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SATB1 Protein Is Associated with a More Aggressive Phenotype of Sporadic Colorectal Cancer

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Open Journal of Pathology 2013年第4期3卷 156-165页

作者： Akueni l. Davelaar Agnieszka M. Rygiel Margriet R. Timmer liudmila l. Kodach Carel J. M. van Noesel Paul Fockens Kausilia K. Krishnadath Center for Experimental and Molecular Medicine Academic Medical Center Amsterdam The Netherlands

Background: Experimental studies have shown that cyclo-oxygenase-2 (cox2) is related to the development and progression of tumors, since this enzyme is induced and expressed by cells such as macrophages, osteoblasts, “activated” endothelial cells, and tumor cells. The activity in tumors includes proliferation, cell transformation, tumor growth, invasion and metastasis and may play an important role in carcinogenesis of the canine osteosarcoma, since it has high expression in tissue fragments. The combination of selective cox2 inhibitors and other treatment modalities is the basis for a new anti-cancer therapy strategy. This in vitro study exposed primary cells of five different canine osteosarcoma cultures to selective cox2 inhibitor at increasing concentrations and times. Results: For cox2 negative cultures, despite the absence of differences, greater sensitivity of cells to treatment was observed. For cox2 positive cultures, a higher number of necrotic cells were observed (P ≤ 0.05), when compared with negative cultures. For exposure times with Cel.coxib doses, no difference (P > 0.05) was found between the three times analyzed for living, apoptotic and apop- totic/necrotic cells. There are similarities in the values of 24 h and 48 h, with slight reduction of living cells, increasing those undergoing apoptosis and apoptosis/necrosis. There was significance for necrosis (P ≤ 0.05). In 72 hours, a significant difference was observed between the other two previous values (P ≤ 0.05). It was found for the group of 100 μM?l?1, that there was a numerically greater signaling for apoptosis and lower (P = 0.08) for necrosis, and this point was the onset of the pharmacodynamic phenomenon, with drop in the values for living cells and increased number of necrotic cells, with a tendency (P = 0.08) for reducing the percentage of necrotic cells for the group of 100 μM?l?1 when compared to that of 10 μM?l?1. Conclusions: For cox2 positive and negative cultures, there was differenc

关键词： SATB1 Biomarker Sporadic Colorectal Cancer

Calcium Affects on Vascular Endpoints (CAVE) Retrospective Cohort Trial

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Open Journal of Endocrine and Metabolic Diseases 2013年第1期3卷 75-79页

作者： Rajib K. Bhattacharya Vaishali B. Patel James l. Vacek Division of Endocrinology Metabolism & Genetics The University of Kansas Medical Center Kansas City USA Mid-America Cardiology The University of Kansas Medical Center Kansas City USA

Purpose The goal of this study was to examine the association of calcium supplements with coronary artery disease and survival. Our initial hypothesis was that when adjusted for risk factors, calcium supplements would not affect overall survival outcomes or coronary artery disease prevalence in a community population followed by a large cardiovascular practice. Methods Data was retrospectively collected for 5 years and 8 months (1/1/2004to 10/8/2009) from the electronic medical record at a large cardiovascular practice at a university. Only patients ≥ age 50 were included in our analysis Results The baseline characteristics of the 8060 study subjects. For the entire study population the mean age was 65 +/– 10 years, 71% were women. On multivariable logistic regression analysis, calcium supplementation was not an independent predictor of all-cause death, nor was calcium supplementation an independent predictor of the diagnosis of coronary artery disease. Survival analysis showed no survival differences for patients on calcium supplements (p = NS). Hazard ratios using the cox proportional hazards model were calculated, showing that calcium supplementation was not an independent predictor of reduced survival. Conclusion This study suggests that there was no association between calcium supplementation and coronary artery disease as well as overall survival in a large retrospective cohort of patients greater than 50 with high rates of significant cardiovascular risk factors.

