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World Journal of Pediatrics 2015年第2期11卷 181-184页

作者： Yoshihiro Maruo Masafumi Suzaki katsuyuki matsui Yu Mimura Asami Mori Haruo Shintaku Yoshihiro Takeuchi Department of Pediatrics Shiga University of Medical ScienceTsukinowaSetaOtsuShiga 520-2192Japan Central Research Laboratory Shiga University of Medical ScienceTsukinowaSetaOtsuShiga 520-2192Japan Department of Pediatrics Osaka City University Graduate School of MedicineOsakaJapan

Background:Phenylketonuria(PKU)is caused by a defect in phenylalanine hydroxylase(PAH).More than 500 mutations have been reported for the gene encoding ***,approximately l%-5%of these include large deletions and large duplications that cannot be detected by conventional ***:In this report we tried to fully characterize a PAH-deficient *** patient was a 2-year-old Japanese boy who was diagnosed with classical PKU at the time of neonatal screening,which was confirmed by the tetrahydrobiopterin-loading ***-related direct sequencing and multiplex ligation-dependent probe amplification(MLPA)were used to analyze of the PAH of the ***:Using PCR-related direct sequencing method,we could detect only a heterozygous novel missense mutation:p.136G>C(p.G46R).A second mutation was detected by *** patient was heterozygous for a novel large deletion of exons 12 and 13:c.1200-?_1359+?del(EX12_13del).For genetic counseling,an accurate genetic diagnosis is often ***:Through a combination of MLPA and conventional methods,the success rate of PAH mutation identification can be close to 100%.

关键词： large deletion multiplex ligation-dependent probe amplification phenylalanine hydroxylase phenylketonuria

A preliminary study on rectal dose reduction associated with hyaluronic acid implantation in brachytherapy for prostate cancer

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Asian Journal of Urology 2024年第2期11卷 286-293页

作者： Tairo Kashihara Yuka Urago Hiroyuki Okamoto Mihiro Takemori Hiroki Nakayama Shohei Mikasa Tetsu Nakaichi Kotaro Iijima Takahito Chiba Junichi Kuwahara Satoshi Nakamura Weishan Chang Yoshiyuki matsui Hiroshi Igaki Department of Radiation Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Radiation Safety and Quality Assurance Division National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Radiological Sciences Graduate School of Human Health SciencesTokyo Metropolitan University7-2-10 Higashi-OguArakawa-kuTokyoJapan Department of Radiological Technology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Urological Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan

Objectives: Hydrogel spacer (HS) was developed to reduce rectal toxicities caused by radiotherapy, but has been reported to cause major adverse events. Our institute has attempted to introduce a hyaluronic acid (HA) as an alternative spacer. This study aimed to compare rectal doses and geometric distributions between the HS and HA implantation in prostate ***: HS and HA were inserted in 20 and 18 patients undergoing high-dose brachytherapy, respectively. The rectum spacer volumes injected were 10 mL and 22 mL, respectively. In the treatment planning system, 13.5 Gy was administered with common catheter positions. The rectal dose indices were assessed between the spacer groups for dosimetry evaluation. Distances between the prostate and rectum and configurations of the spacers were ***: The mean doses irradiated to 0.1 and 2 mL of the rectum were 10.45 Gy and 6.71 Gy for HS, and 6.73 Gy and 4.90 Gy for HA (p<0.001). The mean minimum distances between the prostate and rectum were 1.23 cm and 1.79 cm for HS and HA, respectively (p<0.05). Geometrical configuration comparisons revealed that HA has a higher ability to expand the space than ***: The rectal dose reduction ability of HA is significantly greater than that of HS, suggesting its potential as a new spacer.

关键词： Brachytherapy Hyaluronicacid Hydrogel Prostaticneoplasm Radiotherapy

Using choroidal thickness to detect myopic macular degeneration

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 317-323页

作者： Ran Liu Meng Xuan De-Cai Wang Ou Xiao Xin-Xing Guo Jian Zhang Wei Wang Monica Jong Padmaja Sankaridurg Kyoko Ohno-matsui Qiu-Xia Yin Ming-Guang He Zhi-Xi Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina New England College of Optometry BostonMassachusetts 02115USA Wilmer Eye Institute Johns Hopkins UniversityBaltimoreMD 21231USA Brien Holden Vision Institute Sydney 2052Australia School of Optometry and Vision Science University of New South WalesSydney 2052Australia Department of Ophthalmology and Visual Science Tokyo Medical and Dental UniversityTokyo 113-8510Japan School of Optometry the Hong Kong Polytechnic UniversityHong Kong SARChina Research Centre for SHARP Vision the Hong Kong Polytechnic UniversityHong Kong SARChina Center for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkHong Kong SARChina

