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n.trition.l epigen.tics education.improves diet an. attitude of paren.s of children.with autism or atten.ion.deficit/hyperactivity disorder

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World Journ.l of Psychiatry 2024年第1期14卷 159-178页

作者： Ren.e J Dufault katherine M Adler David O Carpen.er Steven.G Gilbert Raquel A Crider College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Departmen. of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Departmen. of Health Scien.es University of New HavenWest HavenCT 06516United States In.titute for Health an. the En.iron.en. School of Public HealthState University of New YorkAlbanyNY 12222United States Departmen. of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Departmen. of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGROUn. Un.ealthy matern.l diet leads to heavy metal exposures from the con.umption.of ultra-processed foods that may impact gen. behavior across gen.ration.,creatin. con.ition. for the n.urodevelopmen.al disorders kn.wn.as autism an. atten.ion.deficit/hyperactivity disorder(ADHD).Children.with these disorders have difficulty metabolizin. an. excretin. heavy metals from their bloodstream,an. the severity of their symptoms correlates with the heavy metal levels measured in.their *** may play a key role in.helpin. paren.s reduce their ultra-processed food an. dietary heavy metal in.ake by providin. access to effective n.trition.l epigen.tics *** To test the efficacy of n.trition.l epigen.tics in.truction.in.reducin. paren.al ultra-processed food *** The study utilized a semi-ran.omized test an. con.rol group pretest-posttest pilot study design.with participan.s recruited from paren.s havin. a learn.n.-disabled child with autism or ***-two paren.s who met the in.lusion.criteria were ran.omly selected to serve in.the test(n.11)or con.rol(n.11)*** test group participated in.the six-week on.in. n.trition.l epigen.tics tutorial,while the con.rol group did *** efficacy of the n.trition.l epigen.tics in.truction.was determin.d by measurin. chan.es in.paren. diet an. attitude usin. data derived from an.on.in. diet survey admin.stered to the participan.s durin. the pre an. post in.erven.ion.*** in.ake scores were derived for both ultra-processed an. whole/organ.c *** sample t-tests were con.ucted to determin. an. differen.es in.mean.diet scores within.each *** There was a sign.fican. differen.e in.the diet scores of the test group between.the pre-an. post-in.erven.ion.*** paren.s in.the test group sign.fican.ly reduced their in.ake of ultra-processed foods with a prein.erven.ion.diet score of 70(mean.5.385,SD=2.534)an. a post-in.erven.ion.diet score of 113(mean.8.692,SD=1.750)an. the

关键词： Epigen.mics Paren.eral n.trition Autism Atten.ion.deficit/hyperactivity disorder Ultra-processed foods Heavy metals

Creation.an. validation.of a n.vel low-cost dry lab for early residen. train.n. an. assessmen. of robotic prostatectomy techn.cal proficien.y

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Curren. Urology 2024年第2期18卷 133-138页

作者： Kevin.Kun.tsky Abhishek Ven.ataraman. katherine E.Fero Jorge Ballon.Jacob Komberg Robert Reiter Wayn. Brisban. In.titute of Urologic On.ology Department of UrologyDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Charles E.Schmidt College of Medicin. Florida Atlantic UniversityBoca RatonFLUSA

Purpose:To evaluate the prelimin.ry validity an. acceptability of a low-cost low-fidelity robotic surgery dry lab for train.n. an. assessin. residen.s’techn.cal proficien.y with key robotic radical prostatectomy *** an. methods:Three stan.ardized in.n.mate tasks were created to simulate the radical prostatectomy steps of posterior dissection.n.urovascular bun.le release,an. urethrovesical *** train.es an. faculty at a sin.le in.titution.completed an. evaluated each dry lab *** validity was evaluated by comparin. task completion.times an. Global Evaluative Assessmen. of Robotic Skills scores across four participan. cohorts:medical studen.s(n.5),jun.or residen.s(n.5),sen.or residen.s(n.5),an. atten.in. surgeon.(n.7).Con.en. validity,face validity,an. acceptabilitywere evaluated through a posttask survey usin. a 5-poin. Likert ***:There was a sign.fican. differen.e in.the in.ividual an. composite task completion.times an. Global Evaluative Assessmen. of Robotic Skills scores across all participan. cohorts(all pn.terms of its con.en. validity an. acceptability for use in.residen.y ***,model realism,compared with human.tissue,was poorly *** dry lab production.cost was less than.US$***:This low-cost procedure-specific dry lab demon.trated eviden.e of con.en. validity,con.truct validity,an. acceptability for simulatin. key robotic prostatectomy techn.cal steps an. can.be used to augmen. robot-assisted laparoscopic prostatectomy surgical train.n..

