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Elucidating regulatory processes of intense physical activity by multi-omics analysis

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military medical Research 2024年第4期 479-499页

作者： Ernesto S.Nakayasu marina A.Gritsenko Young-mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie munoz kathleen m. Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L. Paurus Kent J. Bloodsworth Kelsey A. Allen Lisa m. Bramer Fernando montes kathleen A. Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National Laboratory Environmental and molecular Sciences Division Pacific Northwest National Laboratory Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Western States Division Computational Analytics Division Pacific Northwest National Laboratory National Security Directorate Pacific Northwest National Laboratory Los Angeles County Fire Department Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Respiratory Health Division Environmental and molecular Toxicology Oregon State University

Background: Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***: To study regulatory processes in intense physical activity simulating real-life conditions, we performed a multi-omics analysis of 3 biofluids(blood plasma, urine, and saliva) collected from 11 wildland firefighters before and after a 45 min, intense exercise regimen. Omics profiles post-vs. pre-exercise were compared by Student's t-test followed by pathway analysis and comparison between the different omics ***: Our multi-omics analysis identified and quantified 3835 proteins, 730 lipids and 182 metabolites combining the 3 different types of samples. The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands. The urine analysis showed a strong, concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites, reabsorption of nutrients and maintenance of fluid balance. In saliva, we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides. A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***: This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility, suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

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脑肿瘤监测的动脉自旋标记mRI：真的需要脑血流图吗？

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国际医学放射学杂志 2024年第1期 126-126页

作者： W.H.T.Teunissen A.Lavrova m.van den Bent A.van der Hoorn E.A.H.Warnert m.smits 武鑫宏

摘要目的动脉自旋标记（ASL）灌注mRI是一种用于脑肿瘤监测的高级mRI技术之一。研究定量脑血流（CBF）与非定量灌注加权成像（ASL-PWI）测量之间的相关性。并研究

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Contemporary climate infuence on variability patterns of Anadenanthera colubrina ***,a key species in seasonally dry tropical forests

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Journal of Forestry Research 2022年第1期33卷 89-101页

作者： maría Victoria García maría Eugenia Barrandeguy kathleen Prinz Genética de Poblaciones y Cuantitativa-Departamento de Genética-Facultad de Ciencias Exactas Químicas y Naturales-Universidad Nacional deMisionesInstituto de Biología Subtropical(UNaM-CONICET)Nodo PosadasFélix de Azara 15523300 PosadasArgentina Consejo Nacional de Investigaciones Científicas Y Técnicas(CONICET) PosadasMisionesArgentina Institute of Systematic Botany With Herbarium Haussknecht and Botanical Gardens Friedrich-Schiller-University Jena07743 JenaGermany

The distribution of many plant species has been shaped by climate changes,and their current phenotypic and genetic variability refect microclimatically suitable *** study relates contemporary climate to variability patterns of phenotypic traits and molecular markers in the Argentinean distribution of Anadenanthera colubrina ***,as well as to identify the most relevant phenotypic trait or molecular marker associated with those *** from four populations in both biogeographic provinces,Paranaense and Yungas,were *** analyses and multiple linear regressions were carried out to determine relationships among phenotypic traits and nuclear microsatellites,respectively,to climatic variables,and to identify the phenotypic traits as well as nuclear microsatellite loci most sensitive to *** and three clusters of individuals were detected based on genetic and phenotypic data,*** clusters based on genetic data refected the biogeographic origin of *** traits were the most relevant indicators of climatic *** microsatellite locus Ac41.1 appeared to be non-neutral presenting a strong correlation with climate variable temperature *** findings show complex patterns of genetic and phenotypic variability in the Argentinean distribution of *** *** related to the present or contemporary climate,and provides an example for an integrative approach to better understand climate impact on contemporary genetic and phenotypic variability in light of global climate change.

关键词： Contemporary climate Curupay Genetic variability Phenotypic variability Seasonally dry tropical forests

management of vascular complications following calcium hydroxylapatite filler injections:a systemic review of cases and experimental studies

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Plastic and Aesthetic Research 2022年第1期9卷 503-528页

作者： Aleksandra L.Lindgren kathleen m.Welsh University of Queensland-Ochsner Clinical School New OrleansLA 70121USA Bay Area Cosmetic Dermatology San FranciscoCA 94115USA

