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石化译文 2000年第1期 17-19页

作者：李永民 katoh,S

Distribution of late gadolinium enhancement in various types of cardiomyopathies:Significance in differential diagnosis, clinical features and prognosis

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World Journal of Cardiology 2014年第7期6卷 585-601页

作者： Hiroshi Satoh Makoto Sano Kenichiro Suwa Takeji Saitoh Mamoru Nobuhara masao Saotome Tsuyoshi Urushida Hideki katoh Hideharu Hayashi Division of Cardiology Internal Medicine ⅢHamamatsu University School of Medicine

The recent development of cardiac magnetic resonance(CMR)techniques has allowed detailed analyses of cardiac function and tissue characterization with high spatial *** review characteristic CMR features in ischemic and non-ischemic cardiomyopathies(ICM and NICM),especially in terms of the location and distribution of late gadolinium enhancement(LGE).CMR in ICM shows segmental wall motion abnormalities or wall thinning in a particular coronary arterial territory,and the subendocardial or transmural *** in NICM generally does not correspond to any particular coronary artery distribution and is located mostly in the mid-wall to subepicardial *** analysis of LGE distribution is valuable to differentiate NICM with diffusely impaired systolic function,including dilated cardiomyopathy,end-stage hypertrophic cardiomyopathy(HCM),cardiac sarcoidosis,and myocarditis,and those with diffuse left ventricular(LV)hypertrophy including HCM,cardiac amyloidosis and Anderson-Fabry disease.A transient low signal intensity LGE in regions of severe LV dysfunction is a particular feature of stress *** arrhythmogenic right ventricular cardiomyopathy/dysplasia,an enhancement of right ventricular(RV)wall with functional and morphological changes of RV becomes ***,the analyses of LGE distribution have potentials to predict cardiac outcomes and response to treatments.

关键词： Cardiomyopathy Cardiac magnetic resonance Late gadolinium enhancement Cardiac function Clinical features Prognosis

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大鼠E_s-4位点的新变异体

实验动物科学 1990年第4期21卷 34-36页

作者： H.katoh 崔树良

本文报道了DK/Nac大鼠肾酯酶的一个新变异体。这个新变异体的酯酶是第五连锁群(LinkageGruop V.)的Es-4位点的第3个复等位基因决定的,暂命名为Es-4C。利用17个近交系做品系的分布调查,除了DK/Nac品系具有Es-4C型外,其它品系都不具有此... 详细信息

本文报道了DK/Nac大鼠肾酯酶的一个新变异体。这个新变异体的酯酶是第五连锁群(LinkageGruop V.)的Es-4位点的第3个复等位基因决定的,暂命名为Es-4C。利用17个近交系做品系的分布调查,除了DK/Nac品系具有Es-4C型外,其它品系都不具有此型。虽然也做了远交群(JcL:Wistar和Jcl:SD),我们也没有发现带有Es-4C的大鼠。Es-4C型的遗传分析是用DK/Nac和BUF/Nac(Es-4B)阔的交配试验来进行的。结果表明,这一新的变异体是由Es-4C位点控制的。命名为Es-4C等位基因。

关键词： Es-4C 第五连锁群 DK品系

Bi-Directional Regulation by Chinese Herbal Formulae to Host and Parasite for Multi-Drug Resistant <i>Staphylococcus aureus</i>in Humans and Rodents

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Open Journal of Immunology 2015年第1期5卷 18-32页

作者： Nobuo Yamaguchi Takanao Ueyama Nurmuhamamt Amat Dilxat Yimit Parida Hoxur Daisuke Sakamoto Yuma katoh Ikkan Watanabe Shan-Yu Su Department of Fundamental Research for CAM Kanazawa Medical University Uchinada Japan Ishikawa Natural Medicinal Products Research Center Kanazawa Japan Department of Medicine II Kansai Medical University Osaka Japan Traditional Uighur Medicine Department Xinjiang Medical University Urumqi China Traditional Chinese Medicine Hospital Xinjiang Medical University Urumqi China Department of Chest Surgery Kanazawa Medical University Himi Citizen Hospital Himi Japan Department of Respiratory Medicine Tohkai Central Hospital Gifu Japan Department of Chinese Medicine China Medical University Hospital Taichung City Taiwan School of Post-Baccalaureate Chinese Medicine College of Chinese Medicine China Medical University Taichung City Taiwan

