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Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第11期19卷 844-852页

作者： Toshinori YOSHIHARA Takao SUGIURA Nobuyuki MIYAJI Yuki YAMAMOTO Tsubasa SHIBAGUCHI Ryo KAKIGI Hisashi NAITO katsumasa goto Daijiro OHMORI Toshitada YOSHIOKA Graduate School of Health and Sports Science Juntendo UniversityInzaiChiba 270-1695Japan Faculty of Education Yamaguchi UniversityYamaguchiYamaguchi 753-8513Japan Toyo Koso Kagaku Co.Ltd. UrayasuChiba 279-0041Japan Institute of Health and Sports Science Kurume UniversityKurumeFukuoka 839-8502Japan Institute of Liberal Arts and Science Kanazawa UniversityKanazawaIshikawa 920-1192Japan Faculty of Medicine Juntendo UniversityBunkyo-kuTokyo 113-0033Japan Graduate School of Health Sciences Toyohashi SOZO UniversityToyohashiAichi 440-8511Japan Department of Chemistry School of MedicineJuntendo UniversityInzaiChiba 270-1695Japan Hirosaki Gakuin University HirosakiAomori 036-8577Japan

We examined the effect of a combination of astaxanthin （AX） supplementation, repeated heat stress, and intermittent reloading （IR） on satellite cells in unloaded rat soleus muscles. Forty-nine male Wistar rats （8-week-old） were divided into control, hind-limb unweighting （HU）, IR during HU, IR with AX supplementation, IR with repeated heat stress （41.0-41.5 ℃ for 30 min）, and IR with AX supplementation and repeated heat stress groups. After the experimental period, the antigravitational soleus muscle was analyzed using an immunohistochemical technique. Our results revealed that the combination of dietary AX supplementation and heat stress resulted in protection against disuse muscle atrophy in the soteus muscle. This protective effect may be partially due to a higher satellite cell number in the atrophied soleus muscle in the IR/AX/heat stress group compared with the numbers found in the other groups. We concluded that the combination treatment with dietary AX supplementation and repeated heat stress attenuates soleus muscle atrophy, in part by increasing the number of satellite cells.

关键词： Antioxidant astaxanthin Disuse muscle atrophy Heat stress Satellite cell

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Multimodal label-free microscopy

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Journal of Innovative Optical Health Sciences 2014年第5期7卷 17-38页

作者： Nicolas Pavillon katsumasa Fujita Nicholas Isaac Smith Biophotonics LaboratoryImmunology Frontier Research Center(IFReC Department of Applied Physics Osaka UniversitySuitaOsaka 565-0871Japan

This paper reviews the different multimodal applications based on a large ext ent of label-freeinaging modalities,ranging from linear to nonlinear optics,while also inchuding *** put specific emphasis on multimodal measurements going across the usual boundaries between imaging modalities,whereas most multimodal platforms combine techniquesbased on similar light interactions or similar hardware *** this review,we limitthe scope to focus on applications for biology such as live cells or tissues,since by their nat ure ofbeing alive or fragile,we are often not free to take liberties with the image acquisition times andare forced to gather the maximum amount of information possible at one *** such samples,imaging by a given label-free method usually presents a challenge in obt aining suficient opticalsignal or is limited in terms of the types of observable *** imaging is thenparticularly attractive for these samples in order to maximize the amount of measured *** multimodal imaging is always useful in the sense of acquiring additional infor-mation from additional modes,at times it is possible to attain information that could not bediscovered using any single mode alone,which is the essence of the progress that is possible usinga multimodal approach.

关键词： Optical microscopy nonlinear optics microspectroscopy

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Effect of annealing temperature on multiferroic properties of Bi_(0.85)Nd_(0.15)FeO_3 thin films prepared by sol-gel method

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Science China(Technological Sciences) 2010年第6期53卷 1572-1575页

作者： goto Takashi Institute for Materials Research Tohoku UniversitySendai 980-8577Japan

Bi0.85Nd0.15FeO3 films were prepared on Pt/Ti/SiO2/Si substrate by a sol-gel method,and annealed at different *** effect of annealing temperature on the crystal structure,dielectric,ferroelectric,and ferromagnetic properties was *** the Bi0.85Nd0.15FeO3 films were annealed at 490-600°C,the single phase was ***0.85Nd0.15FeO3 film annealed at 600°C showed good multiferroic properties with εr of 145 (at 1 MHz),Ms of 44.8 emu/cm3,and 2Pr of 16.6 μC/cm2.

