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Zoledronic acid combined with androgendeprivation therapy may prolong time to castration-resistant prostate cancer in hormone-naı¨ve metastatic prostate cancer patients e A propensity scoring approach

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Asian Journal of Urology 2016年第1期3卷 33-38页

作者： kazuhiro nagao Hideyasu Matsuyama Masahiro Nozawa Isao Hara Tsukasa Nishioka Takahiro Komura Atsunobu Esa Shigeya Uejima Masaaki Imanishi Yasunari Uekado Takatoshi Ogawa Hiroshi Kajikawa Hirotsugu Uemura Department of Urology Graduate School of MedicineYamaguchi UniversityJapan Department of Urology Kinki University Faculty of MedicineJapan Department of Urology Wakayama Medical University School of MedicineJapan Department of Urology Sakai HospitalKinki University Faculty of MedicineJapan Department of Urology Naga HospitalJapan Department of Urology NTT Osaka HospitalJapan Department of Urology National Hospital Organization Osaka Minami Medical CenterJapan Department of Urology Nara Hospital Kinki University Faculty of MedicineJapan Department of Urology Tondabayashi HospitalJapan Department of Urology Wakayama Rosai HospitalJapan Department of Urology Kainan Municipal HospitalJapan Department of Urology Izumiotsu Municipal HospitalJapan

Objective:To clarify the oncological benefit of zoledronic acid for hormone-naive metastatic prostate cancer,patient outcome of androgen deprivation therapy with zoledronic acid(ADT+Z)and androgen deprivation therapy alone(ADT)was ***:Fifty-two patients with pathologically confirmed metastatic prostate cancer were prospectively enrolled and treated with combined androgen blockade(goserelin and bicalutamide)with zoledronic acid(4 mg every 4 weeks for 24 months).A propensity score-match with logistic regression analysis was applied to select 50 pair-matched cohorts(both from ADT+Z and from historical control cohorts who had undergone ADT alone),and patient outcomes were ***:Patients with ADT+Z had significantly longer time to progression(TTP)than those with ADT(median TTP;24.2 vs.14.0 months,p=0.0092),while no significant difference of overall survival between two groups(p=0.1502).Multivariate analysis for biochemical recurrence revealed treatment with ADT was the sole independent prognostic factor(HR:1.724,95%CI:1.06-2.86,p=0.0297).Conclusion:Combination of zoledronic acid with ADT may prolong time to castration resistant prostate cancer.

关键词： Zoledronic acid Hormone-naive prostate cancer Biochemical recurrence Propensity scorematch analysis

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Laparoscopic-assisted catheter insertion for continuous ambulatory peritoneal dialysis:A case report of simple technique for optimal placement

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World Journal of Gastrointestinal Surgery 2013年第10期5卷 268-271页

作者： Tomohide Hori Masaya Nakauchi kazuhiro nagao Fumitaka Oike Takahiro Tanaka Daigo Gunji Noriyuki Okada Department of Surgery Mitsubishi Kyoto Hospital Department of Internal Medicine Mitsubishi Kyoto Hospital

A 40-year-old male underwent tube placement surgery for continuous ambulatory peritoneal dialysis(CAPD).A2-cm skin incision was made,and the peritoneum was reflected enough to perform secure fixation.A swannecked,double-felted silicone CAPD catheter was inserted,and the felt cuff was sutured to the peritoneum to avoid postoperative *** adequate gradient for tube fixation to the abdominal wall was *** CAPD tube was passed through a subcutaneous *** was induced to confirm that there was no air leakage from the sites of CAPD *** trocars were placed,and we confirmed that the CAPD tube led to the rectovesical *** position was reliably observed *** patency of the CAPD tube was confirmed during *** of CAPD catheters by laparoscopic-assisted surgery has clear advantages in simplicity,safety,flexibility,and *** technique should be considered the first choice for CAPD tube insertion.

关键词： Continuous ambulatory peritoneal dialysis Dialysis catheter Tube insertion Surgical technique

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Diffusion-weighted imaging might be useful for reactive lymphoid hyperplasia diagnosis of the liver: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5313-5319页

作者： Taro Tanaka kazuhiro Saito Daisuke Yunaiyama Jun Matsubayashi Yuichi Nagakawa Maki Tanigawa Toshitaka nagao Department of Radiology Tokyo Medical UniversityTokyo 1600023Japan Department of Anatomic Pathology Tokyo Medical UniversityTokyo 1600023Japan Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityTokyo 1600023Japan

BACKGROUND Reactive lymphoid hyperplasia(RLH)of the liver is a rare liver *** is considered difficult to differentiate radiologically from hepatocellular carcinoma,metastatic liver tumor and other *** SUMMARY A 54-year-old woman presented to our hospital with RLH of the *** patient had a diagnosis of metastatic carcinoma of the liver from an unknown origin and subsequently underwent partial ***,histopathological analysis revealed *** lesion showed perinodular enhancement in the arterial phase on contrast-enhanced computed tomography and magnetic resonance *** diffusion-weighted imaging(DWI),we encountered linear hyperintensity along the portal tract consecutive to the liver lesion,which is a new characteristic radiologic *** finding corresponded to the lymphoid cell infiltration of the portal ***,there was strongly restricted diffusion on the apparent diffusion coefficient *** used these characteristic radiologic findings to diagnose the lesion as a lymphoproliferative *** The linear hyperintensity consecutive to the liver lesion on DWI provided additional valuable diagnostic information.

