Yosuke Michikawa Keigo Suetani Ryo Morita Nobuyuki Matsumoto Fumio itoh Division of Gastroenterology and Hepatology Department of Internal Medicine St. Marianna University School of Medicine

We present a unique case of crowned dens syndrome(CDS) that developed after endoscopic retrograde cholangiopancreatography(ERCP) in a patient who presented with fever and neck pain. Administration of non-steroidal anti-inflammatory drugs was extremely effective for relieving fever and neck pain, and in the improvement of inflammatory markers. To the best of our knowledge, this is the first case report of CDS caused by an ERCP procedure. In a patient with fever and neck pain after an ERCP procedure, CDS should be considered in the differential diagnosis.

关键词： Acute cholangitis Pseudogout Endoscopic retrograde cholangiopancreatograhy Crowned dens syndrome

Response of plasma turbulence against externally-controlled perturbations

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Chinese Physics B 2012年第9期21卷 385-395页

作者： S. I. itoh K. itoh Research Institute for Applied Mechanics Kyushu University itoh Research Center for Plasma Turbulence Kyushu University National Institute for Fusion Science

A theory of the dynamic response of the turbulent plasma against the externally-controlled perturbations is reported. Based on Mori＇s method [Prog. Theor. Phys. 33 423 （1965）], the nonlinear force is assmned to be separated into the memory function and the nonlinear fluctuating force. The former corresponds to the damping term, and the latter is categorized into the noise term. The response of the turbulent plasma against the externally-controlled source is formulated. The response kernel, which connects the externally-controlled source and the response of the turbulent field, is shown to have both the nonlocal property （in space） and the non-Markovian response （in time）. A discussion is made on the nonlocal and non-Markovian response, including the case of disparate-scale interactions. A new method is proposed to observe experimentally the nonlocal interaction in the drift wave turbulence via the zonal flows.

关键词： turbulent transport nonlocal and non-Markovian response

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Measurements of the Ca II infrared triplet lines of young stellar objects

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Research in Astronomy and Astrophysics 2013年第10期13卷 1189-1201页

作者： Yoichi itoh Keiko Moto'oka Yoichi itoh The Saga Prefecture Space & Science Museum 16351 Nagashima Takeo Takeo Saga 843-0021 Japan Nishi-Harima Astronomical Observatory Center for Astronomy University of Hyogo 407-2 Nishigaichi Sayo Hyogo 679-5313 Japan yitoh @nhao.jp

Equivalent widths and line widths of Ca II infrared triplet emission lines were measured in the high-resolution optical spectra of 39 young stellar *** found that the equivalent widths of the emission lines decrease with stellar *** has often been claimed that strong chromospheric activity is generated by a dynamo process caused by fast rotation of the ***,we found no clear correlation between the strength of the Ca II lines and the stellar rotation ***,we found that the objects with high mass accretion rates had stronger Ca II emission *** correlation supports the turbulent chromosphere model or the magnetic accretion theory for classical T Tauri *** also noticed that the equivalent widths of Ca II lines in transitional disk objects are one-tenth of those in classical T Tauri stars,even if the masses of the circumstellar disks are comparable.

关键词： stars:pre-main sequence stars:emission lines

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Heavy Ion Beam Probe Measurement in Turbulence Diagnostic Simulator

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Plasma Science and Technology 2011年第3期13卷 326-331页

作者： Naohiro KASUYA Seiya NISHIMURA Masatoshi YAGI Kimitaka itoh Sanae-I itoh National Institute for Fusion Science 322-60roshi-cho Toki Gifu 509-5292 Japan Research Institute for Applied Mechanics Kyushu University 6-1 Kasuga-kouen KasugaFukuoka 816-8580 Japan Japan Atomic Energy Agency 801-1 Mukoyama Naka Ibaraki 311-0193 Japan

A numerical measurement module simulating a heavy ion beam probe was developed, and numerical measurements of electrostatic potential and density fluctuations are carried out for 3-D turbulent data generated by a global simulation of drift-interchange mode turbulence in helical plasmas. The deviation between measured and local values is estimated. It is found that the characteristic structures can be detected in spite of the screening effect due to the finite spatial resolution.

关键词： turbulence structural formation numerical simulation heavy ion beamprobe fluctuation spatial resolution

Fatigue Property of Additively Manufactured Ti-6Al-4V under Nonproportional Multiaxial Loading

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 76-84页

作者： Yuya Kimura Fumio Ogawa Takamoto itoh Graduate School of Science&Engineering Ritsumeikan UniversityShiga 5258577Japan Fracture and Reliability Research Institute Graduate School of Tohoku UniversityMiyagi 9808579Japan Department of Mechani-cal Engineering Ritsumeikan UniversityShiga 5258577Japan

The low cycle fatigue strength properties of the additively manufactured Ti-6Al-4V alloy are experimentally investi-gated under proportional and nonproportional multiaxial *** fatigue tests were conducted using hollow cylinder specimens with and without heat treatments,at room temperature in *** fatigue tests were conducted:one for proportional loading and one for nonproportional *** proportional loading was represented by a push-pull strain path(PP)and the nonproportional loading by a circle strain path(Cl).The failure lives of the additively manufactured specimens were clearly reduced drastically by internal voids and ***,the sizes of the defects were measured,and the defects were found not to cause a reduction in fatigue strength above a critical *** fracture surface was observed using scanning electron microscopy to investigate the fracture mechanisms of the additively manufactured specimens under the two types of strain *** fracture patterns were recognized for each strain paths;however,both showed retention of the crack propagation,despite the presence of numerous defects,probably because of the interaction of the *** crack propagation properties of the materials with numerous defects under nonproportional multiaxial loading were clarified to increase the reliability of the additively manufactured components.

关键词： Additive manufacturing Ti-6Al-4V Low cycle fatigue Multiaxial stress Nonproportional loading Internal defect

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The Coincidence of Critical Day Length Recognition for Florigen Gene Expression and Floral Transition under Long-Day Conditions in Rice

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Molecular Plant 2013年第3期6卷 635-649页

作者： Hironori itoh Takeshi Izawa National Institute of Agrobiological Sciences Functional Plant Research Unit 2-1-2 Kannondai Tsukuba 305-8602 Japan

The photoperiodic control of flowering time is essential for the adaptation of plants to variable environments and for successful reproduction. The identification of genes encoding florigens, which had been elusive but were supposedly synthesized in leaves and then transmitted to shoot apices to induce floral transitions, has greatly advanced our understanding of the photoperiodic regulation of flowering. Studies on the photoperiodism of Arabidopsis, a model long-day plant, revealed the molecular mechanisms regulating the expression of the Arabidopsis florigen gene FT, which is gradually induced in response to increase in day length. By contrast, in rice, a model short-day plant, the expression of the florigen gene Hd3a （an FTortholog in rice） is regulated in an on/off fashion, with strong induction under short-day conditions and repression under long-day conditions. This critical day length dependence of Hd3a expression enables rice to recognize a slight change in the photoperiod as a trigger to initiate floral induction. Rice possesses a second florigen gene, RFT1, which can be expressed to induce floral transition under non-inductive long-day conditions. The complex transcriptional regulation of florigen genes and the resulting precise control over flowering time provides rice with the adaptability required for a crop species of increasing global importance.

关键词： florigen photoperiodic flowering critical day length recognition gating mechanism rice breeding.