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Pedunculated gastric tube interposition in an esophageal cancer patient with prepyloric adenocarcinoma

World Journal of Gastrointestinal Oncology 2011年第5期3卷 75-78页

作者： Tatsuo Kanda Yu Sato kazuhito yajima Shin-ichi Kosugi Atsushi Matsuki Takashi Ishikawa Takeo Bamba Hajime Umezu Tsutomu Suzuki Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Division of Cellular and Molecular Pathology Niigata University Graduate School of Medical and Dental Sciences Department of Nursing School of Health ScienceNiigata University

Gastric carcinoma is one of the malignancies that are most frequently associated with esophageal *** describe herein our device for advanced esophageal cancer associated with early gastric cancer in the antrum.A 57-year-old man presenting with dysphagia and upper abdominal pain was admitted to our *** examinations revealed locally advanced squamous cell carcinoma (SCC) of the middle thoracic esophagus (T3N0M0 Stage ⅡA) and mucosal signetring cell carcinoma of the gastric antrum (T1N0M0 Stage ⅠA).Although the gastric tumor appeared to be an intramucosal carcinoma,its margin was obscure,so endoscopic en-bloc resection was considered *** chose surgical resection of the gastric tumor as well as the esophageal SCC after neoadjuvant chemotherapy with 5-fluorouracil and cisplatin for advanced esophageal *** transthoracic esophagectomy with three-field lymph node dissection,the gastric carcinoma was removed by gastric antrectomy,which preserved the right gastroepiploic vessels,and a pedunculated short gastric tube was used as the esophageal ***-eight months after the surgery,the patient is well with no evidence of cancer *** it minimizes surgical stress and organ sacrifice,gastric tube interposition is a potentially useful technique for esophageal cancer associated with localized early gastric cancer.

关键词： Antrectomy Early gastric cancer Esophageal cancer Esophageal reconstruction Gastric tube

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Successful treatment for esophageal carcinoma with lung metastasis by induction chemotherapy followed by salvage esophagectomy: Report of a case

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World Journal of Gastroenterology 2006年第25期12卷 4101-4103页

作者： Shin Ichi Kosugi Tatsuo Kanda Tadashi Nishimaki Satoru Nakagawa kazuhito yajima Manabu Ohashi Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata CityJapan First department of Surgery Faculty of Medicine University of the RyukyusOkinawaJapan

We here report a case of a 51-year-old man with lung metastasis from esophageal carcinoma that was initially treated by combination chemotherapy consisting of fluorouracil and nedaplatin. Because metastatic disease disappeared, salvage esophagectomy was performed. Although chest wall recurrence developed at the thoracotomy wound, prolonged survival of 48 months was achieved by local tumor resection and additional chemotherapy. This combination chemotherapy is regarded as a promising and considerable treatment for metastatic esophageal carcinoma.

关键词： Esophageal carcinoma Lung metastasis Induction chemotherapy Fluorouracil Nedaplatin Salvage esophagectomy

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Serum Intestinal Fatty Acid Binding Protein in Patients with Small Bowel Obstruction

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Surgical Science 2013年第6期4卷 302-307页

作者： Kaoru Sakamoto Tatsuo Kanda Takeo Bamba Hiroyuki Funaoka Shin-ichi Kosugi kazuhito yajima Takashi Ishikawa Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan DS Pharma Biomedical Co. Ltd. Osaka Japan

Purpose: The aims of this pilot study were to reveal the biological characteristics of serum I-FABP and explore its clinical utility as a biomarker in patients with small bowel obstruction (SBO). Methods: Serum I-FABP levels were measured in 37 consecutive patients with SBO between 2007 and 2008. Serum I-FABP levels were compared between ischemia (n = 10) and non-ischemia (n = 27) groups. Serum I-FABP levels were longitudinally analyzed in 21 patients who showed high (>2.0 ng/ml) serum I-FABP levels. The relationship between serum I-FABP level and length of damaged bowel was also analyzed. Results: Median serum I-FABP levels were 9.2 ng/ml in the ischemia group and 1.9 ng/ml in the non-ischemia group (p < 0.0001). The elevated I-FABP levels rapidly decreased after therapeutic intervention and normalized on the third day in all patients. Linear regression analysis revealed a positive correlation between I-FABP levels and lengths of surgically excised bowels (y = 2.527x - 7.660, r = 0.604, p = 0.0018). By setting the cutoff level at 7.2 ng/ml, the diagnostic ability of serum I-FABP was 70.0% in terms of sensitivity, 92.6% in terms of specificity, and 86.5% in terms of accuracy. Conclusion: Serum I-FABP sensitively reflects bowel damage in SBO patients and seems to be a potential biomarker for detecting small-bowel ischemia.