关键词： Calcium Supplements Heart Attacks Coronary Artery Disease Cardiovascular Risk Factors

l12-Co3X(X=Ti,Ta,Al,W,V)点缺陷结构的理论计算

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特种铸造及有色合金 2020年第9期40卷 929-934页

作者：陈律刘逸众长沙航空职业技术学院航空机电设备维修学院长沙410124 空军航空维修技术学院航空机电设备维修学院湖南省飞机维修工程技术研究中心

运用第一性原理赝势平面波方法,研究了l12-Co3X(X=Ti,Ta,Al,W,V)金属间化合物的基本物性及其点缺陷结构的几何、能态与电子结构。通过对相应合金中两种组元原子的空位和反位点缺陷结构形成热与结合能的计算与比较,分析了l12-Co3X(X=Ti,T... 详细信息

运用第一性原理赝势平面波方法,研究了l12-Co3X(X=Ti,Ta,Al,W,V)金属间化合物的基本物性及其点缺陷结构的几何、能态与电子结构。通过对相应合金中两种组元原子的空位和反位点缺陷结构形成热与结合能的计算与比较,分析了l12-Co3X(X=Ti,Ta,Al,W,V)金属间化合物中点缺陷结构的种类与存在形式。结果表明,l12-Co3X(X=Ti,Ta,Al,W,V)金属间化合物的点缺陷结构与l12-Ni3Al合金保持一致,主要是Co原子晶格以及X原子晶格上出现反位缺陷。基于晶体总电子态密度结构信息的分析,很好地验证了上述计算结果。

关键词：钴基高温合金点缺陷结构赝势平面波方法

核苷(酸)类似物治疗应答不佳转为富马酸丙酚替诺福韦治疗慢性乙型肝患者的早期临床观察

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新发传染病电子杂志 2022年第2期7卷 41-46页

作者：陈妤吕涛韩少伟谭霭明司徒伟基香港大学深圳医院消化与肝病科广东深圳518000 香港大学深圳医院临床药学科广东深圳518000

目的探讨核苷(酸)类似物(NAs)治疗应答不佳转为富马酸丙酚替诺福韦(TAF)治疗慢性乙型肝炎(CHB)患者的早期疗效和安全性。方法回顾性收集2019年4月至2020年1月就诊于香港大学深圳医院连续接受各种类型NAs治疗≥48周的CHB患者换用TAF继续... 详细信息

目的探讨核苷(酸)类似物(NAs)治疗应答不佳转为富马酸丙酚替诺福韦(TAF)治疗慢性乙型肝炎(CHB)患者的早期疗效和安全性。方法回顾性收集2019年4月至2020年1月就诊于香港大学深圳医院连续接受各种类型NAs治疗≥48周的CHB患者换用TAF继续治疗的病例资料,比较既往NAs长期治疗后换用TAF治疗12周的HBV应答率(HBV DNAl)、AlT复常率(男性l,女性l)、肾功能、血脂等水平的变化,以及转换TAF后对不同CKD分期CHB患者肾小球滤过率(eGFR)的影响。结果74例经治CHB患者[77%男性,年龄(49.55±10.52)岁,包括既往替诺福韦酯(TDF)治疗38例,恩替卡韦(ETV)治疗30例,其他类型NAs治疗6例],换用TAF抗病毒治疗12周,总体完全病毒学应答(HBV DNAl)率71.62%(53/74例)较基线40.54%(30/74例)显著升高(PlT水平21.80(15.20,34.85)U/l较基线28.90(19.52,42.70)U/l下降(P=0.016),AlT复常率74.32%(55/74例)较基线56.76%(42/74例)明显升高(P=0.038)。但不同类型NAs转为TAF治疗HBV病毒应答率及AlT复常率无差别。在安全性方面,与基线相比换用TAF治疗12周后总体eGFR有轻微升高,但差异无统计学意义(P>0.05)。处于CKD 2期轻度肾损害患者转换TAF治疗12周后eGFR较基线明显改善[(79.37±10.82)ml/(min·1.73m^(2))比(72.23±9.11)ml/(min·1.73m^(2)),P=0.017]。结论CHB患者既往接受NAs治疗转换为TAF后均能有更显著的病毒应答及生化应答,总体安全性良好,并可改善轻度肾损害CHB患者的肾功能。

关键词：富马酸丙酚替诺福韦乙型肝炎病毒核苷(酸)类似物恩替卡韦替诺福韦

Maternal Mortality Risk Factors in Regional Hospital of Burkina Faso

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Open Journal of Epidemiology 2014年第2期4卷 57-62页