Aim:Dermal fillers are increasingly popular *** intraarterial injection of fillers,particularly with calcium hydroxylapatite(CaHA),can result in devastating consequences.A systemic review was performed to summarize management strategies to treat CaHA-associated vascular ***:The methodology of this review was derived from The Preferred Reporting Items for Systematic Reviews and meta-analyses(PRISmA).In addition,this paper presents a previously unreported case of a CaHA-associated vascular ***:There were 32 articles describing 42 cases,plus our case included in this *** were 15 cases of vision complications,23 cases of non-vision complications,and 5 experimental *** most common injection sites reported were nasal region for vision complications(45%)and nasolabial folds for non-vision complications(40%).Of the 38 human cases,the most prevalent treatment choice was steroids(24 cases,63%).Complete or near complete improvement was reported in 83%of non-vision complications and 40%of vision *** was no noticeable homogeneity in the management strategies and outcomes of the *** the 5 experimental studies,no clear consensus on treatments was ***:Vascular complications of CaHA are seemingly uncommon,but it is widely suspected that this is due to *** best management is prevention,preparation for a potential complication is equally *** from CaHA literature,hyaluronic acid filler complication protocols,findings of this review,and personal experiences,this report proposes management strategies for CaHA-associated vascular *** hope these strategies provide a much-needed framework for injectors to refer to and utilize as needed.

关键词： Filler-associated intravascular complications filler-associated blindness vascular occlusion management calcium hydroxylapatite Radiesse

Expanding Non-Patient COVID-19 Data: Towards the FAIRification of migrants' Data in Tunisia, Libya and Niger

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Data Intelligence 2022年第4期4卷 955-970,1034,1038,1044,1047,1054页

作者： mariem Ghardallou morgane Wirtz Sakinat Folorunso Zohra Touati Ezekiel Ogundepo Klara smits Ali mtiraoui mirjam van Reisen University of Sousse Faculty of Medicine of SousseDepartment of Community MedicineResearch Laboratory LR12ES03Tunisia4002Sousse Tilburg University 1002 Tunisthe Netherlands Department of mathematical Sciences Olabisi Onabanjo UniversityP.M.B 2002Ago-IwoyeOgun StateNigeria 120005Nigeria Data Science Nigeria Lagos 105102 Leiden University 1310 Leidenthe Netherlands Leiden University medical Centre Leiden University1310 Leidenthe Netherlands Virus Outbreak Data Network-Africa

This article describes the FAIRification process(which involves making data Findable, Accessible, Interoperable and Reusable—or FAIR—for both machines and humans) for data related to the impact of COVID-19 on migrants, refugees and asylum seekers in Tunisia, Libya and Niger, according to the scheme adopted by GO FAIR. This process was divided into three phases: pre-FAIRification, FAIRification and postFAIRification. Each phase consisted of seven steps. In the first phase, 118 in-depth interviews and 565 press articles and research reports were collected by students and researchers at the University of Sousse in Tunisia and researchers in Niger. These interviews, articles and reports constitute the dataset for this research. In the second phase, the data were sorted and converted into a machine actionable format and published on a FAIR Data Point hosted at the University of Sousse. In the third phase, an assessment of the implementation of the FAIR Guidelines was undertaken. Certain barriers and challenges were faced in this process and solutions were found. For FAIR data curation, certain changes need to be made to the technical process. People need to be convinced to make these changes and that the implementation of FAIR will generate a long-term return on investment. Although the implementation of FAIR Guidelines is not straightforward, making our resources FAIR is essential to achieving better science together.

关键词： FAIRification process FAIR Guidelines FAIR data Tunisia Niger Libya COVID migrants VODAN-Africa

EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid

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Translational Neurodegeneration 2022年第1期11卷 835-844页

作者： Hannes Devos kathleen Gustafson Ke Liao Pedram Ahmadnezhad Bradley Estes Laura E.martin Jonathan D.mahnken William m.Brooks Jeffrey m.Burns Department of Physical Therapy Rehabilitation Scienceand Athletic TrainingUniversity of Kansas Medical CenterKansas CityKS 66160USA Department of Neurology University of Kansas Medical CenterKansas CityKS 66160USA Hoglund Biomedical Imaging Center University of Kansas Medical CenterKansas CityKS 66160USA Department of Population Health University of Kansas Medical CenterKansas CityKS 66160USA Department of Biostatistics and Data Science University of Kansas Medical CenterKansas CityKS 66160USA University of Kansas Alzheimer’s Disease Center University of Kansas Medical CenterKansas CityKS 66160USA.

