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Minimally invasive surgery for upper gastrointestinal cancer: Our experience and review of the literature

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World Journal of Gastroenterology 2016年第19期22卷 4626-4637页

作者： Koichi Suda Masaya Nakauchi kazuki inaba Yoshinori Ishida Ichiro Uyama Division of Upper GI Department of Surgery Fujita Health University

Minimally invasive surgery (MIS) for upper gastrointestinal (GI) cancer, characterized by minimal access, has been increasingly performed worldwide. It not only results in better cosmetic outcomes, but also reduces intraoperative blood loss and postoperative pain, leading to faster recovery; however, endoscopically enhanced anatomy and improved hemostasis via positive intracorporeal pressure generated by CO2 insufflation have not contributed to reduction in early postoperative complications or improvement in long-term outcomes. Since 1995, we have been actively using MIS for operable patients with resectable upper GI cancer and have developed stable and robust methodology in conducting totally laparoscopic gastrectomy for advanced gastric cancer and prone thoracoscopic esophagectomy for esophageal cancer using novel technology including da Vinci Surgical System (DVSS). We have recently demonstrated that use of DVSS might reduce postoperative local complications including pancreatic fistula after gastrectomy and recurrent laryngeal nerve palsy after esophagectomy. In this article, we present the current status and future perspectives on MIS for gastric and esophageal cancer based on our experience and a review of the literature.

关键词： Stomach neoplasms Esophageal neoplasms Minimally invasive surgical procedures Postoperative complications Robotic surgical procedures

Non-robotic minimally invasive gastrectomy as an independent risk factor for postoperative intra-abdominal infectious complications: A single-center, retrospective and propensity score-matched analysis

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World Journal of Gastroenterology 2020年第11期26卷 1172-1184页

作者： Susumu Shibasaki Koichi Suda Masaya Nakauchi Kenichi Nakamura Kenji Kikuchi kazuki inaba Ichiro Uyama Department of Surgery Fujita Health UniversityToyoake 470-1192AichiJapan Collaborative Laboratory for Research and Development in Advanced Surgical Technology Fujita Health University School of MedicineToyoake 470-1192AichiJapan

BACKGROUND Minimally invasive surgery for gastric cancer(GC) has gained widespread use as a safe curative procedure especially for early *** To determine risk factors for postoperative complications after minimally invasive gastrectomy for *** Between January 2009 and June 2019, 1716 consecutive patients were referred to our division for primary GC. Among them, 1401 patients who were diagnosed with both clinical and pathological Stage Ⅲ or lower GC and underwent robotic gastrectomy(RG) or laparoscopic gastrectomy(LG) were enrolled. Retrospective chart review and multivariate analysis were performed for identifying risk factors for postoperative *** Morbidity following minimally invasive gastrectomy was observed in 7.5% of the patients. Multivariate analyses demonstrated that non-robotic minimally invasive surgery, male gender, and an operative time of ≥ 360 min were significant independent risk factors for morbidity. Therefore, morbidity was compared between RG and LG. Accordingly, propensity-matched cohort analysis revealed that the RG group had significantly fewer intra-abdominal infectious complications than the LG group(2.5% vs 5.9%, respectively;P = 0.038), while no significant differences were noted for other local or systemic *** analyses of the propensity-matched cohort revealed that non-robotic minimally invasive surgery [odds ratio = 2.463(1.070–5.682);P = 0.034] was a significant independent risk factor for intra-abdominal infectious *** The findings showed that robotic surgery might improve short-term outcomes following minimally invasive radical gastrectomy by reducing intra-abdominal infectious complications.

关键词： Stomach neoplasms Gastrectomy Robotic surgical procedure Minimally invasive procedures Morbidity Pancreatic fistula

Pneumatosis cystoides intestinalis associated with massive free air mimicking perforated diffuse peritonitis

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World Journal of Gastroenterology 2008年第43期14卷 6753-6756页

作者： Yoichi Sakurai Masahiro Hikichi Jun Isogaki Shinpei Furuta Risaburo Sunagawa kazuki inaba Yoshiyuki Komori Ichiro Uyama Department of Surgery Fujita Health University School of MedicineToyoake Aichi 470-1192Japan

While pneumatosis cystoides intestinalis （PCI） is a rare disease entity associated with a wide variety of gastrointestinal and non-gastrointestinal disorders, PCI associated with massive intra- and retroperitoneal free air is extremely uncommon, and is difficult to diagnose differentially from perforated peritonitis. We present two cases of PCI associated with massive peritoneal free air and/or retroperitoneal air that mimicked perforated peritonitis. These cases highlight the clinical importance of PCI that mimics perforated peritonitis, which requires emergency surgery. Preoperative imaging modalities and diagnostic laparoscopy are useful to make an accurate diagnosis.

关键词： Pneumatosis cystoides intestinalis Perforated peritonitis Corticosteroid therapy Peritonealfree air

Prognostic factors of minimally invasive surgery for gastric cancer: Does robotic gastrectomy bring oncological benefit?