作者： léon G. Blaise Savadogo Aminata Zombra Cécile Tamini Maurice Kinda Philipe Donnen Centre Hospitalier Régional Banfora Burkina Faso CR3—Politiques et Systèmes de Santé—Santé Internationale School of Public Health Université Libre de Bruxelles Bruxelles Belgique Department of Epidemiology and Public Health—Child and Mother Health Nutrition and Survival Unit—Institut Supérieur des Sciences de la Santé Université Polytechnique Bobo Dioulasso Burkina Faso Ecole National de Santé Publique Bobo Dioulasso Burkina Faso

Individual causes and community determinants are synergic in maternal death occurrence. This study aimed to identify maternal mortality risk factors in a regional hospital. Material and Methods: This was a retrospective cohort study from data of 1807 hospitalized women. To identify maternal mortality risks factors, mortality hazard ratio (HR CI95%) has been calculated in univariate analysis and cox proportional hazard model. Results: During hospitalization, 30 maternal deaths occurred. From cox regression, adjusted mortality HR confirmed that women age older than 35 (HR = 2.5, CI95%: [1.2-5.7] and younger than 19 (HR = 3.02, CI95%: [1.5-6.7]);distance to hospital ≥10 Km (HR = 4.1, CI95%: [1.8-9.4];multiple deliveries (HR = 2.4, CI95%: [1.1-7.3]), less ante natal care (l maternal mortality directs causes (HR = 2.31, CI95%: [1.7-6.21]) and emergently reference (HR = 3.5, CI95%: [1.8-8.32]) were maternal mortality risk factors. Conclusion: In this regional hospital of low income country, identified maternal mortality factors are related to women socio-economic determinants and quality prenatal or obstetric care access. Interventions to reduce maternal mortality rate should be conducted within both household and women socio-economic status development and in maternal health and obstetric care strengthening.

关键词： Maternal Mortality Risk Factors Regional Hospital Burkina Faso

Rhizosphere microbial communities associated to rose replant disease:links to plant growth and root metabolites

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Horticulture Research 2020年第1期7卷 1031-1046页

作者： B.Yim A.Baumann G.Grunewaldt-Stöcker B.liu l.Beerhues S.Zühlke M.Sapp J.Nesme S.J.Sørensen K.Smalla T.Winkelmann Institute of Horticultural Production Systems Leibniz Universität Hannover30419 HannoverGermany Julius Kühn-Institut(JKI) Institute for Epidemiology and Pathogen Diagnostics38104 BraunschweigGermany Institute of Pharmaceutical Biology Technische Universität Braunschweig38106 BraunschweigGermany Faculty of Chemistry and Chemical Biology(CCB) Technische Universität Dortmund44227 DortmundGermany Cluster of Excellence on Plant Sciences(CEPlAS) Institute for Population GeneticsHeinrich Heine University40225 DüsseldorfGermany Section of Microbiology Department of BiologyUniversity of Copenhagen2100 CopenhagenDenmark

Growth depression of Rosa plants at sites previously used to cultivate the same or closely related species is a typical symptom of rose replant disease(RRD).Currently,limited information is available on the causes and the etiology of RRD compared to apple replant disease(ARD).Thus,this study aimed at analyzing growth characteristics,root morphology,and root metabolites,as well as microbial communities in the rhizosphere of the susceptible rootstock Rosa corymbifera‘laxa’grown in RRD-affected soil from two sites(Heidgraben and Sangerhausen),either untreated or disinfected byγ-*** a greenhouse bioassay,plants developed significantly more biomass in theγ-irradiated than in the untreated soils of both *** plant metabolites detected in ***‘laxa’roots were site-and *** aloesin was recorded in significantly higher concentrations in untreated than inγ-irradiated soils from Heidgraben,the concentrations of phenylalanine were significantly lower in roots from untreated soil of both *** microbial communities of 8-week-old plants were studied by sequencing of 16S rRNA,ITS,and cox gene fragments amplified from total community *** by microscopic observations,sequences affiliated to the bacterial genus Streptomyces and the fungal genus Nectria were identified as potential causal agents of RRD in the soils *** relative abundance of oomycetes belonging to the genus Pythiogeton showed a negative correlation to the growth of the ***,the RRD symptoms,the effects of soil treatments on the composition of the rhizosphere microbial community revealed striking similarities to findings related to ARD.

