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Transient occult cardiotoxicity in children receiving continuous beta-agonist therapy

World Journal of Pediatrics 2014年第4期10卷 324-329页

作者： Christopher L Carroll Melinda Coro Allison Cowl kathleen a sala Craig M Schramm Department of Pediatrics Connecticut Children's Medical CenterHartfordCTUSA

Background:Continuous beta-agonist therapy,typically in the form of inhaled albuterol,is the first line therapy for the treatment of acute and severe bronchospasm in *** this treatment is commonly used,concerns about cardiotoxicity have been *** aimed to investigate the cardiotoxic effects of continuous beta-agonist therapy in ***:We conducted a retrospective review of children admitted to the intensive care unit(ICU)between May 2008 and April 2009,who were treated with continuous beta-agonist therapy(intravenous and nebulized).Results:Twenty of the 36 children treated with continuous albuterol had repeated serum troponin-T and lactate levels *** patients(55%)were also treated with continuous intravenous *** levels of troponin-T levels were found in 25%of children,and elevated lactate levels were found in 60%.However,all returned to normal levels within 48 hours of ICU admission,despite continued beta-agonist *** children experienced arrhythmias during *** was no association between intravenous terbutaline use and elevated troponin-T[odds ratio(OR),1.3;95%CI,0.2-10.3]or with elevated serum lactate(OR,0.6;95%CI,0.1-3.7).There was also no association between elevated troponin-T or lactate and ICU or hospital length of ***:In this small study,a significant proportion of children had elevated serum troponin-T and lactate levels while receiving inhaled continuous beta-agonist therapy,irrespective of intravenous ***,these abnormal values all returned to normal within 48 hours of ICU admission and were not associated with increased duration of hospitalization.

关键词： asthma beta-agonist pediatric

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