关键词： Robotic surgery education Radical prostatectomy Simulation Dry laboratory Validation

Resilien.e, the 6th Vital Sign. Con.eptualizin., Con.extualizin., an. Operation.lizin. All Six Vital Sign.

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Health 2024年第7期16卷 657-673页

作者： Rose E. Con.tan.in. Betty J. Braxter Chi Chin. Vivian.Hui Larissa C. Allen.Lillian.J. Wolfe katherine H. En.res Jezyl Cempron.Cutamora Lauren.e L. Garcia Daisy R. Palompon.Kathleen.Thimsen.Brayden.n. Kameg Margarete L. Zalon Departmen. of Health an. Commun.ty Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Un.ergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA The Hon. Kon. Polytechn.c Un.versity Hong Kong China School of n.rsin. Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School of n.rsin. University of Pittsburgh Pittsburgh PA USA Departmen. of Health Promotion.an. Developmen. School of Nursing University of Pittsburgh Pittsburgh PA USA College of n.rsin. Cebu Normal University Cebu City Philippines School of n.rsin. University of Nevada Las Vegas USA Departmen. of Health an. Commun.ty Systems University of Pittsburgh PA USA Departmen. of n.rsin. University of Scranton Scranton PA USA

There are five vital sign. that healthcare providers assess: temperature, pulse, respiration. blood pressure, an. pain. n.rmal levels for the five vital sign. are published by the American.Heart Association. an. other specialty organ.zation., however, the sixth vital sign.(resilien.e) which adopts the measure of immun. resilien.e is suggested in.this paper. Resilien.e is the ability of the immun. system to respon. to attacks an. defen. effectively again.t in.ection. an. in.lammatory stressors, an. psychological resilien.e is the capacity to resist, adapt, recover, thrive, an. grow from a challen.e or a stressor. In.ividuals with better optimal immun. resilien.e had better health outcomes than.those with min.mal immun. resilien.e. The purpose of this paper is to con.eptualize, con.extualize, an. operation.lize all six vital sign.. We suggest measurin. resilien.e subjectively an. objectively. Subjectively, use a 5-item guided in.erview revised from the Con.or-Davidson.Resilien.e Scale (CDRC), a scale of 10 items. The revised CDRC scale is a 5-item scale. The scale is rated on.a 5-poin. Likert scale from 0 (n.t true) to 4 (true all the time). The total score ran.es from 0 to 20, with higher total scores in.icatin. greater resilien.e. The scale demon.trated good con.truct validity an. in.ern.l con.isten.y (α = 0.85) durin. the developmen. of the scale. The CD-RISC had a good Cron.ach’s alpha level of 0.85. The Revised CD-RISC can.be completed in.2 - 4 min.tes. To measure resilien.e objectively, we suggest usin. Immun. Resilien.e (IR) levels, the level of resilien.e to preserve an./or rapidly restore immun. resilien.e fun.tion. that promote disease resistan.e an. con.rol in.lammation.an. other in.lammatory stress. IR levels are gauged with two peripheral blood metrics that quan.ify the balan.e between.CD8 an. CD4 T-cell levels an. gen. expression.sign.tures trackin. lon.evity-associated immun.competen.e an. mortality- or en.ropy-associated in.lammation. IR deregulation.i

关键词： Con.eptualization Con.extualization Operation.lization Body Temperature Pulse Respiration Blood Pressure Pain Resilien.e

Cuticular bacteria appear detrimen.al to social spiders in.mixed but n.t mon.culture exposure

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Curren. Zoology 2016年第4期62卷 377-384页

作者： Carl n. KEISER Taylor A. SHEARER lexan.er E. DEMARCO Hayley A. BRITTIn.HAM Karen.A. Kn.TSOn.Can.ice Kuo katherine ZHAO Jon.than.n. PRUITT Departmen. of Biological Scien.es University of Pittsburgh Pittsburgh PA 15260 USA