关键词： soil roots plant

low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis

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World Journal of Gastroenterology 2016年第45期22卷 10064-10070页

作者： Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero luis Chi-Cervera Silvia l Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán14080 México City México Department of Internal Medicine Ⅲ University Hospital RWTH Aachen52074 Aachen Germany Unit for the Clinical Management of Digestive Diseases Virgen del Rocio-Virgen Macarena University Hospital41009 Sevilla Spain Department of Immunology Complutense University School of Medicine28040 Madrid Spain University of Arkansas for Medical Sciences Little Rock AR 72205 United States Department of Nephrology and Mineral Merabolism Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán México City 14080 México

AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic *** This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic *** Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONClUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis.

关键词： Malnutrition Hepatic encephalopathy Phase angle Cachexia Prognosis

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大肠癌383例的临床病理及预后分析

中华肿瘤防治杂志 2007年第8期14卷 613-616页

作者：吕洋赵坡中国人民解放军总医院病理科北京100853

目的:探讨大肠癌的临床病理特征以及影响患者术后生存的因素。方法:回顾性研究1993年～2001年全部在中国人民解放军总医院外科手术治疗且具有完整病历的383例大肠癌患者(其中312例获得完整的随访资料)的临床资料及病理学指标,进行单因... 详细信息

目的:探讨大肠癌的临床病理特征以及影响患者术后生存的因素。方法:回顾性研究1993年～2001年全部在中国人民解放军总医院外科手术治疗且具有完整病历的383例大肠癌患者(其中312例获得完整的随访资料)的临床资料及病理学指标,进行单因素及多因素cox回归分析。结果:1)383例大肠癌中包括结肠癌298例,直肠癌85例。这些大肠癌患者平均年龄为47.0岁,男女比例为1.41∶1(224/159)。其中,结肠癌患者平均年龄为51.1岁,男女比例为1.59∶1(183/115)。有250例获得随访,其1年生存率为84.0%,5年生存率为58.4%。直肠癌患者平均年龄32.9岁,男女比例为0.93∶1(41/44)。62例获得随访,其1年生存率为72.6%,5年生存率为64.5%。2)单因素分析显示,患者发病年龄、肿瘤的组织学类型、分化程度、肠壁浸润深度、淋巴结转移情况、腹腔及远处转移情况、肿瘤的病理分期及对患者采取的治疗方法均为影响预后的因素。3)多因素回归分析表明腹腔及远处转移情况、肿瘤的病理分期以及对患者采取的治疗方法是影响患者术后生存的独立因素。结论:影响结直肠癌患者术后生存的独立因素仅为腹腔及远处转移情况、肿瘤的病理分期以及对患者采取的治疗方法。

关键词：结直肠肿瘤/病理学预后多因素分析

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安全性高的非甾体抗炎药的研究进展

中国新药杂志 2016年第11期25卷 1258-1265页

作者：吕田叶海张灿中国药科大学新药研究中心南京211100 南京海融医药科技有限公司南京211100

非甾体抗炎药(nonsteroidal anti-inflammatory drugs,NSAIDs)广泛用于多种关节炎的治疗,然而临床使用中发现,传统的非甾体抗炎药缺乏靶点选择性,胃肠道(gastrointestinal,GI)不良反应严重。选择性cox-2抑制剂如罗非昔布等尽管可能降低G... 详细信息

非甾体抗炎药(nonsteroidal anti-inflammatory drugs,NSAIDs)广泛用于多种关节炎的治疗,然而临床使用中发现,传统的非甾体抗炎药缺乏靶点选择性,胃肠道(gastrointestinal,GI)不良反应严重。选择性cox-2抑制剂如罗非昔布等尽管可能降低GI不良反应,但其心血管毒性风险增加。最新研究表明,选择性cox-2抑制剂并没有显著改善传统NSAIDs的GI损伤。近几年,NSAIDs引发的小肠黏膜损伤引起了广泛的关注,且至今还无有效方法消除这一损伤。因此,现有NSAIDs的安全性问题仍然突出。为提高现有NSAIDs的安全性,研究者开始着眼于研发新型安全性更高的非甾体抗炎药。本文主要介绍目前最新的安全性高的NSAIDs,并对其研究进行了展望。

关键词：非甾体抗炎药胃肠道不良反应安全性