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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 57-58页

作者： kawashima M. 王琼 Department ofDermatology Tokyo Women's Medical University8-1Kawada-choShinjuku-kuTokyo 162-8666Japan Dr.

Background:Atopic dermatitis(AD),a significant problemin Japan,has a major impact on health-related quality of life(QOL).The development of steroid phobia in patients with AD may restrict the therapeutic options available to these *** ointment is a safe and effective nonsteroid treatment for *** may be an appropriate alternative for patients with AD and steroid *** aim of this study was to determine the impact of AD on QOL and to investigate the effect of tacrolimus ointment on QOL in patients with steroid ***:Firstly,QOL scores were investigated inpatients with AD and steroid phobia using the World Health Organization Quality of Life instrument,WHOQOL-26,and were compared with QOL scores from a previous study in volunteers from Tokyo,***,patients with steroid phobia received tacrolimus ointment treatment for 12 *** of life scores were assessed using WHOQOL-26 at baseline and study ***:The overall mean QOL score of 106 patients with AD was significantly lower than that of 708 volunteers(3.1 ±0.5 vs.3.3 ±0.5,P ks’tacrolimus ointment treatment in 35 patients with AD and steroid phobia(P < 0.001).Conclusions:Atopic dermatitis significantly lowers *** ointmentis associated with a significant improvement in QOL inpatients with steroid phobia,indicating that it is an effective alternative to topical corticosteroids in these patients.

关键词：特应性皮炎生活质量激素疗法外用糖皮质激素

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Water Quality Monitoring and Cadmium Contamination in the Sediments of Mae Tao Stream,Mae Sot District,Tak Province,Thailand

Water Quality Monitoring and Cadmium Contamination in the Se...

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作者： P.Weeraprapan C.Phalaraksh S.Chantara M.kawashima Environmental Science Program Faculty of ScienceChiang Mai University Department of Biology Faculty of ScienceChiang Mai University Department of Chemistry Faculty of ScienceChiang Mai University

Some lands and streams at Mae Sot District,Tak Province,Thailand are polluted by cadmium(Cd) which leach from the zinc *** objectives of present study were to evaluate physico-chemical parameters of Mae Tao Stream and Cd concentration in the *** water and sediment samples were collected from the upstream and downstream of Mae Tao Stream from April 2011 to February *** downstream sites are affected by the water from the zinc ***-chemical parameters such as Temperature,Water Velocity,p H,Electrical Conductivity,Total Dissolved Solid,Dissolved Oxygen,Nutrients(Nitrate,Ammonium and Orthophosphate),Suspended Solids,Alkalinity and Total Hardness were *** from the parameters,Mae Tao Stream was classified to Type III of the Surface Water Quality Standard of Thailand for agriculture at all sampling *** concentrations in the sediments were measured in the range of 0.84-7.86 mg *** the sediments of polluted sites,Cd concentrations exceeded the European maximum permissible level of 3.0 mg kg for Agricultural *** is important to continue to monitor the physico-chemical parameters and the cadmium concentrations in the sediments,and the bio-assessment should be begun around the stream.

关键词： Water quality cadmium sediment monitoring Mae Tao stream

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用电解法治疗浅层变异型颗粒状角膜营养不良(Reis-Bucklers角膜营养不良)年轻患者的角膜浑浊

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 24-25页

作者： kamoi M. Mashima Y. kawashima M. Tsubota k. 吴琼 Department of Ophth almology Keio University School of Medicine 35 Shinanomachi Shinjuku-ku To kyo 160-8582 Japan Dr.

PURPOSE: To report the efficacy of electrolysis as a treatment of corneal opac ities in a young patient with the superficial variant of granular corneal dystro phy. DESIGN: Interventional case report. METHODS: An 11-year-old boy presented with subepithelial opacities in both eyes. His visual acuity was 0.2 in the lef t eye; he received corneal electrolysis under topical anesthesia. RESULTS: The e lectrolysis, which required only 5 minutes, resulted in the disappearance of the subepithelial opacities. His visual acuity improved to 0.4 on the next day and was 1.0 eight months later. The corneal curvature and thickness were not altered by the electrolysis. CONCLUSIONS: Corneal electrolysis proved to be an effectiv e treatment for subepithelial opacities, and we recommend electrolysis as an eff ective and simple treatment for young patients with SGCD.

关键词：角膜营养不良 Reis-Bucklers 角膜浑浊变异型电解术角膜上皮浅层角膜曲度左眼视力干预性

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小鼠骨髓基质细胞kusa-A1成骨分化中CBF1的作用

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基础医学与临床 2006年第4期26卷 409-414页

作者：王胜朝 kawashima Nobuyuki SAkAMOTO kei kATSUBE ken-Ichi SHINDO kentaro SUDA Hideaki 史俊南第四军医大学口腔医学院牙体牙髓病科陕西西安710032 Pulp Biology andEndodontics Molecular Pathology Graduate School of Tokyo Medical and Dental University1-5-45YushimaBunkyo-kuTokyo 113-8549Japan

目的揭示CBF1在骨髓基质细胞kusa-A1成骨分化过程中的作用。方法采用基因转染法建立CBF1稳定过表达细胞系kusa-A1/CBF1,检测其成骨活性。指标包括细胞钙沉积能力、碱性磷酸酶活性、体外钙化结节(CN)形成、实时PCR测定细胞骨钙素(OC)和... 详细信息