关键词： Bi0.85Nd0.15FeO3 thin films sol-gel method annealing temperature ferroelectric properties ferromagnetic properties

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A Review:Structural Oxide Coatings by Laser Chemical Vapor Deposition

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Journal of Wuhan University of Technology(Materials Science) 2016年第1期31卷 1-5页

作者： Takashi goto Institute for Materials Research Tohoku University

Yttria-stabilized zirconia and-alumina films were prepared by laser chemical vapor deposition at deposition rates of several hundred micrometers per ***,the structural oxide coatings by laser chemical vapor deposition are *** laser can significantly accelerate the chemical reaction and grain growth in CVD,yielding high deposition *** films contain large amounts of nanopores that act as thermal insulation and are thus promising as coating materials for gas turbine blades of Ni-based superalloys and WC-Co cutting tools.

关键词： laser CVD yttria-stabilized zirconia alumina plasma nano-pores

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Recent Advances in Protein Extraction and Chiral Separation of Biomolecules

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Tsinghua Science and Technology 2006年第2期11卷 194-201页

作者： Masahiro goto Department of Applied Chemistry Graduate School of Engineering Kyushu University Fukuoka Japan

Reverse micelles create unique environment in organic media. They are capable of solubilizing hydrophilic biomolecules （e.g., proteins, peptides, amino acids, and DNAs） in their aqueous interior. This feature brings about the practical use of biomaterials in organic media because reverse micelles solubilize them with the intrinsic activity. In this paper, we focus on recent two topics concerning protein extraction and chiral separation of biomolecules using liquid membranes. In the first topic, we present recent attempts to extract proteins from an aqueous solution into isooctane using reverse micelles, and some important operational parameters to achieve an efficient protein transfer are discussed. Furthermore, novel function of reverse micelles as a protein activation medium is introduced. In the reverse micellar phase, denatured proteins were completely reactivated in the reverse micellar solution. The reverse micellar technique is found to be a useful tool not only for protein separation but also for protein refolding. Furthermore, we found that a cyclic ligand carixarene has an extraction ability to set up optimum conditions for protein transfer. In the second topic, we have found that a supported liquid membrane （SLM） encapsulating enzymes shows high enantioselectivity （enantioselective excess value is over 96%） in the transport of racemic pharmaceutical compound ibuprofen. A different experiment also suggests that the α-chymotrypsin-catalyzed reactions droved the enantioselective transport of L-phenylalanine based on the enantioselectivity of the enzyme. The SLM encapsulating the surfactant-enzyme complex enabled the highly enantioselective separation of racemic mixtures. It can be envisioned that arrangement of appropriate enzymes in the SLM system will allow enantioselective separation of various useful organic compounds.

关键词： protein extraction chiral separation reverse micellar technique

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Blood Stasis Syndrome in Japan and Its Molecular Biological Analysis

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Chinese Journal of Integrative Medicine 2014年第7期20卷 490-495页

作者： Hirozo goto Department of Kampo Medicine Hokusei Hospital

Blood stasis syndrome is one of the pathological concepts of Oriental traditional medicine. In Oriental traditional medicine, blood is thought of as not only blood but also as a living component of the body. In fact, blood stasis syndrome is related to not just circulation disorders but dermatological and gynecological and other diseases. In Japan, the concept of blood stasis syndrome is based on the past literature, for instance, Synopsis of Golden Chamber （Jin Kui Yao Lue）, etc. There are many signs of this syndrome, such as a dry mouth, fullness of the abdomen and rough skin. However, the levels of importance of these signs had been unclear. Therefore, in order to determine the levels of seriousness, a scoring system of blood stasis syndrome was made based on multivariate analysis by Dr. Terasawa （Terasawa＇s Blood Stasis Score）. Using the scoring system, we have studied blood stasis syndrome mainly related to blood circulation using modem techniques of analysis. From the results, we found that patients with blood stasis syndrome showed hemorheological abnormalities, and an improvement in these abnormalities was shown after administration of removing-blood stasis formulae. Furthermore, we have studied blood stasis syndrome from the point of view of molecular biology. We searched for the specific protein expression in blood stasis syndrome by proteomic analysis, and found no specific protein expression. However, there may be a possibility of developing a diagnostic algorithm for blood stasis by construction of a decision tree. During the past few years, as one of the molecular biological factors affecting blood stasis syndrome, we have been studying hypoxia inducible factor, which is located in the upstream of many genes. Above all, blood stasis syndrome is more than just circulatory deficit but encompasses the pathological concept of constant multilateral change in the living body.

关键词： blood stasis syndrome Terasawa's Blood Stasis Score hemorheological abnormalities proteomic analysis decision tree hypoxia inducible factor

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Prefrontal cortical dopamine from an evolutionary perspective

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Neuroscience Bulletin 2015年第2期31卷 164-174页

作者： Young-A Lee Yukiori goto Department of Food Science and Nutrition Catholic University of Daegu Kyoto University Primate Research Institute

In this article, we propose the hypothesis that the prefrontal cortex （PFC） acquired neotenic development as a consequence of mesocortical dopamine （DA） innervation, which in turn drove evolution of the PFC into becoming a complex functional system. Accordingly, from the evolutionary perspective, decreased DA signaling in the PFC associated with such adverse conditions as chronic stress may be considered as an environmental adaptation strategy. Psychiatric disorders such as schizophrenia and attention deficit/hyperactivity disorder may also be understood as environmental adaptation or a by-product of such a process that has emerged through evolution in humans. To investigate the evolutionary perspective of DA signaling in the PFC, domestic animals such as dogs may be a useful model.