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World Journal of Gastroenterology 2021年第39期27卷 6659-6672页

作者： Masaya Nakauchi Koichi Suda Susumu Shibasaki Kenichi Nakamura Shinichi Kadoya Kenji Kikuchi kazuki inaba Ichiro Uyama Department of Gastroenterological Surgery Fujita Health UniversityToyoake 470-1192AichiJapan Department of Gastroenterological Surgery Ishikawa Prefectural Central HospitalKanazawa 920-8535IshikawaJapan

BACKGROUND Gastric cancer is the third leading cause of cancer-related death worldwide and surgical resection remains the sole curative treatment for gastric *** invasive gastrectomy including laparoscopic and robotic approaches has been increasingly used in a few *** far,only a few reports have investigated the oncological outcomes following minimally invasive *** To determine the 5-year survival following minimally invasive gastrectomy for gastric cancer and identify prognostic *** This retrospective cohort study identified 939 patients who underwent gastrectomy for gastric cancer during the study *** excluding 125 patients with non-curative surgery(n=77),other synchronous cancer(n=2),remnant gastric cancer(n=25),insufficient physical function(n=13),and open gastrectomy(n=8),a total of 814 consecutive patients with primary gastric cancer who underwent minimally invasive R0 gastrectomy at our institution between 2009 and 2014 were retrospectively ***,5-year overall and recurrence-free survival were analyzed using the Kaplan–Meier method with the log-rank test and Cox regression analyses,while factors associated with survival were determined using multivariate *** Our analysis showed that age>65 years,American Society of Anesthesiologists(ASA)physical status 3,total or proximal gastrectomy,and pathological T4 and N positive status were independent predictors of both 5-year overall and recurrencefree ***,the included patients had a 5-year overall and recurrence-free survival of 80.3%and 78.2%,*** the 814 patients,157(19.3%)underwent robotic gastrectomy,while 308(37.2%)were diagnosed with pathological stage II or III ***,our findings showed that robotic gastrectomy was an independent positive predictor for recurrence-free survival in patients with pathological stage II/III[hazard ratio:0.56(0.33-0.96),P=0.035].Comparison of recurrence-fre

关键词： Laparoscopy Gastric cancer Minimally invasive surgery Prognostic factor Stomach neoplasms

Preparation of Lanthanum Nickel Oxide-Coated Ni Sheet Anodes and Their Application to Electrolytic Production of (CF_3)_3N in (CH_3)_4NF·4.0HF Melt

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Journal of Rare Earths 2006年第1期24卷 1-8页

作者： Yoshio Shodai Minoru inaba kazuki Onoda Akimasa Tasaka Department of Molecular Science and Technology Faculty of Engineering Doshisha University Kyotanabe Kyoto 610-0321 Japan

A new process for electrolytic production of a perfluorinated compound, （CF3）3N, using lanthanum nickel oxide-coated Ni sheet anode in the （CH3）4NF· 4.0HF melt at room temperature, was developed. Thin films of the lanthanum nickel oxides were prepared on Ni sheets by sol-gel coating method using polyvinlylpyrrolidone（PVP）. The main components of the thin films were La2O3, LaNiO3, and La2NiO4 at 500, 750 and 1000℃, respectively. The anode performance in the （CH3）4NF·4.0HF melt depends greatly on the main component of the thin film, and the LaNiO3-coated Ni sheet anode gives the best anode performance. The potential of LaNiO3-coated Ni sheet anode remains constant at 5.9 V during electrolysis at 20 mA·cm^-2 in the （CH3）4NF·4.0HF melt for 100 h. This is because LaNiO3 and NiF3 and/or Ni2F5, the latter of which was formed during electrolysis, in the film give a high electronic conductivity to the surface film during electrolysis. The maximum mole fraction of （CF3）3N （21.4%） was obtained at 20 mA·cm^-2 in （CH3）4NF·4.0HF melt using the LaNiO3-coated Ni sheet.

关键词： electrolytic perfluorination lanthanum nickel oxide perfluorotrimethylamine rare earths

Numerical Simulation of Sand Erosion Phenomena in Rotor/Stator Interaction of Compressor

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Journal of Thermal Science 2008年第2期17卷 125-133页

作者： Masaya Suzuki Kazuaki inaba Makoto Yamamoto Department of Mechanical Engineering Tokyo University of Science

Sand erosion is a phenomenon where solid particles impinging to a wall cause serious mechanical damages to the wall surface. This phenomenon is a typical gas-particle two-phase turbulent flow and a multi-physics problem where the flow field, particle trajectory and wall deformation interact with each other. On the other hand, aircraft engines operating in a particulate environment are subjected to the performance and lifetime deterioration due to sand erosion. Especially, the compressor of the aircraft engines is severely damaged. The flow fields of the compressor have strongly three dimensional and unsteady natures. In order to estimate the deterioration due to sand erosion, the sand erosion simulation for a compressor is required under the consideration of the rotor-stator interaction. In the present study, we apply our three dimensional sand erosion prediction code to a single stage axial flow compressor. We numerically investigate the change of the flow field, the particle trajectories, and the eroded wall shape in the compressor, to clarify the effects of sand erosion in the compressor.