目的揭示CBF1在骨髓基质细胞kusa-A1成骨分化过程中的作用。方法采用基因转染法建立CBF1稳定过表达细胞系kusa-A1/CBF1,检测其成骨活性。指标包括细胞钙沉积能力、碱性磷酸酶活性、体外钙化结节(CN)形成、实时PCR测定细胞骨钙素(OC)和骨桥蛋白(OPN)基因表达、蛋白印迹检测细胞RANkL蛋白。最后用报告基因法检测CBF1对HES1启动子活性的影响。结果经RT-PCR和Western blot鉴定,kusa-A1/CBF1细胞建立成功。与对照细胞系kusa-A1/host相比,kusa-A1/CBF1细胞的钙沉积能力、CN形成能力均显著提高;kusa-A1/CBF1细胞OC和OPN基因表达和RANkL蛋白水平明显高于对照细胞。瞬时转染Notch的细胞内结构域NICD促进HES1的启动子活性,这一作用被CBF1强烈抑制。结论CBF1可以促进kusa-A1的成骨分化,该作用至少部分是通过影响Notch信号实现的。

关键词：转录调控因子CBF1(RBP-Jk) 骨髓基质细胞成骨分化 Notch信号

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External apical root resorption and the release of interleukin-6 in the gingival crevucular fluid induced by a self-ligating system

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Open Journal of Stomatology 2012年第2期2卷 116-121页

作者： Ryoko kawashima-Ichinomiya Masaru Yamaguchi Yasuhiro Tanimoto Masaki Asano kunihiko Yamada Ryo Nakajima Shoji Fujita kazutaka kasai Department of Dental Biomaterials Nihon University School of Dentistry at Matsudo Chiba Japan Department of Orthodontics Nihon University School of Dentistry at Matsudo Chiba Japan

The aim of this study was to investigate the amount of external apical root resorption (EARR) and the release of interleukin (IL)-6 in the gingival crevicular fluid (GCF) in subjects treated with a low-force low-friction system. Sixty patients were assigned to two groups of thirty patients for each: one group received treatment with self-ligating brackets and the other with conventional ligated edgewise brackets. All patients were treated with extraction of the maxillary first premolars. The EARR of the maxillary central incisors was evaluated on the periapical radiographs and cephalograms, taken before and after orthodontic treatment. The GCF was also collected non-invasively from the mesial and distal sides of central incisors by using filter paper strips before and after orthodontic treatment. Enzyme-linked immunosorbent assay (ELISA) kits were used to determine the IL-6 levels in the GCF samples. A significant difference was found in the amount of EARR between the patients with self-ligating brackets and conventional brackets. The mean amount of EARR was significantly lower for self-ligating brackets than conventional brackets (p kets appliance were significantly lower than for those with the conventional brackets (p kets. Therefore, self-ligating brackets may be a useful system for reducing inflammation and EARR.

关键词： IL-6 Gingival Crevucular Fluid External Apical Root Resorption Self-Ligating Brackets

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Association between Daily Living Walking Speed and Lifestyle and Physiological Factors in Older, Female Pokémon GO Players

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Health 2021年第5期13卷 564-573页

作者： Shuhei Nomura Akifumi Eguchi Daisuke Yoneoka Takayuki kawashima Norimichi Hirahara Yuta Tanoue Stuart Gilmour Hisateru Tachimori Hiroaki Miyata Department of Health Policy and Management School of Medicine Keio University Tokyo Japan Department of Global Health Policy Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Sustainable Health Science Center for Preventive Medical Sciences Chiba University Chiba Japan Graduate School of Public Health St. Luke’s International University Tokyo Japan Department of Mathematical and Computing Science Tokyo Institute of Technology Tokyo Japan Institute for Business and Finance Waseda University Tokyo Japan Department of Clinical Epidemiology Translational Medical Center National Center of Neurology and Psychiatry Tokyo Japan Endowed Course for Health System Innovation School of Medicine Keio University Tokyo Japan

Background: Walking speed is a reliable barometer of adverse health outcomes, particularly among older people. Few studies evaluated factors associated with daily actual walking speed, rather than that measured in a laboratory setting or self-reported data. Methods: In a joint effort with The Pokémon Company, we recruited study participants through a women’s magazine and analyzed data from 63 Pokémon GO players. We measured the true walking speed in daily life among older women using a data-gathering mobile application. Then, using questionnaire survey data collected on these participants in 2019, we estimated the relationship between walking speed and their lifestyle and physiological factors. In the analysis, we employed a bi-directional stepwise linear regression approach, with the Akaike information criterion (AIC) for variable selection. Results: The mean age of the 63 participants was 63.03 years (standard deviation, SD 7.46);the average walking speed was 4.56 km per hour (SD 1.54);and 52 (82.5%) and 55 (87.3%) participants answered that they had excellent/good health physically and mentally, respectively. After adjusted for covariates in a stepwise regression approach, we identified a significant association between −1.33 (95% confidence intervals −2.52 to −0.15) km/hour lower walking speed and the experience of outdoor falls within a year. We also demonstrated that the walking speed was 1.07 (0.33 to 1.81) km/hour faster for those who had played Pokémon GO before the study started. Conclusions: The true walking speed in daily life among older women was measured by a data-gathering mobile application. Although all participants were w

关键词： Daily Actual Walking Speed Pokémon GO Players Experience of Outdoor Falls

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