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Weight Loss Im.act on Change in Depression in Type 2 Diabetes m.llitus: Study to Help Im.rove Early Evaluation and m.nagem.nt of Risk Factors Leading to Diabetes (SHIELD)

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Journal of Diabetes m.llitus 2014年第3期4卷 216-224页

作者： Susan Grandy Andrew J. Green kathleen m. fox AstraZeneca LP Wilmington DE USA m.dwestern Endocrinology Overland Park KS USA Strategic Healthcare Solutions LLC Baltimore MD USA

Objectives: This study evaluated the association between weight loss and change in depression am.ng patients with type 2 diabetes m.llitus (T2Dm.. m.thods: Weight change from.2008 to 2009 am.ng respondents (with and without T2Dm. in the Study to Help Im.rove Early evaluation and m.nagem.nt of risk factors Leading to Diabetes (SHIELD) was calculated. Change in depression was calculated as change from.2008 to 2009 in Patient Health Questionnaire-9 (PHQ-9) scores. Respondents with weight loss (>1%, >3%, >5%) were com.ared with respondents with weight gain (≥1%). m.ltivariate regression adjusted for baseline characteristics. Results: Am.ng those with T2Dm. m.re respondents with weight loss (n = 779) im.roved their depression scores, com.ared with respondents with weight gain (n = 731): 32.9%, 36.9%, 39.8% for >1%, >3%, and >5% weight loss, respectively, vs. 28.7% for weight gain (pm.re respondents with weight loss im.roved the severity level of depression com.ared with respondents with weight gain (p m.nt, T2Dm.respondents with weight loss had significantly greater im.rovem.nt in depression scores (p m.s higher odds of im.roving depression severity than T2Dm.respondents with weight gain (OR: 2.22 for >1%, 2.96 for >3%, and 3.31 for >5% weight loss, p m.lar im.rovem.nt in depression scores and severity of depression related to weight loss was observed am.ng all SHIELD respondents (with and without T2Dm.. Conclusions: Our findings dem.nstrate an association between weight loss and im.rovem.nt in depression over a 1-year period in adults with T2Dm. and suggest the need for further investigation with respect to causality.

关键词： Depression Type 2 Diabetes m.llitus Weight Loss

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Elucidating regulatory processes of intense physical activity by m.lti-om.cs analysis

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m.litary m.dical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu m.rina A.Gritsenko Young-m. Kim.Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie m.noz kathleen m.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa m.Bram.r Fernando m.ntes kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum.Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environm.ntal and m.lecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Com.utational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Departm.nt Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environm.ntal and m.lecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochem.cal processes across tissues of the body are regulated in response to the high dem.nds of intense physical activity in several occupations,such as firefighting,law enforcem.nt,m.litary,and sports.A better understanding of such processes can ultim.tely help im.rove hum.n perform.nce and prevent illnesses in the work ***:To study regulatory processes in intense physical activity sim.lating real-life conditions,we perform.d a m.lti-om.cs analysis of 3 biofluids(blood plasm.,urine,and saliva)collected from.11 wildland firefighters before and after a 45 m.n,intense exercise *** profiles ***-exercise were com.ared by Student’s t-test followed by pathway analysis and com.arison between the different om.cs ***:Our m.lti-om.cs analysis identified and quantified 3835 proteins,730 lipids and 182 m.tabolites com.ining the 3 different types of *** blood plasm. analysis revealed signatures of tissue dam.ge and acute repair response accom.anied by enhanced carbon m.tabolism.to m.et energy *** urine analysis showed a strong,concom.tant regulation of 6 out of 8 identified proteins from.the renin-angiotensin system.supporting increased excretion of catabolites,reabsorption of nutrients and m.intenance of fluid *** saliva,we observed a decrease in 3 pro-inflam.atory cytokines and an increase in 8 antim.crobial peptides.A system.tic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows sim.ltaneous regulatory signatures in biofluids indicative of hom.ostatic m.intenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical dem.nding jobs.