Much of an.an.mal＇s health status, life history, an. behavior are dictated by in.eraction. with its en.ogen.us an. exogen.us bacterial commun.ties. Un.ortun.tely, in.eraction. between.hosts an. members of their residen. bacterial commun.ty are often.ign.red in.an.mal behavior an. behavioral ecology. Here, we aim to iden.ify the n.ture of host-microbe in.eraction. in.a n.n.odel organ.sm, the African.social spider Stegodyphus dumicola. We collected an. iden.ified bacteria from the cuticles of spiders in.situ an. then.exposed spiders to bacterial mon.cultures cultures via topical application.or in.ection. We also topically in.culated spiders with a con.omitan. ＂cocktail＂ of bacteria an. measured the behavior of spiders daily for 24 days after in.culation. Lastly, we collected an. iden.ified bacteria from the cuticles of prey items in.the capture webs of spiders, an. then.fed spiders domestic crickets which had been.in.ected with these bacteria. We also in.ected 1 species of prey-born. bacteria in.o the hemolymph of spiders. On.y Bacillus thurin.ien.is caused in.reased mortality when.in.ected in.o the hemolymph of spiders, whereas n. bacterial mon.cultures caused in.reased mortality when.applied topically, relative to con.rol solution.. However, a bacterial cocktail of cuticular bacteria caused weight loss an. mortality when.applied topically, yet did n.t detectibly alter spider behavior. Con.umin. prey in.ected with prey-born. bacteria was associated with an.elon.ated lifespan.in.spiders. Thus, in.irect eviden.e from multiple experimen.s suggests that the effects of these bacteria on.spider survivorship appear con.in.en. on.their mode of colon.zation.an. whether they are applied in.mon.culture or within.a mixed cocktail. We urge that follow-up studies should test these host-microbe in.eraction. across differen. social con.exts to determin. the role that microbes play in.colon. performan.e.

关键词： cuticular bacteria sickn.ss behavior social spider Stegodyphus dumicola.

Additive n.urorestorative effects of exercise an. docosahexaen.ic acid in.ake in.a mouse model of Parkin.on.s disease

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n.ural Regen.ration.Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Min.sa Mi-mba katherine Coulombe Cyn.ia Tremblay Vin.en.Émon. Martin. Sain.-Pierre Clémen.e Rouxel Lin. Berthiaume Pierre Julien.Fran.esca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe n.uroscien.e Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada In.titute of n.trition.an. Fun.tion.l Foods QuebecQCCanada Optin.tribrain.In.ern.tion.l Associated Laboratory(n.trin.uro FranceINAFCanada)QuebecQCCanada Axe En.ocrin.logie et n.phrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Départemen. de Médecin. Facultéde MédecineUniversitéLavalQuebecQCCanada Départemen. de Psychiatrie et n.uroscien.es Facultéde MédecineQuebecQCCanada

There is a n.ed to develop in.erven.ion. to slow or reverse the degen.ration.of dopamin. n.uron. in.Parkin.on.s disease after *** that preclin.cal an. clin.cal studies suggest ben.fits of dietary n.3 polyun.aturated fatty acids,such as docosahexaen.ic acid,an. exercise in.Parkin.on.s disease,we in.estigated whether both could syn.rgistically in.eract to in.uce recovery of the dopamin.rgic ***,mice received a un.lateral stereotactic in.ection.of 6-hydroxydopamin. in.o the striatum to establish an.an.mal model of n.grostriatal *** weeks after lesion.an.mals were fed a docosahexaen.ic acid-en.iched or a con.rol diet for the n.xt 8 *** this period,the an.mals had access to a run.in. wheel,which they could use or *** acid treatmen.,volun.ary exercise,or the combin.tion.of both had n. effect on.i)distan.e traveled in.the open.field test,(ii)the percen.age of con.raversive rotation. in.the apomorphin.-in.uction.test or(iii)the n.mber of tyrosin.-hydroxylase-positive cells in.the substan.ia n.gra pars ***,the docosahexaen.ic acid diet in.reased the n.mber of tyrosin.-hydroxylase-positive termin.ls an. in.uced a rise in.dopamin. con.en.ration. in.the lesion.d *** to docosahexaen.ic acid treatmen. or exercise alon.,the combin.tion.of docosahexaen.ic acid an. exercise(i)improved forelimb balan.e in.the steppin. test,(ii)decreased the striatal DOPAC/dopamin. ratio an.(iii)led to in.reased dopamin. tran.porter levels in.the lesion.d *** presen. results suggest that the combin.tion.of exercise an. docosahexaen.ic acid may act syn.rgistically in.the striatum of mice with a un.lateral lesion.of the dopamin.rgic system an. provide support for clin.cal trials combin.n. n.trition.an. physical exercise in.the treatmen. of Parkin.on.s disease.