AIM:To explore the usage of choroidal thickness measured by swept-source optical coherence tomography(SS-OCT)to detect myopic macular degeneration(MMD)in high myopic ***:Participants with bilateral high myopia(≤−6 diopters)were recruited from a subset of the Guangzhou Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort ***-OCT was performed to determine the choroidal thickness,and myopic maculopathy was graded by the International Meta-Analysis for Pathologic Myopia(META-PM)Classiﬁ*** of MMD was defined as META-PM category 2 or ***:A total of 568 right eyes were included for *** with MMD(n=106,18.7%)were found to have older age,longer axial lengths(AL),higher myopic spherical equivalents(SE),and reduced choroidal thickness in each Early Treatment Diabetic Retinopathy Study(ETDRS)grid sector(P<0.001).The area under the receiver operating characteristic(ROC)curves(AUC)for subfoveal choroidal thickness(0.907)was greater than that of the model,including age,AL,and SE at 0.6249,0.8208,and 0.8205,*** choroidal thickness of the inner and outer nasal sectors was the most accurate indicator of MMD(AUC of 0.928 and 0.923,respectively).An outer nasal sector choroidal thickness of less than 74μm demonstrated the highest odds of predicting MMD(OR=33.8).CONCLUSION:Choroidal thickness detects the presence of MMD with high agreement,particularly of the inner and outer nasal sectors of the posterior pole,which appears to be a biometric parameter more precise than age,AL,or SE.

关键词： high myopia choroidal thickness myopic macular degeneration swept-source optical coherence tomography

Doping and alloying in atomically precise gold nanoparticles

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Nano Research 2014年第3期7卷 285-300页

作者： Rongchao Jin katsuyuki Nobusada Department of Chemistry Carnegie Mellon University Pittsburgh Pennsylvania 15213 USA Department of Theoretical and Computational Molecular Science Institute for Molecular Science Myodaiji Okazaki 444-8585 Japan and Elements Strategy Initiative for Catalysts and Batteries (ESICB) Kyoto University Katsura Kyoto 615-8520 Japan

The recent success in the synthesis and total structure determination of atomically precise gold nanoparticles has provided exciting opportunities for fundamental studies as well as the development of new applications. These unique nanoparticles are of molecular purity and possess well defined formulas （i.e., specific numbers of metal atoms and ligands）, resembling organic compounds. Crystallization of such molecularly pure nanoparticles into macroscopic single crystals allows for the determination of total structures of nanoparticles （i.e., the arrangement of metal core atoms and surface ligands） by X-ray crystallography. In this perspective article, we summarize recent efforts in doping and alloying gold nanoparticles with other metals, including Pd, Pt, Ag and Cu. With atomically precise gold nanoparticles, a specific number of foreign atoms （e.g., Pd, Pt） can be incorporated into the gold core, whereas a range of Ag and Cu substitutions is observed but, interestingly, the total number of metal atoms in the homogold nanoparticle is preserved. The heteroatom substitution of gold nanoparticles allows one to probe the optical, structural, and electronic properties truly at the single-atom level, and thus provides a wealth of information for understanding the intriguing properties of this new class of nanomaterials.

关键词： gold nanoparticle atomic precision total structure doping alloying

Cellular response against cytosolic leakage of mitochondrial DNA: insights into the pathology of Parkinson’s disease

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Neural Regeneration Research 2022年第12期17卷 2682-2684页

作者： Akiko Sakai Hideaki matsui Department of Neuroscience of Disease Brain Research InstituteNiigata UniversityNiigataJapan

Mitochondria are important organelles for cellular metabolism and homeostasis,and their abnormalities are implicated in various *** mitochondria originate from protobacterium,their components are easily recognized by pathogen sensors called pattern-recognition receptors as foreign substances in the *** is prominent for mitochondrial DNA(mtDNA)which has different properties from nuclear DNA,such as low,if any,methylation status,vulnerability to oxidation due to the proximity to the oxidative phosphorylation machinery,and its circular *** studies indicate that perturbations in mitochondrial function and homeostasis cause mtDNA to leak into the cytoplasm,where it triggers the innate immune response(West and Shadel,2017).Although inflammatory response is a cellular strategy to resist viral infections,it can also lead to undesirable outcomes by damaging own cells and tissues.