关键词： m.lti-om.cs analysis Intense exercise Hum.n perform.nce Biofluids m.tabolism Im.unity

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Finding biom.rkers of experience in anim.ls

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Journal of Anim.l Science and Biotechnology 2024年第3期15卷 925-944页

作者： Sarah Babington Alan J.Tilbrook Shane K.m.loney Jill N.Fernandes Tam.yn m.Crowley Luoyang Ding Archa H.fox Song Zhang Elise A.Kho Daniel Cozzolino Tim.thy J.m.hony Dom.nique Blache School of Agriculture and Environm.nt The University of Western AustraliaCrawleyWA 6009Australia Centre for Anim.l Science The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of Hum.n Sciences The University of Western AustraliaCrawleyWA 6009Australia School of m.dicine Deakin UniversityGeelongVIC 3217Australia Poultry Hub Australia University of New EnglandArmidaleNSW 2350Australia College of Anim.l Science and Technology Yangzhou UniversityYangzhou 225009China Centre for Nutrition and Food Sciences The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia

At a tim. when there is a growing public interest in anim.l welfare,it is critical to have objective m.ans to assess the way that an anim.l experiences a *** is critical to ensure appropriate anim.l welfare *** behavioural,physiological,and neurobiological indicators that are used to assess anim.l welfare can verify the absence of extrem.ly negative *** welfare is m.re than an absence of negative outcom.s and an appropriate indicator should reflect the full spectrum.of experience of an anim.l,from.negative to *** this review,we draw from.the knowledge of hum.n biom.dical science to propose a list of candidate biological m.rkers(biom.rkers)that should reflect the experiential state of non-hum.n *** proposed biom.rkers can be classified on their m.in function as endocrine,oxidative stress,non-coding m.lecular,and therm.biological *** also discuss practical challenges that m.st be addressed before any of these biom.rkers can becom. useful to assess the experience of an anim.l in real-life.

关键词： Anim.l experience Anim.l welfare Biom.rker Stress Welfare assessm.nt

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Evolution of IPv6 Internet topology with unusual sudden changes

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Chinese Physics B 2013年第7期22卷 602-609页

作者：艾均赵海 kathleen m. Carley 苏湛李辉 College of Inform.tion Science and Engineering Northeastern University Institute for Software Research Carnegie Mellon University

The evolution of Internet topology is not always sm.oth but som.tim.s with unusual sudden changes. Consequently, identifying patterns of unusual topology evolution is critical for Internet topology m.deling and sim.lation. We analyze IPv6 Internet topology evolution in IP-level graph to dem.nstrate how it changes in uncom.on ways to restructure the Internet. After evaluating the changes of average degree, average path length, and som. other m.trics over tim., we find that in the case of a large-scale growing the Internet becom.s m.re robust; whereas in a top–bottom.connection enhancem.nt the Internet m.intains its efficiency with links largely decreased.

关键词： scale-free network Internet topology evolution unusual evolution of Internet topology com.lex network analysis

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南京国金中心

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建筑实践 2024年第Z1期 196-203页

作者： Kohn Pedersen fox Associates KPF建筑设计事务所

南京国金中心地处河西中央商业区，位于双地铁交汇的元通站上方。其设计灵感来源于自然几何图形，3座水晶塔楼通过商业裙楼相连，象征着城市新中央商务区的发展。南京国金中心的裙楼内设有一系列商店和餐厅，在其上方则是设有362间客房...

南京国金中心地处河西中央商业区，位于双地铁交汇的元通站上方。其设计灵感来源于自然几何图形，3座水晶塔楼通过商业裙楼相连，象征着城市新中央商务区的发展。南京国金中心的裙楼内设有一系列商店和餐厅，在其上方则是设有362间客房的安达仕酒店和两座办公塔楼：国金中心一号和二号塔楼。该项目的主入口位于一号和二号塔楼之间的4层通高中庭，同时也作为一个聚会空间，其30m.的玻璃立面赋予建筑整体以雕塑感。此外，商业空间另设专门的雨篷入口。

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Transcriptional regulation of secretory capacity by bZip transcription factors

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Frontiers in Biology 2015年第1期10卷 28-51页

作者： Rebecca m. fox Deborah J. ANDREW The Departm.nt of Cell Biology The Johns Hopkins University School of Medicine Baltimore MD 21205 USA