关键词： Biomarker I-FABP Small Bowel Obstruction Strangulation

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Gastric cancer surgery for patients with liver cirrhosis

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World Journal of Gastrointestinal Surgery 2009年第1期1卷 49-55页

作者： Yoshiyuki Ikeda Tatsuo Kanda Shin-ichi Kosugi kazuhito yajima Atsushi Matsuki Tsutomu Suzuki Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Department of Nursing School of Health SciencesNiigata University

AIM:To elucidate the influence of liver cirrhosis(LC) on the prognosis of patients with gastric cancer(GC).METHODS:Of the 1347 GC patients who underwent curative gastrectomy for GC between January 1984 and June 2007,25 patients(21 men and 4 women with a median age of 67 years;range 54-77 years) with LC were enrolled in this *** the Child-Pugh classification,15 patients were evaluated as grade A and 10 patients as grade *** grade C patient underwent gastrectomy in this *** outcomes,including postoperative morbidity and survival,were retrospectively analyzed based on medical records and surgical f ***:There was no significant difference in operative blood loss and perioperative blood transfusion between the two *** most common postoperative complication was intractable ascites,which was the single postoperative morbidity noted more frequently in grade B patients(40.0%) than in grade A patients(6.7%) with statistical signif icance(P = 0.041).Operative mortality due to hepatic failure was seen in one grade A *** patients had hepatocellular carcinoma(HCC) at presentation and two patients developed HCC after *** 5-year survival rate was 58.9% in patients with early GC and 33.3% in patients with advanced GC(P = 0.230).GC-specific 5-year survival rate of early GC patients was 90.0% while that of advanced GC patients was 58.3%(P = 0.010).Four patients with early GC died of uncontrolled HCC,of which two were synchronous and two ***:The risk of postoperative intractable ascites is high,particularly in grade B *** detection and complete control of HCC is vital to improve a patient's prognosis.

关键词： Gastric cancer Liver dysfunction Surgery

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Intrathoracic esophagojejunostomy using OrVil^(TM) for gastric adenocarcinoma involving the esophagus

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World Journal of Gastrointestinal Surgery 2014年第12期6卷 235-240页

作者： kazuhito yajima Tatsuo Ka Shin-ichi Kosugi Yosuke Kano Takashi Ishikawa Hiroshi Ichikawa Takaaki Hanyu Toshifumi Wakai Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences

AIM: To demonstrate a new surgical technique of lower mediastinal lymphadenectomy and intrathoracic anastomosis of esophagojejunostomy using OrV il^(TM). METHODS: After a total median phrenotomy, the supradiaphragmatic and lower thoracic paraesophageal lymph nodes were transhiatally dissected. The esophagus was cut off using a liner stapler and OrV il^(TM)was inserted. Finally, end-to-side esophagojejunostomy was created by using a circular stapler. From July 2009,we adopted this surgical technique for five patients with gastric cancer involving the lower esophagus. RESULTS: The median operation time was 314 min(range; 210-367 min), and median blood loss was 210 mL(range; 100-838 mL). The median numbers of dissected lower mediastinal nodes were 3(range; 1-10). None of the patients had postoperative complications including anastomotic leakage and stenosis. Themedian hospital stay was 16 d(range: 15-20 d). The median length of esophageal involvement was 14 mm(range: 6-48 mm) and that of the resected esophagus was 40 mm(range: 35-55 mm); all resected specimens had tumor-free ***: This surgical technique is easy and safe intrathoracic anastomosis for the patients with gastric adenocarcinoma involving the lower esophagus.

关键词： Gastric cancer Esophageal invasion Lower mediastinal lymphadenectomy Or Vil^(TM) Intrathoracic anastomosis

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Endobronchial metastasis from adenocarcinoma of gastric cardia 7 years after potentially curable resection

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World Journal of Gastrointestinal Surgery 2010年第8期2卷 270-274页

作者： Takaaki Hanyu Tatsuo Kanda Atsushi Matsuki Go Hasegawa kazuhito yajima Masanori Tsuchida Shin-ichi Kosugi Makoto Naito Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Division of Cellular and Molecular Pathology Niigata University Graduate School of Medical and Dental Sciences Division of Thoracic and Cardiovascular Surgery Niigata University Graduate School of Medical and Dental Sciences

Endobronchial metastasis(EBM) is a rare form of metas-tasis from extrapulmonary malignant tumors,although there are few reports of EBM from gastric cancer *** report the case of a 51-year-old woman who had undergone gastrectomy for advanced gastric cancer seven years previously but was diagnosed with a solitary lung tumor by follow-up computed *** diagnosis of primary lung cancer,she underwent pulmonary lobectomy,but immunohistochemical examination confirmed the resected tumor to be an EBM from the gastric *** months later,she was diagnosed with peritoneal metastases and underwent chemotherapy with gastric cancer *** is still alive at 33 mo after the ***,the prognosis for EBM is poor although multidisciplinary treatment can lead to long-term *** diagnosis on the basis of detailed pathological and immunohistochemical evaluation can contribute to deciding the most effective treatment and improving prognosis.

