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可诱导基因在心肌预处理中的表达特征

国外医学（麻醉学与复苏分册） 2004年第2期25卷 120-124页

作者： Pavel Sergeev Rafaela da Silva M.S. Eliana Lucchinetti kathrin zaugg Thomas Pasch Marcus C.Schaub Michael zaugg 李军李广明 Institute of Pharmacology and Toxicology University of Zurich. Institute of Pharmacology and Toxicology University of Zurich Department of Medical Biophysics University of TorontoCanadaand the Advanced Medical Discovery InstituteOntario Cancer Institute University Hospital Zurich Cardiovascular Anesthesia Laboratory Institute of AnesthesiologyUniversity Hospital Zurichand Institute of Pharmacology and ToxicologyUniversity of Zurich 徐州医学院江苏省麻醉学重点实验室

和短暂缺血相似,挥发性麻醉药可通过多种复杂的快速磷酸化反应促进心肌组织细胞建立保护状态,这种现象被称为经典或早期预处理,其作用短暂,持续l h～2 h后消失;预处理刺激还可进一步触发第二次长时间持续的基因反应以增加新蛋白质的合成... 详细信息

和短暂缺血相似,挥发性麻醉药可通过多种复杂的快速磷酸化反应促进心肌组织细胞建立保护状态,这种现象被称为经典或早期预处理,其作用短暂,持续l h～2 h后消失;预处理刺激还可进一步触发第二次长时间持续的基因反应以增加新蛋白质的合成,尽管这种延迟性的心肌保护效应(又称为延迟性预处理或第二保护窗)没有早期预处理的作用强,但可持续到72 h,因此在治疗方面更有前景.

关键词：可诱导基因心肌预处理表达特征挥发性麻醉药延迟性预处理

Industrial Experience with Case Hardening of Stainless Steels by Solution Nitriding

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材料热处理学报 2004年第5期25卷 354-359页

作者： Hans Berns Bernd Edenhofer Roland zaugg Ruhr University Materials Technology D-44780 Bochum GermanyIPSEN Industries International GmbH D-47514 Kleve GermanyHdrterei GersterA.G. CH-4622 Egerkingen Switzerland

SolNit(R) is a novel heat treatment to case harden stainless steels with nitrogen instead of carbon. The calculated equilibrium pressure of N2 corresponds well with the nitrogen content in the steel surface. The process is carried out in vacuum furnaces with pressurized gas quenching. Numerous parts of different stainless steels have been successfully SolNit(R) treated in industry leading to superior properties in respect to hardness/strength and corrosion

关键词：不锈钢渗氮表面硬化热处理

Recent advances in ultrafast semiconductor disk lasers

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Light(Science & Applications) 2015年第1期4卷 281-294页

作者： Bauke W Tilma Mario Mangold Christian A zaugg Sandro M Link Dominik Waldburger Alexander Klenner Aline S Mayer Emilio Gini Matthias Golling Ursula Keller Department of Physics Institute for Quantum ElectronicsETH ZurichZurich 8093Switzerland FIRST Center for Micro-and Nanoscience ETH ZurichZurich 8093Switzerland

The performance of ultrafast semiconductor disk lasers has rapidly advanced in recent *** strong interest from industry for inexpensive,compact,and reliable ultrafast laser sources in the picosecond and femtosecond domains has driven this technology toward commercial *** metrology and biomedical applications would benefit from sub-200-femtosecond pulse durations with peak powers in the kilowatt *** aim of this review is to briefly describe the market potential and give an overview of the current status of mode-locked semiconductor disk *** focus is placed on the ongoing efforts to achieve shorter pulses with higher peak powers.

关键词： lasers modelocked lasers semiconductor lasers ultrafast lasers vertical emitting lasers

Industrial Experience with Case Hardening of Stainless Steels by Solution Nitriding

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Industrial Experience with Case Hardening of Stainless Steel...