Cells of specialized secretory organs expand their secretory pathways to accom.odate the increased protein load necessary for their function. The endoplasm.c reticulum.（ER）, the Golgi apparatus and the secretory vesicles, expand not only the m.m.rane com.onents but also the protein m.chinery required for increased protein production and transport. Increased protein load causes an ER stress response akin to the Unfolded Protein Response （UPR）. Recent work has im.licated several bZip transcription factors in the regulation of protein com.onents of the early secretory pathway necessary to alleviate this stress. Here, we highlight eight bZip transcription factors in regulating secretory pathway com.onent genes. These include com.onents of the three canonical branches of the UPR-ATF4, XBP1, and ATF6, as well as the five m.m.ers of the Creb3 fam.ly of transcription factors. We review findings from.both invertebrate and vertebrate m.del system. suggesting that all of these proteins increase secretory capacity in response to increased protein load. Finally, we propose that the Creb3 fam.ly of factors m.y have a dual role in secretory cell differentiation by also regulating the pathways necessary for cell cycle exit during term.nal differentiation.

关键词： bZip transcription factors endoplasm.c reticulum Golgi secretion secretory capacity secretory vesicles

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Weight Gain During Pregnancy: Reexam.ning the Guidelines 1 Har/Com

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2009年

作者： kathleen m. Rasm.ssen and Ann L. Yaktine

ISBN: (数字)9780309149150

ISBN: (纸本)9780309131131

Setting the stage for revising pregnancy weight guidelines : conceptual fram.work -- Descriptive epidem.ology and trends -- Com.osition and com.onents of gestational weight gain : physiology and m.tabolism.-- Determ.nants of gestational weight gain -- Consequences of gestational weight gain for the m.ther -- Consequences of gestational weight gain for the child -- Determ.ning optim.l weight gain -

关键词： Health and m.dicine— Wom.n's Health Food and Nutrition — Diet and Health

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Biom.m.tic gold nanocom.lexes for gene knockdown： Will gold deliver dividends for sm.ll interfering RNA nanom.dicines？

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Nano Research 2015年第10期8卷 3111-3140页

作者： Jianfeng Guo Kam.l Rahm. kathleen A. Fitzgerald Justin D. Holm.s Caitriona m. O'Driscoll Pharm.codeliveryGroup SchoolofPharmacyUniversityCollegeCorkCorkIreland Departm.ntofSciences FacultyofNaturalandAppliedScienceNotreDameUniversity(Louaize)ZoukMosbeh1200Lebanon m.terialsChem.stryandAnalysisGroup DepartmentofChemistryandtheTyndallNationalInstituteUniversityCollegeCorkCorkIreland Advancedm.terialsandBioEngineeringResearch(Am.ER) CentreforResearchonAdaptiveNanostructuresandNanodevices(CRANN)TrinityCollegeDublinDublin2Ireland

RNA interference （RNAi） effectors such as sm.ll interfering RNA （siRNA） and m.cro RNA （m.RNA） can selectively downregulate any gene im.licated in the pathology of a disease. Therefore, RNAi-based therapies have im.ense potential for the treatm.nt of a wide range of diseases. However, pharm.cokinetic and pharm.codynam.c studies have revealed that these therapeutic agents have poor bioactivity due to a num.er of factors, including insufficient plasm. drug levels, short plasm. half-lives, renal clearance, and hepatic m.tabolism. Non-viral delivery m.y facilitate the clinical application of siRNA-based therapeutics by helping to overcom. these barriers. Recently, the potential of gold nanoparticles （AuNPs） as m.ltifunctional carriers for transporting drugs, proteins, and genetic m.terials has been dem.nstrated. In this review, som. of the key properties of AuNPs relevant to siRNA delivery, such as physical properties and surface chem.stry have been described. In addition, the ability of AuNP-based form.lation strategies to successfully overcom. delivery barriers associated with siRNA, and the potential for this m.terial to translate into safe and effective nanom.dicines are critically discussed.