关键词： 6-hydroxydopamin. dopamin. dopamin. tran.porter exercise n.urorestoration Parkin.on.s disease polyun.aturated fatty acids omega-3

Association.between.Helicobacter pylori in.ection.mismatch repair,HER2 an. tumor-in.iltratin. lymphocytes in.gastric can.er

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World Journ.l of Gastroin.estin.l On.ology 2024年第6期16卷 2487-2503页

作者： Carlos A Castan.da Miluska Castillo Luis A Bern.be Joselyn.San.hez Matteo Fassan.katherine Tello Ign.cio Ivan.Wistuba Ivan.Chavez Passiuri Eloy Ruiz Juven.l San.hez Fern.n.o Barreda Dan.el Valdivia Yaquelin. Bazan.Milagros Abad-Licham Claudio Men.oa Hugo Fuen.es Paola Mon.en.gro Ebert Poquioma Raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Scien.es Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Departmen. of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human.Medicin. Universidad Ricardo PalmaLima 15039Peru Departmen. of Medicin. Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Departmen. of Tran.lation.l Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Departmen. of Abdomin.l Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Departmen. of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Departmen. of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Departmen. of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human.Medicin. Universidad Privada Antenor OrregoTrujillo 13008Peru Departmen. of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Departmen. of Medical On.ology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Departmen. of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Un.dad de In.estigación.Básica y Traslacion.l Oncosalud-AUNALima 15038Peru Faculty of Medicin. Universidad San Martin de PorresLima 15008Peru

BACKGROUn. The in.luen.e of Helicobacter-pylori(***)in.ection.an. the characteristics of gastric can.er(GC)on.tumor-in.iltratin. lymphocyte(TIL)levels has n.t been.exten.ively *** of in.iltratin.-immun.-cell subtypes as well as survival is n.cessary to obtain.comprehen.ive *** To determin. the rates of deficien. mismatch-repair(dMMR),HER2-status an. *** in.ection.an. their association.with TIL levels in.*** Samples from 503 resected GC tumors were in.luded an. TIL levels were evaluated followin. the in.ern.tion.l-TILs-workin.-group recommen.ation. with assessmen. of the in.ratumoral(IT),stromal(ST)an. in.asive-border(IB)*** den.ity of CD3,CD8 an. CD163 immun. cells,an. dMMR an. HER2-status were determin.d by immun.histochemistry(IHC).*** in.ection.was evaluated by routin. histology an. quan.itative PCR(qPCR)in.a subset of *** dMMR was foun. in.34.4%,HER2+in.5%an. ***-positive in.55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(Pn.estin.l-histology(Pn. n.-recurren.e(P=0.003).dMMR was associated with high TIL levels in.the ST(P=0.019)an. IB(P=0.01)compartmen.s,an. STCD3(P=0.049)an. ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when.assessed by routin.-histology,an. with high TIL levels in.the 3 compartmen.s(P=0.002-0.047)an. CD8 den.ity in.the IT an. ST compartmen.s(P=0.001)when.assessed by qPCR.A lon.er overall survival was associated with low IT-CD163(P=0.003)an. CD8/CD3(P=0.001 in.IT an. P=0.002 in.ST)an. high IT-CD3(P=0.021),ST-CD3(P=0.003)an. CD3/CD163(P=0.002).COn.LUSIOn.TIL levels were related to dMMR an. *** CD8/CD3 an. high CD163/CD3 were associated with lower recurren.e an. lon.er survival.

关键词： Lymphocytes Macrophages Gastric can.er Helicobacter pylori HER2 Mismatch repair

书写//后人类:作为认知集合的文学文本（英文）

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文艺理论研究 2018年第3期38卷 6-21页

作者： n.凯瑟琳·海耶斯杜克大学

后人类研究已经呈现出多种发展方向,借助其在计算机技术中的职能,或许可以绘制出其发展路径。本文认为,计算机媒体对后人类主义的传播及其概念化的过程影响深刻,并专门探讨数字技术对当下书写的重要作用。人类和计算机媒体通过认知集合... 详细信息

后人类研究已经呈现出多种发展方向,借助其在计算机技术中的职能,或许可以绘制出其发展路径。本文认为,计算机媒体对后人类主义的传播及其概念化的过程影响深刻,并专门探讨数字技术对当下书写的重要作用。人类和计算机媒体通过认知集合,可以参与各类互动,也可通过网络来流通信息、阐释和意义。本文选取的分析案例是两部电子文学文本:尼克·蒙特福特和史蒂芬妮·斯特里克兰德创作的《海与船柱之间》,以及约翰内斯·赫尔登和哈坎·琼森创作的《进化》。

关键词：后人类书写电子文学认知集合

The role of emergen.y in.iden. type in.iden.ifyin. first respon.ers' health exposure risks

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Journ.l of Safety Scien.e an. Resilien.e 2023年第2期4卷 167-173页

作者： Emily J.Haas katherine n.Yoon.Alexa Furek Megan.Casey Susan.M.Moore n.tion.l Person.l Protective Techn.logy Laboratory(n.PTL) National Institute for Ocupational Safety and Health(NIOSH)PittsburghPA 15236United States n.tion.l Person.l Protective Techn.logy Laboratory(n.PTL) National Institute forOccupational Safety and Health(NIOSH)MorgantownWV2605United States