关键词： Endobronchial metastasis Immunohisto-chemistry Gastric cancer

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Using a Musculoskeletal Mathematical Model to Analyze Fatigue of the Muscles in the Lower Limbs during Different Motions

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Computer Modeling in Engineering & Sciences 2018年第2期114卷 191-207页

作者： Kaito Watanabe Masaki Izawa Ayumi Takahashi kazuhito Misaji College of Industrial Technology Nihon University

Under the aim of finding effective rehabilitation solutions,the difference between the extents of fatigue of each muscle used in different motions are *** research suggested methods for estimating muscle torque and muscle tension on the basis of a musculoskeletal *** a result,it has become possible to quantitatively identify the extent of fatigue in each muscle during ***,to evaluate muscle fatigue more quantitatively,driving power and angular momentum are focused *** on the driving torque of joints and the muscle torque calculated by using a three-dimensional musculoskeletal model,a method for calculating the driving power of joints and the angular momentum of a muscle is *** method is applied to analysis of different ***,fatigue of muscles is quantitatively analyzed on the basis of driving power and angular momentum.

关键词： Angular momentum driving power driving torque musculoskeletal model

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Quantifying Roll Feel of a Car by Using a Musculoskeletal Mathematical Model

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Computer Modeling in Engineering & Sciences 2019年第3期118卷 493-507页

作者： Masaki Izawa Ryota Araki Tatsuro Suzuki Kaito Watanabe kazuhito Misaji Showa Corporation 112-1 Haga-daiHaga-machHaga-gunTochigiJapan Ex-Graduate Student Nihon UniversityCollege of Industrial TechnologyDepartment of Mathematical Information EngineeringJapan Nihon University College of Industrial TechnologyDepartment of Mathematical Information EngineeringJapan

Primary purpose of this research is to create a three-dimensional musculoskeletal mathematical model of a driver of a car using a motion capture *** model is then used in an analysis of drive torque around joints and attached muscles as a vehicle travels in different travel modes and damping force settings to examine‘burdens’for the *** studies proposed a method of quantifying the degree of musculoskeletal load in simple human motion from the changes in drive torque around joints and attached ***,examination of the level of burdens for the driver while driving using this method does not seem to *** within the scope of evaluating different travel modes and dampers,there is no other *** of this study are hence a valuable new perspective on quantitative analysis of the burdens for the driver’s joints and muscles depending on the different settings of travel modes and dampers.

关键词： Human engineering biomechanics musculoskeletal mathematical model driving torque motion capture

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Hydriding properties of uranium alloys for purposes of searching for new hydrogen storage materials

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Nuclear Science and Techniques 2015年第1期26卷 121-126页

作者： Michio Yamawaki Takuya Yamamoto Yuji Arita Fumihiro Nakamori kazuhito Ohsawa Kenji Konashi Research Institute of Nuclear Engineering University of Fukui1-2-4 Kanawa-cho Tsuruga Fukui 914-0055 Japan Research Institute for Applied Mechanics Kyushu University6-1 Kasuga-koen Kasuga Fukuoka 816-8580 Japan Institute for Materials Research Tohoku University 2145-2 Narita-choOarai Higashi-Ibaragi-gun Ibaragi 311-1313 Japan

Hydriding properties of uranium alloys have been studied to search for new hydrogen storage materials to be applied to hydrogen energy systems. Application of uranium-base hydrogen storage materials can be expected to alleviate the risk, as well as to reduce the cost incurred by globally-stored large amounts of depleted uranium left after uranium enrichment. Various uranium alloys have been examined in terms of hydrogen absorptiondesorption properties, among which UNi Al intermetallic compound showed promising characteristics, such as lower absorption-desorption temperatures and better anti-powdering strength. First principle calculation has been carried out on UNi Al hydride to predict the change of crystal structure and the lattice constant with increasing hydrogen content, which showed this calculation to be promising in predicting candidates for good hydrogen absorbers.

关键词：氢化性能储氢材料铀合金第一原理计算金属间化合物能源系统解吸温度晶格常数

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Curvature derived from LiDAR digital elevation models as simple indicators of debris-flow susceptibility

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Journal of Mountain Science 2019年第1期16卷 95-107页

作者： Atsuko NONOMURA Shuichi HASEGAWA Hideo MATSUMOTO Mari TAKAHASHI Mina MASUMOTO kazuhito FUJISAWA Faculty of Engineering and design Kagawa University Institute of Education Research and Regional Cooperation for Crisis Management Shikoku Kagawa University Faculty of Engineering Graduate school of Engineering Kagawa University

To mitigate the damage caused by debris flows resulting from heavy precipitation and to aid in evacuation plan preparation, areas at risk should be mapped on a scale appropriate for affected individuals and communities. We tested the effectiveness of simply identifying debris-flow hazards through automated derivation of surface curvatures using LiDAR digital elevation models. We achieved useful correspondence between plan curvatures and areas of existing debris-flow damage in two localities in Japan using the analysis of digital elevation models(DEMs). We found that plan curvatures derived from 10 m DEMs may be useful to indicate areas that are susceptible to debris flow in mountainous areas. In residential areas located on gentle sloping debris flow fans, the greatest damage to houses was found to be located in the elongated depressions that are connected to mountain stream valleys. Plan curvaturederived from 5 m DEM was the most sensitive indicators for susceptibility to debris flows.

关键词： Digital elevation model LiDAR Gridspacing Debris flow Geological hazard Curvature

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