A decline in the immunopotential of the host plays acritical factor(s) in the occurrence of infections with methicillin-resistant Staphylococcus aureus (MRSA) or microorganisms by opportunistic infection. In such an infection, no way out for therapeutic concept, therefore bi-directional trial was the final choice. So we selected aformula, Dang Gui Liu Huang Tang (dLHT), which could both augmentimmune factorsin host and exert bacteriostatic effect. We sought to break through the epidemic by MRSA especially in elderly patient, by the fundamental and clinical trial by employing minor TCM, characterizing bidirectional ability of the decoction by western methods. Animal Experiment: Mitomycin-C (MMC)-treated mice with or without the infection of MRSA were made. The experimental design was made up to examine the bacteriostatic action as well as the immunopo-tentiating bias of the promising Chinese herbal medicine, dLHT, which was first proved for its immune potentiating activities as well as their sensitivity to antibiotics, but not direct aseptic effect was clear for MRSA. Both basic and clinical data showed that this formula was effective on repelling from the infectious focus after the treatment of MRSA infection. After the administration of dLHT, the number of white blood cells in MMC-treated mice recovered to 80% of the normal level. In addition, the phagocytic activity of macrophages increased to 70% in the dLHT-treated group, while that of the non-treated group was only 20%. The bactericidal activity also recovered to the level close to the normal value by dLHT. The ratio of neutrophils in the dLHT-administered group increased to 2.2% (normal mice, 2.6%), whereas that in the non-terated group was only 0.5%. The bacterial count in the liver of MRSA-challenged mice reached the peak at six hours after the challenge in both dLHT-treated and non-treated mice. However, the number of bacteria in dLHT group was much greater than that in the non-treated group. The bacterial

关键词： Drug Sensitivity Multiple Resistance Dang Gui Liu Huang Tang MRSA Nosocomical Infection Host Immunity

Sporadic gastric carcinoid tumor successfully treated by two-stage laparoscopic surgery:A case report

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World Journal of Gastrointestinal Surgery 2010年第11期2卷 385-388页

作者： Takahiro kinoshita Takashi Oshiro Tasuku Urita Yutaka Yoshida Mitsuru Ooshiro Shinichi Okazumi Ryoji katoh Daisuke Sasai Nobuyuki Hiruta Department of Surgery Toho University Sakura Medical CenterShimoshizu 564-1Sakura285-8741 ChibaJapan Department of Pathology Toho University Sakura Medical CenterShimoshizu 564-1Sakura285-8741 ChibaJapan

We report a case of sporadic gastric carcinoid tumor successfully treated by two-stage laparoscopic surgery.A 38-year old asymptomatic woman was referred to our hospital for evaluation of a submucosal tumor of the *** examination showed a solitary submucosal tumor without ulceration or central depression on the posterior wall of the antrum and biopsy specimens were not sufficient to determine the *** ultrasound revealed a tumor nearly 2 cm in diameter arising from the muscle layer and a computed tomography scan showed the tumor enhanced in the arterial *** wedge resection was performed for definitive ***,the tumor was shown to be gastric carcinoid infiltrating the muscle layer which indicated the probability of lymph node *** gastrin levels were *** a radical treatment,laparoscopy-assisted distal gastrectomy with regional lymphadenectomy was performed 3 wk after the initial ***,pathological examination revealed no lymph node metastasis.