关键词： neurodevelopment neoteny psychiatric disorder stress animal model synaptic plasticity environmental adaptation

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Contour detection with bicubic spline surfaces

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International Journal of Digital Earth 2023年第1期16卷 1801-1827页

作者： Hiroyuki goto Taiki Otsuka Department of Industrial and Systems Engineering Hosei UniversityTokyoJapan Faculty of IT and Business Cyber UniversityTokyoJapan

Contour detection has a rich history in multiplefields such as geography,engineering,and earth *** predominant approach is based on piecewise planar tessellation and now being challenged concerning the extraction of contour objects for non-linear elevation functions,particularly with respect to bicubic spline functions.A storage-efficient method was developed in previous research,but the detection of the complete set of contour objects is yet to be *** intractable,theoretical underpinnings pertinent to curvature resulted in an approach to realize the complete detection of *** a digital elevation model dataset,in this study,a bicubic spline surface function wasfirst ***,candidate initial points on the edges across the region of interest were identified,and the recursive disaggregation of rectangles was repeated if the non-existence of a solution could not be assured.A developed tracking method was then *** advancement,other initial points on the same contour curve were identified and eliminated to circumvent duplicate *** completeness of the outlets provides analytical tools for elevation and other geographical *** experiments included the development of a three-dimensional contour-based network and slope *** latter application transforms the slope analysis type from raster-based to *** of a complete set of contour objects amenable to bicubic spline surfaces..Small closure inside a single patch is detectable if size exceeds the standard..Curvature&tolerances central to step length adjustment and tangent angle determination..Redundant initial points are identified and eliminated during the tracking process..Various potential applications in addition to geographical elevations.

关键词： Contour detection bicubic spline surface curvature tolerance patch disaggregation

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Storage-efficient reconstruction framework for planar contours

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Geo-Spatial Information Science 2017年第1期20卷 14-28页

作者： Hiroyuki goto Yoichi Shimakawa Department of industrial and system engineering Hosei UniversitytokyoJapan Department of computer science and technology salesian polytechniquetokyoJapan

A storage-efficient reconstruction framework for cartographic planar contours is *** a smaller number of control points,we aim to calculate the area and perimeter as well as to reconstruct a smooth *** input data forms an oriented contour,each control point of which consists of three values:the Cartesian coordinates(x,y)and tangent angleθ.Two types of interpolation methods are developed,one of which is based on an arc spline while the other one is on a cubic Hermite *** arc spline-based method reconstructs a G1 continuous curve,with which the exact area and perimeter can be *** benefit of using the Hermite spline-based method is that it can achieve G2 continuity on most control points and can obtain the exact area,whereas the resulting perimeter is *** a numerical experiment for analytically defined curves,more accurate computation of the area and perimeter was achieved with a smaller number of control *** another experiment using a digital elevation model data,the reconstructed contours were smoother than those by a conventional method.

关键词： Oriented contour arc spline cubic Hermite spline geometric continuity storage efficient

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IMPLEMENTATION OF 3-VALUED PARACONSISTENT LOGIC PROGRAMMING TOWARDS DECISION MAKING SYSTEM OF AGENTS

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Journal of Systems Science and Systems Engineering 2018年第3期27卷 322-339页

作者： Yuki goto Megumi Fujita Naoyuki Nide Graduate School of System Informatics Kobe University (Until Mar. 2018) Faculty of Science and Engineering Kindai University Faculty Division of Human Life and Environmental Sciences Nara Women's University

Due to the rapid development of applications of artificial intelligence and robotics in recent years, the necessity of reasoning and decision making with uncertain and inaccurate information is increasing. Since robots in the real world are always exposed to behavioral inaccuracies and uncertainty arising from recognition methods, they may occasionally encounter contradictory facts during reasoning on action decision. Paraconsistent logic programming is promising to make appropriate action decisions even when an agent is exposed to such uncertain information or contradictory facts, but there has been no implementation of this programming to the best of our knowledge. We propose a resolution algorithm for the 3-valued paraconsistent logic programming system QMPT0 and its implementation on SWI-Prolog. We also describe an application of the 3-valued paraconsistent logic programming regarding agent decision making.

关键词： Agent-based modelling for complex systems paraconsistent logic programming solver implementation declarative programming application for agents

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