Survey on Raw Milk Quality in Kosovo

14～(th) Congress of International Federation for Heat Treament and Surface Engineering

作者： Hans Berns Bernd Edenhofer Roland zaugg Ruhr University Materials TechnologyD-44780 BochumGermany IPSEN Industries International GmbH D-47514 KleveGermany Hrterei Gerster A.G. CH-4622 EgerkingenSwitzerland

＜正＞ SolNit is a novel heat treatment to case harden stainless steels with nitrogen instead of carbon. The calculated equilibrium pressure of N2 corresponds well with the nitrogen content in the steel surface. The process is carried out in vacuum furnaces with pressurized gas quenching. Numerous parts of different stainless steels have been successfully SolNit treated in industry leading to superior properties in respect to hardness/strength and corrosion resistance

关键词： Case hardening stainless steel solution nitriding applications

来源： cnki会议评论

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Food and Nutrition Sciences 2011年第5期2卷 414-421页

作者： Hysen Bytyqi Stefan Bigler Skender Muji Ardita Jahja Urs zaugg University of Prishtina Faculty of Agriculture and Veterinary. Boulevard “Bill Clinton” Prishtina Republic of Kosovo

In Kosovo, a new regulation on quality standards and grade of fresh milk is valid since January 1, 2007. The regulation was based on the respective EU-regulation and has an ambitious time frame with a transition period of only three years. In order to estimate the impact of this new regulation, a survey on the quality of raw milk delivered to the Kosovar dairies was carried out from January to May 2007. The aim was to get a reliable picture of the current raw milk quality in the dairy channel in Kosovo, to discuss the findings with the relevant actors of the dairy sector and the government, and to draw the necessary conclusions. In total 364 milk samples, from the leading 14 dairies constitute the basis for the statistical analyses of this study. The four most important parameters of raw milk quality: TBC, SCC, FP and AB were analyzed. Regarding TBC, the results show that around 20% of samples meet the Kosovo standard 2008 (< 500,000 CFU/ml) and only around 10% meet the (higher) Kosovo standard 2009 (<100,000 CFU/ml) while for SCC, around 80% of the samples meet the Kosovo standard 2008 (<600,000 cells/ml) and 66% meet the (higher) Kosovo standard 2009 (<400,000 cells/ml). Therefore at the moment the problem of high microbiological content is more prominent than the one of high somatic cell count. Beside this, in one third of the samples, the freezing point is at least questionable. In 2.2% of the samples antibiotics could be proven—a major risk for public health. Raw milk quality in Kosovo still is very poor and must be improved in order the dairy processors be able to produce qualitatively good end products and therefore can compete with imported dairy products or export their products.

关键词： Raw Milk Quality Microorganisms Somatic Cell Count Freezing Point and Antibiotics

Return on Investment after Implementation of a Centralized Automated Storage System in a Hospital Pharmacy

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Journal of Pharmacy and Pharmacology 2016年第10期4卷 526-532页

作者： Sarah Berdot Virginie Savoldelli Vincent zaugg Emmanuel Jaccoulet Patrice Prognon Laetitia MinhMai Le Brigitte Sabatier Pharmacy Department Hopital Europeen Georges Pompidou APHP Paris 75015 France Equipe 22 Centre de Recherche des Cordeliers UMR 1138 INSERt Paris 75015 France Clinical Pharmacy Department Faculty of Pharmacy Universite Paris Sud Chatenay-Malabry 92290 France Lip(Sys)2 EA7357 UFR Pharmacie U-Psud Univ. Paris-Saclay Chdtenay-Malabry 92290 France

