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Reactive Oxygen Species and Oxidative Stress in the Pathogenesis of MAfLD

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 939-946页

作者： kathleen Clare John f.Dillon Paul N.Brennan Royal Alexandra Hospital PaisleyNHS Greater Glasgow and ClydePA29PNUK University of Dundee Ninewells Hospital and Medical SchoolDundeeDD19SYUK University of Edinburgh Edinburgh BioQuarter5 Little France DriveEH164UUUK

The pathogenesis of metabolic-associated fatty liver disease(MAfLD)is complex and thought to be dependent on multiple parallel hits on a background of genetic *** evidence suggests that MAfLD progression is a dynamic two-way process relating to repetitive bouts of metabolic stress and inflammation interspersed with endogenous anti-inflammatory reparative *** MAfLD,excessive hepatic lipid accumulation causes the production of lipotoxins that induce mitochondrial dysfunction,endoplasmic reticular stress,and over production of reactive oxygen species(ROS).Models of MAfLD show marked disruption of mitochondrial function and reduced oxidative capacitance with impact on cellular processes including mitophagy,oxidative phosphorylation,and mitochondrial *** excess,ROS modify insulin and innate immune signaling and alter the expression and activity of essential enzymes involved in lipid *** can also cause direct damage to intracellular structures causing hepatocyte injury and *** select cases,the use of anti-oxidants and ROS scavengers have been shown to diminish the proapoptopic effects of fatty *** this link,endogenous anti-oxidant pathways have been a target of interest,with Nrf2 activation showing a reduction in oxidative stress and inflammation in models of *** hormone receptorβ(THRβ)agonists and nuclear peroxisome proliferationactivated receptor(PPAR)family have also gained interest in reducing hepatic lipotoxicity and restoring hepatic function in models of ***,the true interplay between the clinical and molecular components of MAfLD progression remain only partly *** recently,multiomics-based strategies are being adopted for hypothesis-free analysis of the molecular changes in *** profiling maps the unique genotype-phenotype associations in MAfLD and with various single-cell tran scriptome-based projects underway,there is hope of novel physiological insigh

关键词： fatty liver disease Metabolic-associated fatty liver disease Nonalcoholic steatohepatitis Reactive oxidation species Oxidative stress

Contemporary climate infuence on variability patterns of Anadenanthera colubrina ***,a key species in seasonally dry tropical forests

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Journal of forestry Research 2022年第1期33卷 89-101页

作者： María Victoria García María Eugenia Barrandeguy kathleen Prinz Genética de Poblaciones y Cuantitativa-Departamento de Genética-facultad de Ciencias Exactas Químicas y Naturales-Universidad Nacional deMisionesInstituto de Biología Subtropical(UNaM-CONICET)Nodo PosadasFélix de Azara 15523300 PosadasArgentina Consejo Nacional de Investigaciones Científicas Y Técnicas(CONICET) PosadasMisionesArgentina Institute of Systematic Botany With Herbarium Haussknecht and Botanical Gardens Friedrich-Schiller-University Jena07743 JenaGermany

The distribution of many plant species has been shaped by climate changes,and their current phenotypic and genetic variability refect microclimatically suitable *** study relates contemporary climate to variability patterns of phenotypic traits and molecular markers in the Argentinean distribution of Anadenanthera colubrina ***,as well as to identify the most relevant phenotypic trait or molecular marker associated with those *** from four populations in both biogeographic provinces,Paranaense and Yungas,were *** analyses and multiple linear regressions were carried out to determine relationships among phenotypic traits and nuclear microsatellites,respectively,to climatic variables,and to identify the phenotypic traits as well as nuclear microsatellite loci most sensitive to *** and three clusters of individuals were detected based on genetic and phenotypic data,*** clusters based on genetic data refected the biogeographic origin of *** traits were the most relevant indicators of climatic *** microsatellite locus Ac41.1 appeared to be non-neutral presenting a strong correlation with climate variable temperature *** findings show complex patterns of genetic and phenotypic variability in the Argentinean distribution of *** *** related to the present or contemporary climate,and provides an example for an integrative approach to better understand climate impact on contemporary genetic and phenotypic variability in light of global climate change.

关键词： Contemporary climate Curupay Genetic variability Phenotypic variability Seasonally dry tropical forests

Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis:An opinion review

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World Journal of Gastroenterology 2020年第15期26卷 1683-1690页

作者： Paul Brennan kathleen Clare Jacob George John f Dillon Department of Molecular and Clinical Medicine University of DundeeNinewells Hospital and Medical SchoolDundee DD19SYUnited Kingdom Department of Neurology Queen Elizabeth HospitalGlasgow G514TFUnited Kingdom

There has long been a recognised association between non-alcoholic fatty liver disease(NAfLD)and the composite aspects of the metabolic *** of this association highlighted the supposed co-existence of elevated uric acid levels in those with *** is interest in exploitation of this as a putative diagnostic and prognostic biomarker in *** the increased economic and health burden associated with the NAfLD epidemic,improved methods of population-based,minimally-invasive methods and biomarkers are clearly highly sought and *** this opinion review we review the proposed role of uric acid in the pathogenesis of NAfLD and its potential utilisation in the diagnosis and monitoring of the disease process.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Uric acid Urate Non-invasive fibrosis markers fatty liver index

Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro

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World Journal of Gastroenterology 2012年第16期18卷 1875-1883页

作者： kathleen f Benson Kimberlee A Redman Steve G Carter David Keller Sean farmer John R Endres Gitte S Jensen NIS Labs 1437 EsplanadeKlamath FallsOR 97601United States Ganeden Biotech 5915 Landerbrook DriveMayfield HeightsOH 44124United States AIBMR Life Sciences 4117 S MeridianPuyallupWA 98373United States

AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune ***:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:f human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear *** maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow ***:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell *** biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite *** were also seen for the dendritic cell maturation markers CD80 and *** CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright *** co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell *** selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory ***:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making.

关键词：抗原呈递细胞凝结芽孢杆菌成熟阶段代谢产物益生菌外周血单核细胞调节性T细胞 CD80

Genome of tetraploid sour cherry (Prunus cerasus L.) ‘Montmorency’ identifies three distinct ancestral Prunus genomes

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Horticulture Research 2023年第7期10卷 22-39页

作者： Charity Z.Goeckeritz kathleen E.Rhoades Kevin L.Childs Amy f.Iezzoni Robert VanBuren Courtney A.Hollender Department of Horticulture Michigan State University1066 Bogue StEast LansingMI 48824USA Department of Plant Biology Michigan State University612 Wilson RoadEast LansingMI 48824USA

Sour cherry(Prunus cerasus L.)is a valuable fruit crop in the Rosaceae family and a hybrid between progenitors closely related to extant Prunus fruticosa(ground cherry)and Prunus avium(sweet cherry).Here we report a chromosome-scale genome assembly for sour cherry cultivar Montmorency,the predominant cultivar grown in the *** also generated a draft assembly of *** to use alongside a published *** sequence for syntelog-based subgenome assignments for‘Montmorency’and provide compelling evidence *** is also an *** hierarchal k-mer clustering and phylogenomics,we show‘Montmorency’is trigenomic,containing two distinct subgenomes inherited from a ***-like ancestor(A and A’)and two copies of the same subgenome inherited from a ***-like ancestor(BB).The genome composition of‘Montmorency’is AA’BB and little-to-no recombination has occurred between progenitor subgenomes(A/A’and B).In Prunus,two known classes of genes are important to breeding strategies:the self-incompatibility loci(S-alleles),which determine compatible crosses,successful fertilization,and fruit set,and the Dormancy Associated MADS-box genes(DAMs),which strongly affect dormancy transitions and flowering *** S-alleles and DAMs in‘Montmorency’and *** were manually annotated and support subgenome ***,the hybridization event‘Montmorency’is descended from was estimated to have occurred less than 1.61 million years ago,making sour cherry a relatively recent ***‘Montmorency’genome highlights the evolutionary complexity of the genus Prunus and will inform future breeding strategies for sour cherry,comparative genomics in the Rosaceae,and questions regarding neopolyploidy.

关键词： Prunus cherry breeding

Communicate! Belmont, Calif. :

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THE CHALLENGE Of EffECTIVE SPEAKING 12th ed.

2002年

作者： Rudolph f. Verderber kathleen S. Verderber.

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THE CHALLENGE OF EFFECTIVE SPEAKING

foundations in microbiology 4th ed.

2003年

作者： RUDOLPH f. VERDERBER kathleen S. VERDERBER

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Chinese nurses’ perceived impact of international educational experiences and cultural beliefs following a 1-year study abroad program: an exploratory study

2002年

作者： Talaro, kathleen P

Includes index.

ISBN: (纸本)0072320427

Includes index.

关键词： Microbiology.

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frontiers of Nursing 2020年第1期7卷 23-29页

作者： Debra MWolf Hui-Xin Wub kathleen Spadaro Diane fHunker Nursing and Healthcare Informatics Chatham UniversityPittsburghPennsylvania 15232USA School of Nursing Davis&Elkins CollegeElkinsWest Virginia 26241USA School of Nursing Chatham UniversityPittsburghPennsylvania 15232USA

Objectives:To examine the perceived impact of international educational experiences and cultural beliefs before and after completing a 1-year Masters of Science in Nursing ***:An exploratory study was conducted among Chinese nurses studying abroad in a private medium-sized university in the United *** 27-item electronic pre-survey was administered within 1 week of starting the program and the post-survey was administered 1 year later at the completion of the ***:Majority of participants(n=25)were female,23–36 years of *** revealed that the perceived impact of international educational experiences assessed at the start of the program was similar to the perceived impact measured at the end of the 1-year program,suggesting that the students learned and experienced what they *** was a significant impact on cultural beliefs from the start of the program compared with the end of the program suggesting that a 1-year study abroad program does influence cultural ***:Understanding what is important to provide in a study abroad program and providing the educational experiences identified by students as impactful are avenues to help host universities best develop their *** suggested that the 1-year program can influence foreign students’cultural beliefs,yet the professional and personal impact of this change warrants further study.

关键词： international Chinese nurses cultural beliefs learning needs educational impact