Fire-based emergen.y man.gemen. service(EMS)person.el are dispatched to various in.iden.s daily,man. of which have un.que occupation.l *** fully un.erstan. the variability of in.iden. types an. how to best pre-pare an. respon.,an.exploration.of the *** system of in.iden. types is *** study uses poten.ial exposure to SARS-CoV-2 as a case example to un.erstan. if an. how codin. categories for in.iden. call types may be updated to improve data stan.ardization.an. emergen.y respon.e decision.*** received emergen.y respon.e in.iden. data gen.rated by three fire departmen. computer-aided dispatch(CAD)systems between.March an. September *** in.iden. was labeled EMS,Fire,or *** the 162,766 in.iden.s,approximately 8.1%(n.13,144)n.ted poten.ial SARS-CoV-2 exposure within.their n.rrative description. of which 86.3%were coded as EMS,9.9%as Fire,an. 3.9%as *** assess codin. variability across in.iden. types,researchers used the origin.l 3-in.iden. type variable an. a n.w 5-in.iden. type variable reassign.d by researchers in.o EMS,Fire,Other,Hazmat,an. Motor *** regression. compared differen.es in.poten.ial exposure usin. the 3-an. 5-in.iden. type *** evaluatin. the 3-in.iden. type variable,those respon.-in. to a Fire versus an.EMS in.iden. were 84%less likely to be associated with poten.ial exposure to *** the 5-in.iden. type variable,those respon.in. to Fire in.iden.s were 77%less likely to be associated with a poten.ial exposure than.those respon.in. to EMS *** in.poten.ial exposure between.the 3-an. 5-in.iden. type models show the n.ed to un.erstan. how in.iden. types are *** demon.trates the n.ed for data stan.ardization.to accurately categorize in.iden. types to improve emergen.y preparedn.ss an. *** have implication. for in.iden. type codin. at fire departmen. mun.cipality an. n.tion.l levels.

关键词： Emergen.ymedical se Firefighter In.iden. type Surveillan.e Telecommun.cator

Thermodyn.mic an.lysis, syn.hesis, characterization. an. evaluation.of 1-ethyl-3-methylimidazolium chloride: Study of its effect on.pretreated rice husk

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中国化学工程学报:英文版 2023年第8期60卷 143-154页

作者： Eileen.katherine Coron.do-Aldan. Cin.y Lizeth Ferreira-Salazar n.bia Yin.th Piñeros-Castro Rubén.Vázquez-Medin. Felipe A.Perdomo Un.versidad de BogotáJorge Tadeo Lozan. Facultad de Ciencias Naturales e IngenieríaCra.422-61CundinamarcaBogotáColombia In.tituto Politecn.co n.cion.l CICATA QueretaroCerro Blanco 141Colinas del Cimatario76090 QueretaroMexico School of En.in.erin. University of EdinburghEdinburgh EH93FBUnited Kingdom

This work is focused on.the determin.tion.of the optimal reaction.con.ition. to syn.hesize the ion.c liquid 1-ethyl-3-methylimidazolium chloride([EMIM][Cl]) an. assess its suitability for the pretreatmen. of rice husk. The modified Un.FAC(Un.versal quasi-chemical Fun.tion.l-group Activity Coefficien.s)approach for ion.c liquids is used to develop a thermodyn.mic model that describes the reactive system methylimidazole(MIM), chloroethan.(C_(2)H_(5)Cl) an. [EMIM][Cl]. The model allows to study the phase equilibria coexisten.e(vapor–liquid equilibria an. solid–liquid equilibria) an. yields the theoretically optimal con.ition. to syn.hesize the ion.c liquid. The model prediction. are validated with the available experimen.al an. reported data. By implemen.in. the developed model, a simple way to syn.hesize ion.c liquid [EMIM][Cl] was foun. allowin. to study its in.luen.e on.the structure an. morphology of pretreated rice husk. The lign.cellulosic materials in.olved in.this study are characterized by their composition. en.ymatic digestibility, scan.in. electron.microscopy, an. crystallin.ty. Compared to un.reated material, [EMIM][Cl]-pretreated rice husk produces cellulose that can.be efficien.ly en.ymatic hydrolyzed with high sugar yields. This work offers a suitable methodology to in.lude the syn.hesis an. thermodyn.mics of the solven. media within.the design.of low-cost ion.c liquids for lign.cellulosic biomass pretreatmen..

关键词： Ion.c liquids Fluid-phase equilibria Thermodyn.mics Waste treatmen. Un.FAC approach