关键词： sand erosion axial compressor rotor/stator interaction computational fluid dynamics

3D Computation of Hydrogen-Fueled Combustion around Turbine Blade-Effect of Arrangement of Injector Holes

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Journal of Thermal Science 2006年第3期15卷 233-239页

作者： Makoto YAMAMOTO Junichi IKEDA Kazuaki inaba Department of Mechanical Engineering Tokyo University of Science 1-3 KagurazakaShinjuku-kuTokyo162-8601Japan Graduate School of Mechanical Engineering Tokyo University of Science 1-3 KagurazakaShinjuku-kuTokyo162-8601Japan

Recently, a number of environmental problems caused from fossil fuel combustion have been focused on. In addition, with the eventual depletion of fossil energy resources, hydrogen gas is expected to be an alternative energy resource in the near future. It is characterized by high energy per unit weight, high reaction rate, wide range of flammability and the low emission property. On the other hand, many researches have been underway in several countries to improve a propulsion system for an advanced aircraft. The system is required to have higher power, lighter weight and lower emissions than existing ones. In such a future propulsion system, hydrogen gas would be one of the promising fuels for realizing the requirements. Considering these backgrounds, our group has proposed a new cycle concept for hydrogen-fueled aircraft propulsion system. In the present study, we perform 3 dimensional computations of turbulent flow fields with hydrogen-fueled combustion around a turbine blade. The main objective is to clarify the influence of arrangement of hydrogen injector holes. Changing the chordwise and spanwise spacings of the holes, the 3 dimensional nature of the flow and thermal fields is numerically studied.

关键词： computational fluid dynamics turbine blade hydrogen combustion injector hole arrangement

Numerical Simulation of Tip Leakage Vortex Effect on Hydrogen-Combustion Flow around 3D Turbine Blade

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Journal of Thermal Science 2008年第2期17卷 186-192页

作者： Naoto Miyama Kazuaki inaba Makoto Yamamoto Department of Mechanical Engineering Tokyo University of Science Graduate Aeronautical Laboratories California Institute of Technology

In these years, a lot of environmental problems such as air pollution and exhaustion of fossil fuels have been discussed intensively. In our laboratory, a hydrogen-fueled propulsion system has been researched as an alternative to conventional systems. A hydrogen-fueled propulsion system is expected to have higher power, lighter weight and lower emissions. However, for the practical use, there exist many problems that must be overcome. Considering these backgrounds, jet engines with hydrogen-fueled combustion within a turbine blade passage have been studied. Although some studies have been made on injecting and burning hydrogen fuel from a stator surface, little is known about the interaction between a tip leakage vortex near the suction side of a rotor tip and hydrogen-fueled combustion. The purpose of this study is to clarify the influence of the tip leakage vortex on the characteristics of the 3-dimensional flow field with hydrogen-fueled combustion within a turbine blade passage. Reynolds-averaged compressible Navier-Stokes equations are solved with incorporating a k-ε turbulence and a reduced chemical mechanism models. Using the computational results, the 3-dimensional turbulent flow field with chemical reactions is numerically visualized, and the three-dimensional turbulent flow fields with hydrogen combustion and the structure of the tip leakage vortex are investigated.

关键词： numerical simulation CFD gas turbine hydrogen combustion tip leakage vortex

Electron scattering by Friedel oscillations in carbon nanotubes

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Nano Research 2022年第2期15卷 889-897页

作者： Takumi inaba Takahiro Morimoto Satoshi Yamazaki Toshiya Okazaki CNT-Application Research Center National Institute of Advanced Industrial Science and TechnologyTsukuba 305-8565Japan Research Association of High-Throughput Design and Development for Advanced Functional Materials Tsukuba 305-8565Japan

Multi-walled carbon nanotube networks were confirmed to exhibit a linear decrease in resistivity with increasing temperature from 100 to above 400 *** linearity was explained using a defect scattering model that involved Friedel oscillations(that is,electron-electron interactions).The applicability of this model,which was originally proposed for graphene,to carbon nanotubes was assessed based on a comparison of various experimental *** in the slopes of the resistivity-temperature plots following the introduction of defects,as well as an effect of charge concentration on the slope were key predictions of this *** results obtained from few-walled carbon nanotube networks are also *** the literature,linear resistivity-temperature plots were obtained from other graphene derivatives,indicating that the linearity originates from the hexagonal symmetry of these *** present work also indicated a relationship between the appearance of linearity and negative magnetoresistance above 100 *** on a mechanism incorporating scattering in association with Friedel oscillations and conventional electron conduction models,the universality of resistivity-temperature plots obtained from carbon nanotube networks is introduced.

关键词： carbon nanotube electron transport electron-electron interaction Friedel oscillations magnetoresistance