关键词： Reactive lymphoid hyperplasia Pseudolymphoma Magnetic resonance imaging Diffusion-weighted imaging Perinodular enhancement Portal tract infiltration Case report

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Diagnostic efficacy of gadoxetic acid-enhanced MRI for hepatocellular carcinoma and dysplastic nodule

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World Journal of Gastroenterology 2011年第30期17卷 3503-3509页

作者： kazuhiro Saito Ryota Nishio Toru Saguchi Soichi Akata Koichi Tokuuye Fuminori Moriyasu Katsutoshi Sugimoto Junichi Taira Toshitaka nagao Department of Radiology Tokyo Medical University160-0023 TokyoJapan Department of Gastroenterology and Hepatology Tokyo Medical University160-0023 TokyoJapan Department of Diagnostic Pathology Tokyo Medical University160-0023 TokyoJapan

AIM:To evaluate the relationship between the signal intensity of hepatobiliary phase images on gadoxetic acid-enhanced magnetic resonance imaging(MRI)and histological ***:Fifty-nine patients with 82 hepatocellular lesions were evaluated *** phase images on gadoxetic acid-enhanced MRI were classified into 3 groups:low,iso or *** computed tomography(CT)findings were also classified into 3 groups:CT during arterial portography,and CT hepatic arteriography:A:iso,iso or low;B:slightly low,iso or low;;and C:low,*** correlated angiography-assisted CT,hepatobiliary phase findings during gadoxetic acid-enhanced MRI and histological ***,correlations between MRI findings and histological grade for each hemodynamic pattern were *** among radiologicaland pathological findings were statistically evaluated using the chi-square test and Fisher's exact ***:There was a significant correlation between histological grade and hemodynamic pattern(P0.05).CONCLUSION:Signal intensity in the hepatobiliary phase correlated with histological grade in the lesions that maintained portal blood flow,but did not correlate in lesions that showed decreased or defective portal blood flow.

关键词： HepatocellularGadoxetic acid Primovist nomacarcinoma Gd-EOB-DTPA Early hepatocellular carcinoma

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Indium chloride bone marrow scintigraphy for hepatic myelolipoma: A case report

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World Journal of Clinical Cases 2023年第18期11卷 4377-4383页

作者： Akio Sato kazuhiro Saito Koichiro Abe Katsutoshi Sugimoto Toshitaka nagao Aoi Sukeda Daisuke Yunaiyama Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Gastroenterology and Hepatology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Anatomic Pathology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan

BACKGROUND As hepatic myelolipoma is rarely encountered,its radiological diagnosis using ultrasonography(US),computed tomography(CT),and magnetic resonance imaging(MRI)is *** myelolipoma is similar to fat-contained hepatic lesions seen in hepatocellular carcinoma and ***,further development of techniques to diagnose hepatic myelolipoma is *** SUMMARY A 44-year-old obese man was found to have a hepatic lesion during his medical *** lesion was 50 mm×57 mm in size and was detected in segment 8(S8)of the liver by *** patient was diagnosed with hepatic lesion 20 years ago,but it was left *** patient had no symptoms,liver dysfunction,hepatitis virus antibody,or tumor marker *** CT showed a welldefined lesion in S8 of the *** central and peripheral areas of the lesion primarily exhibited fat density and hypodensity,*** revealed a capsule-like *** was performed to address the probability of hepatocellular *** lesion was pathologically confirmed as a *** marrow scintigraphy performed using 111InCl3 revealed accumulation of the radiopharmaceutical in the soft tissue component,except in the fat-dominant part of the tumor,as well as in the surrounding liver parenchyma due to the presence of reticuloendothelial cells in the *** This is the first report on the diagnosis of hepatic myelolipoma using 111InCl3 *** effectiveness of bone marrow scintigraphy for diagnosing hepatic myelolipoma might be *** radiopharmaceuticals accumulate in both hematopoietic and reticuloendothelial cells,the accumulation of radiopharmaceuticals in the lesion is obscure.

关键词： Liver 111InCl3 Myelolipoma Magnetic resonance imaging Benign tumor Case report

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