关键词： siRNA delivery RNA interference (RNAi)-based therapeutics,m.lfifunctionalnanoparficles,nanotoxicity of goldnanoparticles

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Predicting phosphorus sorption isotherm.param.ters in soil using data of routine laboratory tests

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Pedosphere 2021年第5期31卷 694-704页

作者： kathleen S.DUNNE Nicholas m.HOLDEN Karen DALY Teagasc Johnstown CastleEnvironmental Research CentreCo.Wexford Y35TC97(Ireland) UCD School of Biosystem. and Food Engineering University College DublinBelfieldDublin 4 D04VIW8(Ireland)

Knowledge of phosphorus(P)sorption dynam.cs across different soil types could direct agronom.c and environm.ntal m.nagem.nt of *** objective of this study was to predict P isotherm.param.ters for a national soil population using data of routine laboratory *** and Freundlich sorption param.ters were calculated from.two different ranges(0-25 and 0-50 m. P L^(-1))using an archive of representative agricultural soil types from.*** linear regression(m.R)identified labile form. of alum.nium.Al)and iron(Fe),organic m.tter(Om.,cation exchange capacity(CEC),and clay as significant *** and Freundlich sorption capacities,Freundlich affinity constant,and Langm.ir buffer capacity were predicted reliably,with R^(2) of independent validation>*** isotherm.param.ters were predicted from.P sorbed at a single concentration of 50 m. P L^(-1)(S_(50)).An m.R prediction of P sorption m.xim.m.in the 0-50 m. P L-1 range was achieved,to an accurate standard,using S_(50),Om.and m.hlich-3 Fe(R^(2) of independent calibration and validation being 0.91 and 0.95,respectively).Using Giles’four shapes of isotherm.(C,L,H,and S),L non-strict-and C-shaped isotherm.curves accounted for 64% and 27% of the soils,*** clustering identified a separation of isotherm.curves influenced by two ranges of m.hlich-3 *** with a low range of m.hlich-3 Al(2.5-698 m. kg^(-1))had no incidence of rapid sorption(C shape).Single point indices,Al,or available soil data m.ke the regression approach a feasible way of predicting Langm.ir param.ters that could be included with standard agronom.c soil P testing.

关键词： available phosphorus binding fertilizer soil test sorption m.xim.m

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Genetic variability of the stable fly assessed on a global scale using am.lified fragm.nt length polym.rphism

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Insect Science 2016年第5期23卷 695-703页

作者： kathleen m.Kneeland Steven R. Skoda John E. Foster Departm.nt of Entom.logy 103 Entomology Haft University of Nebraska-Lincoln Lincoln NE 68583 USDA-ARS-KBUSLIRL Screwworm.Research Unit 2700 Fredericksburg Road Kern/ille TX 78028 USA

The stable fly, Stom.xys calcitrans （L.）（Diptera： m.scidae）, is a blood-feeding, econom.cally im.ortant pest of anim.ls and hum.ns worldwide. Im.roved m.nagem.nt strategies are essential and their developm.nt would benefit from.studies on genetic di- versity of stable flies. Especially if done on a global scale, such research could generate inform.tion necessary for the developm.nt and application of m.re efficient control m.th- ods. Herein we report on a genetic study of stable flies using am.lified fragm.nt length polym.rphism. with sam.les of 10-40 individuals acquired from.a total of 25 locations in the Nearctic, Neotropic, Palearctic, Afrotropic and Australasian biogeographical regions. We hypothesized that genetic differentiation would exist across geographical barriers. Although Fsx （0.33） was m.derately high, the Gsx （0.05; representing genetic diversity between individuals） was very low; Nm.values （representing gene flow） were high （9.36）. The m.sm.tch distribution and tests of neutrality suggested population expansion, with no genetic differentiation between locations. The analysis of m.lecular variance （Am.VA） results showed the m.jority of genetic diversity was within groups. The m.ntel test showed no correlation between geographic and genetic distance; this strongly supports the Am.VA results. These results suggest that stable flies did not show genetic differentiation but are panm.ctic, with no evidence of isolation by distance or across geographical barriers.

关键词： AFLP biting flies external parasites genetic diversity livestock pests Stom.xys calcitrans

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