An ADS （automated dispensing system） was implemented in our hospital pharmacy in 2008 to optimize and secure the medication process. The main objective of this study was to compare the projected and the real ROI （return on investment）, after seven years of use. ROI was calculated annually （from 2008 to 2015）, by deducting the cost of investment （ADS buying and implementation, maintenance, repairs and ADS upgrade） from the cost saving （drugs stock reduction and decrease of pharmacy staff dedicated to global dispensing）. In 2015, total costs saving （＋$1,141,987） were divided between decreasing drug stock value and reduction of pharmacy staff. Total costs of investment （-$978,656） were acquisition, maintenance, repairs and an unplanned upgrade costs. Finally, the real ROI was ＋$163,331 after seven years of use. In 2008, projected ROI was ＋$410,786. The real payback period has been increased by approximately two years （six years of use, instead of four years as expected）. Despite their cost, ADSs are a worthwhile investment, leading to a ROI within a few years. These economic considerations should be put into perspective with optimization of drugs stock management, greater efficiency of the global dispensing process, securitization of medication process and redeployment of pharmacy staff.

关键词： Centralized automated dispensing system return on investment medication process payback redeployment ofpharmacy staff.

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耳鸣听力学管理临床指南Ⅰ：评估

听力学及言语疾病杂志 2019年第6期27卷 690-693页

作者：陈劭立吴双剑李明张剑宁 Henry JA zaugg TL Schechter MA 上海中医药大学附属岳阳中西医结合医院耳鼻咽喉科

听力障碍的临床管理包含各医疗机构间能广泛适用的、统一的完善流程,听力师能借此评估听力状况并为交流障碍提供康复服务。然而,当患者以耳鸣为主诉就诊时,他们的治疗却得不到系统保障。耳鸣有许多治疗方案,但是大多都没有明确依据。因... 详细信息

听力障碍的临床管理包含各医疗机构间能广泛适用的、统一的完善流程,听力师能借此评估听力状况并为交流障碍提供康复服务。然而,当患者以耳鸣为主诉就诊时,他们的治疗却得不到系统保障。耳鸣有许多治疗方案,但是大多都没有明确依据。因此,耳鸣患者很难对最适合自己的治疗做出判断,只有为耳鸣的临床管理建立协商一致的指导方针,这种状况才能改变。评估和干预是耳鸣管理的两个主要组成部分,本文提供了一个循序渐进的指南,描述了耳鸣听力学管理(audiologic tinnitus management,ATM)的过程是如何展开的,供听力师对耳鸣患者进行基本的评估,其核心为使用现有问卷和标准听力检测设备。

关键词：临床指南听力检测康复服务交流障碍耳鸣医疗机构协商一致完善流程

在真空炉中不锈钢采用SoINit(固溶氮化)工艺并高压气淬

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国外金属热处理 2004年第5期25卷 62-63页

作者： R.zaugg 金华兰德国Hrterei Gerster AG 南昌大学机电学院

1 SoINit-A和SoINit-M这二种工艺是Bochum Ruhr大学工艺博士***教授研发的.两年前,我们在Gerster股份公司用IPSEN公司改良的VTTC-K(W)真空炉着手一项系统发展项目,为了把SoINit-A和SoINit-M固溶氮化工艺引入生产中.我们现在正用这些工... 详细信息

1 SoINit-A和SoINit-M这二种工艺是Bochum Ruhr大学工艺博士***教授研发的.两年前,我们在Gerster股份公司用IPSEN公司改良的VTTC-K(W)真空炉着手一项系统发展项目,为了把SoINit-A和SoINit-M固溶氮化工艺引入生产中.我们现在正用这些工艺不断地为客户服务.

关键词：高压气淬固溶氮化真空炉不锈钢氮化热处理工艺

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气调贮藏冷却风机功效

中国果品研究 1991年第4期11卷 29-32页

作者： Henry Waelti Ralph Cavalieri Keith zaugg 郁网庆华盛顿州大学农业工程系商业部济南果品研究所

虽然华盛顿州苹果产区电费是目前世界各地区最便宜的,但是,人们预言将来这些地区所有用电户要支付昂贵的电费。随着人们需求高品质标准所带来的成本增加,经济效益下降,只有节约电能才能提高经济效益是显而易见的。

关键词：气调贮藏冷却风机气调库贮期苹果产区华盛顿州贮藏温度品质标准贮藏品质库内