关键词： Gastric carcinoid Laparoscopic surgery Laparoscopy-assisted distal gastrectomy Completion surgery Submucosal tumor

Clinicopathological Evaluation and Prognostic Analysis in Breast Cancer Patients with Brain Metastasis

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Journal of Cancer Therapy 2015年第8期6卷 727-734页

作者： Naoko Minatani Hirokazu Tanino Yoshimasa Kosaka Mariko kikuchi Hiroshi Nishimiya Mina Waraya Hiroshi katoh Takumo Enomoto Norihiko Sengoku masahiko Watanabe Department of Surgery Kitasato University School of Medicine Kanagawa Japan

Background: Brain metastases are diagnosed in 5% - 15% of patients with breast cancer. Clinical management of brain metastases appears to be crucial in improving the prognosis of patients with breast cancer that has metastasized to the brain. However, few studies have investigated whether treatment of metastatic brain tumors would lead to improved prognosis. Methods: A total of 41 breast cancer patients whose tumors metastasized to the brain and who were diagnosed and treated at our hospital were enrolled. This study was conducted to determine the characteristics of brain metastases and to identify the factors that may affect the treatment and prognosis of patients with brain metastases. Results: There were more patients with HER2 and triple negative subtypes than of the luminal subtype. The median time from the initiation of breast cancer treatment to the onset of brain metastasis was 31 months (range, 7 - 134 months). Significantly greater disease-specific survival (DSS) was observed in patients who had a performance status of 0 - 2 at the time of diagnosis of metastatic brain tumors than those with a performance status of 3 - 4 (p = 0.04). DSS was also significantly greater in patients who underwent surgery to remove brain metastases and in patients treated with systemic therapy (p = 0.0007 and 0.0001, respectively). Conclusions: It may be possible to improve the prognosis of patients with brain metastases if lesions are detected early enough when the patients’ performance status is still good. In order for these findings to be definitive, however, results of future prospective studies are eagerly awaited.

关键词： Brain Metastasis Breast Cancer Performance Status

Oxidative Dehydrogenation of Isobutane to Isobutene on FSM-16 Doped with Cr and Related Catalysts

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Journal of Chemistry and Chemical Engineering 2013年第11期7卷 1014-1020页

作者： Shigeru Sugiyama Yoshihisa Nitta Yukimi Furukawa Ai Itagaki Takuya Ehiro Keizo Nakagawa masahiro katoh Yuuki Katou Shuji Akihara Wataru Ninomiya Department of Advanced Materials Institute of Technology and Science The University of Tokushima Tokushima 770-8506Japan Department of Resource Circulation Engineering Center for Frontier Research of Engineering The University of TokushimaTokushima 770-8506 Japan Department of Chemical Science and Technology The University of Tokushima Tokushima 770-8506 Japan Otake Research Laboratories Mitsubishi Rayon Co. Ltd. Hiroshima 739-0693 Japan

The oxidative dehydrogenation of isobutane to isobutene was examined for the use in the preparation of FSM-16 and related compounds doped by chromium with expectations that a yield of isobutene of greater than 8% could be achieved. The activity depended on the molding procedure of the catalyst and the doping method of the chromium species. In the present study, 8.8% and 8.3% of the yield of isobutene were obtained at 0.75 h and 6 h on-stream for the catalyst （Cr-loading; 6.2 wt.%） molded using wet treatment hut not pressurization treatment, in which the chromium species were directly added into the aqueous solution containing raw FSM-16 （hydrated sodium silicate powder） at an initial stage of the catalyst preparation. The structure information was based on XRD （X-ray diffraction）, the specific surface area was determined using a conventional BET （Brunauer-Emmett-Teller） nitrogen adsorption and the loading of chromium was estimated using ICP （inductively coupled plasma）. All those parameters combined with the molding method indicated that the catalytic activity was more influenced by the loading of chromium into bulk but not on surface of the catalyst rather than by the hexagonal structure of FSM-16 and the surface area.

关键词： Oxidative dehydrogenation isobutane isobutene FSM-16 chromium-doping.

Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis

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World Journal of Gastroenterology 2006年第39期12卷 6325-6330页

作者： Toshihito Kosaka Junji Yoshino Kazuo Inui Takao Wakabayashi Kazumu Okushima Takashi Kobayashi Hironao Miyoshi Yuta Nakamura Shigekazu Hayashi Taizou Shiraishi masatoshi Watanabe Takayuki Yamamoto Ai Nakahara Takahiko katoh Department of Internal Medicine Second Teaching Hospital Fujita Health University School of Medicine 3-6-10 Otobashi Nakagawaku Nagoya 454-8509 Japan Department of Gastroenterology Nagoya Ekisaikai Hospital 4-66 Shounencho Nakagawaku Nagoya 454-8502 Japan Department of Pathologic Oncology Mie University Graduate School of Medicine 2-174 Edobashi Tsu Mie 514-8507 Japan School of Engineering Yokohama National University 79-5 Tokiwadai Hodogaya-ku Yokohama 240-8501 Japan Inflammatory bowel disease centre and department of surgery Yokkaichi Social Insulance Hospital 10-8 Hazuyamacho Yokkaichi Mie Japan Department of Public Health Miyazaki Medical College University of Miyazaki 5200 Kihara Miyazaki 889-1692 Japan

AIM： To examine the influence of lipoprotein lipase （LPL） gene polymorphism in ulcerative colitis （UC） patients.METHODS： Peripheral blood was obtained from 131 patients with UC and 106 healthy controls for DNA extraction. We determined LPL gene polymorphisms affecting the enzyme at Ser447stop, as well as Hind Ⅲ and Pvu Ⅱ polymorphisms using PCR techniques. PCR products were characterized by PCR-RFLP and direct sequencing. Polymorphisms were examined for association with clinical features in UC patients. Genotype frequencies for LPL polymorphisms were also compared between UC patients and controls.RESULTS： In patients with onset at age 20 years or younger, C/G and G/G genotypes for Ser447stop polymorphism were more prevalent than C/C genotype （OR = 3.13, 95% CI = 0.95-10.33）. Patients with H^＋/- or H^-/- genotype for Hind Ⅲ polymorphism also were more nu merous than those with H^＋/＋ genotype （OR = 2.51, 95% CI = 0.85-7.45）. In the group with H^＋/＋ genotype for Hind Ⅲ polymorphism, more patients had serum triglyceride concentrations over 150 mg/dL than patients with H^＋/- or H^- genotype （P 〈 0.01, OR = 6.46, 95% CI = 1.39-30.12）. Hypertriglycemia was also more prevalent in patients with P^＋/＋ genotypes for Pvu Ⅱ polymorphism （P 〈 0.05, OR = 3.0, 95% CI = 1.06-8.50）. Genotype frequency for LPL polymorphism did not differ significantly between UC patients and controls.

关键词： Ulcerative colitis Lipoprotein lipase Lipid metabolism Triglyceride

11和14千兆赫低噪声砷化镓场效应晶体管放大器

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微纳电子技术 1978年第3期37卷 63-70页

作者： S.Aihara H.katoh 李春发

采用亚微米栅砷化镓场效应晶体管(NEC V-388)研制成11和14千兆赫低噪声放大器。两级放大器实现的最小噪声系数,在11.2千兆赫时为4.2分贝,14千兆赫时为5.7分贝。该放大器将用作接收机前置级。它由未封装的砷化镓场效应晶体管管芯与制作... 详细信息

采用亚微米栅砷化镓场效应晶体管(NEC V-388)研制成11和14千兆赫低噪声放大器。两级放大器实现的最小噪声系数,在11.2千兆赫时为4.2分贝,14千兆赫时为5.7分贝。该放大器将用作接收机前置级。它由未封装的砷化镓场效应晶体管管芯与制作在兰宝石衬底上的薄膜微带输入和输出电路组成。本文介绍了这类放大器的设计、结构和性能。

关键词：千兆赫噪声系数砷化镓场效应晶体管谐振器共振器放大器电路场效应晶体管放大器低噪声

Characterization and Manipulation of Spin of Single-Molecule-Magnet Double-Decker Phthalocyanine Molecule

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Characterization and Manipulation of Spin of Single-Molecule...