关键词： homeostasis metabolism insight

A Compact Narrow-Band Tunable Optical Transversal Filter

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光学学报 2003年第S1期23卷 201-202页

作者： katsuyuki Utaka School of Science and Engineering WASEDA University 3-4-1 Okubo Shinjuku Tokyo 169-8555 Japan.

We present a compact narrow-band tunable optical transversal filter with phase-variable taps. A transmission bandwidth of the comb filter is less than 0.2nm and can be continuously tuned in the entire FSR.

关键词： DWDM be of with FSR as on line FWHM

Long-Term Effect of TMD on Vibration Control of An MDOF Offshore Fixed Platform

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China Ocean Engineering 2003年第4期18卷 481-494页

作者：石湘 Tetsuya matsui WU Minger Graduate School of Environmental Studies Nagoya University Nagoya 464-8603 Japan Department of Architecture Meijo University Nagoya 468-8503 Japan

A three-dimensional fixed offshore platform in deep water modeled by the finite element method is studied in this paper. Analysis of the dynamic response of the MDOF structure is realized taking the non-linearity of the wave drag force and the wave-structure interaction into account. The structural response statistics, which have Gaussian distributions, are used to evaluate the vibration effect of the structure without TMD and with TMD. And an optimal method to design TMD controlling the first mode of the multi-mode structure is proposed. Moreover, the probabilities of occurrence of sea states at the platform site are considered for prediction of the long-term effect of a TMD. Simulation results demonstrate that the long-term effect of a well-designed TMD is good and the practical use is possible due to the good stability of its optimal parameters under different sea states.

关键词： offshore fixed platform vibration control tuned mass damper multi degree of freedom optimal design

A study of optimal switching problem in limited-cycle with multiple periods

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 933-937页

作者： Jing SUN Hisashi YAMAMOTO Masayuki matsui Graduate School of Engineering Nagoya Institute of Technology Gokiso-cho Showa-ku Nagoya Aichi 466-8555 Japan Department of System Design Management Systems Engineering Tokyo Metropolitan University 6-6 Asahigaoka Hino Tokyo 191-0065 Japan Department of lnformatics Graduate School of lnformatics and Engineering The University of Electro-Communications 1-5-1 Chofugaoka Chofu-shi Tokyo 182-8585 Japan

In a social system or production line,the restrictions of the cost and the due-time exist in each ***,whether these restrictions are satisfied is dependent not only on the risks of this period,but also on the risks generated *** consider controlling the production process by switching the processing rate to a faster one at a given *** paper deals with the optimal switching period to minimize the total expected cost of the production *** first propose the optimal switching period model,and then the mathematic formulation of the total expectation is ***,the policy of optimal switching period is investigated in detail by numerical experiments.

关键词： Limited-cycle problem Multi-period Optimal switching period Production seat system Manufacturing line

Mutual regulation between Hippo signaling and actin cytoskeleton

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Protein & Cell 2013年第12期4卷 904-910页

作者： Yurika matsui Zhi-Chun Lai I ntercollege Graduate Degree Program in Cell and Developmental Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biochemistry and Molecular Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA

Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation,apoptosis,and *** Hippo signaling is regulated has been under extensive *** the past three years,an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector,Yki/Yap/*** the other hand,Hippo signaling negatively regulates actin cytoskeleton *** review p rovides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development,and points out outstanding questions for further investigations.

关键词： Hippo signaling actin cytoskeleton negative feedback growth control development

Effects of Vertical Angle of Conical Punch on Stretch Flangeability of High Strength Steel

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Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1503-1509页

作者： Yasuhiro Ito Yoshiaki Nakazawa Yukihisa Kuriyama katsuyuki Suzuk Noriyuki Suzuki Nippon Steel and Sumitomo Metal Corporation The University of Tokyo

To clarify the effects of the vertical angle of a conical punch on stretch flangeability, hole expansion forming tests were conducted. Test results showed that the hole expansion ratio becomes larger as the vertical angle *** also showed that the fracture strain at the fracture location on the hole edge was constant and independent of the vertical angle. This is because the hole expansion ratio was controlled not only by the fracture strain, which is independent of the vertical angle, but also by deformation uniformity along the hole edge. From the result of numerical analyses, it was determined that deformation uniformity depends on the gradient of circumferential stress along the radius direction. When the vertical angle is sharp, the circumferential stress showed a steep decline and the deformation localization was suppressed. Consequently, the hole edge deformed more uniformly and the hole expansion ratio became larger. It is concluded that in order to improve stretch flangeability of high strength steel, it is important to uniformly deform the hole edge by applying a conical punch with a sharp vertical angle.

关键词： Formability Ductile fracture Finite element analysis Hole expansion test