Background: Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The first aim of the study was to determine the association between elevated Aβ (Aβ+) and cognitive processes measured by the P3 event-related potential (ERP) in cognitively normal (CN) older adults. The second aim was to compare the event- related power between CNAβ+ and CNAβ−. methods: Seventeen CNAβ+ participants (age: 73 ± 5, 11 females, montreal Cognitive Assessment [moCA] score 26 ± 2) and 17 CNAβ- participants group-matched for age, sex, and mOCA completed a working memory task (n-back with n = 0, 1, 2) test while wearing a 256-channel electro-encephalography net. P3 peak amplitude and latency of the target, nontarget and task difference effect (nontarget−target), and event-related power in the delta, theta, alpha, and beta bands, extracted from Fz, Cz, and Pz, were compared between groups using linear mixed models. P3 ampli-tude of the task difference effect at Fz and event-related power in the delta band were considered main outcomes. Correlations of mean Aβ standard uptake value ratios (SUVR) using positron emission tomography with P3 amplitude and latency of the task difference effect were analyzed using Pearson Correlation Coefficient r. Results: The P3 peak amplitude of the task difference effect at Fz was lower in the CNAβ+ group (P = 0.048). Simi-larly, power was lower in the delta band for nontargets at Fz in the CNAβ+ participants (P = 0.04). The CNAβ+ partici-pants also demonstrated higher theta and alpha power in channels at Cz and Pz, but no changes in P3 ERP. Strong correlations were found between the mean Aβ SUVR and the latency of the 1-back (r = − 0.69;P = 0.003) and 2-back (r = − 0.69;P = 0.004) of the task difference effect at channel Fz in the CNAβ+ group. Conclusions: Our data suggest that the elevated amyloid in cognitively normal ol

关键词： Event-related potentials Electro-encephalography Working memory Older adults Preclinical Beta-amyloid

Evolution of IPv6 Internet topology with unusual sudden changes

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Chinese Physics B 2013年第7期22卷 602-609页

作者：艾均赵海 kathleen m. Carley 苏湛李辉 College of Information Science and Engineering Northeastern University Institute for Software Research Carnegie Mellon University

The evolution of Internet topology is not always smooth but sometimes with unusual sudden changes. Consequently, identifying patterns of unusual topology evolution is critical for Internet topology modeling and simulation. We analyze IPv6 Internet topology evolution in IP-level graph to demonstrate how it changes in uncommon ways to restructure the Internet. After evaluating the changes of average degree, average path length, and some other metrics over time, we find that in the case of a large-scale growing the Internet becomes more robust; whereas in a top–bottom connection enhancement the Internet maintains its efficiency with links largely decreased.

关键词： scale-free network Internet topology evolution unusual evolution of Internet topology complex network analysis

Adrenomedullin and endocrine control of immune cells during pregnancy

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Cellular & molecular Immunology 2014年第5期11卷 456-459页

作者： Brooke C matson kathleen m Caron Departments of Cell Biology & Physiology University of North Carolina at Chapel Hill Chapel Hill NC USA Genetics University of North Carolina at Chapel Hill Chapel Hill NC USA

The immunology of pregnancy is complex and incompletely understood. Aberrant immune activity in the decidua and in the placenta is believed to play a role in diseases of pregnancy, such as infertility, miscarriage, fetal growth restriction and preeclampsia. Here, we briefly review the endocrine control of uterine natural killer cell populations and their functions by the peptide hormone adrenomedullin. Studies in genetic animal models have revealed the critical importance of adrenomedullin dosage at the maternal-fetal interface, with cells from both the maternal and fetal compartments contributing to essential aspects underlying appropriate uterine receptivity, implantation and vascular remodeling of spiral arteries. These basic insights into the crosstalk between the endocrine and immune systems within the maternal- fetal interface may ultimately translate to a better understanding of the functions and consequences of dysregulated adrenomedullin levels in clinically complicated pregnancies.

关键词： adrenomedullin preeclampsia pregnancy spiral artery remodeling uNK cells

Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility

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Genes & Diseases 2023年第2期10卷 381-384页

作者： Jeroen Vierstraete Charlotte Fieuws David Creytens Jo Van Dorpe Andy Willaert Anne Vral kathleen Bm Claes Center for medical Genetics Department of Biomolecular MedicineGhent University Hospital and Ghent University9000 GhentBelgium Department of Human Structure and Repair Ghent University9000 GhentBelgium Cancer Research Institute Ghent (CRIG) Ghent University and Ghent University Hospital9000 GhentBelgium Department of Pathology Ghent University and Ghent University Hospital9000 GhentBelgium

Biallelic loss-of-function variants in ATm (Ataxia Telangiectasia mutated) cause Ataxia Telangiectasia (AT), a rare disorder associated with cerebellar degeneration and ataxia, cancer predisposition, infertility, growth retardation, etc. ATm is a phosphoinositide 3-kinase-related kinase (PIKK) with a role in DNA repair and maintenance of genome stability. Studying a multisystem genetic disease like AT requires animal models to ascertain its pathogenesis at the level of tissues, organs and the organism. Due to its small size, cheap maintenance, large progeny, rapid development and initial transparency, zebrafish (Danio rerio) is an increasingly popular vertebrate model organism, suitable for genetic modifications and large-scale in vivo therapeutic screens as embryos are chemically permeable to small compounds. Currently, no zebrafish model for AT exists.1 We generated atm knock-outs through CRIPSR-Cas9 mutagenesis. We show that atm conserved its function as a tumour suppressor gene and is involved in gametogenesis and fertility. Therefore, this mutant is of great value for further studies investigating the role of atm in reproduction and tumorigenesis.

关键词： ATm function transparency